The severity of hypoxic changes and oxidative DNA damage in the placenta of early-onset preeclamptic women and fetal growth restriction

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 26, Issue 5, 2013, Pages 491-496

  Kimura, Chiharu ^a   Watanabe, Kazushi ^a   Iwasaki, Ai ^a   Mori, Toshitaka ^a   Matsushita, Hiroshi ^a   Shinohara, Koichi ^a   Wakatsuki, Akihiko ^a  

^a AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

8 OHdG; FGR; HIF 1 ; Oxidative stress; Preeclampsia; Ref 1

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DNA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE; REDOX EFFECTOR FACTOR 1;

ADULT; ARTICLE; BLOOD ANALYSIS; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA DAMAGE; DNA REPAIR; FEMALE; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; INTRAUTERINE GROWTH RETARDATION; MATERNAL BLOOD; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PLACENTA; PLACENTA CIRCULATION; PREECLAMPSIA; PRIORITY JOURNAL; TROPHOBLAST; UMBILICAL CORD BLOOD;

ADULT; CELL HYPOXIA; DEOXYGUANOSINE; DNA DAMAGE; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; FEMALE; FETAL GROWTH RETARDATION; GESTATIONAL AGE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; OXIDATION-REDUCTION; OXIDATIVE STRESS; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; REACTIVE OXYGEN SPECIES; UMBILICAL ARTERIES;

EID: 84874079433     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2012.733766     Document Type: Article

References (44)

