Increased basal phosphorylation of mitogen-activated protein kinases and reduced responsiveness to inflammatory cytokines in neutrophils from patients with rheumatoid arthritis

Clinical and Experimental Rheumatology

Volumn 26, Issue 1, 2008, Pages 52-60

  Inaba, Masaaki ^a   Takahashi, Tatsuji ^a   Kumeda, Yasuro ^a   Kato, Takayuki ^a   Hato, Fumihiko ^a   Yutani, Yasutaka ^a   Goto, Hitoshi ^a   Nishizawa, Yoshiki ^a   Kitagawa, Seiichi ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytokines; Mitogen activated protein kinases; Neutrophil; Rheumatoid arthritis

Indexed keywords

ACTARIT; ANTIRHEUMATIC AGENT; AURANOFIN; BUCILLAMINE; CYTOKINE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MIZORIBINE; NONSTEROID ANTIINFLAMMATORY AGENT; OXYGEN; PREDNISOLONE; SALAZOSULFAPYRIDINE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; APOPTOSIS; ARTICLE; BLOOD LEVEL; CELL ADHESION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; KNEE; LEUKOCYTE ACTIVATION; MALE; NEUTROPHIL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID LEVEL;

APOPTOSIS; ARTHRITIS, RHEUMATOID; CELL ADHESION; CELL SURVIVAL; CYTOKINES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; NEUTROPHIL ACTIVATION; NEUTROPHILS; OXYGEN; PHOSPHORYLATION; SYNOVIAL FLUID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 40749150668     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. FELDMANN M, BRENNAN FM, MAINI RN: Rheumatoid arthritis. Cell 1996; 85: 307-10.
2. DULARAY B, ELSON CJ, DIEPPE PA: Enhanced oxidative response of polymorphonuclear leukocytes from synovial fluids of patients with rheumatoid arthritis. Autoimmunity 1988; 1:159-69.
3. DEN BROEDER AA, WANTEN GJ, OYEN WJ, NABER T, VAN RIEL PL, BARRERA P: Neutrophil migration and production of reactive oxygen species during treatment with a fully human anti-tumor necrosis factor-α monoclonal antibody in patients with rheumatoid arthritis. J Rheumatol 2003; 30: 232-7.
4. HARTMANN P, FRANZEN C, RUBBERT A, ROGOWSKI J, KAILUS M, SALZBERGER B: Blockade of TNF does not alter oxygen burst and phagocytosis of human neutrophils in patients with rheumatoid arthritis. Immunobiology 2005; 209: 669-79.
5. CAPSONI F, SARZI-PUTTINI P, ATZENI F et al.: Effect of adalimumab on neutrophil function in patients with rheumatoid arthritis. Arthritis Res Ther 2005; 7: R250-R255.
6. XU WD, FIRESTEIN GS, TAETLE R, KAUSHANSKY K, ZVAIFLER NJ: Cytokines in chronic inflammatory arthritis: II. Granulocyte-macrophage colony stimulating factor in rheumatoid synovial effusions. J Clin Invest 1989; 83: 876-82.
7. TETTA C, CAMUSSI G, MODENA V, VITTORIO CD, BAGLIONI C: Tumor necrosis factor in serum and synovial fluid of patients with active and severe rheumatoid arthritis. Ann Rheum Dis 1990; 49: 665-7.
8. SUZUKI K, HINO M, HATO F, TATSUMI N, KITAGAWA S: Cytokine-specific activation of distinct mitogen-activated protein kinase subtype cascades in human neutrophils stimulated by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-α. Blood 1999; 93: 341-9.
9. SUZUKI K, HINO M, KUTSUNA H et al.: Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by JL-1β. J Immunol 2001; 167: 5940-7.
10. KUTSUNA H, SUZUKI K, KAMATA N et al.: Actin reorganization and morphological changes in human neutrophils stimulated by TNF, GM-CSF and G-CSF: Role of mitogen-activated protein kinases. Am J Physiol Cell Physiol 2004; 286: C55-C64.
11. NAKAMAE-AKAHORI M, KATO T, MASUDA S et al.: Enhanced neutrophil motility by granulocyte colony-stimulating factor: The role of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. Immunology 2006; 119: 393-403.
12. ARNETT FC, EDWORTHY SM, BLOCH DA et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
