The repair of gamma-radiation-induced DNA damage is inhibited by microcystin-LR, the PP1 and PP2A phosphatase inhibitor

Mutagenesis

Volumn 21, Issue 1, 2006, Pages 83-90

  Lankoff, A ^a   Bialczyk, J ^b   Dziga, D ^b   Carmichael, W W ^c   Gradzka, I ^d   Lisowska, H ^a   Kuszewski, T ^e   Gozdz, S ^e   Piorun, I ^a   Wojcik, A ^a,d  

^a JAN KOCHANOWSKI UNIVERSITY   (Poland)

^b JAGIELLONIAN UNIVERSITY   (Poland)

^c WRIGHT STATE UNIVERSITY   (United States)

^d INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY   (Poland)

^e Swietokrzyskie Centrum Onkologii Poland   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOGINOSIN LR; DNA; ESTERASE INHIBITOR; PHOSPHATASE;

APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; COMET ASSAY; CONTROLLED STUDY; DICENTRIC CHROMOSOME; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; GAMMA RADIATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IONIZING RADIATION; IRRADIATION; KINETICS; LYMPHOCYTE; PRIORITY JOURNAL; RADIATION DOSE; TIME; TUMOR CELL LINE;

APOPTOSIS; CHROMOSOME ABERRATIONS; COMET ASSAY; DNA DAMAGE; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; ENZYME INHIBITORS; FLOW CYTOMETRY; G0 PHASE; GAMMA RAYS; GLIOBLASTOMA; HISTONES; HUMANS; KINETICS; LYMPHOCYTES; MARINE TOXINS; MICROCYSTINS; PEPTIDES, CYCLIC; PHOSPHOPROTEIN PHOSPHATASE; RECEPTORS, NEUROPEPTIDE Y;

EID: 33344456947     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/gel002     Document Type: Article

References (46)

