Ghrelin inhibits autonomic function in healthy controls, but has no effect on obese and vagotomized subjects

Clinical Endocrinology

Volumn 73, Issue 5, 2010, Pages 678-685

  Huda, M S B ^a   Mani, H ^a   Dovey, T ^a   Halford, J C G ^a   Boyland, E ^a   Daousi, C ^a   Wilding, J P H ^a   Pinkney, J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GLUCOSE; GROWTH HORMONE; INSULIN; PLACEBO;

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD PRESSURE; BODY MASS; BORDERLINE STATE; CALORIC INTAKE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GASTRECTOMY; GLUCOSE BLOOD LEVEL; HEART RATE; HEART RATE VARIABILITY; HUMAN; INSULIN BLOOD LEVEL; MALE; MORBID OBESITY; OBESITY; PARASYMPATHETIC TONE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYMPATHETIC TONE; THERMOGENESIS; VAGOTOMY;

ADULT; AGED; AUTONOMIC NERVOUS SYSTEM; BLOOD GLUCOSE; BLOOD PRESSURE; CROSS-OVER STUDIES; FEMALE; GASTRECTOMY; GHRELIN; HEART RATE; HUMANS; INSULIN; MALE; MIDDLE AGED; OBESITY, MORBID; PARASYMPATHETIC NERVOUS SYSTEM; STOMACH NEOPLASMS; SYMPATHETIC NERVOUS SYSTEM; THERMOGENESIS; VAGOTOMY; VAGUS NERVE;

EID: 78449270553     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2010.03865.x     Document Type: Article

References (41)

