메뉴 건너뛰기




Volumn 64, Issue 3, 2014, Pages 450-454

Ghrelin as a treatment for cardiovascular diseases

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GHRELIN RECEPTOR; MESSENGER RNA;

EID: 84907335174     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.03726     Document Type: Review
Times cited : (37)

References (85)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 2
    • 3843104682 scopus 로고    scopus 로고
    • The role of pituitary ghrelin in growth hormone (GH) secretion: GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content
    • Kamegai J, Tamura H, Shimizu T, Ishii S, Tatsuguchi A, Sugihara H, Oikawa S, Kineman RD. The role of pituitary ghrelin in growth hormone (GH) secretion: GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content. Endocrinology. 2004;145:3731-3738.
    • (2004) Endocrinology , vol.145 , pp. 3731-3738
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Tatsuguchi, A.5    Sugihara, H.6    Oikawa, S.7    Kineman, R.D.8
  • 3
    • 33947536063 scopus 로고    scopus 로고
    • Physiological, pathological and potential therapeutic roles of ghrelin
    • Leite-Moreira AF, Soares JB. Physiological, pathological and potential therapeutic roles of ghrelin. Drug Discov Today. 2007;12:276-288.
    • (2007) Drug Discov Today , vol.12 , pp. 276-288
    • Leite-Moreira, A.F.1    Soares, J.B.2
  • 4
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • van der Lely AJ, Tschöp M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004;25:426-457.
    • (2004) Endocr Rev. , vol.25 , pp. 426-457
    • Van Der Lely, A.J.1    Tschöp, M.2    Heiman, M.L.3    Ghigo, E.4
  • 6
    • 0037164747 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
    • Baldanzi G, Filigheddu N, Cutrupi S, et al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol. 2002;159:1029-1037.
    • (2002) J Cell Biol. , vol.159 , pp. 1029-1037
    • Baldanzi, G.1    Filigheddu, N.2    Cutrupi, S.3
  • 7
    • 29244463345 scopus 로고    scopus 로고
    • Cardiac and peripheral actions of growth hormone and its releasing peptides: Relevance for the treatment of cardiomyopathies
    • Marleau S, Mulumba M, Lamontagne D, Ong H. Cardiac and peripheral actions of growth hormone and its releasing peptides: relevance for the treatment of cardiomyopathies. Cardiovasc Res. 2006;69:26-35.
    • (2006) Cardiovasc Res. , vol.69 , pp. 26-35
    • Marleau, S.1    Mulumba, M.2    Lamontagne, D.3    Ong, H.4
  • 9
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone- releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M. Ghrelin, a novel growth hormone- releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 2000;141:4255-4261.
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3    Sawaguchi, A.4    Mondal, M.S.5    Suganuma, T.6    Matsukura, S.7    Kangawa, K.8    Nakazato, M.9
  • 12
    • 0035085099 scopus 로고    scopus 로고
    • Presence of ghrelin in normal and adenomatous human pituitary
    • Korbonits M, Kojima M, Kangawa K, Grossman AB. Presence of ghrelin in normal and adenomatous human pituitary. Endocrine. 2001;14:101-104.
    • (2001) Endocrine , vol.14 , pp. 101-104
    • Korbonits, M.1    Kojima, M.2    Kangawa, K.3    Grossman, A.B.4
  • 14
    • 0037066587 scopus 로고    scopus 로고
    • Neuroendocrine and peripheral activities of ghrelin: Implications in metabolism and obesity
    • Muccioli G, Tschöp M, Papotti M, Deghenghi R, Heiman M, Ghigo E. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol. 2002;440:235-254.
    • (2002) Eur J Pharmacol , vol.440 , pp. 235-254
    • Muccioli, G.1    Tschöp, M.2    Papotti, M.3    Deghenghi, R.4    Heiman, M.5    Ghigo, E.6
  • 15
    • 0034841199 scopus 로고    scopus 로고
    • GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils
    • Hattori N, Saito T, Yagyu T, Jiang BH, Kitagawa K, Inagaki C. GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils. J Clin Endocrinol Metab. 2001;86:4284-4291.
