Continuous antagonism of the ghrelin receptor results in early induction of salt-sensitive hypertension

Journal of Molecular Neuroscience

Volumn 43, Issue 2, 2011, Pages 193-199

  Sato, Takahiro ^a   Nakashima, Yoshiki ^a   Nakamura, Yuki ^a   Ida, Takanori ^a   Kojima, Masayasu ^a  

^a KURUME UNIVERSITY   (Japan)

Author keywords

Catecholamine biosynthetic enzymes; Ghrelin; Salt sensitive hypertension

Indexed keywords

CATECHOLAMINE; DOPAMINE BETA MONOOXYGENASE; GHRELIN; GHRELIN RECEPTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; MESSENGER RNA; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE REGULATION; CATECHOLAMINE SYNTHESIS; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; FOOD INTAKE; GENE EXPRESSION; HEART RATE; HORMONE BLOOD LEVEL; HORMONE RELEASE; HYPERTENSION; MALE; NONHUMAN; OSMOTIC PUMP; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; AUTONOMIC PATHWAYS; BLOOD PRESSURE; EATING; EPINEPHRINE; GHRELIN; HEART RATE; HUMANS; HYPERTENSION; NOREPINEPHRINE; OLIGOPEPTIDES; RATS; RATS, INBRED DAHL; RECEPTORS, GHRELIN; SODIUM CHLORIDE, DIETARY;

ANIMALIA; RATTUS;

EID: 79951674161     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-010-9414-1     Document Type: Article

References (19)

