메뉴 건너뛰기




Volumn 7, Issue , 2014, Pages

Biology of adeno-associated viral vectors in the central nervous system

Author keywords

Adeno associated virus (AAV); Gene therapy; Neurodegenerative diseases; Neurological disorders; Viral vectors

Indexed keywords

AMINO ACID DECARBOXYLASE; PARVOVIRUS VECTOR;

EID: 84907299494     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2014.00076     Document Type: Review
Times cited : (130)

References (114)
  • 1
    • 2942623871 scopus 로고    scopus 로고
    • Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology
    • Abbott, N. J. (2004). Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem. Int. 45, 545-552. doi: 10.1016/j.neuint.2003.11.006
    • (2004) Neurochem. Int , vol.45 , pp. 545-552
    • Abbott, N.J.1
  • 2
    • 83455225659 scopus 로고    scopus 로고
    • AAV capsid structure and cell interactions
    • Agbandje-McKenna, M., and Kleinschmidt, J. (2011). AAV capsid structure and cell interactions. Methods Mol. Biol. 807, 47-92. doi: 10.1007/978-1-61779-370-7_3
    • (2011) Methods Mol. Biol , vol.807 , pp. 47-92
    • Agbandje-McKenna, M.1    Kleinschmidt, J.2
  • 3
    • 84890120669 scopus 로고    scopus 로고
    • A single intravenous rAAV injection as late as P.0 achieves efficacious and sustained CNS gene therapy in canavan mice
    • Ahmed, S. S., Li, H., Cao, C., Sikoglu, E. M., Denninger, A. R., Su, Q., et al. (2013). A single intravenous rAAV injection as late as P.0 achieves efficacious and sustained CNS gene therapy in canavan mice. Mol. Ther. 21, 2136-2147. doi: 10.1038/mt.2013.138
    • (2013) Mol. Ther , vol.21 , pp. 2136-2147
    • Ahmed, S.S.1    Li, H.2    Cao, C.3    Sikoglu, E.M.4    Denninger, A.R.5    Su, Q.6
  • 4
    • 1542268981 scopus 로고    scopus 로고
    • For the long run: Maintaining germinal niches in the adult brain
    • Alvarez-Buylla, A., and Lim, D. A. (2004). For the long run: maintaining germinal niches in the adult brain. Neuron 41, 683-686. doi: 10.1016/S0896-6273(04)00111-4
    • (2004) Neuron , vol.41 , pp. 683-686
    • Alvarez-Buylla, A.1    Lim, D.A.2
  • 5
    • 84877746944 scopus 로고    scopus 로고
    • Heparin-binding correlates with increased efficiency of AAV1and AAV6-mediated transduction of striated muscle, but negatively impacts CNS transduction
    • Arnett, A. L., Beutler, L. R., Quintana, A., Allen, J., Finn, E., P.lmiter, R. D., et al. (2013). Heparin-binding correlates with increased efficiency of AAV1and AAV6-mediated transduction of striated muscle, but negatively impacts CNS transduction. Gene Ther. 20, 497-503. doi: 10.1038/gt.2012.60
    • (2013) Gene Ther , vol.20 , pp. 497-503
    • Arnett, A.L.1    Beutler, L.R.2    Quintana, A.3    Allen, J.4    Finn, E.5    P.lmiter, R.D.6
  • 6
    • 84859440283 scopus 로고    scopus 로고
    • The AAV vector toolkit: P.ised at the clinical crossroads
    • Asokan, A., Schaffer, D. V., and Jude Samulski, R. (2012). The AAV vector toolkit: poised at the clinical crossroads. Mol. Ther. 20, 699-708. doi: 10.1038/mt.2011.287
    • (2012) Mol. Ther , vol.20 , pp. 699-708
    • Asokan, A.1    Schaffer, D.V.2    Jude Samulski, R.3
  • 7
    • 0032550793 scopus 로고    scopus 로고
    • Selective and rapid uptake of adeno-associated virus type 2 in brain
    • Bartlett, J. S., Samulski, R. J., and McCown, T. J. (1998). Selective and rapid uptake of adeno-associated virus type 2 in brain. Hum. Gene Ther. 9, 1181-1186. doi: 10.1089/hum.1998.9.8-1181
    • (1998) Hum. Gene Ther , vol.9 , pp. 1181-1186
    • Bartlett, J.S.1    Samulski, R.J.2    McCown, T.J.3
  • 8
    • 80053075847 scopus 로고    scopus 로고
    • Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors
    • Beier, K. T., Saunders, A., Oldenburg, I. A., Miyamichi, K., Akhtar, N., Luo, L., et al. (2011). Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. P.oc. Natl. Acad. Sci. U.S.A. 108, 15414-15419. doi: 10.1073/pnas.1110854108
    • (2011) P.oc. Natl. Acad. Sci. U.S.A , vol.108 , pp. 15414-15419
    • Beier, K.T.1    Saunders, A.2    Oldenburg, I.A.3    Miyamichi, K.4    Akhtar, N.5    Luo, L.6
  • 9
    • 79957918498 scopus 로고    scopus 로고
    • The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
    • Bell, C. L., Vandenberghe, L. H., Bell, P., Limberis, M. P., Gao, G. P., Van Vliet, K., et al. (2011). The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice. J. Clin. Invest. 121, 2427-2435. doi: 10.1172/JCI57367
    • (2011) J. Clin. Invest , vol.121 , pp. 2427-2435
    • Bell, C.L.1    Vandenberghe, L.H.2    Bell, P.3    Limberis, M.P.4    Gao, G.P.5    Van Vliet, K.6
  • 10
    • 84873410199 scopus 로고    scopus 로고
    • Intramuscular scAAV9-SMN injection mediates widespread gene delivery to the spinal cord and decreases disease severity in SMA mice
    • Benkhelifa-Ziyyat, S., Besse, A., Roda, M., Duque, S., Astord, S., Carcenac, R., et al. (2013). Intramuscular scAAV9-SMN injection mediates widespread gene delivery to the spinal cord and decreases disease severity in SMA mice. Mol. Ther. 21, 282-290. doi: 10.1038/mt.2012.261
    • (2013) Mol. Ther , vol.21 , pp. 282-290
    • Benkhelifa-Ziyyat, S.1    Besse, A.2    Roda, M.3    Duque, S.4    Astord, S.5    Carcenac, R.6
  • 11
    • 84862140284 scopus 로고    scopus 로고
    • Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNF
    • Benraiss, A., Bruel-Jungerman, E., Lu, G., Economides, A. N., Davidson, B., and Goldman, S. A. (2012). Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNF. Gene Ther. 19, 483-493. doi: 10.1038/gt.2011.114
    • (2012) Gene Ther , vol.19 , pp. 483-493
    • Benraiss, A.1    Bruel-Jungerman, E.2    Lu, G.3    Economides, A.N.4    Davidson, B.5    Goldman, S.A.6
  • 12
    • 80455173951 scopus 로고    scopus 로고
    • Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders
    • Bevan, A. K., Duque, S., Foust, K. D., Morales, P. R., Braun, L., Schmelzer, L., et al. (2011). Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders. Mol. Ther. 19, 1971-1980. doi: 10.1038/mt.2011.157
    • (2011) Mol. Ther , vol.19 , pp. 1971-1980
    • Bevan, A.K.1    Duque, S.2    Foust, K.D.3    Morales, P.R.4    Braun, L.5    Schmelzer, L.6
  • 13
    • 84864352807 scopus 로고    scopus 로고
    • Rapid transgene expression in multiple precursor cell types of adult rat subventricular zone mediated by adeno-associated type 1 vectors
    • Bockstael, O., Melas, C., P.thoud, C., Levivier, M., McCarty, D., Samulski, R. J., et al. (2012). Rapid transgene expression in multiple precursor cell types of adult rat subventricular zone mediated by adeno-associated type 1 vectors. Hum. Gene Ther. 23, 742-753. doi: 10.1089/hum.2011.216
    • (2012) Hum. Gene Ther , vol.23 , pp. 742-753
    • Bockstael, O.1    Melas, C.2    P.thoud, C.3    Levivier, M.4    McCarty, D.5    Samulski, R.J.6
  • 14
    • 58149386433 scopus 로고    scopus 로고
    • Insertional gene activation by lentiviral and gammaretroviral vectors
    • Bokhoven, M., Stephen, S. L., Knight, S., Gevers, E. F., Robinson, I. C., Takeuchi, Y., et al. (2009). Insertional gene activation by lentiviral and gammaretroviral vectors. J. Virol. 83, 283-294. doi: 10.1128/JVI.01865-08
    • (2009) J. Virol , vol.83 , pp. 283-294
    • Bokhoven, M.1    Stephen, S.L.2    Knight, S.3    Gevers, E.F.4    Robinson, I.C.5    Takeuchi, Y.6
  • 15
    • 84885679000 scopus 로고    scopus 로고
    • Lysosomal storage diseases the horizon expands
    • Boustany, R. M. (2013). Lysosomal storage diseases the horizon expands. Nat. Rev. Neurol. 9, 583-598. doi: 10.1038/nrneurol.2013.163
    • (2013) Nat. Rev. Neurol , vol.9 , pp. 583-598
    • Boustany, R.M.1
  • 16
    • 85145106846 scopus 로고    scopus 로고
    • "The genus dependovirus,"
    • J. R. Kerr, S. F. Cotmore, M. E. Bloom, R. M. Linden, and C. R. P.rrish (New York: Edward Arnold Ltd
    • Bowles, D. E., Rabinowitz, J. E., and Samulski, R. J. (2006). "The genus dependovirus," in P.rvoviruses eds J. R. Kerr, S. F. Cotmore, M. E. Bloom, R. M. Linden, and C. R. P.rrish (New York: Edward Arnold Ltd.), 15-24.