    • (2001) J Clin Endocrinol Metab. , vol.86 , pp. 4284-4291
    • Hattori, N.1    Saito, T.2    Yagyu, T.3    Jiang, B.H.4    Kitagawa, K.5    Inagaki, C.6
  • 16
    • 0035846447 scopus 로고    scopus 로고
    • Testis-specific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse
    • Tanaka M, Hayashida Y, Nakao N, Nakai N, Nakashima K. Testis-specific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse. Biochim Biophys Acta. 2001;1522:62-65.
    • (2001) Biochim Biophys Acta , vol.1522 , pp. 62-65
    • Tanaka, M.1    Hayashida, Y.2    Nakao, N.3    Nakai, N.4    Nakashima, K.5
  • 17
    • 0029809414 scopus 로고    scopus 로고
    • Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone-releasing peptide mimetic, L-692, 429, in older adults-A clinical research center study
    • Chapman IM, Hartman ML, Pezzoli SS, Thorner MO. Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone-releasing peptide mimetic, L-692, 429, in older adults-a clinical research center study. J Clin Endocrinol Metab. 1996;81:2874-2880.
    • (1996) J Clin Endocrinol Metab. , vol.81 , pp. 2874-2880
    • Chapman, I.M.1    Hartman, M.L.2    Pezzoli, S.S.3    Thorner, M.O.4
  • 22
    • 0034676324 scopus 로고    scopus 로고
    • Structurefunction studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
    • Bednarek MA, Feighner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV, Warren VA, Howard AD, Van Der Ploeg LH, Heck JV. Structurefunction studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem. 2000;43:4370-4376.
    • (2000) J Med Chem. , vol.43 , pp. 4370-4376
    • Bednarek, M.A.1    Feighner, S.D.2    Pong, S.S.3    McKee, K.K.4    Hreniuk, D.L.5    Silva, M.V.6    Warren, V.A.7    Howard, A.D.8    Van Der Ploeg, L.H.9    Heck, J.V.10
  • 25
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue
    • Hosoda H, Kojima M, Matsuo H, Kangawa K. Ghrelin and des-acyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun. 2000;279:909-913.
    • (2000) Biochem Biophys Res Commun. , vol.279 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 26
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev. 2005;85:495-522.
    • (2005) Physiol Rev. , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 27
    • 17744396454 scopus 로고    scopus 로고
    • Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines
    • Cassoni P, Papotti M, Ghè C, Catapano F, Sapino A, Graziani A, Deghenghi R, Reissmann T, Ghigo E, Muccioli G. Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. J Clin Endocrinol Metab. 2001;86:1738-1745.
    • (2001) J Clin Endocrinol Metab. , vol.86 , pp. 1738-1745
    • Cassoni, P.1    Papotti, M.2    Ghè, C.3    Catapano, F.4    Sapino, A.5    Graziani, A.6    Deghenghi, R.7    Reissmann, T.8    Ghigo, E.9    Muccioli, G.10
  • 28
    • 0242383502 scopus 로고    scopus 로고
    • Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart
    • Frascarelli S, Ghelardoni S, Ronca-Testoni S, Zucchi R. Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart. Basic Res Cardiol. 2003;98:401-405.
    • (2003) Basic Res Cardiol. , vol.98 , pp. 401-405
    • Frascarelli, S.1    Ghelardoni, S.2    Ronca-Testoni, S.3    Zucchi, R.4
  • 29
    • 0034802108 scopus 로고    scopus 로고
    • Minireview: Ghrelin and the regulation of energy balance-A hypothalamic perspective
    • Horvath TL, Diano S, Sotonyi P, Heiman M, Tschöp M. Minireview: ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology. 2001;142:4163-4169.
    • (2001) Endocrinology , vol.142 , pp. 4163-4169
    • Horvath, T.L.1    Diano, S.2    Sotonyi, P.3    Heiman, M.4    Tschöp, M.5
  • 31
  • 36
    • 17944379112 scopus 로고    scopus 로고
    • Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans
    • Ariyasu H, Takaya K, Tagami T, et al. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab. 2001;86:4753-4758.
