The Diagnosis, Management, and Postnatal Prevention of Intraventricular Hemorrhage in the Preterm Neonate

Clinics in Perinatology

Volumn 35, Issue 4, 2008, Pages 777-792

  McCrea, Heather J ^a   Ment, Laura R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ibuprofen; Indomethacin; Intraventricular hemorrhage; Phenobarbital; Preterm; Prevention

Indexed keywords

ALPHA TOCOPHEROL; BLOOD CLOTTING FACTOR 7A; ETAMSYLATE; IBUPROFEN; INDOMETACIN; NEUROPROTECTIVE AGENT; PANCURONIUM BROMIDE; PHENOBARBITAL;

BRAIN BLOOD FLOW; BRAIN DEVELOPMENT; BRAIN HEMORRHAGE; CLINICAL TRIAL; DISEASE COURSE; DNA POLYMORPHISM; DRUG MECHANISM; ENCEPHALOMALACIA; FOLLOW UP; GESTATIONAL AGE; HEREDITY; HUMAN; HYDROCEPHALUS; LOW BIRTH WEIGHT; MICROVASCULATURE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR; TREATMENT OUTCOME;

CEREBRAL HEMORRHAGE; CEREBRAL VENTRICLES; COAGULANTS; CYCLOOXYGENASE INHIBITORS; FACTOR VIIA; HUMANS; IBUPROFEN; INDOMETHACIN; INFANT, NEWBORN; INFANT, PREMATURE; PHENOBARBITAL;

EID: 56249148193     PISSN: 00955108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clp.2008.07.014     Document Type: Review

References (100)