1. MacKay AP, Berg CJ, Atrash HK. Pregnancy-related mortality from preeclampsia and eclampsia. Obstet Gynecol 2001;97:533-538.
2. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989;161:1200-1204.
3. Hubel CA, Roberts JM, Taylor RN, Musci TJ, Rogers GM, McLaughlin MK. Lipid peroxidation in pregnancy: new perspectives on preeclampsia. Am J Obstet Gynecol 1989;161:1025-1034.
4. Mori T, Shinohara K, Wakatsuki A, Watanabe K, Fujimaki A. Adipocytokines and endothelial function in preeclamptic women. Hypertens Res 2010:33:250-254.
5. Mise H, Sagawa N, Matsumoto T, Yura S, Nanno H, Itoh H, Mori T, et al. Augmented placental production of leptin in preeclampsia: possible involvement of placental hypoxia. J Clin Endocrinol Metab 1998;83:3225-3229.
6. Zamudio S, Palmer SK, Regensteiner JG, Moore LG. High altitude and hypertension during pregnancy. Am J Human Biol 1995:7:183-193.
7. Soothill PW, Nicolaides KH, Campbell S. Prenatal asphyxia, hyperlacticaemia, hypoglycaemia, and erythroblastosis in growth retarded fetuses. Br Med J (Clin Res Ed) 1987;294:1051-1053.
8. Salafia CM, Vintzileos AM, Silberman L, Bantham KF, Vogel CA. Placental pathology of idiopathic intrauterine growth retardation at term. Am J Perinatol 1992;9:179-184.
9. Fujimaki A, Watanabe K, Mori T, Kimura C, Shinohara K, Wakatsuki A. Placental oxidative DNA damage and its repair in preeclamptic women with fetal growth restriction. Placenta 2011;32:367-372.
10. Sibai BM. Preeclampsia as a cause of preterm and late preterm (nearterm) births. Semin Perinatol 2006;30:16-19.
11. Murphy DJ, Striate GM. Mortality and morbidity associated with earlyonset preeclampsia. Hypertens Pregnancy 2000;19:221-231.
12. Ness RB, Sibai BM. Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia. Am J Obstet Gynecol 2006;195:40-49.
13. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005;365:785-799.
14. von Dadelszen P, Magee LA, Roberts JM. Subclassification of preeclampsia. Hypertens Pregnancy 2003;22:143-148.
15. Huppertz B. Placental origins of preeclampsia: challenging the current hypothesis. Hypertension 2008;51:970-975.
16. Trotti R, Carratelli M, Barbieri M. Performance and clinical application of a new, fast method for the detection of hydroperoxides in serum. Panminerva Med 2002:44:37-40.
17. Parmigiani S, Payer C, Massari A, Bussolati G, Bevilacqua G. Normal values of reactive oxygen metabolites on the cord-blood of full-term infants with a colorimetric method. Acta Biomed Ateneo Parmense 2000;71:59-64.
18. Cesarone MR, Belcaro G, Carratelli M, Cornelli U, De Sanctis MT, Incandela I, Barsotti A, et al. A simple test to monitor oxidative stress. Int Angiol 1998:18:127-130.
19. Ames BN. Endogenous oxidative DNA damage, aging, and cancer. Free Radic Res Commun 1989;7:121-128.
20. Kasai H, Nishimura S. Formation of 8-hydroxydeoxy-guanosine in DNA by oxygen radicals and its biological significance. In: Sies H, editor. Oxidative Stress: Oxidants and Antioxidants. London: Academic Press Ltd.; 1991. pp 99-116.
21. Doetsch PW, Cunningham RP. The enzymology of apurinic/apyrimidinic endonucleases. Mutat Res 1990;236:173-201.
22. Xanthoudakis S, Curran T. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J 1992;11:653-665.
23. Xanthoudakis S, Curran T. Analysis of c-Fos and c-Jun redox-dependent DNA binding activity. Meth Enzymol 1994;234:163-174.
24. Demple B, Herman T, Chen DS. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc Natl Acad Sci USA 1991;88:11450-11454.
25. Robson CN, Hickson ID. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants. Nucleic Acids Res 1991;19:5519-5523.
26. Robson CN, Milne AM, Pappin DJ, Hickson ID. Isolation of cDNA clones encoding an enzyme from bovine cells that repairs oxidative DNA damage in vitro: homology with bacterial repair enzymes. Nucleic Acids Res 1991;19:1087-1092.
27. Wang ZQ, Ovitt C, Grigoriadis AE, Möhle-Steinlein U, Rüther U, Wagner EF. Bone and haematopoietic defects in mice lacking c-fos. Nature 1992;360:741-745.
28. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12:5447-5454.
29. Rajakumar A, Conrad K. Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Biol Reprod 2000;63:559-569.
30. Caniggia I, Mostachfi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M, Post M. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3. J Clin Invest. 2000; 105: 577-587.
31. Rajakumar A, Brandon HM, Daftary A, Ness R, Conrad KP. Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta 2004;25:763-769.
32. Caniggia I, Winter JL. Adriana and Luisa Castellucci Award Lecture 2001. Hypoxia inducible factor-1: oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies-A review. Placenta. 2002;23 (Suppl A):S47-S57.
33. Gu Y, Lewis DF, Wang Y. Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies. J Clin Endocrinol Metab 2008;93:260-266.
34. Jeyabalan A, McGonigal S, Gilmour C, Hubel CA, Rajakumar A. Circulating and placental endoglin concentrations in pregnancies complicated by intrauterine growth restriction and preeclampsia. Placenta 2008;29:555-563.
35. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, et al.; CPEP Study Group. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006;355:992-1005.
36. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004;350:672-683.
37. Wallner W, Sengenberger R, Strick R, Strissel PL, Meurer B, Beckmann MW, Schlembach D. Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction. Clin Sci 2007;112:51-57.
38. Stepan H, Geipel A, Schwarz F, Kramer T, Wessel N, Faber R. Circulatory soluble endoglin and its predictive value for preeclampsia in secondtrimester pregnancies with abnormal uterine perfusion. Am J Obstet Gynecol 2008:198:175 e171-176.
39. Romero R, Nien JK, Espinoza J, Todem D, Fu W, Chung H, Kusanovic JP, et al. A longitudinal study of angiogenic (placental growth factor) and anti-Angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med 2008;21:9-23.
40. Nevo O, Many A, Xu J, Kingdom J, Piccoli E, Zamudio S, Post M, et al. Placental expression of soluble fms-like tyrosine kinase 1 is increased in singletons and twin pregnancies with intrauterine growth restriction. J Clin Endocrinol Metab 2008;93:285-292.
41. Yinon Y, Nevo O, Xu J, Many A, Rolfo A, Todros T, Post M, Caniggia I. Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3. Am J Pathol 2008;172:77-85.
42. Nevo O, Soleymanlou N, Wu Y, Xu J, Kingdom J, Many A, Zamudio S, Caniggia I. Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am J Physiol Regul Integr Comp Physiol 2006;291:R1085-R1093.
43. Sánchez-Elsner T, Botella LM, Velasco B, Langa C, Bernabéu C. Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. J Biol Chem 2002;277:43799-43808.
44. Llurba E, Carreras E, Gratacós E, Juan M, Astor J, Vives A, Hermosilla E, et al. Maternal history and uterine artery Doppler in the assessment of risk for development of early-And late-onset preeclampsia and intrauterine growth restriction. Obstet Gynecol Int 2009;2009:275613.