Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition

Cancer Research

Volumn 72, Issue 24, 2012, Pages 6414-6424

  Kalev, Peter ^a   Simicek, Michal ^a   Vazquez, Iria ^a   Munck, Sebastian ^a   Chen, Liping ^b   Soin, Thomas ^a   Danda, Natasha ^a   Chen, Wen ^b   Sablina, Anna ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BRCA1 PROTEIN; CHECKPOINT KINASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PHOSPHOPROTEIN PHOSPHATASE 2A; PPP2R2A PROTEIN; RAD51 PROTEIN; SERINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; COMPLEX FORMATION; DISEASE MARKER; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; DRUG SENSITIVITY; DRUG SENSITIZATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DEPLETION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RECOMBINATION REPAIR; S PHASE CELL CYCLE CHECKPOINT; TUMOR SENSITIVITY; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOMARKERS, PHARMACOLOGICAL; CARCINOMA, NON-SMALL-CELL LUNG; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; GENE DELETION; HUMANS; LUNG NEOPLASMS; MICE; NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; PROGNOSIS; PROTEIN PHOSPHATASE 2; RECOMBINATIONAL DNA REPAIR; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84871198111     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-1667     Document Type: Article

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