Fluoxetine suppresses AMP-activated protein kinase signaling pathway to promote hepatic lipid accumulation in primary mouse hepatocytes

International Journal of Biochemistry and Cell Biology

Volumn 54, Issue , 2014, Pages 236-244

  Xiong, Jing ^a   Yang, Huan ^b   Wu, Lili ^a   Shang, Wei ^a   Shan, Enfang ^a   Liu, Wei ^a   Hu, Gang ^a   Xi, Tao ^b   Yang, Jian ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

AMPK; Carboxylesterases; Fluoxetine; Hepatic lipid accumulation; SREBP

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; FAT DROPLET; FATTY ACID SYNTHASE; FLUOXETINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPID; PYRROLIDINE DITHIOCARBAMATE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; CARBOXYLESTERASE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SEROTONIN UPTAKE INHIBITOR; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; ANTIDIABETIC AGENT; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE; RIBONUCLEOTIDE; SREBF1 PROTEIN, MOUSE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STK11 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL FRACTIONATION; CYTOPLASM; DOWN REGULATION; ENZYME PHOSPHORYLATION; FATTY ACID SYNTHESIS; GENE EXPRESSION; IMMUNOFLUORESCENCE TEST; LIPID DEGRADATION; LIPID LIVER LEVEL; LIPID STORAGE; LIPOGENESIS; LIPOLYSIS; LIVER CELL; MALE; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL EXPERIMENT; ANIMAL MODEL; ATTENUATION; DYSLIPIDEMIA; ENZYME SYNTHESIS; INTRACELLULAR SIGNALING; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; QUALITY CONTROL; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE; FLUOXETINE; HEPATOCYTES; HYPOGLYCEMIC AGENTS; LIPOGENESIS; LIPOLYSIS; MALE; MICE; MICE, INBRED ICR; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEOTIDES; RNA, MESSENGER; SEROTONIN UPTAKE INHIBITORS; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84907325902     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.07.019     Document Type: Article

References (53)