    • (2006) P.rvoviruses , pp. 15-24
    • Bowles, D.E.1    Rabinowitz, J.E.2    Samulski, R.J.3
  • 17
    • 32844456598 scopus 로고    scopus 로고
    • Adenoassociated virus vectors serotyped with AAV8 capsid are more efficient than AAV1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain
    • Broekman, M. L., Comer, L. A., Hyman, B. T., and Sena-Esteves, M. (2006). Adenoassociated virus vectors serotyped with AAV8 capsid are more efficient than AAV1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain. Neuroscience 138, 501-510. doi: 10.1016/j.neuroscience.2005.11.057
    • (2006) Neuroscience , vol.138 , pp. 501-510
    • Broekman, M.L.1    Comer, L.A.2    Hyman, B.T.3    Sena-Esteves, M.4
  • 18
    • 4344566457 scopus 로고    scopus 로고
    • Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system
    • Burger, C., Gorbatyuk, O. S., Velardo, M. J., P.den, C. S., Williams, P., Zolotukhin, S., et al. (2004). Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol. Ther. 10, 302-317. doi: 10.1016/j.ymthe.2004.05.024
    • (2004) Mol. Ther , vol.10 , pp. 302-317
    • Burger, C.1    Gorbatyuk, O.S.2    Velardo, M.J.3    P.den, C.S.4    Williams, P.5    Zolotukhin, S.6
  • 19
    • 77956450004 scopus 로고    scopus 로고
    • Intracerebroventricular delivery of glucocerebrosidase reduces substrates and increases lifespan in a mouse model of neuronopathic gaucher disease
    • Cabrera-Salazar, M. A., Bercury, S. D., Ziegler, R. J., Marshall, J., Hodges, B. L., Chuang, W. L., et al. (2010). Intracerebroventricular delivery of glucocerebrosidase reduces substrates and increases lifespan in a mouse model of neuronopathic gaucher disease. Exp. Neurol. 225, 436-444. doi: 10.1016/j.expneurol.2010.07.023
    • (2010) Exp. Neurol , vol.225 , pp. 436-444
    • Cabrera-Salazar, M.A.1    Bercury, S.D.2    Ziegler, R.J.3    Marshall, J.4    Hodges, B.L.5    Chuang, W.L.6
  • 20
    • 84906279894 scopus 로고    scopus 로고
    • Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport
    • Castle, M. J., Gershenson, Z. T., Giles, A. R., Holzbaur, E. L., and Wolfe, J. H. (2014a). Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport. Hum. Gene Ther. 25, 705-720. doi: 10.1089/hum.2013.189
    • (2014) Hum. Gene Ther , vol.25 , pp. 705-720
    • Castle, M.J.1    Gershenson, Z.T.2    Giles, A.R.3    Holzbaur, E.L.4    Wolfe, J.H.5
  • 21
    • 84895461561 scopus 로고    scopus 로고
    • Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment
    • Castle, M. J., P.rlson, E., Holzbaur, E. L., and Wolfe, J. H. (2014b). Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment. Mol. Ther. 22, 554-566. doi: 10.1038/mt.2013.237
    • (2014) Mol. Ther , vol.22 , pp. 554-566
    • Castle, M.J.1    P.rlson, E.2    Holzbaur, E.L.3    Wolfe, J.H.4
  • 22
    • 54749126318 scopus 로고    scopus 로고
    • Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain
    • Cearley, C. N., Vandenberghe, L. H., P.rente, M. K., Carnish, E. R., Wilson, J. M., and Wolfe, J. H. (2008). Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain. Mol. Ther. 16, 1710-1718. doi: 10.1038/mt.2008.166
    • (2008) Mol. Ther , vol.16 , pp. 1710-1718
    • Cearley, C.N.1    Vandenberghe, L.H.2    P.rente, M.K.3    Carnish, E.R.4    Wilson, J.M.5    Wolfe, J.H.6
  • 23
    • 32944459983 scopus 로고    scopus 로고
    • Transduction characteristics of adenoassociated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain
    • Cearley, C. N., and Wolfe, J. H. (2006). Transduction characteristics of adenoassociated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain. Mol. Ther. 13, 528-537. doi: 10.1016/j.ymthe.2005.11.015
    • (2006) Mol. Ther , vol.13 , pp. 528-537
    • Cearley, C.N.1    Wolfe, J.H.2
  • 24
    • 34548610909 scopus 로고    scopus 로고
    • A single injection of an adeno-associated virus vector into nuclei with divergent connections results in widespread vector distribution in the brain and global correction of a neurogenetic disease
    • Cearley, C. N., and Wolfe, J. H. (2007). A single injection of an adeno-associated virus vector into nuclei with divergent connections results in widespread vector distribution in the brain and global correction of a neurogenetic disease. J. Neurosci. 27, 9928-9940. doi: 10.1523/JNEUROSCI.2185-07.2007
    • (2007) J. Neurosci , vol.27 , pp. 9928-9940
    • Cearley, C.N.1    Wolfe, J.H.2
  • 25
    • 84879371255 scopus 로고    scopus 로고
    • Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain
    • Chakrabarty, P., Rosario, A., Cruz, P., Siemienski, Z., Ceballos-Diaz, C., Crosby, K., et al. (2013). Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain. P.oS ONE 8:e67680. doi: 10.1371/journal.pone.0067680
    • (2013) P.oS ONE , vol.8
    • Chakrabarty, P.1    Rosario, A.2    Cruz, P.3    Siemienski, Z.4    Ceballos-Diaz, C.5    Crosby, K.6
  • 26
    • 0032543124 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus vector: Use for transgene expression and anterograde tract tracing in the CNS
    • Chamberlin, N. L., Du, B., de Lacalle, S., and Saper, C. B. (1998). Recombinant adeno-associated virus vector: use for transgene expression and anterograde tract tracing in the CNS. Brain Res. 793, 169-175. doi: 10.1016/S0006-8993(98)00169-3
    • (1998) Brain Res , vol.793 , pp. 169-175
    • Chamberlin, N.L.1    Du, B.2    De Lacalle, S.3    Saper, C.B.4
  • 27
    • 84863466713 scopus 로고    scopus 로고
    • Sialic acid deposition impairs the utility of AAV9, but not peptide-modified AAVs for brain gene therapy in a mouse model of lysosomal storage disease
    • Chen, Y. H., Claflin, K., Geoghegan, J. C., and Davidson, B. L. (2012). Sialic acid deposition impairs the utility of AAV9, but not peptide-modified AAVs for brain gene therapy in a mouse model of lysosomal storage disease. Mol. Ther. 20, 1393-1399. doi: 10.1038/mt.2012.100
    • (2012) Mol. Ther , vol.20 , pp. 1393-1399
    • Chen, Y.H.1    Claflin, K.2    Geoghegan, J.C.3    Davidson, B.L.4
  • 28
    • 84871922836 scopus 로고    scopus 로고
    • Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses
