Mitochondrial dynamics in astrocytes

Biochemical Society Transactions

Volumn 42, Issue 5, 2014, Pages 1302-1310

  Stephen, Terri Leigh ^a   Gupta Agarwal, Swati ^a   Kittler, Josef T ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASTROCYTE; CALCIUM CELL LEVEL; CELL COMMUNICATION; CELL MEMBRANE; CELL METABOLISM; CELL MIGRATION; CELL STRUCTURE; CYTOSOL; ENDOPLASMIC RETICULUM; HUMAN; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NERVE CELL PLASTICITY; REVIEW; SYNAPTIC TRANSMISSION; TURNOVER TIME; ANIMAL; BIOLOGICAL MODEL; CALCIUM SIGNALING; CYTOLOGY; DEGENERATIVE DISEASE; METABOLISM; PATHOLOGY;

ANIMALS; ASTROCYTES; CALCIUM SIGNALING; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MODELS, BIOLOGICAL; NEURODEGENERATIVE DISEASES;

EID: 84907226800     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20140195     Document Type: Review

References (112)

1. Araque, A., Sanzgiri, R.P., Parpura, V. and Haydon, P.G. (1999) Astrocyte-induced modulation of synaptic transmission. Can. J. Physiol. Pharmacol. 77, 699-706 PubMed
2. Castonguay, A., Levesque, S. and Robitaille, R. (2001) Glial cells as active partners in synaptic functions. Prog. Brain Res. 132, 227-240 CrossRef PubMed
3. Haydon, P.G. (2001) Glia: listening and talking to the synapse. Nat. Rev. Neurosci. 2, 185-193 CrossRef PubMed
4. Nedergaard, M., Ransom, B. and Goldman, S.A. (2003) New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci. 26, 523-530 CrossRef PubMed
5. Panatier, A., Vallee, J., Haber, M., Murai, K.K., Lacaille, J.C. and Robitaille, R. (2011) Astrocytes are endogenous regulators of basal transmission at central synapses. Cell 146, 785-798 CrossRef PubMed
6. Charles, A.C., Merrill, J.E., Dirksen, E.R. and Sanderson, M.J. (1991) Intercellular signaling in glial cells: calcium waves and oscillations in response to mechanical stimulation and glutamate. Neuron 6, 983-992 CrossRef PubMed
7. Verkhratsky, A., Orkand, R.K. and Kettenmann, H. (1998) Glial calcium: homeostasis and signaling function. Physiol. Rev. 78, 99-141 PubMed
8. Carmignoto, G. (2000) Reciprocal communication systems between astrocytes and neurones. Prog. Neurobiol. 62, 561-581 CrossRef PubMed
9. 2+detection and modulation of synaptic release by astrocytes. Nat. Neurosci. 14, 1276-1284 CrossRef PubMed
10. Parpura, V., Basarsky, T.A., Liu, F., Jeftinija, K., Jeftinija, S. and Haydon, P.G. (1994) Glutamate-mediated astrocyte-neuron signalling. Nature 369, 744-747 CrossRef PubMed
11. Pasti, L., Volterra, A., Pozzan, T. and Carmignoto, G. (1997) Intracellular calcium oscillations in astrocytes: a highly plastic, bidirectional form of communication between neurons and astrocytes in situ. J. Neurosci. 17, 7817-7830 PubMed
12. Grosche, J., Matyash, V., Moller, T., Verkhratsky, A., Reichenbach, A. and Kettenmann, H. (1999) Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells. Nat. Neurosci. 2, 139-143 CrossRef PubMed
13. 2+signaling in Bergmann glial cells in situ. FASEB J. 11, 566-572 PubMed
14. 2+-dependent exocytotic release of glutamate from rat cortical astrocytes. ASN NEURO 4, AN20110059 CrossRef PubMed
15. MacAskill, A.F., Atkin, T.A. and Kittler, J.T. (2010) Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses. Eur. J. Neurosci. 32, 231-240 CrossRef PubMed
16. MacAskill, A.F. and Kittler, J.T. (2010) Control of mitochondrial transport and localization in neurons. Trends Cell Biol. 20, 102-112 CrossRef PubMed
17. Miller, K.E. and Sheetz, M.P. (2004) Axonal mitochondrial transport and potential are correlated. J. Cell Sci. 117, 2791-2804 CrossRef PubMed
18. Schwarz, T.L. (2013) Mitochondrial trafficking in neurons. Cold Spring Harb. Perspect. Biol. 5, a011304 CrossRef PubMed
19. Dienel, G.A. (2013) Astrocytic energetics during excitatory neurotransmission: what are contributions of glutamate oxidation and glycolysis? Neurochem. Int. 63, 244-258 CrossRef PubMed
