Oxidative stress-mediated aging during the fetal and perinatal periods

Oxidative Medicine and Cellular Longevity

Volumn 2014, Issue , 2014, Pages

  Marseglia, Lucia ^a   D'Angelo, Gabriella ^a   Manti, Sara ^a   Arrigo, Teresa ^a   Barberi, Ignazio ^a   Reiter, Russel J ^b   Gitto, Eloisa ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; FREE RADICALS; OBSTETRICS;

ANTIOXIDANT SYSTEMS; FREE RADICAL GENERATION; FREE-RADICAL DAMAGE; FUNDAMENTAL COMPONENT; PERIVENTRICULAR LEUKOMALACIA; PREMATURE RUPTURE OF MEMBRANES; RECURRENT PREGNANCY LOSS; RETINOPATHY OF PREMATURITY;

OXIDATIVE STRESS;

AGING; HUMAN; NEWBORN DISEASE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PERINATAL PERIOD; PREGNANCY; PREGNANCY DISORDER; PRENATAL PERIOD; REVIEW; FEMALE; METABOLISM; NEWBORN; PATHOLOGY;

REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

AGING; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; OXIDATIVE STRESS; PERIPARTUM PERIOD; PREGNANCY; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES;

EID: 84907389787     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2014/358375     Document Type: Review

References (114)

1. D. D. Haines, B. Juhasz, and A. Tosaki, "Management of multicellular senescence and oxidative stress," Journal of Cellular and Molecular Medicine, vol. 17, no. 8, pp. 936-957, 2013.
2. S. Rodríguez-Rodero, J. L. Fernández-Morera, E. Menéndez-Torre et al., "Aging genetics and aging," Aging and Disease, vol. 2, pp. 186-195, 2011.
3. P. X. Shaw, G. Werstuck, and Y. Chen, "Editorial oxidative stress and aging diseases," Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID569146, 2 pages, 2014.
4. A. Brunet and S. L. Berger, "Epigenetics of aging and aging-related disease," The Journals of Gerontology A: Biological Sciences and Medical Sciences, vol. 1, pp. S17-S20, 2014.
5. Z. A. Medvedev, "An attempt at a rational classification of theories of ageing," Biological Reviews of the Cambridge Philosophical Society, vol. 65, no. 3, pp. 375-398, 1990.
6. M. de la Fuente, "Effects of antioxidants on immune system ageing," European Journal of Clinical Nutrition, vol. 56, pp. S5-S8, 2002.
7. L. W. S. Finley and M. C. Haigis, "The coordination of nuclear and mitochondrial communication during aging and calorie restriction," Ageing Research Reviews, vol. 8, no. 3, pp. 173-188, 2009.
8. M. Ristow, K. Zarse, A. Oberbach et al., "Antioxidants prevent health-promoting effects of physical exercise in humans," Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 21, pp. 8665-8670, 2009.
9. E. J. Calabrese, K. A. Bachmann, A. J. Bailer et al., "Biological stress response terminology: integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework," Toxicology and Applied Pharmacology, vol. 222, no. 1, pp. 122-128, 2007.
10. M. Ristow and K. Zarse, "How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis)," Experimental Gerontology, vol. 45, no. 6, pp. 410-418, 2010.
11. G. Bjelakovic, D. Nikolova, L. L. Gluud, R. G. Simonetti, and C. Gluud, "Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis," The Journal of the American Medical Association, vol. 297, no. 8, pp. 842-857, 2007.
12. K. Hensley, K. A. Robinson, S. P. Gabbita, S. Salsman, and R. A. Floyd, "Reactive oxygen species, cell signaling, and cell injury," Free Radical Biology and Medicine, vol. 28, no. 10, pp. 1456-1462, 2000.
13. C. W. G. Redman and I. L. Sargent, "Pre-eclampsia, the placenta and the maternal systemic inflammatory response - a review," Placenta, vol. 24, pp. S21-S27, 2003.