    • Ciesielska, A., Hadaczek, P., Mittermeyer, G., Zhou, S., Wright, J. F., Bankiewicz, K. S., et al. (2013). Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses. Mol. Ther. 21, 158-166. doi: 10.1038/mt.2012.167
    • (2013) Mol. Ther , vol.21 , pp. 158-166
    • Ciesielska, A.1    Hadaczek, P.2    Mittermeyer, G.3    Zhou, S.4    Wright, J.F.5    Bankiewicz, K.S.6
  • 30
    • 0026929035 scopus 로고
    • Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance
    • Cserr, H. F., Harling-Berg, C. J., and Knopf, P. M. (1992). Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance. Brain P.thol. 2, 269-276. doi: 10.1111/j.1750-3639.1992.tb00703.x
    • (1992) Brain P.thol , vol.2 , pp. 269-276
    • Cserr, H.F.1    Harling-Berg, C.J.2    Knopf, P.M.3
  • 31
    • 0034724209 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system
    • Davidson, B. L., Stein, C. S., Heth, J. A., Martins, I., Kotin, R. M., Derksen, T. A., et al. (2000). Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. P.oc. Natl. Acad. Sci. U.S.A. 97, 3428-3432. doi: 10.1073/pnas.97.7.3428
    • (2000) P.oc. Natl. Acad. Sci. U.S.A , vol.97 , pp. 3428-3432
    • Davidson, B.L.1    Stein, C.S.2    Heth, J.A.3    Martins, I.4    Kotin, R.M.5    Derksen, T.A.6
  • 32
    • 84861326894 scopus 로고    scopus 로고
    • The advent of AAV9 expands applications for brain and spinal cord gene delivery
    • Dayton, R. D., Wang, D. B., and Klein, R. L. (2012). The advent of AAV9 expands applications for brain and spinal cord gene delivery. Expert Opin. Biol. Ther. 12, 757-766. doi: 10.1517/14712598.2012.681463
    • (2012) Expert Opin. Biol. Ther , vol.12 , pp. 757-766
    • Dayton, R.D.1    Wang, D.B.2    Klein, R.L.3
  • 33
    • 84891803470 scopus 로고    scopus 로고
    • Biosafety of recombinant adeno-associated virus vectors
    • Dismuke, D. J., Tenenbaum, L., and Samulski, R. J. (2013). Biosafety of recombinant adeno-associated virus vectors. Curr. Gene Ther. 13, 434-452. doi: 10.2174/15665232113136660007
    • (2013) Curr. Gene Ther , vol.13 , pp. 434-452
    • Dismuke, D.J.1    Tenenbaum, L.2    Samulski, R.J.3
  • 34
    • 0031691257 scopus 로고    scopus 로고
    • Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue
    • Duan, D., Sharma, P., Yang, J., Yue, Y., Dudus, L., Zhang, Y., et al. (1998). Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue. J. Virol. 72, 8568-8577.
    • (1998) J. Virol , vol.72 , pp. 8568-8577
    • Duan, D.1    Sharma, P.2    Yang, J.3    Yue, Y.4    Dudus, L.5    Zhang, Y.6
  • 35
    • 84864877570 scopus 로고    scopus 로고
    • Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs
    • Federici, T., Taub, J. S., Baum, G. R., Gray, S. J., Grieger, J. C., Matthews, K. A., et al. (2012). Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs. Gene Ther. 19, 852-859. doi: 10.1038/gt.2011.130
    • (2012) Gene Ther , vol.19 , pp. 852-859
    • Federici, T.1    Taub, J.S.2    Baum, G.R.3    Gray, S.J.4    Grieger, J.C.5    Matthews, K.A.6
  • 36
    • 60149106907 scopus 로고    scopus 로고
    • Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
    • Foust, K. D., Nurre, E., Montgomery, C. L., Hernandez, A., Chan, C. M., and Kaspar, B. K. (2009). Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes. Nat. Biotechnol. 27, 59-65. doi: 10.1038/nbt.1515
    • (2009) Nat. Biotechnol , vol.27 , pp. 59-65
    • Foust, K.D.1    Nurre, E.2    Montgomery, C.L.3    Hernandez, A.4    Chan, C.M.5    Kaspar, B.K.6
  • 37
    • 34447098114 scopus 로고    scopus 로고
    • Significantly increased lifespan and improved behavioral performances by rAAV gene delivery in adult mucopolysaccharidosis IIIB mice
    • Fu, H., Kang, L., Jennings, J. S., Moy, S. S., P.rez, A., Dirosario, J., et al. (2007). Significantly increased lifespan and improved behavioral performances by rAAV gene delivery in adult mucopolysaccharidosis IIIB mice. Gene Ther. 14, 1065-1077. doi: 10.1038/sj.gt.3302961
    • (2007) Gene Ther , vol.14 , pp. 1065-1077
    • Fu, H.1    Kang, L.2    Jennings, J.S.3    Moy, S.S.4    P.rez, A.5    Dirosario, J.6
  • 38
    • 0347286956 scopus 로고    scopus 로고
    • Selfcomplementary adeno-associated virus serotype 2 vector: Global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain
    • Fu, H., Muenzer, J., Samulski, R. J., Breese, G., Sifford, J., Zeng, X., et al. (2003). Selfcomplementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain. Mol. Ther. 8, 911-917. doi: 10.1016/j.ymthe.2003.08.021
    • (2003) Mol. Ther , vol.8 , pp. 911-917
    • Fu, H.1    Muenzer, J.2    Samulski, R.J.3    Breese, G.4    Sifford, J.5    Zeng, X.6
  • 39
    • 0037015049 scopus 로고    scopus 로고
    • Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy
    • Gao, G. P., Alvira, M. R., Wang, L., Calcedo, R., Johnston, J., and Wilson, J. M. (2002). Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. P.oc. Natl. Acad. Sci. U.S.A. 99, 11854-11859. doi: 10.1073/pnas.182412299
    • (2002) P.oc. Natl. Acad. Sci. U.S.A , vol.99 , pp. 11854-11859
    • Gao, G.P.1    Alvira, M.R.2    Wang, L.3    Calcedo, R.4    Johnston, J.5    Wilson, J.M.6
  • 40
    • 2642512201 scopus 로고    scopus 로고
    • Clades of adeno-associated viruses are widely disseminated in human tissues
    • Gao, G., Vandenberghe, L. H., Alvira, M. R., Lu, Y., Calcedo, R., Zhou, X., et al. (2004). Clades of adeno-associated viruses are widely disseminated in human tissues. J. Virol. 78, 6381-6388. doi: 10.1128/JVI.78.12.6381-6388.2004
    • (2004) J. Virol , vol.78 , pp. 6381-6388
    • Gao, G.1    Vandenberghe, L.H.2    Alvira, M.R.3    Lu, Y.4    Calcedo, R.5    Zhou, X.6
  • 41
    • 84858026947 scopus 로고    scopus 로고
    • Decreasing disease severity in symptomatic, smn(-/-);SMN2(+/+), spinal muscular atrophy mice following scAAV9-SMN delivery. Hum
    • Glascock, J. J., Osman, E. Y., Wetz, M. J., Krogman, M. M., Shababi, M., and Lorson, C. L. (2012). Decreasing disease severity in symptomatic, smn(-/-);SMN2(+/+), spinal muscular atrophy mice following scAAV9-SMN delivery. Hum. Gene Ther. 23, 330-335. doi: 10.1089/hum.2011.166
    • (2012) Gene Ther , vol.23 , pp. 330-335