1. J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis and liver injury J Clin Invest 114 2004 147 152 (Pubitemid 39071617)
2. N.N. Bumpus, and E.F. Johnson 5-Aminoimidazole-4-carboxyamide- ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor alpha-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent J Pharmacol Exp Ther 339 2011 886 895
3. E. Cascade, A.H. Kalali, and S.H. Kennedy Real-world data on SSRI antidepressant side effects Psychiatry (Edgmont) 6 2009 16 18
4. J.J. Chang, M.J. Hsu, H.P. Huang, D.J. Chung, Y.C. Chang, and C.J. Wang Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance J Agric Food Chem 61 25 2013 6069 6076
5. H. Chen, L. Zhang, X. Li, G.Q. Sun, X. Yuan, and L. Lei et al. Adiponectin activates the AMPK signaling pathway to regulate lipid metabolism in bovine hepatocytes J Steroid Biochem Mol Biol 138 2013 445 454
6. D. Cheng, C.H. Chu, L. Chen, J.N. Feder, G.A. Mintier, and Y. Wu et al. Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes Protein Expr Purif 51 2007 11 21 (Pubitemid 44821859)
7. J.E. Desmarais, L. Beauclair, and H.C. Margolese Switching from brand-name to generic psychotropic medications: a literature review CNS Neurosci Ther 17 2011 750 760
8. V.W. Dolinsky, D. Gilham, M. Alam, D.E. Vance, and R. Lehner Triacylglycerol hydrolase: role in intracellular lipid metabolism Cell Mol Life Sci 61 2004 1633 1651 (Pubitemid 38962045)
9. D. Eberle, B. Hegarty, P. Bossard, P. Ferre, and F. Foufelle SREBP transcription factors: master regulators of lipid homeostasis Biochimie 86 2004 839 848 (Pubitemid 39602764)
10. X.M. Feng, J. Xiong, H. Qin, W. Liu, R.N. Chen, and W. Shang et al. Fluoxetine induces hepatic lipid accumulation via both promotion of the SREBP1c-related lipogenesis and reduction of lipolysis in primary mouse hepatocytes CNS Neurosci Ther 18 2012 974 980
11. P. Ferre, and F. Foufelle Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c Diabetes Obes Metab 12 Suppl. 2 2010 83 92
12. D.G. Hardie, and D.A. Pan Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase Biochem Soc Trans 30 2002 1064 1070 (Pubitemid 36002407)
13. S.A. Hawley, J. Boudeau, J.L. Reid, K.J. Mustard, L. Udd, and T.P. Makela et al. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade J Biol 2 2003 28
14. J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J Clin Invest 109 2002 1125 1131 (Pubitemid 34496588)
15. S. Jazayeri, M. Tehrani-Doost, S.A. Keshavarz, M. Hosseini, A. Djazayery, and H. Amini et al. Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder Aust N Z J Psychiatry 42 2008 192 198 (Pubitemid 351234188)
16. B.B. Kahn, T. Alquier, D. Carling, and D.G. Hardie AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism Cell Metab 1 2005 15 25 (Pubitemid 43960587)
17. M.K. Kim, S.H. Kim, H.S. Yu, H.G. Park, U.G. Kang, and Y.M. Ahn et al. The effect of clozapine on the AMPK-ACC-CPT1 pathway in the rat frontal cortex Int J Neuropsychopharmacol 2011 1 11
18. M. Kivimaki, M. Hamer, G.D. Batty, J.R. Geddes, A.G. Tabak, and J. Pentti et al. Antidepressant medication use, weight gain, and risk of type 2 diabetes: a population-based study Diabetes Care 33 2010 2611 2616
19. K.W. Ko, B. Erickson, and R. Lehner Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes Biochim Biophys Acta 1791 2009 1133 1143
20. R. Lehner, and D.E. Vance Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol Biochem J 343 Pt. 1 1999 1 10 (Pubitemid 29473871)
21. Y. Li, S. Xu, M.M. Mihaylova, B. Zheng, X. Hou, and B. Jiang et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice Cell Metab 13 2011 376 388
22. Z. Mao, Y. Li, Y. Peng, X. Luan, H. Gui, and X. Feng et al. Lipopolysaccharide down-regulates carbolesterases 1 and 2 and reduces hydrolysis activity in vitro and in vivo via p38MAPK-NF-kappaB pathway Toxicol Lett 201 2011 213 220
23. C. Mastronardi, G.J. Paz-Filho, E. Valdez, J. Maestre-Mesa, J. Licinio, and M.L. Wong Long-term body weight outcomes of antidepressant-environment interactions Mol Psychiatry 16 2011 265 272
24. J.A. Menendez, A. Vazquez-Martin, F.J. Ortega, and J.M. Fernandez-Real Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer Clin Chem 55 2009 425 438
25. F. Nassir, O.L. Adewole, E.M. Brunt, and N.A. Abumrad CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis in ob/ob mice J Lipid Res 54 11 2013 2988 2997
26. M. Olfson, and S.C. Marcus National patterns in antidepressant medication treatment Arch Gen Psychiatry 66 2009 848 856
27. E.M. Penas-Lledo, H.D. Trejo, P. Dorado, A. Ortega, H. Jung, and E. Alonso et al. CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitriptyline monotherapy treatment in major depressive patients Mol Psychiatry 18 2013 8 9