14. R. M. Lewis, J. K. Cleal, and M. A. Hanson, "Review: placenta, evolution and lifelong health," Placenta, vol. 33, pp. S28-S32, 2012.
15. Ü. Mutlu-Türkoʇlu, E. Ademoʇlu, L. Ibrahimoʇlu, G. Ayka¸-Toker, and M. Uysal, "Imbalance between lipid peroxidation and antioxidant status in preeclampsia," Gynecologic and Obstetric Investigation, vol. 46, no. 1, pp. 37-40, 1998.
16. G. J. Burton and E. Jauniaux, "Oxidative stress," Best Practice & Research Clinical Obstetrics&Gynaecology, vol. 25, pp. 287-299, 2011.
17. M. Klingler, H. Demmelmair, E. Larque, and B. Koletzko, "Analysis of FA contents in individual lipid fractions from human placental tissue," Lipids, vol. 38, no. 5, pp. 561-566, 2003.
18. J. M. Morris, N. K. Gopaul, M. J. R. Endresen et al., "Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia," British Journal of Obstetrics and Gynaecology, vol. 105, no. 11, pp. 1195-1199, 1998.
19. R. E. Little and B. C. Gladen, "Levels of lipid peroxides in uncomplicated pregnancy: a review of the literature," Reproductive Toxicology, vol. 13, no. 5, pp. 347-352, 1999.
20. O. D. Saugstad, "Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease," Acta Paediatrica, International Journal of Paediatrics, vol. 85, no. 1, pp. 1-4, 1996.
21. A. H. Sarker, S. Watanabe, S. Seki, T. Akiyama, and S. Okada, "Oxygen radical-induced single-strand DNA breaks and repair of the damage in a cell-free system," Mutation Research, vol. 337, no. 2, pp. 85-95, 1995.
22. E. Jauniaux, L. Poston, and G. J. Burton, "Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution," Human Reproduction Update, vol. 12, no. 6, pp. 747-755, 2006.
23. Y. Li, P. Gonzalez, and L. Zhang, "Fetal stress and programming of hypoxic/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions," Progress in Neurobiology, vol. 98, no. 2, pp. 145-165, 2012.
24. D. A. Giussani, E. J. Camm, Y. Niu et al., "Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress," PLoS ONE, vol. 7, no. 2, Article ID e31017, 2012.
25. P. Casanello, D. Schneider, E. A. Herrera, R. Uauy, and B. J. Krause, "Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity," Frontiers in Pharmacology, vol. 5, article 49, 2014.
26. G. D. Georgeson, B. J. Szony, K. Streitman et al., "Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section," European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 103, no. 2, pp. 136-139, 2002.
27. J. W. Lee and J. M. Davis, "Future applications of antioxidants in premature infants," Current Opinion in Pediatrics, vol. 23, no. 2, pp. 161-166, 2011.
28. O. D. Saugstad, "Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production," Pediatric Research, vol. 23, no. 2, pp. 143-150, 1988.
29. L. Myatt and X. Cui, "Oxidative stress in the placenta," Histochemistry and Cell Biology, vol. 122, no. 4, pp. 369-382, 2004.
30. S. W. Walsh and Y. Wang, "Secretion of lipid peroxides by the human placenta," American Journal of Obstetrics and Gynecology, vol. 169, no. 6, pp. 1462-1466, 1993.
31. C. A. Hubel, "Oxidative stress in the pathogenesis of preeclampsia," Proceedings of the Society for Experimental Biology and Medicine, vol. 222, no. 3, pp. 222-235, 1999.
32. L. Poston and M. T. M. Raijmakers, "Trophoblast oxidative stress, antioxidants and pregnancy outcome - a review," Placenta, vol. 25, pp. S72-S78, 2004.
33. E. Jauniaux, A. L. Watson, J. Hempstock, Y. Bao, J. N. Skepper, and G. J. Burton, "Onset of maternal arterial blood flow and placental oxidative stress: a possible factor in human early pregnancy failure," The American Journal of Pathology, vol. 157, no. 6, pp. 2111-2122, 2000.