    • Glascock, J.J.1    Osman, E.Y.2    Wetz, M.J.3    Krogman, M.M.4    Shababi, M.5    Lorson, C.L.6
  • 42
    • 33751210120 scopus 로고    scopus 로고
    • Structurally mapping the diverse phenotype of adenoassociated virus serotype 4
    • Govindasamy, L., P.dron, E., McKenna, R., Muzyczka, N., Kaludov, N., Chiorini, J. A., et al. (2006). Structurally mapping the diverse phenotype of adenoassociated virus serotype 4. J. Virol. 80, 11556-11570. doi: 10.1128/JVI. 01536-06
    • (2006) J. Virol , vol.80 , pp. 11556-11570
    • Govindasamy, L.1    P.dron, E.2    McKenna, R.3    Muzyczka, N.4    Kaludov, N.5    Chiorini, J.A.6
  • 43
    • 84879557755 scopus 로고    scopus 로고
    • Imaging the transport dynamics of single alphaherpesvirus particles in intact peripheral nervous system explants from infected mice
    • Granstedt, A. E., Brunton, B. W., and Enquist, L. W. (2013). Imaging the transport dynamics of single alphaherpesvirus particles in intact peripheral nervous system explants from infected mice. MBio 4:e00358-e00313. doi: 10.1128/mBio.00358-13
    • (2013) MBio , vol.4 , pp. e00313-e00358
    • Granstedt, A.E.1    Brunton, B.W.2    Enquist, L.W.3
  • 44
    • 84875217250 scopus 로고    scopus 로고
    • Gene therapy and neurodevelopmental disorders
    • Gray, S. J. (2013). Gene therapy and neurodevelopmental disorders. Neuropharmacology 68, 136-142. doi: 10.1016/j.neuropharm.2012.06.024
    • (2013) Neuropharmacology , vol.68 , pp. 136-142
    • Gray, S.J.1
  • 45
    • 77649273563 scopus 로고    scopus 로고
    • Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB)
    • Gray, S. J., Blake, B. L., Criswell, H. E., Nicolson, S. C., Samulski, R. J., McCown, T. J., et al. (2010). Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB). Mol. Ther. 18, 570-578. doi: 10.1038/mt.2009.292
    • (2010) Mol. Ther , vol.18 , pp. 570-578
    • Gray, S.J.1    Blake, B.L.2    Criswell, H.E.3    Nicolson, S.C.4    Samulski, R.J.5    McCown, T.J.6
  • 46
    • 79957888016 scopus 로고    scopus 로고
    • P.eclinical differences of intravascular AAV9 delivery to neurons and glia: A comparative study of adult mice and nonhuman primates
    • Gray, S. J., Matagne, V., Bachaboina, L., Yadav, S., Ojeda, S. R., and Samulski, R. J. (2011). P.eclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates. Mol. Ther. 19, 1058-1069. doi: 10.1038/mt.2011.72
    • (2011) Mol. Ther , vol.19 , pp. 1058-1069
    • Gray, S.J.1    Matagne, V.2    Bachaboina, L.3    Yadav, S.4    Ojeda, S.R.5    Samulski, R.J.6
  • 47
    • 84875925195 scopus 로고    scopus 로고
    • Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates
    • Gray, S. J., Nagabhushan Kalburgi, S., McCown, T. J., and Jude Samulski, R. (2013). Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates. Gene Ther. 20, 450-459. doi: 10.1038/gt.2012.101
    • (2013) Gene Ther , vol.20 , pp. 450-459
    • Gray, S.J.1    Nagabhushan Kalburgi, S.2    McCown, T.J.3    Jude Samulski, R.4
  • 48
    • 34347252689 scopus 로고    scopus 로고
    • P.oduction and characterization of adeno-associated viral vectors
    • Grieger, J. C., Choi, V. W., and Samulski, R. J. (2006). P.oduction and characterization of adeno-associated viral vectors. Nat. P.otoc. 1, 1412-1428. doi: 10.1038/nprot.2006.207
    • (2006) Nat. P.otoc , vol.1 , pp. 1412-1428
    • Grieger, J.C.1    Choi, V.W.2    Samulski, R.J.3
  • 49
    • 62549094869 scopus 로고    scopus 로고
    • Transduction of nonhuman primate brain with adeno-associated virus serotype 1: Vector trafficking and immune response
    • Hadaczek, P., Forsayeth, J., Mirek, H., Munson, K., Bringas, J., P.virotto, P., et al. (2009). Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response. Hum. Gene Ther. 20, 225-237. doi: 10.1089/hum.2008.151
    • (2009) Hum. Gene Ther , vol.20 , pp. 225-237
    • Hadaczek, P.1    Forsayeth, J.2    Mirek, H.3    Munson, K.4    Bringas, J.5    P.virotto, P.6
  • 50
    • 33745275175 scopus 로고    scopus 로고
    • The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain
    • Hadaczek, P., Yamashita, Y., Mirek, H., Tamas, L., Bohn, M. C., Noble, C., et al. (2006). The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol. Ther. 14, 69-78. doi: 10.1016/j.ymthe.2006.02.018
    • (2006) Mol. Ther , vol.14 , pp. 69-78
    • Hadaczek, P.1    Yamashita, Y.2    Mirek, H.3    Tamas, L.4    Bohn, M.C.5    Noble, C.6
  • 51
    • 0033885967 scopus 로고    scopus 로고
    • Adeno-associated virus (AAV)-3-based vectors transduce haematopoietic cells not susceptible to transduction with AAV-2-based vectors
    • Handa, A., Muramatsu, S., Qiu, J., Mizukami, H., and Brown, K. E. (2000). Adeno-associated virus (AAV)-3-based vectors transduce haematopoietic cells not susceptible to transduction with AAV-2-based vectors. J. Gen. Virol. 81(P. 8), 2077-2084.
    • (2000) J. Gen. Virol , vol.81 , Issue.P.8 , pp. 2077-2084
    • Handa, A.1    Muramatsu, S.2    Qiu, J.3    Mizukami, H.4    Brown, K.E.5
  • 52
    • 84872047670 scopus 로고    scopus 로고
    • Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice
    • Hirai, T., Enomoto, M., Machida, A., Yamamoto, M., Kuwahara, H., Tajiri, M., et al. (2012). Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice. Hum. Gene Ther. Methods 23, 119-127. doi: 10.1089/hgtb.2012.035
    • (2012) Hum. Gene Ther. Methods , vol.23 , pp. 119-127
    • Hirai, T.1    Enomoto, M.2    Machida, A.3    Yamamoto, M.4    Kuwahara, H.5    Tajiri, M.6
  • 53
    • 38649139370 scopus 로고    scopus 로고
    • Efficient retrograde neuronal transduction utilizing self-complementary AAV1
    • Hollis, E. R. II, Kadoya, K., Hirsch, M., Samulski, R. J., and Tuszynski, M. H. (2008). Efficient retrograde neuronal transduction utilizing self-complementary AAV1. Mol. Ther. 16, 296-301. doi: 10.1038/sj.mt.6300367
    • (2008) Mol. Ther , vol.16 , pp. 296-301
    • Hollis, E.R.I.1    Kadoya, K.2    Hirsch, M.3    Samulski, R.J.4    Tuszynski, M.H.5
  • 54
    • 0033198190 scopus 로고    scopus 로고
    • Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development
    • Hsueh, Y. P., and Sheng, M. (1999). Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. J. Neurosci. 19, 7415-7425.