1. Carmichael,W.W. (2001) Health effects of toxin-producing cyanobacteria. Hum. Ecol. Risk Asses., 7, 1393-1407.
2. Nishiwaki-Matsushima,R., Ohta,T., Nishiwaki,S., Suganuma,M., Kohyama,K., Ishikawa,T. and Carmichael,W.W. (1992) Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. J. Cancer Res. Clin. Oncol., 118, 420-424.
3. Ueno,Y., Nagata,S. and Tsutsumi,T. (1996) Detection of microcystin a blue-green algae in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis, 96, 1317-1321.
4. Falconer,I.R. and Humpage,A.R. (2001) Preliminary evidence for in vivo tumor initiation by oral administration of extracts of the blue-green alga Cylindrospermopsis raciborskii containing the toxin cylindrospermopsin. Environ. Toxicol., 2, 192-195.
5. Ito,E., Kondo,F., Terao,K. and Harada,K.-I. (1997) Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injections of microcystin-LR. Toxicon., 35, 1453-1457.
6. Carmichael,W.W. (1992) Cyanobacteria secondary metabolites. The cyanotoxins. J. Appl. Bacterial., 72, 445-459.
7. MacKintosh,C., Beattie,K.A., Klumpps,S., Kohen,P. and Codd,G.A. (1990) Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett., 264, 189-192.
8. Ohta,T., Sueoka,E., Iida,N., Komori,A., Saganuma,M., Nishiwaki,R., Tatematsu,M., Kim,S.J., Carmichael,W.W. and Fujiki,H. (1994) Nodularin. A potent inhibitor of protein phosphatases 1 and 2A is a new environmental carcinogen in male F 344 rat liver. Cancer Res., 54, 6402-6406.
9. Ding,W.X., Shen,H.M. ,Zhu,H.G., Lee,B.L. and Ong,C.N. (1999) Genotoxicity of microcystic cyanobacteria extract of a water source in China. Mutat. Res., 442, 69-74.
10. Mankiewicz,J., Walter,Z., Tarczynska,M., Palyvoda,O., Wojtysiak-Staniaszczyk,M. and Zalewski,M. (2002) Genotoxicity of cyanobacterial extracts containing microcystins from Polish water reservoirs as determined by SOS chromotest and comet assay. Environ. Toxicol., 17, 341-350.
11. Zhan,L, Sakamoto,H, Sakuraba,M, Wude,S., Zhang,L.S., Suzuki,T., Hayashi,M. and Honma,M (2004) Genotoxicity of microcystin-LR in human lymphoblastoid TK6 cells. Mutat. Res., 557, 1-6.
12. Rao,P.V.L., Bhattacharya,R., Parida,M.M., Jana,A.M. and Bhaskar,A.S.B. (1998) Freshwater cyanobacterium Microcystis aeruginosa (UTEX 2385) induced DNA damage in vivo and in vitro. Environ. Toxicol. Pharmacol., 5, 1-6.
13. Žegura,B., Sedmak,B. and Filipic,M. (2003) Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2. Toxicon., 41, 41-48.
14. Repavich,W.M., Sonzogoni,W.C., Standridge,J.H., Wedepohl,R.E. and Meisner,L.F. (1990) Cyanobacteria (blue-green algae) in Wisconsin waters: acute and chronic toxicity. Water Res., 24, 225-231.
15. Grabow,W.O.K., Du Randt,W.C., Prozesky,O.W. and Scott,W.E. (1982) Microcystis aeruginosa toxins: cell culturotoxicity, hemolysis and mutagenicity assays. Appl. Environ. Microbiol., 43, 1425-1433.
16. Lankoff,A., Banasik,A., Obe,G., Deperas,M., Kuźmiński,K., Tarczyńska,M., Jurczak,T. and Wójcik,A. (2003) Effect of microcystin-LR and cyanobacterial extract from Polish reservoir of drinking water on cell cycle progression, mitotic spindle and apoptosis in CHO-K1 cells. Toxicol. Appl. Pharmacol., 189, 204-213.
17. Lankoff,A., Krzowski,L., Glab,J., Banasik,A., Lisowska,H., Kuszewski,T., Gozdz,S. and Wojcik,A. (2004) DNA damage and repair in human peripheral blood lymphocytes following treatment with microcystin-LR. Mutat. Res., 559, 131-142.
18. Douglas,P., Moorhead,G.B.G., Ye,R. and Lees-Millers,S.P. (2001) Protein phosphatases regulate DNA-dependent protein kinase activity. J. Biol. Chem., 22, 18992-18998.
19. Gajdek,P., Lechowski,Z., Bochnia,T. and Kȩpczyński,M. (2001) Decomposition of microcystin-LR by Fenton oxidation. Toxicon., 39, 1575-1578.
20. Gajdek,P., Lechowski,Z., Dziga,D. and Bralczyk,J. (2003) Detoxofication of microcystin-LR using Fenton reagent. Fresen. Environ. Bull., 12, 1258-1262.
21. Lawton,L.A, Edwards,C. and Codd,G.A. (1994) Extraction and high performance liquid chromatographic methods for the determination of microcystins in raw and treated water. Analyst, 119, 1525-1530.