34. Y. Wang and S. W. Walsh, "Placental mitochondria as a source of oxidative stress in pre-eclampsia," Placenta, vol. 19, no. 8, pp. 581-586, 1998.
35. T. Cindrova-Davies, O. Spasic-Boskovic, E. Jauniaux, D. S. Charnock-Jones, and G. J. Burton, "Nuclear factor-κB, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitamins," American Journal of Pathology, vol. 170, no. 5, pp. 1511-1520, 2007.
36. A. Fujimaki, K. Watanabe, T. Mori, C. Kimura, K. Shinohara, and A. Wakatsuki, "Placental oxidative DNA damage and its repair in preeclamptic women with fetal growth restriction," Placenta, vol. 32, no. 5, pp. 367-372, 2011.
37. S. Gupta, A. Agarwal, and R. K. Sharma, "The role of placental oxidative stress and lipid peroxidation in preeclampsia," Obstetrical and Gynecological Survey, vol. 60, no. 12, pp. 807-816, 2005.
38. J. Vanderlelie, K. Venardos, V. L. Clifton, N. M. Gude, F. M. Clarke, and A. V. Perkins, "Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae," Placenta, vol. 26, no. 1, pp. 53-58, 2005.
39. R. Negi, D. Pande, K. Karki et al., "Associationof oxidative DNA damage, protein oxidation and antioxidant function with oxidative stress induced cellular injury in pre-eclamptic/eclamptic mothers during fetal circulation," Chemico-Biological Interactions, vol. 208, pp. 77-83, 2014.
40. D. Lanoix, P. Guérin, and C. Vaillancourt, "Placental melatonin production and melatonin receptor expression are altered in preeclampsia: New insights into the role of this hormone in pregnancy," Journal of Pineal Research, vol. 53, no. 4, pp. 417-425, 2012.
41. R. Gagnon, "Placental insufficiency and its consequences," European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 110, pp. S99-S107, 2003.
42. M. Longini, S. Perrone, A. Kenanidis et al., "Isoprostanes in amniotic fluid: a predictive marker for fetal growth restriction in pregnancy," Free Radical Biology and Medicine, vol. 38, no. 11, pp. 1537-1541, 2005.
43. C. Kimura, K. Watanabe, A. Iwasaki et al., "The severity of hypoxic changes and oxidative DNA damage in the placenta of early-onset preeclamptic women and fetal growth restriction," Journal of Maternal-Fetal and Neonatal Medicine, vol. 26, no. 5, pp. 491-496, 2013.
44. V. G. Safronova, N. K. Matveeva, N. V. Avkhacheva, V. M. Sidel'nikova, L. V. Van'ko, and G. T. Sukhikh, "Changes in regulation of oxidase activity of peripheral blood granulocytes in women with habitual abortions," Bulletin of Experimental Biology and Medicine, vol. 136, no. 3, pp. 257-260, 2003.
45. M. Şimşek, M. Naziroʇlu, H. Şimşek, M. Çay, M. Aksakal, and S. Kumru, "Blood plasma levels of lipoperoxides, glutathione peroxidase, beta carotene, vitamin A and E in women with habitual abortion," Cell Biochemistry and Function, vol. 16, no. 4, pp. 227-231, 1998.
46. J. Kwak-Kim, S. Bao, S. K. Lee et al., "Immunological modes of pregnancy loss: inflammation, immune effectors and stress," American Journal of Reproductive Immunology, vol. 72, no. 2, pp. 129-140, 2014.
47. J. Cha, Y. Hirota, and S. K. Dey, "Sensing senescence in preterm birth," Cell Cycle, vol. 11, no. 2, pp. 205-206, 2012.
48. Y. Hirota, J. Cha, M. Yoshie, T. Daikoku, and S. K. Dey, "Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice," Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 44, pp. 18073-18078, 2011.
