Ghrelin and cardiovascular diseases

Journal of Cardiology

Volumn 59, Issue 1, 2012, Pages 8-13

  Kishimoto, Ichiro ^a   Tokudome, Takeshi ^a   Hosoda, Hiroshi ^a   Miyazato, Mikiya ^a   Kangawa, Kenji ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Ghrelin; GHS receptor; Heart failure; Myocardial infarction; Pulmonary hypertension; Sympathetic nerve; Vagus nerve

Indexed keywords

GHRELIN; GHRELIN RECEPTOR; GROWTH HORMONE; SOMATOMEDIN;

ADRENERGIC SYSTEM; ANTIINFLAMMATORY ACTIVITY; APPETITE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CARDIOVASCULAR DISEASE; CORONARY ARTERY LIGATION; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENERGY BALANCE; HEART ARRHYTHMIA; HEART FAILURE; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART VENTRICLE REMODELING; HUMAN; HUNGER; MORTALITY; NONHUMAN; PROTEIN LOCALIZATION; PULMONARY HYPERTENSION; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

ANIMALS; CARDIOVASCULAR DISEASES; GHRELIN; HUMANS;

EID: 84855199907     PISSN: 09145087     EISSN: 18764738     Source Type: Journal    
DOI: 10.1016/j.jjcc.2011.11.002     Document Type: Review

References (37)

