Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma

Molecular Cancer Therapeutics

Volumn 13, Issue 7, 2014, Pages 1873-1881

  Agarwal, Jasmin R ^a   Wang, Qiuju ^a   Tanno, Toshihiko ^a   Rasheed, Zeshaan ^a   Merchant, Akil ^b   Ghosh, Nilanjan ^a   Borrello, Ivan ^a   Huff, Carol Ann ^a   Parhami, Farhad ^c   Matsui, William ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

22 HYDROXYCHOLESTEROL; 3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ABC TRANSPORTER A1; ABC TRANSPORTER G1; CYCLOPAMINE; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; PROTEIN PATCHED 1; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR GLI1; FLUORINATED HYDROCARBON; ORPHAN NUCLEAR RECEPTOR; SULFONAMIDE; TO-901317;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL RENEWAL; CLONOGENESIS; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LIGAND BINDING; MOUSE; MULTIPLE MYELOMA; MULTIPLE MYELOMA CELL LINE; MYELOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CLONE; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CLONE CELLS; HEDGEHOG PROTEINS; HUMANS; HYDROCARBONS, FLUORINATED; MICE; MICE, INBRED NOD; MULTIPLE MYELOMA; ORPHAN NUCLEAR RECEPTORS; SIGNAL TRANSDUCTION; SULFONAMIDES; TRANSFECTION;

EID: 84904152245     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-13-0997     Document Type: Article

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