49. R. Menon, "Spontaneous preterm birth, a clinical dilemma: etiologic, pathophysiologic and genetic heterogeneities and racial disparity," Acta Obstetricia et Gynecologica Scandinavica, vol. 87, no. 6, pp. 590-600, 2008.
50. R. Menon and S. J. Fortunato, "Fetal membrane inflammatory cytokines: a switching mechanism between the preterm premature rupture of the membranes and preterm labor pathways," Journal of Perinatal Medicine, vol. 32, no. 5, pp. 391-399, 2004.
51. S. Argüelles, M. J. Machado, A. Ayala, A. Machado, and B. Hervías, "Correlation between circulating biomarkers of oxidative stress of maternal and umbilical cord blood at birth," Free Radical Research, vol. 40, no. 6, pp. 565-570, 2006.
52. A. R. Rumbold, C. A. Crowther, R. R. Haslam, G. A. Dekker, and J. S. Robinson, "Vitamins C and E and the risks of preeclampsia and perinatal complications," New England Journal of Medicine, vol. 354, no. 17, pp. 1796-1806, 2006.
53. L. Poston, A. L. Briley, P. T. Seed, F. Kelly, and A. Shennan, "Vitamin C and vitamin E in pregnant women at risk for preeclampsia (VIP trial): randomised placebo-controlled trial," The Lancet, vol. 367, no. 9517, pp. 1145-1154, 2006.
54. A. Conde-Agudelo, R. Romero, J. P. Kusanovic, and S. S. Hassan, "Supplementation with vitamins C and e during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis," American Journal of Obstetrics and Gynecology, vol. 204, no. 6, pp. 503.e1-503.e12, 2011.
55. K. H. Cheeseman and T. F. Slater, "An introduction to free radical biochemistry," British Medical Bulletin, vol. 49, no. 3, pp. 481-493, 1993.
56. B. Poljšak and P. Raspor, "The antioxidant and pro-oxidant activity of vitamin C and trolox in vitro: a comparative study," Journal of Applied Toxicology, vol. 28, no. 2, pp. 183-188, 2008.
57. R. J. Reiter, S. D. Paredes, L. C. Manchester, and D. Tan, "Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin," Critical Reviews in Biochemistry and Molecular Biology, vol. 44, no. 4, pp. 175-200, 2009.
58. A. Galano, D. X. Tan, and R. J. Reiter, "On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK," Journal of Pineal Research, vol. 54, no. 3, pp. 245-257, 2013.
59. S. Aversa, S. Pellegrino, I. Barberi, R. J. Reiter, and E. Gitto, "Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period," Journal of Maternal-Fetal and Neonatal Medicine, vol. 25, no. 3, pp. 207-221, 2012.
60. R. Milczarek, A. Hallmann, E. Sokołowska, K. Kaletha, and J. Klimek, "Melatonin enhances antioxidant action of α-tocopherol and ascorbate against NADPH- and iron-dependent lipid peroxidation in human placentalmitochondria," Journal of Pineal Research, vol. 49, no. 2, pp. 149-155, 2010.
61. D. Lanoix, A. Lacasse, R. J. Reiter, and C. Vaillancourt, "Melatonin: the smart killer: the human trophoblast as a model," Molecular and Cellular Endocrinology, vol. 348, no. 1, pp. 1-11, 2012.
62. D. X. Tan, R. J. Reiter, L. C. Manchester et al., "Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger," Current Topics in Medicinal Chemistry, vol. 2, no. 2, pp. 181-197, 2002.
63. C. Rodriguez, J. C. Mayo, R. M. Sainz et al., "Regulation of antioxidant enzymes: a significant role for melatonin," Journal of Pineal Research, vol. 36, no. 1, pp. 1-9, 2004.
64. D. Lanoix, H. Beghdadi, J. Lafond, and C. Vaillancourt, "Human placental trophoblasts synthesize melatonin and express its receptors," Journal of Pineal Research, vol. 45, no. 1, pp. 50-60, 2008.