1. McCormick M.C., Gortmaker S.L., and Sobel A.M. Very low birth weight children: behavior problems and school difficulty in a national sample. J Pediatr 117 (1990) 687-693
2. Whitaker A.G., Feldman J.F., Rossem R.V., et al. Neonatal cranial ultrasound abnormalities in low birth weight infants: Relation to cognitive outcomes at six years of age. Pediatrics 98 (1996) 719-729
3. Anderson A., Swank P., and Wildin S. Modeling analysis of change of neurologic abnormalities in children born prematurely: a novel approach. J Child Neurol 14 (1999) 502-508
4. Hansen B.M., Dinesen J., Hoff B., et al. Intelligence in preterm children at four years of age as a predictor of school function: a longitudinal controlled study. Dev Med Child Neurol 44 (2002) 517-521
5. Koller H., Lawson K., and Rose S.A. Patterns of cognitive development in very low birth weight children during the first six years of life. Pediatrics 99 (1997) 383-389
6. Ment L.R., Vohr B.R., Allan W.A., et al. Change in cognitive function over time in very low-birth-weight infants. JAMA 289 (2003) 705-711
7. Morris B.H., Smith K.E., Swank P.R., et al. Patterns of physical and neurologic development in preterm children. J Perinatol 22 (2002) 31-36
8. Tommiska V., Heinonen K., Kero P., et al. A national two year follow up of extremely low birthweight infants born in 1996-1997. Arch Dis Child Fetal Neonatal Ed 88 (2003) F29-F35
9. Vollmer B., Roth S., Baudin J., et al. Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound. Pediatrics 112 (2003) 1108-1114
10. Papile L.S., Burstein J., and Burstein R. Incidence and evolution of the subependymal intraventricular hemorrhage: a study of infants with weights less than 1500 grams. J Pediatr 92 (1978) 529-534
11. Volpe J.J. Neurology of the newborn. 4th edition (2001), W.B.Saunders, Philadelphia
12. Whitelaw A. Intraventricular haemorrhage and posthaemorrhagic hydrocephalus: pathogenesis, prevention and future interventions. Semin Neonatol 6 (2001) 135-146
13. Arzoumanian Y., Mirmiran M., Barnes P.D., et al. Diffusion tensor brain imaging findings at term-equivalent age may predict neurologic abnormalities in low birth weight preterm infants. AJNR Am J Neuroradiol 24 (2003) 1646-1653
14. de Vries L.S., Roelants-van Rijn A.M., Rademaker K.J., et al. Unilateral parenchymal haemorrhagic infarction in the preterm infant. Eur J Paediatr Neurol 5 (2001) 139-149
15. Krishnamoorthy K.S., Shannon D.C., DeLong G.E., et al. Neurologic sequelae in the survivors of neonatal intraventricular hemorrhage. Pediatrics 64 (1979) 233-237
16. Ment L.R., Bada H.S., Barnes P.D., et al. Practice parameter: neuroimaging of the neonate. Neurology 58 (2002) 1726-1738
17. Pinto-Martin J.A., Whitaker A.H., Feldman J., et al. Relation of cranial ultrasound abnormalities in low-birthweight infants to motor or cognitive performance at ages 2, 6 and 9 years. Dev Med Child Neurol 41 (1999) 826-833
18. Szymonowicz W., Yu V.Y.H., Bajuk B., et al. Neurodevelopmental outcome of periventricular hemorrhage and leukomalacia in infants. Early Hum Dev 14 (1986) 1-7
19. Vohr B., Garcia-Coll C., Flanagan P., et al. Effects of intraventricular hemorrhage and socioeconomic status of perceptual cognitive and neurologic status of low birth weight infants at 5 years of age. J Pediatr 121 (1992) 280-285
20. Vohr B.R., Allan W.A., Westerveld M., et al. School age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial. Pediatrics 111 (2003) e340-e346
21. Ancel P.-Y., Marret S., Larroque B., et al. Are maternal hypertension and small-for-gestational age risk factors for severe intraventricular hemorrhage and cystic periventricular leukomalacia? Results of the EPIPAGE cohort study. Am J Obstet Gynecol 193 (2005) 178-184
22. Hall R.W., Kronsberg S.S., Barton B.A., et al. Morphine, hypotension, and adverse outcomes among preterm neonates: who's to blame? Secondary results from the NEOPAIN Trial. Pediatrics 115 (2005) 1351-1359
23. Kaiser J.R., Gauss C.H., Pont M.M., et al. Hypercapnia during the first 3 days of life is associated with severe intraventricular hemorrhage in very low birth weight infants. J Perinatol 26 5 (2006) 279-285 Epub
24. Kluckow M. Low systemic blood flow and pathophysiology of the preterm transitional circulation. Early Hum Dev 81 (2005) 429-437