    • (2001) J Clin Endocrinol Metab. , vol.86 , pp. 4753-4758
    • Ariyasu, H.1    Takaya, K.2    Tagami, T.3
  • 39
    • 0034919731 scopus 로고    scopus 로고
    • Reversal of cancer anorexia by blockade of central melanocortin receptors in rats
    • Wisse BE, Frayo RS, Schwartz MW, Cummings DE. Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology. 2001;142:3292-3301.
    • (2001) Endocrinology , vol.142 , pp. 3292-3301
    • Wisse, B.E.1    Frayo, R.S.2    Schwartz, M.W.3    Cummings, D.E.4
  • 40
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature. 2000;407:908-913.
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschöp, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 44
    • 9444246501 scopus 로고    scopus 로고
    • A receptor in pituitary and hypothalamus that functions in growth hormone release
    • Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273:974-977.
    • (1996) Science , vol.273 , pp. 974-977
    • Howard, A.D.1    Feighner, S.D.2    Cully, D.F.3
  • 46
    • 0035688260 scopus 로고    scopus 로고
    • Purification and distribution of ghrelin: The natural endogenous ligand for the growth hormone secretagogue receptor
    • Kojima M, Hosoda H, Kangawa K. Purification and distribution of ghrelin: The natural endogenous ligand for the growth hormone secretagogue receptor. Horm Res. 2001;56(Suppl 1):93-97.
    • (2001) Horm Res. , vol.56 , Issue.SUPPL. 1 , pp. 93-97
    • Kojima, M.1    Hosoda, H.2    Kangawa, K.3
  • 47
    • 0029947291 scopus 로고    scopus 로고
    • Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs
    • Chen C, Wu D, Clarke IJ. Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs. J Endocrinol. 1996;148:381-386.
    • (1996) J Endocrinol. , vol.148 , pp. 381-386
    • Chen, C.1    Wu, D.2    Clarke, I.J.3
  • 48
    • 0032739022 scopus 로고    scopus 로고
    • Neuroendocrine regulation and actions of leptin
    • Casanueva FF, Dieguez C. Neuroendocrine regulation and actions of leptin. Front Neuroendocrinol. 1999;20:317-363.
    • (1999) Front Neuroendocrinol. , vol.20 , pp. 317-363
    • Casanueva, F.F.1    Dieguez, C.2
  • 50
    • 0031952281 scopus 로고    scopus 로고
    • Molecular cloning and gene expression of growth hormone-releasing peptide receptor in rat tissues
    • Yokote R, Sato M, Matsubara S, Ohye H, Niimi M, Murao K, Takahara J. Molecular cloning and gene expression of growth hormone-releasing peptide receptor in rat tissues. Peptides. 1998;19:15-20.
    • (1998) Peptides , vol.19 , pp. 15-20
    • Yokote, R.1    Sato, M.2    Matsubara, S.3    Ohye, H.4    Niimi, M.5    Murao, K.6    Takahara, J.7
  • 51
    • 0035910313 scopus 로고    scopus 로고
    • Generation of polyclonal antiserum against the growth hormone secretagogue receptor (GHS-R): Evidence that the GHS-R exists in the hypothalamus, pituitary and stomach of rats
    • Shuto Y, Shibasaki T, Wada K, Parhar I, Kamegai J, Sugihara H, Oikawa S, Wakabayashi I. Generation of polyclonal antiserum against the growth hormone secretagogue receptor (GHS-R): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach of rats. Life Sci. 2001;68:991-996.
    • (2001) Life Sci. , vol.68 , pp. 991-996
    • Shuto, Y.1    Shibasaki, T.2    Wada, K.3    Parhar, I.4    Kamegai, J.5    Sugihara, H.6    Oikawa, S.7    Wakabayashi, I.8
  • 54
    • 0035097594 scopus 로고    scopus 로고
    • The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors
    • Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG, Kangawa K, Grossman AB. The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. J Clin Endocrinol Metab. 2001;86:881-887.
