Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in Vitro ischemia/reperfusion heart

Endocrinology

Volumn 153, Issue 11, 2012, Pages 5480-5490

  Ma, Yi ^a   Zhang, Lin ^b   Launikonis, Bradley S ^a   Chen, Chen ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; CASPASE 9; GHRELIN; GHRELIN RECEPTOR; GROWTH HORMONE SECRETAGOGUE; HEXARELIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POTASSIUM CHANNEL; SODIUM CHANNEL; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CURRENT; CELL ISOLATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MODIFICATION; ENZYME PHOSPHORYLATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART PERFUSION; HEART PROTECTION; HORMONE RECEPTOR INTERACTION; IN VITRO STUDY; ISOLATED HEART; MALE; MOUSE; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPERFUSION INJURY; SODIUM CURRENT; WHOLE CELL;

ANIMALS; CELLS, CULTURED; GHRELIN; MALE; MICE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCYTES, CARDIAC; OLIGOPEPTIDES; PHOSPHORYLATION; RECEPTORS, GHRELIN; SIGNAL TRANSDUCTION;

EID: 84867771904     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1404     Document Type: Article

References (42)

1. del Monte F, Lebeche D, Guerrero JL, Tsuji T, Doye AA, Gwathmey JK, Hajjar RJ 2004 Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. Proc Natl Acad Sci USA 101:5622-5627
2. Murphy E, Steenbergen C 2008 Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev 88:581-609
3. Bell RM, Yellon DM 2011 There is more to life than revascularization: therapeutic targeting of myocardial ischemia/reperfusion injury. Cardiovasc Ther 29:e67-e79
4. Rodríguez B, Trayanova N, Noble D 2006 Modeling cardiac ischemia. Ann N Y Acad Sci 1080:395-414
5. Carmeliet E 1999 Cardiac ionic currents and acute ischemia: from channels to arrhythmias. Physiol Rev 79:917-1017
6. Yellon DM, Hausenloy DJ 2007 Myocardial reperfusion injury. N Engl J Med 357:1121-1135
7. Sanada S, Komuro I, Kitakaze M 2011 Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures. Am J Physiol Heart Circ Physiol 301:H1723-H1741
8. Xu XL, Chen XJ, Ji H, Li P, Bian YY, Yang D, Xu JD, Bian ZP, Zhang JN 2008 Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca-ATPase. Pharmacology 81:325-332
9. Hernández G, Lal H, Fidalgo M, Guerrero A, Zalvide J, Force T, Pombo CM 2011 A novel cardioprotective p38-MAPK/mTOR pathway. Exp Cell Res 317:2938-2949
10. Qin Y, Vanden Hoek TL, Wojcik K, Anderson T, Li CQ, Shao ZH, Becker LB, Hamann KJ 2004 Caspase-dependent cytochrome c release and cell death in chick cardiomyocytes after simulated ischemia-reperfusion. Am J Physiol Heart Circ Physiol 286:H2280-H2286
11. Shao ZH, Wojcik KR, Qin Y, Li CQ, Vanden Hoek TL, Hamann KJ 2011 Blockade of caspase-2 activity inhibits ischemia/reperfusion-induced mitochondrial reactive oxygen burst and cell death in cardiomyocytes. J Cell Death 4:7-18
12. Yao YT, Fang NX, Shi CX, Li LH 2010 Sevoflurane postconditioning protects isolated rat hearts against ischemia-reperfusion injury. Chin Med J (Engl) 123:1320-1328
13. Ma Y, Zhang L, Edwards JN, Launikonis BS, Chen C 2012 Growth Hormone Secretagogues Protect Mouse Cardiomyocytes from in vitro Ischemia/Reperfusion Injury through Regulation of Intracellular Calcium. PLoS One 7:e35265
14. Frascarelli S, Ghelardoni S, Ronca-Testoni S, Zucchi R 2003 Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart. Basic Res Cardiol 98:401-405
15. Chang L, Ren Y, Liu X, Li WG, Yang J, Geng B, Weintraub NL, Tang C 2004 Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart. J Cardiovasc Pharmacol 43:165-170
16. Zhang GG, Teng X, Liu Y, Cai Y, Zhou YB, Duan XH, Song JQ, Shi Y, Tang CS, Yin XH, Qi YF 2009 Inhibition of endoplasm reticulum stress by ghrelin protects against ischemia/reperfusion injury in rat heart. Peptides 30:1109-1116
17. 2+ homeostasis of isolated adult rat ventricular myocytes. Endocrinology 151:4446-4454
18. + current via phospholipase C/protein kinase C signaling pathway in rat ventricular myocytes. Endocrinology 151:1228-1235
19. Borchi E, Parri M, Papucci L, Becatti M, Nassi N, Nassi P, Nediani C 2009 Role of NADPH oxidase in H9c2 cardiac muscle cells exposed to simulated ischaemia-reperfusion. J Cell Mol Med 13: 2724-2735
20. Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey 2nd WH, Salvesen GS, Connolly Jr ES, Troy CM 2011 Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. J Neurosci 31:8894-8904
21. Halem HA, Taylor JE, Dong JZ, Shen Y, Datta R, Abizaid A, Diano S, Horvath T, Zizzari P, Bluet-Pajot MT, Epelbaum J, Culler MD 2004 Novel analogs of ghrelin: physiological and clinical implications. Eur J Endocrinol 151(Suppl 1):S71-S75
22. Wasson S, Reddy HK, Dohrmann ML 2004 Current perspectives of electrical remodeling and its therapeutic implications. J Cardiovasc Pharmacol Ther 9:129-144
23. ten Eick RE, Whalley DW, Rasmussen HH 1992 Connections: heart disease, cellular electrophysiology, and ion channels. FASEB J 6:2568-2580
24. 2+ and L-type calcium current in rat cardiomyocytes post ischemia-reperfusion injury]. Zhonghua Xin Xue Guan Bing Za Zhi 38:225-229 (Chinese)
25. Louch WE, Ferrier GR, Howlett SE 2000 Losartan improves recovery of contraction and inhibits transient inward current in a cellular model of cardiac ischemia and reperfusion. J Pharmacol Exp Ther 295:697-704
26. Ding C, Fu XH, He ZS, Chen HX, Xue L, Li JX 2008 Cardioprotective effects of simvastatin on reversing electrical remodeling induced by myocardial ischemia-reperfusion in normocholesterolemic rabbits. Chin Med J (Engl) 121:551-556
27. Zheng MQ, Tang K, Zimmerman MC, Liu L, Xie B, Rozanski GJ 2009 Role of gamma-glutamyl transpeptidase in redox regulation of K+ channel remodeling in postmyocardial infarction rat hearts. Am J Physiol Cell Physiol 297:C253-C262
28. Zhang Y, Zhong N, Zhou ZN 2010 Effects of chronic intermittent hypobaric hypoxia on the L-type calcium current in rat ventricular myocytes. High Alt Med Biol 11:61-67
29. 2+ current to β-adrenergic receptor stimulation via a C2 region-containing protein kinase C isoform. Circ Res 87:1164-1171
30. Torsello A, Bresciani E, Rossoni G, Avallone R, Tulipano G, Cocchi D, Bulgarelli I, Deghenghi R, Berti F, Locatelli V 2003 Ghrelin plays a minor role in the physiological control of cardiac function in the rat. Endocrinology 144:1787-1792
31. Schwenke DO, Tokudome T, Kishimoto I, Horio T, Shirai M, Cragg PA, Kangawa K 2008 Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. Endocrinology 149:5172-5176
32. Ost'ádal BK, Frantisek K 1999 Cardiac ischemia: from injury to protection. Boston: Kluwer Academic
33. Zhou L, Cortassa S, Wei AC, Aon MA, Winslow RL, O'Rourke B 2009 Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes. Biophys J 97:1843-1852
34. Zima AV, Blatter LA 2006 Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res 71:310-321
35. Liu M, Liu H, Dudley Jr SC 2010 Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel. Circ Res 107:967-974
36. Zhang Q, Huang WD, Lv XY, Yang YM 2011 Ghrelin protects H9c2 cells from hydrogen peroxide-induced apoptosis through NF-κB and mitochondria- mediated signaling. Eur J Pharmacol 654: 142-149
37. Zhao H, Liu G, Wang Q, Ding L, Cai H, Jiang H, Xin Z 2007 Effect of ghrelin on human endothelial cells apoptosis induced by high glucose. Biochem Biophys Res Commun 362:677-681
38. El Eter E, Al Tuwaijiri A, Hagar H, Arafa M 2007 In vivo and in vitro antioxidant activity of ghrelin: Attenuation of gastric ischemic injury in the rat. J Gastroenterol Hepatol 22:1791-1799
39. Ravindran J, Gupta N, Agrawal M, Bala Bhaskar AS, Lakshmana Rao PV 2011 Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism. Apoptosis 16:145-161
40. Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubini A, Malan D, Baj G, Granata R, Broglio F, Papotti M, Surico N, Bussolino F, Isgaard J, Deghenghi R, Sinigaglia F, Prat M, Muccioli G, Ghigo E, Graziani A 2002 Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 159:1029-1037
41. Lee JY, Oh TH, Yune TY 2011 Ghrelin inhibits hydrogen peroxide-induced apoptotic cell death of oligodendrocytes via ERK and p38MAPK signaling. Endocrinology 152:2377-2386
42. Wang W, Zhang D, Zhao H, Chen Y, Liu Y, Cao C, Han L, Liu G 2010 Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line. Regul Pept 161:43-50