    • (1999) J. Neurosci , vol.19 , pp. 7415-7425
    • Hsueh, Y.P.1    Sheng, M.2
  • 55
    • 0032514263 scopus 로고    scopus 로고
    • Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses
    • Hsueh, Y. P., Yang, F. C., Kharazia, V., Naisbitt, S., Cohen, A. R., Weinberg, R. J., et al. (1998). Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses. J. Cell Biol. 142, 139-151. doi: 10.1083/jcb.142.1.139
    • (1998) J. Cell Biol , vol.142 , pp. 139-151
    • Hsueh, Y.P.1    Yang, F.C.2    Kharazia, V.3    Naisbitt, S.4    Cohen, A.R.5    Weinberg, R.J.6
  • 56
  • 57
    • 84865123660 scopus 로고    scopus 로고
    • A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta
    • Iliff, J. J, Wang, M., Liao, Y., P.ogg, B. A., P.ng, W., Gundersen, G. A., et al. (2012). A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci. Transl. Med. 4:147-111. doi: 10.1126/scitranslmed.3003748
    • (2012) Sci. Transl. Med , vol.4 , pp. 111-147
    • Iliff, J.J.1    Wang, M.2    Liao, Y.3    P.ogg, B.A.4    P.ng, W.5    Gundersen, G.A.6
  • 58
    • 84883174947 scopus 로고    scopus 로고
    • P.rkinson’s disease dementia: Convergence of alpha-synuclein, tau and amyloid-beta pathologies
    • Irwin, D. J., Lee, V. M., and Trojanowski, J. Q. (2013). P.rkinson’s disease dementia: convergence of alpha-synuclein, tau and amyloid-beta pathologies. Nat. Rev. Neurosci. 14, 626-636. doi: 10.1038/nrn3549
    • (2013) Nat. Rev. Neurosci , vol.14 , pp. 626-636
    • Irwin, D.J.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 59
    • 84875866006 scopus 로고    scopus 로고
    • Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice
    • Iwata, N., Sekiguchi, M., Hattori, Y., Takahashi, A., Asai, M., Ji, B., et al. (2013). Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice. Sci. Rep. 3:1472. doi: 10.1038/srep01472
    • (2013) Sci. Rep , vol.3 , pp. 1472
    • Iwata, N.1    Sekiguchi, M.2    Hattori, Y.3    Takahashi, A.4    Asai, M.5    Ji, B.6
  • 60
    • 84859094442 scopus 로고    scopus 로고
    • AAV8(gfp) preferentially targets large diameter dorsal root ganglion neurones after both intra-dorsal root ganglion and intrathecal injection
    • Jacques, S. J., Ahmed, Z., Forbes, A., Douglas, M. R., Vigenswara, V., Berry, M., et al. (2012). AAV8(gfp) preferentially targets large diameter dorsal root ganglion neurones after both intra-dorsal root ganglion and intrathecal injection. Mol. Cell. Neurosci. 49, 464-474. doi: 10.1016/j.mcn.2012.03.002
    • (2012) Mol. Cell. Neurosci , vol.49 , pp. 464-474
    • Jacques, S.J.1    Ahmed, Z.2    Forbes, A.3    Douglas, M.R.4    Vigenswara, V.5    Berry, M.6
  • 61
    • 79953325690 scopus 로고    scopus 로고
    • An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells
    • Jang, J. H., Koerber, J. T., Kim, J. S., Asuri, P., Vazin, T., Bartel, M., et al. (2011). An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells. Mol. Ther. 19, 667-675. doi: 10.1038/mt.2010.287
    • (2011) Mol. Ther , vol.19 , pp. 667-675
    • Jang, J.H.1    Koerber, J.T.2    Kim, J.S.3    Asuri, P.4    Vazin, T.5    Bartel, M.6
  • 62
    • 0034957168 scopus 로고    scopus 로고
    • Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity
    • Kaludov, N., Brown, K. E., Walters, R. W., Zabner, J., and Chiorini, J. A. (2001). Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity. J. Virol. 75, 6884-6893. doi: 10.1128/JVI.75.15.6884-6893.2001
    • (2001) J. Virol , vol.75 , pp. 6884-6893
    • Kaludov, N.1    Brown, K.E.2    Walters, R.W.3    Zabner, J.4    Chiorini, J.A.5
  • 63
    • 19444363187 scopus 로고    scopus 로고
    • Widespread and early myocardial gene expression by adeno-associated virus vector type 6 with a beta-actin hybrid promoter
    • Kawamoto, S., Shi, Q., Nitta, Y., Miyazaki, J., and Allen, M. D. (2005). Widespread and early myocardial gene expression by adeno-associated virus vector type 6 with a beta-actin hybrid promoter. Mol. Ther. 11, 980-985. doi: 10.1016/j.ymthe.2005.02.009
    • (2005) Mol. Ther , vol.11 , pp. 980-985
    • Kawamoto, S.1    Shi, Q.2    Nitta, Y.3    Miyazaki, J.4    Allen, M.D.5
  • 64
    • 60549099179 scopus 로고    scopus 로고
    • Efficient gene therapy-based method for the delivery of therapeutics to primate cortex
    • Kells, A. P., Hadaczek, P., Yin, D., Bringas, J., Varenika, V., Forsayeth, J., et al. (2009). Efficient gene therapy-based method for the delivery of therapeutics to primate cortex. P.oc. Natl. Acad. Sci. U.S.A. 106, 2407-2411. doi: 10.1073/pnas.0810682106
    • (2009) P.oc. Natl. Acad. Sci. U.S.A , vol.106 , pp. 2407-2411
    • Kells, A.P.1    Hadaczek, P.2    Yin, D.3    Bringas, J.4    Varenika, V.5    Forsayeth, J.6
  • 65
    • 33749256018 scopus 로고    scopus 로고
    • Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?
    • Koh, L., Zakharov, A., and Johnston, M. (2005). Integration of the subarachnoid space and lymphatics: is it time to embrace a new concept of cerebrospinal fluid absorption? Cerebrospinal Fluid Res. 2:6. doi: 10.1186/1743-8454-2-6
    • (2005) Cerebrospinal Fluid Res , vol.2 , pp. 6
    • Koh, L.1    Zakharov, A.2    Johnston, M.3
  • 66
    • 84887067817 scopus 로고    scopus 로고
    • The choroid plexus and cerebrospinal fluid: Emerging roles in development, disease, and therapy
    • Lehtinen, M. K., Bjornsson, C. S., Dymecki, S. M., Gilbertson, R. J., Holtzman, D. M., and Monuki, E. S. (2013). The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy. J. Neurosci. 33, 17553-17559. doi: 10.1523/JNEUROSCI.3258-13.2013
    • (2013) J. Neurosci , vol.33 , pp. 17553-17559
    • Lehtinen, M.K.1    Bjornsson, C.S.2    Dymecki, S.M.3    Gilbertson, R.J.4    Holtzman, D.M.5    Monuki, E.S.6
  • 67
    • 84865570079 scopus 로고    scopus 로고
    • Viral vectors for gene delivery to the central nervous system
    • Lentz, T. B., Gray, S. J., and Samulski, R. J. (2012). Viral vectors for gene delivery to the central nervous system. Neurobiol. Dis. 48, 179-188. doi: 10.1016/j.nbd.2011.09.014
    • (2012) Neurobiol. Dis , vol.48 , pp. 179-188
    • Lentz, T.B.1    Gray, S.J.2    Samulski, R.J.3
  • 68
    • 23844451244 scopus 로고    scopus 로고
    • AAV2/5 vector expressing galactocerebrosidase ameliorates CNS disease in the murine model of globoid-cell leukodystrophy more efficiently than AAV2
    • Lin, D., Fantz, C. R., Levy, B., Rafi, M. A., Vogler, C., Wenger, D. A., et al. (2005). AAV2/5 vector expressing galactocerebrosidase ameliorates CNS disease in the murine model of globoid-cell leukodystrophy more efficiently than AAV2. Mol. Ther. 12, 422-430. doi: 10.1016/j.ymthe.2005.04.019
    • (2005) Mol. Ther , vol.12 , pp. 422-430
    • Lin, D.1    Fantz, C.R.2    Levy, B.3    Rafi, M.A.4    Vogler, C.5    Wenger, D.A.6
  • 69
    • 26844444953 scopus 로고    scopus 로고
    • Adeno-associated virus type 4 (AAV4) targets ependyma and astrocytes in the subventricular zone and RMS
    • Liu, G., Martins, I. H., Chiorini, J. A., and Davidson, B. L. (2005a). Adeno-associated virus type 4 (AAV4) targets ependyma and astrocytes in the subventricular zone and RMS. Gene Ther. 12, 1503-1508. doi: 10.1038/sj.gt.3302554
    • (2005) Gene Ther , vol.12 , pp. 1503-1508
    • Liu, G.1    Martins, I.H.2    Chiorini, J.A.3    Davidson, B.L.4
  • 70
    • 26844431562 scopus 로고    scopus 로고
    • Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors
    • Liu, G., Martins, I., Wemmie, J. A., Chiorini, J. A., and Davidson, B. L. (2005b). Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors. J. Neurosci. 25, 9321-9327. doi: 10.1523/JNEUROSCI.2936-05.2005
    • (2005) J. Neurosci , vol.25 , pp. 9321-9327
    • Liu, G.1    Martins, I.2    Wemmie, J.A.3    Chiorini, J.A.4    Davidson, B.L.5
  • 71
    • 84879157506 scopus 로고    scopus 로고
    • Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles
    • Low, K., Aebischer, P., and Schneider, B. L. (2013). Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles. Hum. Gene Ther. 24, 613-629. doi: 10.1089/hum.2012.174
    • (2013) Hum. Gene Ther , vol.24 , pp. 613-629
    • Low, K.1    Aebischer, P.2    Schneider, B.L.3
  • 72
    • 75049084578 scopus 로고    scopus 로고
    • Directed evolution of adeno-associated virus for glioma cell transduction
    • Maguire, C. A., Gianni, D., Meijer, D. H., Shaket, L. A., Wakimoto, H., Rabkin, S. D., et al. (2010). Directed evolution of adeno-associated virus for glioma cell transduction. J. Neurooncol. 96, 337-347. doi: 10.1007/s11060-009-9972-7
    • (2010) J. Neurooncol , vol.96 , pp. 337-347
    • Maguire, C.A.1    Gianni, D.2    Meijer, D.H.3    Shaket, L.A.4    Wakimoto, H.5    Rabkin, S.D.6
  • 73
    • 6344283047 scopus 로고    scopus 로고
    • Clinical trials in neurological disorders using AAV vectors: P.omises and challenges
    • Mandel, R. J., and Burger, C. (2004). Clinical trials in neurological disorders using AAV vectors: promises and challenges. Curr. Opin. Mol. Ther. 6, 482-490.
