Nasopharyngeal Carcinoma Treated With Reduced-Volume Intensity-Modulated Radiation Therapy: Report on the 3-Year Outcome of a Prospective Series

International Journal of Radiation Oncology Biology Physics

Volumn 75, Issue 4, 2009, Pages 1071-1078

  Lin, Shaojun ^a   Pan, Jianji ^a   Han, Lu ^a   Zhang, Xiuchun ^a   Liao, Xiyi ^a   Lu, Jiade J ^b,c  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^c FUDAN UNIVERSITY   (China)

Author keywords

Chemoradiation; IMRT; Intensity modulated radiation therapy; Nasopharyngeal carcinoma; Radiotherapy

Indexed keywords

AFTER-TREATMENT; CHEMORADIATION; CIS-PLATIN; CLINICAL TARGET VOLUMES; DISEASE FREE SURVIVAL; GROSS TUMOR VOLUME; INTENSITY MODULATED RADIATION THERAPY; INTENSITY-MODULATED RADIOTHERAPY; LOCAL CONTROL; LYMPH NODE; MULTI VARIATE ANALYSIS; NASOPHARYNGEAL CARCINOMA; OVERALL SURVIVAL; PREDICTIVE VALUES; RADIATION THERAPY ONCOLOGY GROUPS; TARGET VOLUMES; XEROSTOMIA;

CHEMOTHERAPY; DISEASE CONTROL; FLUORINE CONTAINING POLYMERS; MULTIVARIANT ANALYSIS; PATHOLOGY; PHYSICAL THERAPY; PLATINUM COMPOUNDS; RISK PERCEPTION; TOXICITY; TUMORS;

RADIOTHERAPY;

CISPLATIN; PACLITAXEL;

ACUTE TOXICITY; ADJUVANT THERAPY; ADULT; ADVANCED CANCER; ARTICLE; CANCER CLASSIFICATION; CANCER CONTROL; CANCER STAGING; CERVICAL LYMPH NODE; CHRONIC TOXICITY; CLINICAL PROTOCOL; CLINICAL TARGET VOLUME; CONSENSUS; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FEMALE; FOLLOW UP; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LEUKOPENIA; LOCAL METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MINIMAL RESIDUAL DISEASE; MUCOSA; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; MULTIVARIATE ANALYSIS; NASOPHARYNX CARCINOMA; OVERALL SURVIVAL; PREDICTION AND FORECASTING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; RADIATION INJURY; REGIONAL METASTASIS; RISK ASSESSMENT; SKIN EXFOLIATION; SURVIVAL RATE; TREATMENT OUTCOME; TUMOR VOLUME; XEROSTOMIA; COMPUTER ASSISTED RADIOTHERAPY; METHODOLOGY; MIDDLE AGED; MORTALITY; NASOPHARYNX TUMOR; PATHOLOGY;

DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NASOPHARYNGEAL NEOPLASMS; NEOPLASM STAGING; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, INTENSITY-MODULATED; TUMOR BURDEN;

EID: 70350613966     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.12.015     Document Type: Article

References (24)

1. Kwong D.L., Pow E.H., Sham J.S., et al. Intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: A prospective study on disease control and preservation of salivary function. Cancer 101 (2004) 1584-1593
2. Lee N., Xia P., Quivey J.M., et al. Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: An update of the UCSF experience. Int J Radiat Oncol Biol Phys 53 (2002) 12-22
3. Kam M.K., Teo P.M., Chau R.M., et al. Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: The Hong Kong experience. Int J Radiat Oncol Biol Phys 60 (2004) 1440-1450
4. Chau R.M., Teo P.M., Choi P.H., et al. Three-dimensional dosimetric evaluation of a conventional radiotherapy technique for treatment of nasopharyngeal carcinoma. Radiother Oncol 58 (2001) 143-153
5. Chau R.M., Teo P.M., Kam M.K., et al. Dosimetric comparison between 2-dimensional radiation therapy and intensity modulated radiation therapy in treatment of advanced T-stage nasopharyngeal carcinoma: To treat less or more in the planning organ-at-risk volume of the brainstem and spinal cord. Med Dosim 32 (2007) 263-270
6. Dawson L.A., Anzai Y., Marsh L., et al. Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys 46 (2000) 1117-1126
7. Hall E.J., and Wuu C.S. Radiation-induced second cancers: The impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys 56 (2003) 83-88
8. th ed (1997), Lippincott-Raven, Philadelphia
9. Gregoire V, Levendag P, Ang KK, et al. Guidelines for CT-based delineation of lymph node levels in the N0 neck. Available at: http://www.rtog.org/hnatlas/main.html. Accessed August 26, 2008.
10. Radiation Therapy Oncology Group Protocol 02-25. Available at: http://www.rtog.org/members/protocols/0225/0225.pdf. Accessed August 26, 2008.
11. Radiation Therapy Oncology Group Protocol 06-15. Available at: http://www.rtog.org/members/protocols/0615/0615.pdf. Accessed August 26, 2008.
12. Xia P., Fu K.K., Wong G.W., et al. Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 48 (2000) 329-337
13. Cox J.D., Stetz J., and Pajak T.F. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31 (1995) 1341-1346
14. Kaplan E.L., and Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 53 (1958) 457-481
15. Kong L., Lu J.J., Hu C., et al. The risk of second primary tumors in patients with nasopharyngeal carcinoma after definitive radiotherapy. Cancer 107 (2006) 1287-1293
16. Al-Sarraf M., LeBlanc M., Giri P.G., et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized Intergroup study 0099. J Clin Oncol 16 (1998) 1310-1317
17. Chan A.T., Teo P.M., Ngan R.K., et al. Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: Progression-free survival analysis of a phase III randomized trial. J Clin Oncol 20 (2002) 2038-2044
18. Wee J., Tan E.H., Tai B.C., et al. Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncol 23 (2005) 6730-6738
19. Wolden S.L., Chen W.C., Pfister D.G., et al. Intensity-modulated radiation therapy (IMRT) for nasopharynx cancer: Update of the Memorial Sloan-Kettering experience. Int J Radiat Oncol Biol Phys 64 (2006) 57-62
20. Sanguineti G., Geara F., Garden A., et al. Carcinoma of the nasopharynx treated by radiotherapy alone: Determinants of local and regional control. Int J Radiat Oncol Biol Phys 37 (1997) 985-996
21. Vikram B., Mishra U.B., Strong E.W., et al. Patterns of failure in carcinoma of the nasopharynx: I. Failure at the primary site. Int J Radiat Oncol Biol Phys 11 (1985) 1455-1459
22. Bedwinek J.M., Perez C.A., and Keys D.J. Analysis of failures after definitive irradiation for epidermoid carcinoma of the nasopharynx. Cancer 45 (1980) 2725-2729
23. Yang T.S., Ng K.T., Wang H.M., et al. Prognostic factors of locoregionally recurrent nasopharyngeal carcinoma-a retrospective review of 182 cases. Am J Clin Oncol 19 (1996) 337-343
24. Ma X., Lu J.J., Loh K.S., et al. Role of computed tomography imaging in predicting response of nasopharyngeal carcinoma to definitive radiation therapy. Laryngoscope 116 (2006) 2162-2165