25. Linder N., Haskin O., Levit O., et al. Risk factors for intraventricular hemorrhage in very low birth weight premature infants: a retrospective case-control study. Pediatrics 111 (2003) e590-e595
26. Osborne D.A., and Evans N. Early volume expansion for prevention of morbidity and mortality in very preterm infants. Cochrane Database Syst Rev 2 (2004) CD002055.pub2
27. Synnes A.R., Chien L.-Y., Peliowski A., et al. Variations in intraventricular hemorrhage incidence rates among Canadian neonatal intensive care units. J Pediatr 138 (2001) 525-531
28. Leffler C.W., Busija D.W., and Beasley D.G. Effects of Indomethacin on cardiac outcome distribution in normal and asphyxiated piglets. Prostaglandins 31 (1986) 183-190
29. Leffler C.W., Busija D.W., Fletcher A.M., et al. Effects of indomethacin upon cerebral hemodynamics of newborn pigs. Pediatr Res 19 (1985) 1160-1164
30. Ment L.R., Stewert W.B., Duncan C.C., et al. Beagle puppy model of intraventicular hemorrhage. Effect of indomethacin on cerebral blood flow. J Neurosurg 58 (1983) 857-862
31. Ackerman IV W.E., Rovin B.H., and Kniss D.A. Epidermal growth factor and interleukin-1 (beta) utilize divergent signaling pathways to synergistically upregulate cyclooxygenase-2 gene expression in human amnion-derived WISH cells. Biol Reprod 71 (2004) 2079-2086
32. Dammann O., and Leviton A. Inflammatory brain damage in preterm newborns - dry numbers, wet lab, and causal inferences. Early Hum Dev 79 (2004) 1-15
33. Hedtjarn M., Mallard C., Eklind S., et al. Global gene expression in the immature brain after hypoxia-ischemia. J Cereb Blood Flow Metab 24 (2004) 1317-1332
34. Heep A., Behrendt D., Nitsch P., et al. Increased serum levels of interleukin 6 are associated with severe intraventricular haemorrhage in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 88 (2003) F501-F504
35. Kuwano T., Nakao S., Yamamoto H., et al. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. FASEB J 18 (2004) 300-310
36. Pan J.Z., Jornsten R., and Hart R.P. Screening anti-inflammatory compounds in injured spinal cord with microarrays: a comparison of bioinformatics analysis approaches. Physiol Genomics 17 (2004) 201-214
37. Parfenova H., Levine V., Gunther W.M., et al. COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal microvascular endothelial cells. Pediatr Res 52 (2002) 342-348
38. Ribeiro M.L., Ogando D., Farina M., et al. Epidermal growth factor modulation of prostaglandins and nitrite biosynthesis in rat fetal membranes. Prostaglandins Leukot Essent Fatty Acids 70 (2004) 33-40
39. Richardson C.M., Sharma R.A., Cox G., et al. Epidermal growth factor receptors and cyclooxygenase-2 in the pathogenesis of non-small cell lung cancer: potential targets for chemoprevention and systemic therapy. Lung Cancer 39 (2003) 1-13
40. Seibert K., Masferrer J., Zhang Y., et al. Mediation of inflammation by cyclooxygenase-2. Agents Actions Suppl 46 (1995) 41-50
41. Stanimirovic D., and Satoh K. Inflammatory mediators of cerebral endothelium. Brain Pathol 10 (2000) 113-126
42. Takada Y., Bhardwaj A., Paotdar P., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expresion cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23 (2004) 9247-9258
43. Smith W.L., Meade E.A., and DeWitte D.L. Interactions of PGH synthase isozymes-1 and -2 with NSAIDs. Ann N Y Acad Sci 774 (1994) 50-57
44. Chao C.C., Hu S., Molitor T.W., et al. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 149 (1992) 2736-2741
45. Colton C.A., and Gilbert D.L. Microglia, an in vivo source of reactive oxygen species in the brain. Adv Neurol 59 (1993) 321-326
46. Possel H., Noack H., Putzke J., et al. Selective upregulation of inducible nitric oxide synthase (INOS) by lipopolysaccharide (LPS) and cytokines in microglia: in vitro and in vivo studies. Glia 32 (2000) 51-59
47. Rezaie P., Dean A., Male D., et al. Microglia in the cerebral wall of the human telencephalon at second trimester. Cereb Cortex 15 7 (2005) 938-949
48. Akundi R.S., Candelario-Jalil E., Hess S., et al. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-actived primary rat microglia. Glia 51 (2005) 199-208
49. Folkert R.D., Haynes R.L., Borenstein N.S., et al. Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated telencephalic white matter. J Neuropathol Exp Neurol 63 (2004) 990-999
