Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair

Oncotarget

Volumn 5, Issue 17, 2014, Pages 7512-7524

  Lv, Peng ^a,b   Wang, Yue ^c   Ma, Jie ^a   Wang, Zheng ^a   Li, Jing Li ^c   Hong, Christopher S ^d   Zhuang, Zhengping ^d   Zeng, Yi Xin ^a,e  

^a CANCER HOSPITAL   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL   (China)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^e SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

LB100; Nasopharyngeal carcinoma; Protein phosphatase 2A; Radiosensitization

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE 1; LB 100; PHOSPHOPROTEIN PHOSPHATASE 2A; POLO LIKE KINASE 1; PROTEIN P53; UNCLASSIFIED DRUG; PHOSPHOPROTEIN PHOSPHATASE 2; PPP2CA PROTEIN, HUMAN; RADIOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CANCER RADIOTHERAPY; CANCER REGRESSION; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EXPOSURE; DRUG SCREENING; ENZYME INHIBITION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IONIZING RADIATION; MALE; MITOSIS; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; RADIATION DOSE REDUCTION; RADIOSENSITIZATION; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOBLOTTING; NASOPHARYNX TUMOR; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DNA REPAIR; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOBLOTTING; MICE; MICE, INBRED BALB C; MITOSIS; NASOPHARYNGEAL NEOPLASMS; PROTEIN PHOSPHATASE 2; RADIATION-SENSITIZING AGENTS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84907485878     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2258     Document Type: Article

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