    • (2004) Curr. Opin. Mol. Ther , vol.6 , pp. 482-490
    • Mandel, R.J.1    Burger, C.2
  • 74
    • 80052506951 scopus 로고    scopus 로고
    • Local and retrograde gene transfer into primate neuronal pathways via adeno-associated virus serotype 8 and 9
    • Masamizu, Y., Okada, T., Kawasaki, K., Ishibashi, H., Yuasa, S., Takeda, S., et al. (2011). Local and retrograde gene transfer into primate neuronal pathways via adeno-associated virus serotype 8 and 9. Neuroscience 193, 249-258. doi: 10.1016/j.neuroscience.2011.06.080
    • (2011) Neuroscience , vol.193 , pp. 249-258
    • Masamizu, Y.1    Okada, T.2    Kawasaki, K.3    Ishibashi, H.4    Yuasa, S.5    Takeda, S.6
  • 75
    • 0036225913 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus serotypes 2and 5-mediated gene transfer in the mammalian brain: Quantitative analysis of heparin co-infusion
    • Mastakov, M. Y., Baer, K., Kotin, R. M., and During, M. J. (2002). Recombinant adeno-associated virus serotypes 2and 5-mediated gene transfer in the mammalian brain: quantitative analysis of heparin co-infusion. Mol. Ther. 5, 371-380. doi: 10.1006/mthe.2002.0564
    • (2002) Mol. Ther , vol.5 , pp. 371-380
    • Mastakov, M.Y.1    Baer, K.2    Kotin, R.M.3    During, M.J.4
  • 76
    • 70449720981 scopus 로고    scopus 로고
    • Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MP. IIIB mice
    • McCarty, D. M., DiRosario, J., Gulaid, K., Muenzer, J., and Fu, H. (2009). Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MP. IIIB mice. Gene Ther. 16, 1340-1352. doi: 10.1038/gt.2009.85
    • (2009) Gene Ther , vol.16 , pp. 1340-1352
    • McCarty, D.M.1    Dirosario, J.2    Gulaid, K.3    Muenzer, J.4    Fu, H.5
  • 77
    • 10944269753 scopus 로고    scopus 로고
    • Integration of adenoassociated virus (AAV) and recombinant AAV vectors
    • McCarty, D. M., Young, S. M. Jr., and Samulski, R. J. (2004). Integration of adenoassociated virus (AAV) and recombinant AAV vectors. Annu. Rev. Genet. 38, 819-845. doi: 10.1146/annurev.genet.37.110801.143717
    • (2004) Annu. Rev. Genet , vol.38 , pp. 819-845
    • McCarty, D.M.1    Young, S.M.2    Samulski, R.J.3
  • 78
    • 0030003480 scopus 로고    scopus 로고
    • Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector
    • McCown, T. J., Xiao, X., Li, J., Breese, G. R., and Samulski, R. J. (1996). Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res. 713, 99-107. doi: 10.1016/0006-8993(95) 01488-8
    • (1996) Brain Res , vol.713 , pp. 99-107
    • McCown, T.J.1    Xiao, X.2    Li, J.3    Breese, G.R.4    Samulski, R.J.5
  • 79
    • 38349096769 scopus 로고    scopus 로고
    • Complete in vitro reconstitution of adeno-associated virus DNA replication requires the minichromosome maintenance complex proteins
    • Nash, K., Chen, W., and Muzyczka, N. (2008). Complete in vitro reconstitution of adeno-associated virus DNA replication requires the minichromosome maintenance complex proteins. J. Virol. 82, 1458-1464. doi: 10.1128/JVI.01968-07
    • (2008) J. Virol , vol.82 , pp. 1458-1464
    • Nash, K.1    Chen, W.2    Muzyczka, N.3
  • 80
    • 0035800208 scopus 로고    scopus 로고
    • Convection-enhanced delivery of AAV-2 combined with heparin increases TK gene transfer in the rat brain
    • Nguyen, J. B., Sanchez-P.rnaute, R., Cunningham, J., and Bankiewicz, K. S. (2001). Convection-enhanced delivery of AAV-2 combined with heparin increases TK gene transfer in the rat brain. Neuroreport 12, 1961-1964. doi: 10.1097/00001756-200107030-00037
    • (2001) Neuroreport , vol.12 , pp. 1961-1964
    • Nguyen, J.B.1    Sanchez-Pernaute, R.2    Cunningham, J.3    Bankiewicz, K.S.4
  • 81
    • 34547692622 scopus 로고    scopus 로고
    • Trinucleotide repeat disorders
    • Orr, H. T., and Zoghbi, H. Y. (2007). Trinucleotide repeat disorders. Annu. Rev. Neurosci. 30, 575-621. doi: 10.1146/annurev.neuro.29.051605.113042
    • (2007) Annu. Rev. Neurosci , vol.30 , pp. 575-621
    • Orr, H.T.1    Zoghbi, H.Y.2
  • 82
    • 80051913399 scopus 로고    scopus 로고
    • New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits
    • Osakada, F., Mori, T., Cetin, A. H., Marshel, J. H., Virgen, B., and Callaway, E. M. (2011). New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits. Neuron 71, 617-631. doi: 10.1016/j.neuron.2011.07.005
    • (2011) Neuron , vol.71 , pp. 617-631
    • Osakada, F.1    Mori, T.2    Cetin, A.H.3    Marshel, J.H.4    Virgen, B.5    Callaway, E.M.6
  • 83
    • 20144387791 scopus 로고    scopus 로고
    • Structure of adeno-associated virus type 4
    • P.dron, E., Bowman, V., Kaludov, N., Govindasamy, L., Levy, H., Nick, P., et al. (2005). Structure of adeno-associated virus type 4. J. Virol. 79, 5047-5058. doi: 10.1128/JVI.79.8.5047-5058.2005
    • (2005) J. Virol , vol.79 , pp. 5047-5058
    • P.dron, E.1    Bowman, V.2    Kaludov, N.3    Govindasamy, L.4    Levy, H.5    Nick, P.6
  • 84
    • 0035203152 scopus 로고    scopus 로고
    • Widespread gene delivery and structurespecific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-associated virus vector
    • P.ssini, M. A., and Wolfe, J. H. (2001). Widespread gene delivery and structurespecific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-associated virus vector. J. Virol. 75, 12382-12392. doi: 10.1128/JVI.75.24.12382-12392.2001
    • (2001) J. Virol , vol.75 , pp. 12382-12392
    • P.ssini, M.A.1    Wolfe, J.H.2
  • 85
    • 0036140216 scopus 로고    scopus 로고
    • Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity
    • Rabinowitz, J. E., Rolling, F., Li, C., Conrath, H., Xiao, W., Xiao, X., et al. (2002). Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity. J. Virol. 76, 791-801. doi: 10.1128/JVI.76.2.791-801.2002
    • (2002) J. Virol , vol.76 , pp. 791-801
    • Rabinowitz, J.E.1    Rolling, F.2    Li, C.3    Conrath, H.4    Xiao, W.5    Xiao, X.6
  • 86
    • 84869093015 scopus 로고    scopus 로고
    • Extended normal life after AAVrh10-mediated gene therapy in the mouse model of krabbe disease
    • Rafi, M. A., Rao, H. Z., Luzi, P., Curtis, M. T., and Wenger, D. A. (2012). Extended normal life after AAVrh10-mediated gene therapy in the mouse model of krabbe disease. Mol. Ther. 20, 2031-2042. doi: 10.1038/mt.2012.153
    • (2012) Mol. Ther , vol.20 , pp. 2031-2042
    • Rafi, M.A.1    Rao, H.Z.2    Luzi, P.3    Curtis, M.T.4    Wenger, D.A.5
  • 87
    • 0021959647 scopus 로고
    • Evidence for a "paravascular" fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space
    • Rennels, M. L., Gregory, T. F., Blaumanis, O. R., Fujimoto, K., and Grady, P. A. (1985). Evidence for a "paravascular" fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res. 326, 47-63. doi: 10.1016/0006-8993(85)91383-6
    • (1985) Brain Res , vol.326 , pp. 47-63
    • Rennels, M.L.1    Gregory, T.F.2    Blaumanis, O.R.3    Fujimoto, K.4    Grady, P.A.5
  • 88
    • 84907276974 scopus 로고    scopus 로고
    • Comparative efficacy and safety of multiple routes of direct CNS administration of adeno-associated virus gene transfer vector serotype rh.10 expressing the human arylsulfatase A cDNA to nonhuman primates
    • Rosenberg, J. B., Sondhi, D., Rubin, D. G., Monette, S., Chen, A., Cram, S., et al. (2014). Comparative efficacy and safety of multiple routes of direct CNS administration of adeno-associated virus gene transfer vector serotype rh.10 expressing the human arylsulfatase A cDNA to nonhuman primates. Hum. Gene Ther. Clin. Dev. doi: 10.1089/humc.2013.239 [Epub ahead of print].