65. R. J. Reiter, D. X. Tan, A. Korkmaz et al., "Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology," Human Reproduction Update, vol. 20, pp. 293-307, 2014.
66. D. Lanoix, A.-A. Lacasse, R. J. Reiter, and C. Vaillancourt, "Melatonin: the watchdog of villous trophoblast homeostasis against hypoxia/reoxygenation-induced oxidative stress and apoptosis," Molecular and Cellular Endocrinology, vol. 381, no. 1-2, pp. 35-45, 2013.
67. R. Nagai, K. Watanabe, A. Wakatsuki et al., "Melatonin preserves fetal growth in rats by protecting against ischemia/reperfusion-induced oxidative/nitrosative mitochondrial damage in the placenta," Journal of Pineal Research, vol. 45, no. 3, pp. 271-276, 2008.
68. Y. Okatani, K. Okamoto, K. Hayashi, A. Wakatsuki, S. Tamura, and Y. Sagara, "Maternal-fetal transfer of melatonin in pregnant women near term," Journal of Pineal Research, vol. 25, no. 3, pp. 129-134, 1998.
69. Y. Okatani, A. Wakatsuki, and C. Kaneda, "Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain," Journal of Pineal Research, vol. 28, no. 2, pp. 89-96, 2000.
70. F. Hamada, K. Watanabe, A. Wakatsuki et al., "Therapeutic effects of maternal melatonin administration on ischemia/reperfusion-induced oxidative cerebral damage in neonatal rats," Neonatology, vol. 98, no. 1, pp. 33-40, 2010.
71. S. L. Miller, E. B. Yan, M. Castillo-Meléndez, G. Jenkin, and D. W. Walker, "Melatonin provides neuroprotection in the late-gestation fetal sheep brain in response to umbilical cord occlusion," Developmental Neuroscience, vol. 27, no. 2-4, pp. 200-210, 2005.
72. F. Fulia, E. Gitto, S. Cuzzocrea et al., "Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin," Journal of Pineal Research, vol. 31, no. 4, pp. 343-349, 2001.
73. T. Yawno, M. Castillo-Melendez, G. Jenkin, E. M. Wallace, D. W. Walker, and S. L. Miller, "Mechanisms of melatonin-induced protection in the brain of late gestation fetal sheep in response to hypoxia," Developmental Neuroscience, vol. 34, no. 6, pp. 543-551, 2013.
74. K. Watanabe, F. Hamada, A. Wakatsuki et al., "Prophylactic administration of melatonin to the mother throughout pregnancy can protect against oxidative cerebral damage in neonatal rats," Journal of Maternal-Fetal and Neonatal Medicine, vol. 25, no. 8, pp. 1254-1259, 2012.
75. H. Shoji and B. Koletzko, "Oxidative stress and antioxidant protection in the perinatal period," Current Opinion in Clinical Nutrition and Metabolic Care, vol. 10, no. 3, pp. 324-328, 2007.
76. J. Kattwinkel, S. Niermeyer, V. Nadkarni et al., "ILCOR advisory statement: resuscitation of the newly born infant: an advisory statement from the pediatric working group of the International Liaison Committee on Resuscitation," Circulation, vol. 99, no. 14, pp. 1927-1938, 1999.
77. S. Niermeyer, J. Kattwinkel, P. van Reempts et al., "International Guidelines for Neonatal Resuscitation: an excerpt from the Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care: international consensus on science. Contributors and reviewers for the neonatal resuscitation guidelines," Pediatrics, vol. 106, pp. 3-29, 2000.
78. W. Lefkowitz, "Oxygen and resuscitation: beyond the myth," Pediatrics, vol. 109, no. 3, pp. 517-519, 2002.
79. J. Kattwinkel, J. M. Perlman, K. Aziz et al., "American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care," Circulation, vol. 122, no. 3, pp. 909-919, 2010.
80. E. Gitto, R. J. Reiter, M. Karbownik et al., "Causes of oxidative stress in the pre- and perinatal period," Biology of the Neonate, vol. 81, no. 3, pp. 146-157, 2002.