50. Debus O., Koch H.G., Kurlemann G., et al. Factor V Leiden and genetic defects of thrombophilia in childhoold porencephaly. Arch Dis Child Fetal Neonatal Ed 78 (1998) 121-124
51. Gopel W., Gortner L., Kohlmann T., et al. Low prevalence of large intraventricular haemorrhage in very low birthweight infants carrying the factor V Leiden or prothrombin G20210A mutation. Acta paediatr 90 (2001) 1021-1024
52. Gopel W., Kattner E., Seidenberg J., et al. The effect of the Val37Leu polymorphism in the factor XIII gene in infants with a birth weight below 1500 g. J Pediatr 140 (2002) 688-692
53. Petaaja J., Hiltunen L., and Fellman V. Increased risk of intraventricular hemorrhage in preterm infants with thrombophilia. Pediatr Res 49 (2001) 643-646
54. Adcock K., Hedberg C., Loggins J., et al. The TNF-alpha - 308, MCP - 1-2518 and TGF - beta 1 + 915 polymorphisms are not associated with the development of chronic lung disease in very low birth weight infants. Genes Immun 4 (2003) 420-426
55. Alberts M.J., and Tournier-Lasserve E. Update on the genetics of stroke and cerebrovascular disease 2005. Stroke 36 (2005) 179-181
56. Gould D.B., Phalan C., Breedveld G.J., et al. Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly. Science 308 (2005) 1167-1171
57. Gould D.B., Phalan C., van Mil S.E., et al. Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N Engl J Med 354 (2006) 1489-1496
58. Woo D., Sauerbeck L.R., Kissela B.M., et al. Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke 33 (2002) 1190-1195
59. Gopel W., Hartel C., Ahrens P., et al. Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants. Genes Immun 7 (2006) 65-68
60. Harding D.R., Dhamrait S., Whitelaw A., et al. Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth?. Pediatrics 114 (2004) 941-947
61. Harding D., Brull D., Humphries S.E., et al. Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: a preliminary study. Pediatr Res 58 (2005) 117-120
62. Choi S.-H., Lee D.Y., SKim S.U., et al. Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in viv: role of microglial NADPH oxidase. J Neurosci 25 (2005) 4082-4090
63. Dammann O., Leviton A., Gappa M., et al. Lung and brain damage in preterm newborns and their association with gestational age, prematurity subgroup, infection/inflammation and longterm outcome. BJOG 112 Suppl 1 (2005) 4-9
64. Leviton A., and Dammann O. Coagulation, inflammation, and risk of neonatal white matter disease. Pediatr Res 55 (2004) 541-545
65. Volpe J.J. Brain injury in the premature infant. Clin Perinatol 24 (1997) 567-587
66. Whitelaw A., Evans D., Carter M., et al. Randomized clinical trial of prevention of hydrocephalus after intraventricular hemorrhage in preterm infants: brain-washing versus tapping fluid. Pediatrics 119 (2007) e1071-e1078
67. Whitelaw A., and Odd D.E. Intraventricular streptokinase after intraventricular hemorrhage in newborn infants. Cochrane Database Syst Rev 4 (2007) CD000498
68. Wellons J, Shannon C, Oakes W, et al. Comparison of conversion rates from temporary CSF management to permanent shunting in premature IVH infants. Presented at the 36th Annual Meeting of the AANS/CNS Section on Pediatric Neurological Surgery. South Beach (Miami), Florida, November 26-December 1, 2007. p. 35.
69. Banker B.Q., and Larroche J.C. Periventricular leukomalacia of infancy: a form of neonatal anoxic encephalopathy. Arch Neurol 7 (1962) 32-50
70. Deguchi K., Oguchi K., and Takashima S. Characteristic neuropathology of leukomalacia in extremely low birth weight infants. Pediatr Neurol 16 (1997) 296-300
71. Grant E.G., Schellinger D., Smith Y., et al. Periventricular leukomalacia in combination with intraventricular hemorrhage: sonographic features and sequelae. AJNR Am J Neuroradiol 7 (1986) 443-447
72. Bax M., Tydeman C., and Flodmark O. Clinical and MRI correlates of cerebral palsy: the European Cerebral Palsy Study. JAMA 296 (2006) 1602-1608
73. Graham M., Levene M.I., Trounce J.Q., et al. Prediction of cerebral palsy in very low birthweight infants: prospective ultrasound study. Lancet 2 (1987) 593-596
74. Ment L.R. Intraventricular hemorrhage of the preterm neonate. In: Swaiman K.F., Ashwal S., and Ferriero D.M. (Eds). Pediatric neurology; principles and practice. 4th edition Vol I (2006), Mosby, Philadelphia 309-328