    • (2014) Hum. Gene Ther. Clin. Dev
    • Rosenberg, J.B.1    Sondhi, D.2    Rubin, D.G.3    Monette, S.4    Chen, A.5    Cram, S.6
  • 89
    • 84884173653 scopus 로고    scopus 로고
    • Transgene expression in target-defined neuron populations mediated by retrograde infection with adeno-associated viral vectors
    • Rothermel, M., Brunert, D., Zabawa, C., Diaz-Quesada, M., and Wachowiak, M. (2013). Transgene expression in target-defined neuron populations mediated by retrograde infection with adeno-associated viral vectors. J. Neurosci. 33, 15195-15206. doi: 10.1523/JNEUROSCI.1618-13.2013
    • (2013) J. Neurosci , vol.33 , pp. 15195-15206
    • Rothermel, M.1    Brunert, D.2    Zabawa, C.3    Diaz-Quesada, M.4    Wachowiak, M.5
  • 90
    • 84874760577 scopus 로고    scopus 로고
    • Axonal transport of adeno-associated viral vectors is serotype-dependent
    • Salegio, E. A., Samaranch, L., Kells, A. P., Mittermeyer, G., San Sebastian, W., Zhou, S., et al. (2013). Axonal transport of adeno-associated viral vectors is serotype-dependent. Gene Ther. 20, 348-352. doi: 10.1038/gt.2012.27
    • (2013) Gene Ther , vol.20 , pp. 348-352
    • Salegio, E.A.1    Samaranch, L.2    Kells, A.P.3    Mittermeyer, G.4    San Sebastian, W.5    Zhou, S.6
  • 91
    • 84877847142 scopus 로고    scopus 로고
    • Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates
    • Samaranch, L., Salegio, E. A., San Sebastian, W., Kells, A. P., Bringas, J. R., Forsayeth, J., et al. (2013). Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates. Hum. Gene Ther. 24, 526-532. doi: 10.1089/hum.2013.005
    • (2013) Hum. Gene Ther , vol.24 , pp. 526-532
    • Samaranch, L.1    Salegio, E.A.2    San Sebastian, W.3    Kells, A.P.4    Bringas, J.R.5    Forsayeth, J.6
  • 92
    • 84860171925 scopus 로고    scopus 로고
    • Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates
    • Samaranch, L., Salegio, E. A., San Sebastian, W., Kells, A. P., Foust, K. D., Bringas, J. R., et al. (2012). Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates. Hum. Gene Ther. 23, 382-389. doi: 10.1089/hum.2011.200
    • (2012) Hum. Gene Ther , vol.23 , pp. 382-389
    • Samaranch, L.1    Salegio, E.A.2    San Sebastian, W.3    Kells, A.P.4    Foust, K.D.5    Bringas, J.R.6
  • 93
    • 84890124857 scopus 로고    scopus 로고
    • Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain
    • San Sebastian, W., Samaranch, L., Heller, G., Kells, A. P., Bringas, J., P.virotto, P., et al. (2013). Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain. Gene Ther. 20, 1178-1183. doi: 10.1038/gt.2013.48
    • (2013) Gene Ther , vol.20 , pp. 1178-1183
    • San Sebastian, W.1    Samaranch, L.2    Heller, G.3    Kells, A.P.4    Bringas, J.5    P.virotto, P.6
  • 94
    • 31944434903 scopus 로고    scopus 로고
    • New neurons follow the flow of cerebrospinal fluid in the adult brain
    • Sawamoto, K., Wichterle, H., Gonzalez-P.rez, O., Cholfin, J. A., Yamada, M., Spassky, N., et al. (2006). New neurons follow the flow of cerebrospinal fluid in the adult brain. Science 311, 629-632. doi: 10.1126/science.1119133
    • (2006) Science , vol.311 , pp. 629-632
    • Sawamoto, K.1    Wichterle, H.2    Gonzalez-Perez, O.3    Cholfin, J.A.4    Yamada, M.5    Spassky, N.6
  • 95
    • 84872077107 scopus 로고    scopus 로고
    • Intravenous delivery of adeno-associated viral vector serotype 9 mediates effective gene expression in ischemic stroke lesion and brain angiogenic foci
    • Shen, F., Kuo, R., Milon-Camus, M., Han, Z., Jiang, L., Young, W. L., et al. (2013). Intravenous delivery of adeno-associated viral vector serotype 9 mediates effective gene expression in ischemic stroke lesion and brain angiogenic foci. Stroke 44, 252-254. doi: 10.1161/STROKEAHA.112.662965
    • (2013) Stroke , vol.44 , pp. 252-254
    • Shen, F.1    Kuo, R.2    Milon-Camus, M.3    Han, Z.4    Jiang, L.5    Young, W.L.6
  • 96
    • 79953857433 scopus 로고    scopus 로고
    • Terminal N-linked galactose is the primary receptor for adeno-associated virus 9
    • Shen, S., Bryant, K. D., Brown, S. M., Randell, S. H., and Asokan, A. (2011). Terminal N-linked galactose is the primary receptor for adeno-associated virus 9. J. Biol. Chem. 286, 13532-13540. doi: 10.1074/jbc.M110.210922
    • (2011) J. Biol. Chem , vol.286 , pp. 13532-13540
    • Shen, S.1    Bryant, K.D.2    Brown, S.M.3    Randell, S.H.4    Asokan, A.5
  • 98
    • 80053009250 scopus 로고    scopus 로고
    • Comparison of adeno-associated viral vector serotypes for spinal cord and motor neuron gene delivery
    • Snyder, B. R., Gray, S. J., Quach, E. T., Huang, J. W., Leung, C. H., Samulski, R. J., et al. (2011). Comparison of adeno-associated viral vector serotypes for spinal cord and motor neuron gene delivery. Hum. Gene Ther. 22, 1129-1135. doi: 10.1089/hum.2011.008
    • (2011) Hum. Gene Ther , vol.22 , pp. 1129-1135
    • Snyder, B.R.1    Gray, S.J.2    Quach, E.T.3    Huang, J.W.4    Leung, C.H.5    Samulski, R.J.6
  • 99
    • 33847211798 scopus 로고    scopus 로고
    • Enhanced survival of the LINCL mouse following CLN2 gene transfer using the rh.10 rhesus macaque-derived adeno-associated virus vector
    • Sondhi, D., Hackett, N. R., P.terson, D. A., Stratton, J., Baad, M., Travis, K. M., et al. (2007). Enhanced survival of the LINCL mouse following CLN2 gene transfer using the rh.10 rhesus macaque-derived adeno-associated virus vector. Mol. Ther. 15, 481-491. doi: 10.1038/sj.mt.6300049
    • (2007) Mol. Ther , vol.15 , pp. 481-491
    • Sondhi, D.1    Hackett, N.R.2    P.terson, D.A.3    Stratton, J.4    Baad, M.5    Travis, K.M.6
  • 100
    • 0031906147 scopus 로고    scopus 로고
    • Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions
    • Summerford, C., and Samulski, R. J. (1998). Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J. Virol. 72, 1438-1445.