13. LOWRY OH, ROSEBROUGH NJ, FARR AL, RANDALL RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
14. SUZUKI K, HASEGAWA T, SAKAMOTO C et al.: Cleavage of mitogen-activated protein kinases in human neutrophils undergoing apoptosis: Role in decreased responsiveness to inflammatory cytokines. J Immunol 2001; 166: 1185-92.
15. SAKAMOTO C, SUZUKI K, HATO F et al.: Antiapoptotic effect of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and cyclic AMP on human neutrophils: Protein synthesis-dependent and protein synthesis-independent mechanisms and the role of the Janus kinase-STAT pathway. Int J Hematol 2003; 77: 60-70.
16. HASEGAWA T, SUZUKI K, SAKAMOTO C et al.: Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia. Blood 2003; 101: 1164-71.
17. SAKAMOTO E, HATO F, KATO T et al.: Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2. J Leukoc Biol 2005; 78: 301-9.
18. KETTRITZ R, GAIDO ML, HALLER H, LUFT FC, JENNETTE CJ, FALK RJ: Interleukin-8 delays spontaneous and tumor necrosis factor-α-mediated apoptosis of human neutrophils. Kidney Int 1998; 53: 84-91.
19. DAIN L, BRAUN-MOSCOVICI Y, BAUM E, NAHIR AM, HOFFER E: Modification of neutrophil function by plasma of rheumatoid arthritis patients treated with infliximab. Clin Exp Rheumatol 2006; 24: 38-44.
20. DORAN MF, CROWSON CS, POND GR, O'FALLON WM, GABRIEL SE: Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheum 2002; 46: 2287-93.
21. VOLLMER KL, ALBERTS JS, CARPER HT, MANDELL GL: Tumor necrosis factor-α decreases neutrophil chemotaxis to N-formyl-L-methionyl-L-leucyl-L- phenylalanine: Analysis of single cell movement. J Leukoc Biol 1992; 52: 630-6.
22. BINDER R, KRESS A, KAN G, HERRMANN K, KIRSCHFINK M: Neutrophil priming by cytokines and vitamin D binding protein (Gc-globulin): Impact on C5a-mediated chemotaxis, degranulation and respiratory burst. Mol Immunol 1999; 36: 885-92.
23. TAKAHASHI T, HATO F, YAMANE T et al.: Activation of human neutrophil by cytokine-activated endothelial cells. Circ Res 2001; 88: 422-9.
24. ABRAHAM E: Neutrophils and acute lung injury. Crit Care Med 2003; 31: S195-S199.
25. SOLOMON DH, KARLSON EW, RIMM EB et al.: Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation 2003; 107: 1303-7.
26. SOLOMON DH, CURHAN GC, RIMM EB, CANNUSCIO CC, KARLSON EW: Cardiovascular risk factors in women with and without rheumatoid arthritis. Arthritis Rheum 2004; 50: 3444-9.
27. WOLFE F, FREUNDLICH B, STRAUS WL: Increase in cardiovascular and cerebrovascular disease prevalence in rheumatoid arthritis. J Rheumatol 2003; 30: 36-40.
28. DESSEIN PH, JOFFE BI, VELLER MG et al.: Traditional and nontraditional cardiovascular risk factors are associated with atherosclerosis in rheumatoid arthritis. J Rheumatol 2005; 32: 435-42.
29. HAN C, ROBINSON DW JR. HACKEIT MV, PARAMORE LC, FRAEMAN KH, BALA MV: Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. J Rheumatol 2006; 33: 2167-72.
30. KUMEDA Y, INABA M, GOTO H et al.: Increased thickness of the arterial intima-media detected by ultrasonography in patients with rheumatoid arthritis. Arthritis Rheum 2002; 46: 1489-97.
31. CAMPS M, RUCKLE T, JI H et al.: Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 2005; 11: 936-43.
32. KAMATA N, KUTSUNA H, HATO F et al.: Activation of human neutrophils by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-α: The role of phosphatidylinositol 3-kinase. Int J Hematol 2004; 80: 421-7.
33. JEFFREY KL, BRUMMER T, ROLPH MS et al.: Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. Nat Immunol 2006; 7: 274-83.
34. NISHIKI S, HATO F, KAMATA N et al.: Selective activation of STAT3 in human monocytes stimulated by G-CSF: Implication in inhibition of LPS-induced TNF-α production. Am J Physiol Cell Physiol 2004; 286: C1302-C1311.