1. Kojima, M., Hosoda, H., Date, Y., et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402, 656 - 660.
2. Nagaya, N., Kojima, M., Uematsu, M., et al. (2001) Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 280, R1483 - R1487.
3. Soeki, T., Kishimoto, I., Schwenke, D.O., et al. (2008) Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction. American Journal of Physiology. Heart and Circulatory Physiology, 294, H426 - H432.
4. Wu, R., Zhou, M., Das, P., et al. (2007) Ghrelin inhibits sympathetic nervous activity in sepsis. American Journal of Physiology. Endocrinology and Metabolism, 293, E1697 - E1702.
5. Matsumura, K., Tsuchihashi, T., Fujii, K., et al. (2002) Central ghrelin modulates sympathetic activity in conscious rabbits. Hypertension, 40, 694 - 699.
6. Broglio, F., Gottero, C., Van, K.P., et al. (2004) Acetylcholine regulates ghrelin secretion in humans. Journal of Clinical Endocrinology and Metabolism, 89, 2429 - 2433.
7. Cummings, D.E., Weigle, D.S., Frayo, R.S., et al. (2002) Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. New England Journal of Medicine, 346, 1623 - 1630.
8. Yasuda, T., Masaki, T., Kakuma, T., et al. (2003) Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats. Neuroscience Letters, 349, 75 - 78.
9. Neary, N.M., Small, C.J., Wren, A.M., et al. (2004) Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. Journal of Clinical Endocrinology and Metabolism, 89, 2832 - 2836.
10. Druce, M.R., Wren, A.M., Park, A.J., et al. (2005) Ghrelin increases food intake in obese as well as lean subjects. International Journal of Obesity, 29, 1130 - 1136.
11. Wren, A.M., Seal, L.J., Cohen, M.A., et al. (2001) Ghrelin enhances appetite and increases food intake in humans. Journal of Clinical Endocrinology and Metabolism, 86, 5992.
12. Matthews, D.R., Hosker, J.P., Rudenski, A.S., et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412 - 419.
13. Akselrod, S., Gordon, D., Ubel, F.A., et al. (1981) Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science, 213, 220 - 222.
14. Task Force (1996) Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. European Heart Journal, 17, 354 - 381.
15. Cerutti, S., Bianchi, A., &, Mainardi, L.T., (1995) Spectral analysis of the heart rate signal. In:, A.J. Camm, ed. Heart Rate Variability. Futura Publishing Company, New York, 53 - 74.
16. Hartikainen, J.E., Tahvanainen, K.U., &, Kuusela, T.A., (1998) Short term measurement of heart rate variability. In:, M. Malik, ed. Clinical Guide to Cardiac Autonomic Tests. Kluwer Academic Publishers, Dordrecht, A.H. 149 - 176.
17. Matsumoto, T., Miyawaki, C., Ue, H., et al. (2001) Comparison of thermogenic sympathetic response to food intake between obese and non-obese young women. Obesity Research, 9, 78 - 85.
18. Matsumoto, T., Miyawaki, T., Ue, H., et al. (1999) Autonomic responsiveness to acute cold exposure in obese and non-obese young women. International Journal of Obesity and Related Metabolic Disorders, 23, 793 - 800.
19. Matsumoto, T., Miyawaki, C., Ue, H., et al. (2000) Effects of capsaicin-containing yellow curry sauce on sympathetic nervous system activity and diet-induced thermogenesis in lean and obese young women. Journal of Nutritional Science and Vitaminology, 46, 309 - 315.
20. Huda, M.S., Dovey, T., Wong, S.P., et al. (2009) Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects. International Journal of Obesity, 33, 317 - 325.
21. Le Roux, C.W., Neary, N.M., Halsey, T.J., et al. (2005) Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy. Journal of Clinical Endocrinology and Metabolism, 90, 4521 - 4524.
22. Agelink, M.W., Malessa, R., Baumann, B., et al. (2001) Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate. Clinical Atomic Research, 11, 99 - 108.
23. Katugampola, S.D., Pallikaros, Z., &, Davenport, A.P., (2001) [125I-His(9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with athersclerosis. British Journal of Pharmacology, 134, 143 - 149.
24. Kawczynska-Drozdz, A., Olszanecki, R., Jawien, J., et al. (2006) Ghrelin inhibits vascular superoxide production in spontaneously hypertensive rats. American Journal of Hypertension, 19, 764 - 767.
25. Date, Y., Nakazato, M., Murakami, N., et al. (2001) Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochemical and Biophysical Research Communications, 280, 904 - 907.
26. Lin, Y., Matsumura, K., Fukuhara, M., et al. (2004) Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats. Hypertension, 43, 977 - 982.
27. Matsumura, K., Abe, I., Tsuchihashi, T., et al. (2000) Central effects of leptin on cardiovascular and neurohormonal responses in conscious rabbits. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 278, R1314 - R1320.
28. Shintani, M., Ogawa, Y., Ebihara, K., et al. (2001) Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes, 50, 227 - 232.
29. Kamegai, J., Tamura, H., Shimizu, T., et al. (2001) Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes, 50, 2438 - 2443. (Pubitemid 33642759)
30. Matsumura, K., Tsuchihashi, T., &, Abe, I., (2000) Central cardiovascular action of neuropeptide Y in conscious rabbits. Hypertension, 36, 1040 - 1044.
31. Haynes, W.G., Morgan, D.A., Djalali, A., et al. (1999) Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension, 33 (1 Pt 2), 542 - 547.
32. Bisi, G., Podio, V., Valetto, M.R., et al. (1999) Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans. Journal of Endocrinological Investigation, 22, 266 - 272.
33. Leong, K.S., Mann, P., Wallymahmed, M., et al. (2000) Abnormal heart rate variability in adults with growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism, 85, 628 - 633.
34. Akehi, Y., Yoshimatsu, H., Kurokawa, M., et al. (2001) VLCD-induced weight loss improves heart rate variability in moderately obese Japanese. Experimental Biology and Medicine (Maywood), 226, 440 - 445.
35. Karason, K., Molgaard, H., Wikstrand, J., et al. (1999) Heart rate variability in obesity and the effect of weight loss. American Journal of Cardiology, 83, 1242 - 1247.
36. Laederach-Hofmann, K., Mussgay, L., &, Ruddel, H., (2000) Autonomic cardiovascular regulation in obesity. Journal of Endocrinology, 164, 59 - 66.
37. Bergholm, R., Westerbacka, J., Vehkavaara, S., et al. (2001) Insulin sensitivity regulates autonomic control of heart rate variation independent of body weight in normal subjects. Journal of Clinical Endocrinology and Metabolism, 86, 1403 - 1409.
38. Popovic, V., Miljic, D., Pekic, S., et al. (2005) Low plasma ghrelin level in gastrectomized patients is accompanied by enhanced sensitivity to the ghrelin-induced growth hormone release. Journal of Clinical Endocrinology and Metabolism, 90, 2187 - 2191.
39. Nogueiras, R., Perez-Tilve, D., Veyrat-Durebex, C., et al. (2009) Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. Journal of Neuroscience, 29, 5916 - 5925.
40. Broglio, F., Gottero, C., Prodam, F., et al. (2004) Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans. Journal of Clinical Endocrinology and Metabolism, 89, 3062 - 3065.
41. Neary, N.M., Druce, M.R., Small, C.J., et al. (2006) Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect. Gut, 55, 135.