    • (2001) J Clin Endocrinol Metab. , vol.86 , pp. 881-887
    • Korbonits, M.1    Bustin, S.A.2    Kojima, M.3    Jordan, S.4    Adams, E.F.5    Lowe, D.G.6    Kangawa, K.7    Grossman, A.B.8
  • 55
    • 0031439845 scopus 로고    scopus 로고
    • Widespread transcription of the growth hormone-releasing peptide receptor gene in neuroendocrine human tumors
    • de Keyzer Y, Lenne F, Bertagna X. Widespread transcription of the growth hormone-releasing peptide receptor gene in neuroendocrine human tumors. Eur J Endocrinol. 1997;137:715-718.
    • (1997) Eur J Endocrinol. , vol.137 , pp. 715-718
    • De Keyzer, Y.1    Lenne, F.2    Bertagna, X.3
  • 58
    • 77956031818 scopus 로고    scopus 로고
    • Effects of gh secretagogues on contractility and Ca2+ homeostasis of isolated adult rat ventricular myocytes
    • Sun Q, Ma Y, Zhang L, Zhao YF, Zang WJ, Chen C. Effects of GH secretagogues on contractility and Ca2+ homeostasis of isolated adult rat ventricular myocytes. Endocrinology. 2010;151:4446-4454.
    • (2010) Endocrinology , vol.151 , pp. 4446-4454
    • Sun, Q.1    Ma, Y.2    Zhang, L.3    Zhao, Y.F.4    Zang, W.J.5    Chen, C.6
  • 59
    • 0034741715 scopus 로고    scopus 로고
    • [125I-His(9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: Up-regulation of receptors with athersclerosis
    • Katugampola SD, Pallikaros Z, Davenport AP. [125I-His(9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with athersclerosis. Br J Pharmacol. 2001;134:143-149.
    • (2001) Br J Pharmacol. , vol.134 , pp. 143-149
    • Katugampola, S.D.1    Pallikaros, Z.2    Davenport, A.P.3
  • 61
    • 84862740198 scopus 로고    scopus 로고
    • Ghrelin prevents incidence of malignant arrhythmia after acute myocardial infarction through vagal afferent nerves
    • Mao Y, Tokudome T, Otani K, Kishimoto I, Nakanishi M, Hosoda H, Miyazato M, Kangawa K. Ghrelin prevents incidence of malignant arrhythmia after acute myocardial infarction through vagal afferent nerves. Endocrinology. 2012;153:3426-3434.
    • (2012) Endocrinology , vol.153 , pp. 3426-3434
    • Mao, Y.1    Tokudome, T.2    Otani, K.3    Kishimoto, I.4    Nakanishi, M.5    Hosoda, H.6    Miyazato, M.7    Kangawa, K.8
  • 64
    • 0036842016 scopus 로고    scopus 로고
    • Central ghrelin modulates sympathetic activity in conscious rabbits
    • Matsumura K, Tsuchihashi T, Fujii K, Abe I, Iida M. Central ghrelin modulates sympathetic activity in conscious rabbits. Hypertension. 2002;40:694-699.
    • (2002) Hypertension , vol.40 , pp. 694-699
    • Matsumura, K.1    Tsuchihashi, T.2    Fujii, K.3    Abe, I.4    Iida, M.5
  • 65
    • 2342620868 scopus 로고    scopus 로고
    • Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats
    • Lin Y, Matsumura K, Fukuhara M, Kagiyama S, Fujii K, Iida M. Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats. Hypertension. 2004;43:977-982.
    • (2004) Hypertension , vol.43 , pp. 977-982
    • Lin, Y.1    Matsumura, K.2    Fukuhara, M.3    Kagiyama, S.4    Fujii, K.5    Iida, M.6
  • 68
    • 0142089853 scopus 로고    scopus 로고
    • Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats
    • Yasuda T, Masaki T, Kakuma T, Yoshimatsu H. Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats. Neurosci Lett. 2003;349:75-78.
    • (2003) Neurosci Lett. , vol.349 , pp. 75-78
    • Yasuda, T.1    Masaki, T.2    Kakuma, T.3    Yoshimatsu, H.4
  • 70
    • 53249154955 scopus 로고    scopus 로고
    • Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality
    • Schwenke DO, Tokudome T, Kishimoto I, Horio T, Shirai M, Cragg PA, Kangawa K. Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. Endocrinology. 2008;149:5172-5176.
