A critical role of autocrine sonic hedgehog signaling in human CD138+myeloma cell survival and drug resistance

Blood

Volumn 124, Issue 13, 2014, Pages 2061-2071

  Liu, Zhiqiang ^a   Xu, Jingda ^a   He, Jin ^a   Zheng, Yuhuan ^a   Li, Haiyan ^a   Lu, Yong ^a   Qian, Jianfei ^a   Lin, Pei ^a   Weber, Donna M ^a   Yang, Jing ^a   Yi, Qing ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; CD19 ANTIGEN; CYTOCHROME C; M PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; NEUTRALIZING ANTIBODY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; SONIC HEDGEHOG PROTEIN ANTIBODY; SYNDECAN 1; TRANSCRIPTION FACTOR GLI1; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 2; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; GLI PROTEIN; ONCOPROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; B LYMPHOCYTE; BONE MARROW STROMA CELL; CANCER GROWTH; CANCER RESISTANCE; CANCER SURVIVAL; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STROMA CELL; MICROENVIRONMENT; MOUSE; MYELOMA CELL; NONHUMAN; PARACRINE SIGNALING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SURVIVAL TIME; TUMOR VOLUME; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOPSY; BONE MARROW; CASE CONTROL STUDY; DISEASE MODEL; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; GENE EXPRESSION; GENETICS; METABOLISM; MORTALITY; MULTIPLE MYELOMA; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOCRINE COMMUNICATION; BIOPSY; BONE MARROW; CASE-CONTROL STUDIES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION; HEDGEHOG PROTEINS; HUMANS; MULTIPLE MYELOMA; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; SYNDECAN-1; TRANS-ACTIVATORS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84907276398     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-03-557298     Document Type: Article

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