28. T. Porstmann, C.R. Santos, B. Griffiths, M. Cully, M. Wu, and S. Leevers et al. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth Cell Metab 8 2008 224 236
29. A. Poso, and P. Honkakoski Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies Mini Rev Med Chem 6 2006 937 947
30. H.Y. Quan, Y. Kim do, S.J. Kim, H.K. Jo, G.W. Kim, and S.H. Chung Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway Biochem Pharmacol 85 2013 1330 1340
31. A.D. Quiroga, and R. Lehner Liver triacylglycerol lipases Biochim Biophys Acta 1821 5 2012 762 769
32. A.D. Quiroga, and R. Lehner Role of endoplasmic reticulum neutral lipid hydrolases Trends Endocrinol Metab 22 2011 218 225
33. M.B. Raeder, J. Ferno, M. Glambek, C. Stansberg, and V.M. Steen Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells Neurosci Lett 395 2006 185 190 (Pubitemid 43213141)
34. R. Raghow, C. Yellaturu, X. Deng, E.A. Park, and M.B. Elam SREBPs: the crossroads of physiological and pathological lipid homeostasis Trends Endocrinol Metab 19 2008 65 73 (Pubitemid 351317897)
35. M. Rahmadi, M. Narita, A. Yamashita, S. Imai, N. Kuzumaki, and T. Suzuki Sleep disturbance associated with an enhanced orexinergic system induced by chronic treatment with paroxetine and milnacipran Synapse 65 2011 652 657
36. J. Richard, and I. Lingvay Hepatic steatosis and Type 2 diabetes: current and future treatment considerations Expert Rev Cardiovasc Ther 9 2011 321 328
37. A. Roth, R. Looser, M. Kaufmann, and U.A. Meyer Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes Pharmacogenet Genomics 18 2008 325 337 (Pubitemid 351367526)
38. G.A. Rutter, G. Da Silva Xavier, and I. Leclerc Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis Biochem J 375 2003 1 16 (Pubitemid 37255376)
39. E. Severus, N. Schaaff, and H.J. Moller State of the art: treatment of bipolar disorders CNS Neurosci Ther 18 2012 214 218
40. A. Sfikas, C. Batsi, E. Tselikou, G. Vartholomatos, N. Monokrousos, and P. Pappas et al. The canonical NF-kappaB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage Cell Signal 24 11 2012 2007 2023
41. S. Shindo, S. Numazawa, and T. Yoshida A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction Biochem J 401 2007 735 741 (Pubitemid 46219267)
42. J.L. Staudinger, C. Xu, Y.J. Cui, and C.D. Klaassen Nuclear receptor-mediated regulation of carboxylesterase expression and activity Expert Opin Drug Metab Toxicol 6 2010 261 271
43. M. Tiainen, K. Vaahtomeri, A. Ylikorkala, and T.P. Makela Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1) Hum Mol Genet 11 2002 1497 1504 (Pubitemid 34679250)
44. R. Uher, A. Farmer, N. Henigsberg, M. Rietschel, O. Mors, and W. Maier et al. Adverse reactions to antidepressants Br J Psychiatry 195 2009 202 210
45. V. Vu, P. Bui, M. Eguchi, A. Xu, and G. Sweeney Globular adiponectin induces LKB1/AMPK-dependent glucose uptake via actin cytoskeleton remodeling J Mol Endocrinol 51 2013 155 165
46. D. Warden, M.H. Trivedi, S.R. Wisniewski, B. Kurian, S. Zisook, and S.G. Kornstein et al. Early adverse events and attrition in selective serotonin reuptake inhibitor treatment: a suicide assessment methodology study report J Clin Psychopharmacol 30 2010 259 266
47. D.T. Wong, J.S. Horng, F.P. Bymaster, K.L. Hauser, and B.B. Molloy A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p- trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine Life Sci 15 1974 471 479
48. D.T. Wong, K.W. Perry, and F.P. Bymaster Case history: the discovery of fluoxetine hydrochloride (Prozac) Nat Rev Drug Discov 4 2005 764 774 (Pubitemid 43090497)
49. 2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells Cell Metab 2 2005 21 33 (Pubitemid 43239822)
50. D. Xiao, Y.T. Chen, D. Yang, and B. Yan Age-related inducibility of carboxylesterases by the antiepileptic agent phenobarbital and implications in drug metabolism and lipid accumulation Biochem Pharmacol 84 2012 232 239
51. Z. Xie, Y. Dong, R. Scholz, D. Neumann, and M.H. Zou Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells Circulation 117 2008 952 962 (Pubitemid 351272593)
52. M. You, M. Matsumoto, C.M. Pacold, W.K. Cho, and D.W. Crabb The role of AMP-activated protein kinase in the action of ethanol in the liver Gastroenterology 127 2004 1798 1808 (Pubitemid 39575858)
53. J. Zhou, M.X. Shi, T.D. Mitchell, G.N. Smagin, S.R. Thomas, and D.H. Ryan et al. Changes in rat adipocyte and liver glucose metabolism following repeated restraint stress Exp Biol Med (Maywood) 226 2001 312 319