    • (2008) Endocrinology , vol.149 , pp. 5172-5176
    • Schwenke, D.O.1    Tokudome, T.2    Kishimoto, I.3    Horio, T.4    Shirai, M.5    Cragg, P.A.6    Kangawa, K.7
  • 71
    • 79952267286 scopus 로고    scopus 로고
    • Ghrelin inhibits visceral afferent activation of catecholamine neurons in the solitary tract nucleus
    • Cui RJ, Li X, Appleyard SM. Ghrelin inhibits visceral afferent activation of catecholamine neurons in the solitary tract nucleus. J Neurosci. 2011;31:3484-3492.
    • (2011) J Neurosci. , vol.31 , pp. 3484-3492
    • Cui, R.J.1    Li, X.2    Appleyard, S.M.3
  • 74
    • 79951674161 scopus 로고    scopus 로고
    • Continuous antagonism of the ghrelin receptor results in early induction of salt-sensitive hypertension
    • Sato T, Nakashima Y, Nakamura Y, Ida T, Kojima M. Continuous antagonism of the ghrelin receptor results in early induction of salt-sensitive hypertension. J Mol Neurosci. 2011;43:193-199.
    • (2011) J Mol Neurosci. , vol.43 , pp. 193-199
    • Sato, T.1    Nakashima, Y.2    Nakamura, Y.3    Ida, T.4    Kojima, M.5
  • 75
    • 84876772269 scopus 로고    scopus 로고
    • Excessive sympathoactivation and deteriorated heart function after myocardial infarction in male ghrelin knockout mice
    • Mao Y, Tokudome T, Otani K, Kishimoto I, Miyazato M, Kangawa K. Excessive sympathoactivation and deteriorated heart function after myocardial infarction in male ghrelin knockout mice. Endocrinology. 2013;154:1854-1863.
    • (2013) Endocrinology , vol.154 , pp. 1854-1863
    • Mao, Y.1    Tokudome, T.2    Otani, K.3    Kishimoto, I.4    Miyazato, M.5    Kangawa, K.6
  • 78
    • 84859485950 scopus 로고    scopus 로고
    • Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium
    • Ma Y, Zhang L, Edwards JN, Launikonis BS, Chen C. Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. PLoS One. 2012;7:e35265.
    • (2012) PLoS One , vol.7
    • Ma, Y.1    Zhang, L.2    Edwards, J.N.3    Launikonis, B.S.4    Chen, C.5
  • 79
    • 84867771904 scopus 로고    scopus 로고
    • Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in vitro ischemia/reperfusion heart
    • Ma Y, Zhang L, Launikonis BS, Chen C. Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in vitro ischemia/reperfusion heart. Endocrinology. 2012;153:5480-5490.
    • (2012) Endocrinology , vol.153 , pp. 5480-5490
    • Ma, Y.1    Zhang, L.2    Launikonis, B.S.3    Chen, C.4
  • 82
    • 20844460120 scopus 로고    scopus 로고
    • Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
    • Nagaya N, Moriya J, Yasumura Y, Uematsu M, Ono F, Shimizu W, Ueno K, Kitakaze M, Miyatake K, Kangawa K. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation. 2004;110:3674-3679.
    • (2004) Circulation , vol.110 , pp. 3674-3679
    • Nagaya, N.1    Moriya, J.2    Yasumura, Y.3    Uematsu, M.4    Ono, F.5    Shimizu, W.6    Ueno, K.7    Kitakaze, M.8    Miyatake, K.9    Kangawa, K.10
  • 85
    • 9444264700 scopus 로고    scopus 로고
    • Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: Implication in the glycemic control in rodents
    • Dezaki K, Hosoda H, Kakei M, Hashiguchi S, Watanabe M, Kangawa K, Yada T. Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes. 2004;53:3142-3151.
    • (2004) Diabetes , vol.53 , pp. 3142-3151
    • Dezaki, K.1    Hosoda, H.2    Kakei, M.3    Hashiguchi, S.4    Watanabe, M.5    Kangawa, K.6    Yada, T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.