Differential down-regulation of β3-adrenergic receptor mRNA and signal transduction by cold exposure in brown adipose tissue of young and senescent rats

Pflugers Archiv European Journal of Physiology

Volumn 437, Issue 3, 1999, Pages 479-483

  Scarpace, Philip J ^a,b   Matheny, Michael ^a,b   Tümer, Nihal ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

3 Adrenergic receptors; 3 Receptor mRNA; Adenylyl cyclase; BRL 37344

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; CATECHOLAMINE RELEASE; COLD EXPOSURE; CONTROLLED STUDY; ENZYME ACTIVITY; MESSENGER RNA SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; THERMOGENESIS; THERMOREGULATION;

ADENYLATE CYCLASE; ADIPOSE TISSUE, BROWN; ADRENERGIC BETA-AGONISTS; AGING; ANIMALS; COLD; ETHANOLAMINES; FORSKOLIN; GENE EXPRESSION REGULATION; MALE; RATS; RATS, INBRED F344; RECEPTORS, ADRENERGIC, BETA; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 0032961616     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050804     Document Type: Article

References (19)

1. 1. Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
2. 2. Cannon B, Bengtsson T, Dicker A, Jacobsson A, Kuusela P, Thonberg H, Tvrdik P, Zhao J, Nedergaard J (1994) The role of adrenergic stimulation in regulation of heat production and recruitment of brown adipose tissue. In: Zeisberger E, Schönbaum E, Lomax P (eds) Thermal balance in health and disease. Recent basic research and clinical progress. Birkhäuser, Berlin, pp 87-102
3. 3. De Lean A, Hancock AA, Lefkowitz RJ (1982) Validation and statistical analysis of a computer modeling method for qualitative analysis of radioligand binding for mixtures of pharmacological receptor subtypes. Mol Pharmacol 21:5-16
4. 3-adrenoreceptor messenger ribonucleic acids in adipose tissues. Endocrinology 130:109-114
5. 5. Himms-Hagen J (1990) Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB J 4:2890-2898
6. 6. McDonald RB, Horwitz BA, Hamilton JS, Stern JS (1988) Cold-and norepinephrine-induced thermogenesis in younger and older Fischer 344 rats. Am J Physiol 254: R457-R462
7. 7. McDonald RB, Stern JS, Horwitz BA (1989) Thermogenic responses of younger and older rats to cold exposure: comparison of two strains. J Gerontol 44:B37-B42
8. 8. Scarpace PJ, Abrass IB (1982) Desensitization of adenylate cyclase and down regulation of beta-adrenergic receptors following in vivo administration of beta-agonist. J Pharmacol Exp Ther 223:327-331
9. 9. Scarpace PJ, Matheny M (1996) Thermogenesis in brown adipose tissue with age: Post-receptor activation by forskolin. Pflügers Arch 431:388-394
10. 10. Scarpace PJ, Baresi LA, Morley JE (1987) Modulation of receptors and adenylate cyclase activity during sucrose feeding, food deprivation, and cold exposure. Am J Physiol 253:E629-E635
11. 11. Scarpace PJ, Mooradian AD, Morley JE (1988) Age-associated decrease in beta-adrenergic receptors and adenylate cyclase activity in rat brown adipose tissue. J Gerontol 43:B65-B70
12. 12. Scarpace PJ, Matheny M, Borst SE (1992) Thermogenesis and mitochondrial GDP binding with age in response to the novel agonist CGP-12177A. Am J Physiol 262:E185-E190
13. 13. Scarpace PJ, Matheny M, Borst, SE, Tümer N (1994) Thermoregulation with age: role of thermogenesis and uncoupling protein expression in brown adipose tissue. Proc Soc Exp Biol Med 205:154-161
14. 14. Scarpace PJ, Matheny M, Tümer NS (1996) Myocardial adenylyl cyclase type V and VI mRNA: differential regulation with age. J Cardiovasc Pharmacol 27:86-90
15. 15. Scarpace, PJ, Dove J, Matheny M (1996) Effect of age on β-adrenergic subtype activation of adenylyl cyclase in brown adipose tissue. Proc Soc Exp Biol Med 213: 262-267
16. 3-adrenergic responsiveness in brown adipose tissue by cold acclimation. Proc Soc Exp Biol Med 211: 374-380
17. 17. Svoboda P, Unelius L, Cannon B, Nedergaard J (1993) Attenuation of Gsα coupling efficiency in brown-adipose-tissue plasma membranes from cold-acclimated hamsters. Biochem J 295: 655-661
18. 3-adrenoceptor-generated cAMP in brown fat cells. J Biochem 272:32847-32856
19. 19. Zhao J, Unelius L, Bengtsson T, Cannon B, Nedergaard J (1994) Coexisting β-adrenoceptor subtypes: significance for thermogenic process in brown fat cells. Am J Physiol 267:C969-C979