75. Synnes A.R., Macnab Y.C., Qiu Z., et al. Neonatal intensive care unit characteristics affect the incidence of severe intraventricular hemorrhage. Med Care 44 (2006) 754-759
76. Whitelaw A., and Odd D. Postnatal phenobarbital for the prevention of intraventricular hemorrhage in preterm infants. Cochrane Database Syst Rev 4 (2007) CD001691
77. Kuban K.C., Leviton A., Krishnamoorthy K.S., et al. Neonatal intracranial hemorrhage and phenobarbital. Pediatrics 77 (1986) 443-450
78. Donn S.M., Roloff D.W., and Goldstein G.W. Prevention of intraventricular hemorrhage in preterm infants by phenobarbitone: a controlled trial. Lancet 2 (1981) 215-217
79. Pourcyrous M., Busija D.W., Shibata M., et al. Cerebrovascular responses to therapeutic dose of indomethacin in newborn pigs. Pediatr Res 45 (1999) 582-587
80. Van Bel F., Klautz J.M., Steenduk P., et al. The influence of indomethacin on the autoregulatory ability of the cerebral vascular bed in the newborn lamb. Pediatr Res 34 (1993) 278-281
81. Ment L.R., Stewert W.B., Ardito T.A., et al. Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup. Stroke 23 (1992) 1132-1137
82. Ment L.R., Oh W., Ehrenkranz R.A., et al. Low dose indomethacin and prevention of intraventicular hemorrhage: A multicenter randomized trial. Pediatrics 93 (1994) 543-550
83. Schmidt B., and David P. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. N Engl J Med 344 (2001) 1966-1972
84. Harding D.R., Humphries S.E., Whitelaw A., et al. Cognitive outcome and cyclo-oxygenase-2 gene (-765 G/C) variation in the preterm infant. Arch Dis Child Fetal Neonatal Ed 92 (2007) F108-F112
85. Scheel J.R., Ray J., Gage F.H., et al. Quantitative analysis of gene expression in living adult neural stem cells by gene trapping. Nat Methods 2 (2005) 363-370
86. Monje M.L., Toda H., and Palmer T.D. Inflammatory blockade restores adult hippocampal neurogenesis. Science 302 (2003) 1760-1765
87. Fowlie P.W., and Davis P.G. Prophylactic indomethacin for preterm infants: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 88 (2003) F464-F466
88. Ment L.R., Vohr B.R., Makuch R.W., et al. Indomethacin for the prevention of intraventricular hemorrhage is effective only in boys. J Pediatr 145 (2004) 832-834
89. Chemtob S., Beharry K., Barna T., et al. Differences in the effects in the newborn piglet of various nonsteroidal anti-inflamatory drugs on cerebral blood flow but not on cerebrovascular protaglandin. Pediatr Res 30 (1991) 106-111
90. Aranda J.V., and Thomas R. Systematic review: intravenous Ibuprofen in preterm newborns. Semin Perinatol 30 (2006) 114-120
91. Brinkhous K.M., Hedner U., Garris J.B., et al. Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease. Proc Natl Acad Sci U S A 86 (1989) 1382-1386
92. Macik B.G., Lindley C.M., Lusher J., et al. Safety and initial clinical efficacy of three dose levels of recombinant activated factor VII (rFVIIa): results of a phase I study. Blood Coagul Fibrinolysis 4 (1993) 521-527
93. Labattaglia M.P., and Ihle B. Recombinant activated factor VII: current perspectives and Epworth experience. Heart Lung Circ 16 Suppl 3 (2007) S96-S101
94. Ghorashian S., and Hunt B.J. "Off-license" use of recombinant activated factor VII. Blood Rev 18 (2004) 245-259
95. Greisen G., and Andreasen R.B. Recombinant factor VIIa in preterm neonates with prolonged prothrombin time. Blood Coagul Fibrinolysis 14 (2003) 117-120
96. Brady K.M., Easley R.B., and Tobias J.D. Recombinant activated factor VII (rFVIIa) treatment in infants with hemorrhage. Paediatr Anaesth 16 (2006) 1042-1046
97. Mitsiakos G., Papaioannou G., Giougi E., et al. Is the use of rFVIIa safe and effective in bleeding neonates? A retrospective series of 8 cases. J Pediatr Hematol Oncol 29 (2007) 145-150
98. Robertson J.D. Prevention of intraventricular haemorrhage: a role for recombinant activated factor VII?. J Paediatr Child Health 42 (2006) 325-331
99. Chiswick M., Gladman G., Sinha S., et al. Vitamin E supplementation and periventricular hemorrhage in the newborn. Am J Clin Nutr 53 (1991) 370S-372S
100. Cools F., and Offringa M. Neuromuscular paralysis for newborn infants receiving mechanical ventilation. Cochrane Database Syst Rev 2 (2005) CD002773