22. Darzynkiewicz,Z. (2003) Current protocols in Cell Biology. John Wiley & Sons, Inc.
23. Singh,N.P., Tice,R.R., Stephens,R.E. and Schneider,E.L. (1991) A microgel electrophoresis technique for the direct quantification of DNA damage and repair in individual fibroblasts cultured on microscope slides. Mutat. Res., 252, 289-296.
24. Konca,K., Lankoff,A., Banasik,A., Lisowska,H., Kuszewski,T., Gozdz,S., Koza,Z. and Wojcik,A. (2003) A cross platform public domain PC image analysis program for the comet assay. Mutat. Res., 534, 15-20.
25. Perry,P. and Wolff,S. (1974) New Giemsa method for the differential staining of sister chromatids. Nature, 251, 156-158.
26. Savage,J.R.K. (1975) Classification and relationships of induced chromosomal structural changes. J. Med. Genet., 12, 103-122.
27. Lavin,M.F., Birrell,G., Chen,P., Kozlov,S., Scott,S. and Gueven,N. (2005) ATM signaling and genomic stability in response to DNA damage. Mutat. Res., 569, 123-132.
28. Hartmann,A, Schumacher,M., Plappert-Helbig,U., Lowe,P., Suter,W. and Mueller,L. (2004) Use of the alkaline in vivo Comet assay for mechanistic genotoxicity investigations, Mutagenesis, 19, 51-59.
29. Choucroun,P., Gillet,D., Dorange,G., Sawicki,B. and Dewitte,J.D. (2001) Comet assay and early apoptosis. Mutat. Res., 478, 89-96.
30. Lankoff,A., Carmichael,W.W., Grasman,K.A. and Yuan,M. (2004) The uptake kinetics and immunotoxic effects of microcystin-LR in human and chicken peripheral blood lymphocytes in vitro. Toxicology, 204, 23-40.
31. Engeland,M., Nieland,L.J.W., Ramaekers,F.C.S., Schutte,B. and Reutelingsperger,C.P.M. (1998) Annexin V-affinity assay. A review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry, 31, 1-9.
32. Olive,P.L., Banath,J.P. and Durand,R.E. (1990) Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. Radiat. Res., 122, 86-94.
33. Khanna,K.K. and Jackson,S.P. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet., 27, 247-254.
34. Blaise,R., Alapetite,C., Masdehors,P., Marle-Beral,C., Roulin,C., Delic,J. and Sabatier,L. (2002) High levels of chromosome aberrations correlate with impaired in vitro radiation-induced apoptosis and DNA repair in human B-chronic lymphocytic leukaemia cells. Int. J. Radiat. Biol., 78, 671-679.
35. Sachs,R.K., Hlatky,L.R. and Trask,B.J. (2000) Radiation-produced chromosome aberrations-colourful clues. Trends Genet., 16, 143-146.
36. Pfeiffer,P., Goedecke,W. and Obe,G. (2000) Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis, 4, 289-302.
37. Rogakou,E.P., Pilch,D.R., Orr,A.H., Ivanova, V.S. and Bonner,W. (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem., 273, 5858-5868.
38. Fernandez-Capetillo,O., Lee,A., Nussenzweig,M. and Nussenzweig,A. (2004) H2AX: the histone guardian of the genome. DNA Repair, 3, 959-967.
39. Kaczmarek,L., Calabretta,B., Elfenbein,I.B. and Mercer,W.E. (1987) Cell cycle analysis of human peripheral blood T lymphocytes in long-term culture. Exp. Cell Res., 173, 70-79.
40. Karran,P. (2000) DNA double strand break repair in mammalian cells. Curr. Opin. Genet Dev., 10, 144-150.
41. Dawson,R.M. (1998) The toxicology of microcystins. Toxicon., 36, 953-1063.
42. Borthwick,E.B., Zeke,T., Prescott,A.R. and Cohen,P.T.W. (2001) Nuclear localization of protein phosphatase 5 is dependent on the carboxy-terminal region. FEBS Lett., 491, 279-284.
43. Falconer,I.R. (2005) Microcystin and phosphatase Inhibition. In Falconer,I.R. (eds), Cyanobacterial Toxins of Drinking Water Supplies. CRC Press, Washington, pp. 121-123.
44. Wechsler,T., Chen,B.C.C., Harpen,R., Morotomi-Yano,K., Huang,B.C.B., Meek,K., Cleaver,J.E., Chen,D.J. and Wabl,M. (2004) DNA-PKcs function regulated specifically by protein phosphatase 5. Proc. Natl Acad. Sci. USA, 101, 1247-1252.
45. Douglas,P., Sapkota,G.P., Morrice,N., Yu,Y., Goodarzi,A.A., Merkle,D., Meek,K., Alessi,D.R. and Lees-Miller,S.P. (2002) Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem. J., 368, 243-251.
46. Lees-Miller,S.P., Godbout,R., Chan,D.W., Weinfeld,M., Day,R.S.III, Barron,G.M. and Allalunis-Turner,J. (1995) Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science, 267, 1183-1185.