81. E. Gitto, L. Marseglia, S. Manti et al., "Protective role of melatonin in neonatal diseases," Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 980374, 6 pages, 2013.
82. H. J. McCrea and L. R. Ment, "The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate," Clinics in Perinatology, vol. 35, no. 4, pp. 777-792, 2008.
83. R. L. Haynes, R. D. Folkerth, R. J. Keefe et al., "Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia," Journal of Neuropathology and Experimental Neurology, vol. 62, no. 5, pp. 441-450, 2003.
84. O. D. Saugstad, "Bronchopulmonary dysplasia: oxidative stress and antioxidants," Seminars in Neonatology, vol. 8, no. 1, pp. 39-49, 2003.
85. S. Perrone, P. Vezzosi, M. Longini et al., "Biomarkers of oxidative stress in babies at high risk for retinopathy of prematurity," Frontiers in Bioscience, vol. 1, no. 2, pp. 547-552, 2009.
86. J. Neu and W. A. Walker, "Necrotizing enterocolitis," The New England Journal of Medicine, vol. 364, no. 3, pp. 255-264, 2011.
87. R. I. Clyman, O. D. Saugstad, and F. Mauray, "Reactive oxygen metabolites relax the lamb ductus arteriosus by stimulating prostaglandin production," Circulation Research, vol. 64, no. 1, pp. 1-8, 1989.
88. S. L. Archer, D. Peterson, D. P. Nelson et al., "Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung," Journal of Applied Physiology, vol. 66, no. 1, pp. 102-111, 1989.
89. C. O. Chua, G. Vinukonda, F. Hu et al., "Effect of hyperoxic resuscitation on propensity of germinal matrix haemorrhage and cerebral injury," Neuropathology and Applied Neurobiology, vol. 36, no. 5, pp. 448-458, 2010.
90. V. S. Ten and A. Starkov, "Hypoxic-ischemic injury in the developing brain: the role of reactive oxygen species originating in mitochondria," Neurology Research International, vol. 2012, Article ID 542976, 10 pages, 2012.
91. S. Waldbaum and M. Patel, "Mitochondrial dysfunction and oxidative stress: a contributing link to acquired epilepsy?" Journal of Bioenergetics and Biomembranes, vol. 42, no. 6, pp. 449-455, 2010.
92. B. H. Yoon, R. Romero, and S. H. Yang, "Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia," The American Journal of Obstetrics and Gynecology, vol. 174, no. 5, pp. 1433-1440, 1996.
93. F. M. Vaccarino and L. R. Ment, "Injury and repair in developing brain," Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 89, no. 3, pp. F190-F192, 2004.
94. Z. S. Tan, A. S. Beiser, R. S. Vasan et al., "Inflammatory markers and the risk of Alzheimer disease: the Framingham study," Neurology, vol. 68, no. 22, pp. 1902-1908, 2007.
95. M. Mines, Y. Ding, and G. Fan, "The many roles of Chemokine receptors in neurodegenerative disorders: emerging new therapeutical strategies," Current Medicinal Chemistry, vol. 14, no. 23, pp. 2456-2470, 2007.
96. S. A. Rosales-Corral, D. Acuña-Castroviejo, A. Coto-Montes et al., "Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin," Journal of Pineal Research, vol. 52, no. 2, pp. 167-202, 2012.
97. V. Bhandari, N. Maulik, and M. Kresch, "Hyperoxia causes an increase in antioxidant enzyme activity in adult and fetal rat type II pneumocytes," Lung, vol. 178, no. 1, pp. 53-60, 2000.
98. M. Ikegami, S. Kallapur, J. Michna, and A. H. Jobe, "Lung injury and surfactant metabolism after hyperventilation of premature lambs," Pediatric Research, vol. 47, no. 3, pp. 398-404, 2000.