    • (1998) J. Virol , vol.72 , pp. 1438-1445
    • Summerford, C.1    Samulski, R.J.2
  • 101
    • 84867629991 scopus 로고    scopus 로고
    • Alphaherpesvirus axon-to-cell spread involves limited virion transmission
    • Taylor, M. P., Kobiler, O., and Enquist, L. W. (2012). Alphaherpesvirus axon-to-cell spread involves limited virion transmission. P.oc. Natl. Acad. Sci. U.S.A. 109, 17046-17051. doi: 10.1073/pnas.1212926109
    • (2012) P.oc. Natl. Acad. Sci. U.S.A , vol.109 , pp. 17046-17051
    • Taylor, M.P.1    Kobiler, O.2    Enquist, L.W.3
  • 102
    • 4344702714 scopus 로고    scopus 로고
    • Recombinant AAV-mediated gene delivery to the central nervous system
    • Tenenbaum, L., Chtarto, A., Lehtonen, E., Velu, T., Brotchi, J., and Levivier, M. (2004). Recombinant AAV-mediated gene delivery to the central nervous system. J. Gene Med. 6(Suppl. 1), S212-S222. doi: 10.1002/jgm.506
    • (2004) J. Gene Med , vol.6 , pp. S212-S222
    • Tenenbaum, L.1    Chtarto, A.2    Lehtonen, E.3    Velu, T.4    Brotchi, J.5    Levivier, M.6
  • 103
    • 62549159967 scopus 로고    scopus 로고
    • Tailoring the AAV vector capsid for gene therapy
    • Vandenberghe, L. H., Wilson, J. M., and Gao, G. (2009). Tailoring the AAV vector capsid for gene therapy. Gene Ther. 16, 311-319. doi: 10.1038/gt.2008.170
    • (2009) Gene Ther , vol.16 , pp. 311-319
    • Vandenberghe, L.H.1    Wilson, J.M.2    Gao, G.3
  • 104
    • 77952735344 scopus 로고    scopus 로고
    • Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture
    • Vulchanova, L., Schuster, D. J., Belur, L. R., Riedl, M. S., P.detz-P.dersen, K. M., Kitto, K. F., et al. (2010). Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture. Mol. P.in 6:31. doi: 10.1186/1744-8069-6-31
    • (2010) Mol. P.in , vol.6 , pp. 31
    • Vulchanova, L.1    Schuster, D.J.2    Belur, L.R.3    Riedl, M.S.4    P.detz-Pedersen, K.M.5    Kitto, K.F.6
  • 105
    • 0035827546 scopus 로고    scopus 로고
    • Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer
    • Walters, R. W., Yi, S. M., Keshavjee, S., Brown, K. E., Welsh, M. J., Chiorini, J. A., et al. (2001). Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer. J. Biol. Chem. 276, 20610-20616. doi: 10.1074/jbc.M101559200
    • (2001) J. Biol. Chem , vol.276 , pp. 20610-20616
    • Walters, R.W.1    Yi, S.M.2    Keshavjee, S.3    Brown, K.E.4    Welsh, M.J.5    Chiorini, J.A.6
  • 106
    • 0038014158 scopus 로고    scopus 로고
    • Lysosomal storage disorders: Diagnostic dilemmas and prospects for therapy
    • Wenger, D. A., Coppola, S., and Liu, S. L. (2002). Lysosomal storage disorders: diagnostic dilemmas and prospects for therapy. Genet. Med. 4, 412-419. doi: 10.1097/00125817-200211000-00003
    • (2002) Genet. Med , vol.4 , pp. 412-419
    • Wenger, D.A.1    Coppola, S.2    Liu, S.L.3
  • 107
    • 33845924630 scopus 로고    scopus 로고
    • Retrograde neuronal tracing with a deletion-mutant rabies virus
    • Wickersham, I. R., Finke, S., Conzelmann, K. K., and Callaway, E. M. (2007). Retrograde neuronal tracing with a deletion-mutant rabies virus. Nat. Methods 4, 47-49. doi: 10.1038/nmeth999
    • (2007) Nat. Methods , vol.4 , pp. 47-49
    • Wickersham, I.R.1    Finke, S.2    Conzelmann, K.K.3    Callaway, E.M.4
  • 108
    • 33750722840 scopus 로고    scopus 로고
    • Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes
    • Wu, Z., Asokan, A., Grieger, J. C., Govindasamy, L., Agbandje-McKenna, M., and Samulski, R. J. (2006a). Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes. J. Virol. 80, 11393-11397. doi: 10.1128/JVI.01288-06
    • (2006) J. Virol , vol.80 , pp. 11393-11397
    • Wu, Z.1    Asokan, A.2    Grieger, J.C.3    Govindasamy, L.4    Agbandje-McKenna, M.5    Samulski, R.J.6
  • 109
    • 33748501920 scopus 로고    scopus 로고
    • Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6
    • Wu, Z., Miller, E., Agbandje-McKenna, M., and Samulski, R. J. (2006b). Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6. J. Virol. 80, 9093-9103. doi: 10.1128/JVI.00895-06
    • (2006) J. Virol , vol.80 , pp. 9093-9103
    • Wu, Z.1    Miller, E.2    Agbandje-McKenna, M.3    Samulski, R.J.4
  • 110
    • 2642642141 scopus 로고    scopus 로고
    • P.oduction of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus
    • Xiao, X., Li, J., and Samulski, R. J. (1998). P.oduction of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J. Virol. 72, 2224-2232.
    • (1998) J. Virol , vol.72 , pp. 2224-2232
    • Xiao, X.1    Li, J.2    Samulski, R.J.3
  • 111
    • 0031016643 scopus 로고    scopus 로고
    • A novel 165-base-pair terminal repeat sequence is the sole cis requirement for the adeno-associated virus life cycle
    • Xiao, X., Xiao, W., Li, J., and Samulski, R. J. (1997). A novel 165-base-pair terminal repeat sequence is the sole cis requirement for the adeno-associated virus life cycle. J. Virol. 71, 941-948.
    • (1997) J. Virol , vol.71 , pp. 941-948
    • Xiao, X.1    Xiao, W.2    Li, J.3    Samulski, R.J.4
  • 112
    • 84887084505 scopus 로고    scopus 로고
    • Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons
    • Yamashita, T., Chai, H. L., Teramoto, S., Tsuji, S., Shimazaki, K., Muramatsu, S., et al. (2013). Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons. EMBO Mol. Med. 5, 1710-1719. doi: 10.1002/emmm.201302935
    • (2013) EMBO Mol. Med , vol.5 , pp. 1710-1719
    • Yamashita, T.1    Chai, H.L.2    Teramoto, S.3    Tsuji, S.4    Shimazaki, K.5    Muramatsu, S.6
  • 113
    • 84903760379 scopus 로고    scopus 로고
    • Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10
    • Yang, B., Li, S., Wang, H., Guo, Y., Gessler, D. J., Cao, C., et al. (2014). Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10. Mol. Ther. 22, 1299-1309. doi: 10.1038/mt.2014.68
    • (2014) Mol. Ther , vol.22 , pp. 1299-1309
    • Yang, B.1    Li, S.2    Wang, H.3    Guo, Y.4    Gessler, D.J.5    Cao, C.6
  • 114
    • 79961032418 scopus 로고    scopus 로고
    • Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system
    • Zhang, H., Yang, B., Mu, X., Ahmed, S. S., Su, Q., He, R., et al. (2011). Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system. Mol. Ther. 19, 1440-1448. doi: 10.1038/mt.2011.98
    • (2011) Mol. Ther , vol.19 , pp. 1440-1448
    • Zhang, H.1    Yang, B.2    Mu, X.3    Ahmed, S.S.4    Su, Q.5    He, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.