1. Smith R.G., Cheng K., Schoen W.R., Pong S.S., Hickey G., Jacks T. A nonpeptidyl growth hormone secretagogue. Science 1993, 260:1640-1643.
2. Howard A.D., Fieghner S.D., Cully D.F., Arena J.P., Liberator P.A., Rosenblum C.I. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996, 273:974-977.
3. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
4. Nakazato M., Murakami N., Date Y., Kojima M., Matsuo H., Kangawa K., Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 2001, 409:194-198.
5. Horvath T.L., Diano S., Sotonyi P., Heiman M., Tschop M. Minireview: ghrelin and the regulation of energy balance - a hypothalamic perspective. Endocrinology 2001, 142:4163-4169.
6. Kojima M., Kangawa K. drug insight: the functions of ghrelin and its potential as a multitherapeutic hormone. Nat Clin Pract Endocrinol Metab 2006, 2:80-88.
7. Nagaya N., Kojima M., Uematsu M., Yamagishi M., Hosoda H., Oya H., Hayashi Y., Kangawa K. Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol 2001, 280:R1483-R1487.
8. Date Y., Murakami N., Toshinai K., Matsukura S., Niijima A., Matsuo H., Kangawa K., Nakazato M. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 2002, 123:1120-1128.
9. Kishimoto I., Tokudome T., Schwenke D.O., Soeki T., Hosoda H., Nagaya N., Kangawa K. Therapeutic potential of ghrelin in cardiac diseases. Exp Rev Endocrinol Metab 2009, 4:283-289.
10. Cummings D.E., Weigle D.S., Frayo R.S., Breen P.A., Ma M.K., Dellinger E.P., Purnell J.Q. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002, 346:1623-1630.
11. Kojima M., Kangawa K. Ghrelin: structure and function. Physiol Rev 2005, 85:495-522.
12. Yang J., Brown M.S., Liang G., Grishin N.V., Goldstein J.L. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008, 132:387-396.
13. Cummings D.E., Purnell J.Q., Frayo R.S., Schmidova K., Wisse B.E., Weigle D.S. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001, 50:1714-1719.
14. Tschop M., Weyer C., Tataranni P.A., Devanarayan V., Ravussin E., Heiman M.L. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001, 50:707-709.
15. Tschop M., Smiley D.L., Heiman M.L. Ghrelin induces adiposity in rodents. Nature 2000, 407:908-913.
16. Wren A.M., Seal L.J., Cohen M.A., Brynes A.E., Frost G.S., Murphy K.G., Dhillo W.S., Ghatei M.A., Bloom S.R. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001, 86:5992-5995.
17. Akamizu T., Takaya K., Irako T., Hosoda H., Teramukai S., Matsuyama A., Tada H., Miura K., Shimizu A., Fukushima M., Yokode M., Tanaka K., Kangawa K. Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur J Endocrinol 2004, 150:447-455.
18. Druce M.R., Wren A.M., Park A.J., Milton J.E., Patterson M., Frost G., Ghatei M.A., Small C., Bloom S.R. Ghrelin increases food intake in obese as well as lean subjects. Int J Obes (Lond) 2005, 29:1130-1136.
19. Nagaya N., Moriya J., Yasumura Y., Uematsu M., Ono F., Shimizu W., Ueno K., Kitakaze M., Miyatake K., Kangawa K. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation 2004, 110:3674-3679.
20. Nagaya N., Itoh T., Murakami S., Oya H., Uematsu M., Miyatake K., Kangawa K. Treatment of cachexia with ghrelin in patients with COPD. Chest 2005, 128:1187-1193.
21. Neary N.M., Small C.J., Wren A.M., Lee J.L., Druce M.R., Palmieri C., Frost G.S., Ghatei M.A., Coombes R.C., Bloom S.R. Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. J Clin Endocrinol Metab 2004, 89:2832-2836.
22. Akamizu T., Iwakura H., Ariyasu H., Hosoda H., Murayama T., Yokode M., Teramukai S., Seno H., Chiba T., Noma S., Nakai Y., Fukunaga M., Nakai Y., Kangawa K. Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite. Eur J Endocrinol 2008, 158:481-498. FD Clinical Study Team.
23. Hotta M., Ohwada R., Akamizu T., Shibasaki T., Takano K., Kangawa K. Ghrelin increases hunger and food intake in patients with restricting-type anorexia nervosa: a pilot study. Endocr J 2009, 56:1119-1128.
24. Yamamoto K., Takiguchi S., Miyata H., Adachi S., Hiura Y., Yamasaki M., Nakajima K., Fujiwara Y., Mori M., Kangawa K., Doki Y. Randomized phase II study of clinical effects of ghrelin after esophagectomy with gastric tube reconstruction. Surgery 2010, 148:31-38.
25. Okumura H., Nagaya N., Enomoto M., Nakagawa E., Oya H., Kangawa K. Vasodilatory effect of ghrelin, an endogenous peptide from the stomach. J Cardiovasc Pharmacol 2002, 39:779-783.
26. Baldanzi G., Filigheddu N., Cutrupi S., Catapano F., Bonissoni S., Fubini A., Malan D., Baj G., Granata R., Broglio F., Papotti M., Surico N., Bussolino F., Isgaard J., Deghenghi R., et al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 2002, 159:1029-1037.
27. Li W.G., Gavrila D., Liu X., Wang L., Gunnlaugsson S., Stoll L.L., McCormick M.L., Sigmund C.D., Tang C., Weintraub N.L. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation 2004, 109:2221-2226.
28. Nagaya N., Uematsu M., Kojima M., Ikeda Y., Yoshihara F., Shimizu W., Hosoda H., Hirota Y., Ishida H., Mori H., Kangawa K. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 2001, 104:1430-1435.
29. Soeki T., Kishimoto I., Schwenke D.O., Tokudome T., Horio T., Yoshida M., Kangawa K. Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction. Am J Physiol 2008, 294:H426-H432.
30. Schwenke D.O., Tokudome T., Kishimoto I., Horio T., Shirai M., Cragg P.A., Kangawa K. Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. Endocrinology 2008, 149:5172-5176.
31. Chang L., Ren Y., Liu X., Li W.G., Yang J., Geng B., Weintraub N.L., Tang C. Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart. J Cardiovasc Pharmacol 2004, 43:165-170.
32. Schwenke D.O., Tokudome T., Shirai M., Hosoda H., Horio T., Kishimoto I., Craig P., Kangawa K. Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats. Endocrinology 2008, 149:237-244.
33. Lambert E., Lambert G., Ika-Sari C., Dawood T., Lee K., Chopra R., Straznicky N., Eikelis N., Drew S., Tilbrook A., Dixon J., Esler M., Schlaich M.P. Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men. Hypertension 2011, 58:43-50.
34. Matsumura K., Tsuchihashi T., Fujii K., Abe I., Iida M. Central ghrelin modulates sympathetic activity in conscious rabbits. Hypertension 2002, 40:694-699.
35. Lin Y., Matsumura K., Fukuhara M., Kagiyama S., Fujii K., Iida M. Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats. Hypertension 2004, 43:977-982.
36. Huda M.S., Mani H., Dovey T., Halford J.C., Boyland E., Daousi C., Wilding J.P., Pinkney J. Ghrelin inhibits autonomic function in healthy controls, but has no effect on obese and vagotomized subjects. Clin Endocrinol (Oxf) 2010, 73:678-685.
37. Kishimoto I., Tokudome T., Hosoda H., Miyazato M., Nishikimi T. Ghrelin and Cardiovascular Diseases. Handbook of the Biologically Active Peptides 2012, in press. A.J. Kastin (Ed.).