99. B. A. Banks, H. Ischiropoulos, M. McClelland, P. L. Ballard, and R. A. Ballard, "Plasma 3-nitrotyrosine is elevated in premature infants who develop bronchopulmonary dysplasia," Pediatrics, vol. 101, no. 5, pp. 870-874, 1998.
100. S. Singh, J. Wort, and T. W. Evans, "Inhaled nitric oxide in acute lung injury and acute respiratory distress syndrome. Inability to translate physiologic benefit to clinical outcome benefit in adult clinical trials," Intensive Care Medicine, vol. 25, no. 9, pp. 881-883, 1999.
101. C. V. Smith and S. E. Welty, "Molecular mechanisms of oxygen induced lung injury," in Chronic Lung Disease of Early Infancy, R. D. Bland, J. Coalson, and C. Lenfant, Eds., Lung Biology in Health and Diseases, pp. 749-778, Marcel Dekker, New York, NY, USA, 1999.
102. R. A. Ehrenkranz and M. R. Mercurio, "Bronchopulmonary dysplasia," in Effective Care of the Newborn Infant, J. C. Sinclair and M. B. Bracken, Eds., pp. 399-424, Oxford University Press, Oxford, UK, 1992.
103. E. Gitto, R. J. Reiter, G. Sabatino et al., "Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: improvement with melatonin treatment," Journal of Pineal Research, vol. 39, no. 3, pp. 287-293, 2005.
104. J. E. Balinotti, C. J. Tiller, C. J. Llapur et al., "Growth of the lung parenchyma early in life," The American Journal of Respiratory and Critical Care Medicine, vol. 179, no. 2, pp. 134-137, 2009.
105. J. E. Balinotti, V. C. Chakr, C. Tiller et al., "Growth of lung parenchyma in infants and toddlers with chronic lung disease of infancy," American Journal of Respiratory and Critical Care Medicine, vol. 181, no. 10, pp. 1093-1097, 2010.
106. J. M. Di Fiore, J. N. Bloom, F. Orge et al., "A higher incidence of intermittent hypoxemic episodes is associated with severe retinopathy of prematurity," Journal of Pediatrics, vol. 157, no. 1, pp. 69-73, 2010.
107. W. A. Silverman, "Retinopathy of prematurity: oxygen dogma challenged," Archives of Disease in Childhood, vol. 57, no. 10, pp. 731-733, 1982.
108. R. J. Coleman, K. D. A. Beharry, R. S. Brock, P. Abad-Santos, M. Abad-Santos, and H. D. Modanlou, "Effects of brief, clustered versus dispersed hypoxic episodes on systemic and ocular growth factors in a rat model of oxygen-induced retinopathy," Pediatric Research, vol. 64, no. 1, pp. 50-55, 2008.
109. D. A. Antonetti, R. Klein, and T. W. Gardner, "Diabetic retinopathy," New England Journal of Medicine, vol. 366, no. 13, pp. 1227-1239, 2012.
110. C. J. Stewart, E. C. L. Marrs, A. Nelson et al., "Development of the preterm gut microbiome in twins at risk of necrotising enterocolitis and sepsis," PLoS ONE, vol. 8, no. 8, Article ID e73465, 2013.
111. S. Perrone, M. L. Tataranno, S. Negro et al., "May oxidative stress biomarkers in cord blood predict the occurrence of necrotizing enterocolitis in preterm infants?" Journal of Maternal-Fetal and Neonatal Medicine, vol. 25, no. 1, pp. 128-131, 2012.
112. E. Granot and R. Kohen, "Oxidative stress in childhood: in health and disease states," Clinical Nutrition, vol. 23, no. 1, pp. 3-11, 2004.
113. S. Perrone, M. L. Tataranno, S. Negro et al., "Early identification of the risk for free radical-related diseases in preterm newborns," Early Human Development, vol. 86, no. 4, pp. 241-244, 2010.
114. G. Jahnke, M. Marr, C. Myers, R. Wilson, G. Travlos, and C. Price, "Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats," Toxicological Sciences, vol. 50, no. 2, pp. 271-279, 1999.