1. Y Date N Murakami K Toshinai S Matsukura A Niijima H Matsuo K Kangawa M Nakazato 2002 The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats Gastroenterology 123 4 1120 1128 1:CAS:528:DC%2BD38Xotl2gu7s%3D 10.1053/gast.2002.35954 12360474
2. JC Erickson KE Clegg RD Palmiter 1996 Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y Nature 381 6581 415 421 1:CAS:528:DyaK28XjsVWgtr8%3D 10.1038/381415a0 8632796 (Pubitemid 26162729)
3. XM Guan H Yu OC Palyha KK McKee SD Feighner DJ Sirinathsinghji RG Smith LH Van der Ploeg AD Howard 1997 Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues Brain Res Mol Brain Res 48 1 23 29 1:CAS:528:DyaK2sXkt1Slt7k%3D 10.1016/S0169-328X(97)00071-5 9379845 (Pubitemid 27298124)
4. J Kamegai H Tamura T Shimizu S Ishii H Sugihara I Wakabayashi 2000 Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression Endocrinology 141 12 4797 4800 1:CAS:528:DC%2BD3cXosVSqt7Y%3D 10.1210/en.141.12.4797 11108296 (Pubitemid 32055162)
5. M Kojima H Hosoda Y Date M Nakazato H Matsuo K Kangawa 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 6762 656 660 1:CAS:528:DC%2BD3cXjs1Ki 10.1038/45230 10604470 (Pubitemid 129516334)
6. Y Makino H Hosoda K Shibata I Makino M Kojima K Kangawa T Kawarabayashi 2002 Alteration of plasma ghrelin levels associated with the blood pressure in pregnancy Hypertension 39 3 781 784 1:CAS:528:DC%2BD38XisVegsbs%3D 10.1161/hy0302.105221 11897763 (Pubitemid 34252875)
7. Y Masuda T Tanaka N Inomata N Ohnuma S Tanaka Z Itoh H Hosoda M Kojima K Kangawa 2000 Ghrelin stimulates gastric acid secretion and motility in rats Biochem Biophys Res Commun 276 3 905 908 1:CAS:528:DC%2BD3cXntFOqsrg%3D 10.1006/bbrc.2000.3568 11027567
8. K Matsuda T Miura H Kaiya K Maruyama M Uchiyama K Kangawa S Shioda 2005 Stimulatory effect of n-octanoylated ghrelin on locomotor activity in the goldfish, Carassius auratus Peptides 27 6 1335 1340 10.1016/j.peptides.2005.10. 011 16297501 (Pubitemid 43766986)
9. K Matsumura T Tsuchihashi K Fujii I Abe M Iida 2002 Central ghrelin modulates sympathetic activity in conscious rabbits Hypertension 40 5 694 699 1:CAS:528:DC%2BD38XotFWlt7c%3D 10.1161/01.HYP.0000035395.51441.10 12411464 (Pubitemid 35278606)
10. N Nagaya M Kojima M Uematsu M Yamagishi H Hosoda H Oya Y Hayashi K Kangawa 2001 Hemodynamic and hormonal effects of human ghrelin in healthy volunteers Am J Physiol Regul Integr Comp Physiol 280 5 R1483 1487 1:CAS:528:DC%2BD3MXjsVequrY%3D 11294772
11. M Nakazato N Murakami Y Date M Kojima H Matsuo K Kangawa S Matsukura 2001 A role for ghrelin in the central regulation of feeding Nature 409 6817 194 198 1:CAS:528:DC%2BD3MXlvFSmsg%3D%3D 10.1038/35051587 11196643 (Pubitemid 32144284)
12. M Papotti C Ghè P Cassoni F Catapano R Deghenghi E Ghigo G Muccioli 2000 Growth hormone secretagogue binding sites in peripheral human tissues J Clin Endocrinol Metab 85 10 3803 3807 1:CAS:528:DC%2BD3cXnsFOgurY%3D 10.1210/jc.85.10.3803 11061542
13. S Qian H Chen D Weingarth ME Trumbauer DE Novi X Guan H Yu Z Shen Y Feng E Frazier A Chen RE Camacho LP Shearman S Gopal-Truter DJ MacNeil LH Van der Ploeg DJ Marsh 2002 Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice Mol Cell Biol 22 14 5027 5035 1:CAS:528:DC%2BD38XltVOqsbY%3D 10.1128/MCB.22.14.5027-5035. 2002 12077332 (Pubitemid 34700694)
14. T Sato M Kurokawa Y Nakashima T Ida T Takahashi Y Fukue M Ikawa M Okabe K Kangawa M Kojima 2008 Ghrelin deficiency does not influence feeding performance Regul Pept 145 1-3 7 11 1:CAS:528:DC%2BD2sXhsVOltrjK 10.1016/j.regpep.2007.09. 010 17913260 (Pubitemid 350296364)
15. S Shousha K Nakahara M Kojima M Miyazato H Hosoda K Kangawa N Murakami 2005 Different effects of peripheral and central ghrelin on regulation of food intake in the Japanese quail Gen Comp Endocrinol 141 2 178 183 1:CAS:528:DC%2BD2MXhvVChsb0%3D 10.1016/j.ygcen.2004.12.021 15748719 (Pubitemid 40312725)
16. Y Sun S Ahmed RG Smith 2003 Deletion of ghrelin impairs neither growth nor appetite Mol Cell Biol 23 22 7973 7981 1:CAS:528:DC%2BD3sXovVKjsLg%3D 10.1128/MCB.23.22.7973-7981.2003 14585959 (Pubitemid 37377491)
17. M Tschöp DL Smiley ML Heiman 2000 Ghrelin induces adiposity in rodents Nature 407 6806 908 913 10.1038/35038090 11057670
18. KE Wortley KD Anderson K Garcia JD Murray L Malinova R Liu M Moncrieffe K Thabet HJ Cox GD Yancopoulos SJ Wiegand MW Sleeman 2004 Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference Proc Natl Acad Sci USA 101 21 8227 8232 1:CAS:528:DC%2BD2cXkslCitLY%3D 10.1073/pnas.0402763101 15148384 (Pubitemid 38698082)
19. AM Wren CJ Small HL Ward KG Murphy CL Dakin S Taheri AR Kennedy GH Roberts DG Morgan MA Ghatei SR Bloom 2000 The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion Endocrinology 141 11 4325 4328 1:CAS:528:DC%2BD3cXnslKgsLw%3D 10.1210/en.141.11.4325 11089570