20. 2+exchange in mitochondrial dysfunction in astrocytes following in vitro ischemia. Am. J. Physiol. Cell Physiol. 292, C1113-C1122 PubMed
21. 2+signaling, gliotransmission, and proliferation of astrocytes. J. Neurosci. 33, 7206-7219 CrossRef PubMed
22. Drago, I., Pizzo, P. and Pozzan, T. (2011) After half a century mitochondrial calcium in- and efflux machineries reveal themselves. EMBO J. 30, 4119-4125 CrossRef PubMed
23. 2+exchange. Proc. Natl. Acad. Sci. U.S.A. 107, 436-441 CrossRef PubMed
24. Kirichok, Y., Krapivinsky, G. and Clapham, D.E. (2004) The mitochondrial calcium uniporter is a highly selective ion channel. Nature 427, 360-364 CrossRef PubMed
25. Hua, X., Malarkey, E.B., Sunjara, V., Rosenwald, S.E., Li, W.H. and Parpura, V. (2004) Ca2 + -dependent glutamate release involves two classes of endoplasmic reticulum Ca2 + stores in astrocytes. J. Neurosci. Res. 76, 86-97 CrossRef PubMed
26. 2+waves in rat cortical astrocytes. J. Cell Biol. 145, 795-808 CrossRef PubMed
27. 2+-dependent glutamate release from rat cortical astrocytes. J. Neurosci. 28, 9682-9691 CrossRef PubMed
28. 2+dynamics and consequent glutamate release from rat astrocytes. Glia 56, 821-835 CrossRef PubMed
29. Singaravelu, K., Lohr, C. and Deitmer, J.W. (2006) Regulation of store-operated calcium entry by calcium-independent phospholipase A2 in rat cerebellar astrocytes. J. Neurosci. 26, 9579-9592 CrossRef PubMed
30. Golovina, V.A. (2005) Visualization of localized store-operated calcium entry in mouse astrocytes: close proximity to the endoplasmic reticulum. J. Physiol. 564, 737-749 CrossRef PubMed
31. Lo, K.J., Luk, H.N., Chin, T.Y. and Chueh, S.H. (2002) Store depletion-induced calcium influx in rat cerebellar astrocytes. Br. J. Pharmacol. 135, 1383-1392 PubMed
32. 2+and pH in response to thapsigargin in human glioblastoma cells and normal astrocytes. Am. J. Physiol. Cell Physiol. 289, C361-C371 PubMed
33. 2+-release microdomains in cultured glia. Biochem. J. 325, 239-247 PubMed
34. Csordas, G., Varnai, P., Golenar, T., Roy, S., Purkins, G., Schneider, T.G., Balla, T. and Hajnoczky, G. (2010) Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface. Mol. Cell 39, 121-132 CrossRef PubMed
35. Shin, D.M. and Muallem, S. (2010) What the mitochondria see. Mol. Cell 39, 6-7 CrossRef PubMed
36. Giorgi, C., De Stefani, D., Bononi, A., Rizzuto, R. and Pinton, P. (2009) Structural and functional link between the mitochondrial network and the endoplasmic reticulum. Int. J. Biochem. Cell Biol. 41, 1817-1827 PubMed
37. Scharwey, M., Tatsuta, T. and Langer, T. (2013) Mitochondrial lipid transport at a glance. J. Cell Sci. 126, 5317-5323 CrossRef PubMed
38. Hayashi, T., Rizzuto, R., Hajnoczky, G. and Su, T.P. (2009) MAM: more than just a housekeeper. Trends Cell Biol. 19, 81-88 CrossRef PubMed
39. Birsa, N., Norkett, R., Higgs, N., Lopez-Domenech, G. and Kittler, J.T. (2013) Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins. Biochem. Soc. Trans. 41, 1525-1531 PubMed
40. Macaskill, A.F., Rinholm, J.E., Twelvetrees, A.E., Arancibia-Carcamo, I.L., Muir, J., Fransson, A., Aspenstrom, P., Attwell, D. and Kittler, J.T. (2009) Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron 61, 541-555 CrossRef PubMed
41. Frederick, R.L. and Shaw, J.M. (2007) Moving mitochondria: establishing distribution of an essential organelle. Traffic 8, 1668-1675 CrossRef PubMed
42. Jackson, J.G., O'Donnell, J.C., Takano, H., Coulter, D.A. and Robinson, M.B. (2014) Neuronal activity and glutamate uptake decrease mitochondrial mobility in astrocytes and position mitochondria near glutamate transporters. J. Neurosci. 34, 1613-1624 CrossRef PubMed
43. Lavialle, M., Aumann, G., Anlauf, E., Prols, F., Arpin, M. and Derouiche, A. (2011) Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors. Proc. Natl. Acad. Sci. U.S.A. 108, 12915-12919 CrossRef PubMed
44. Ito, U., Hakamata, Y., Kawakami, E. and Oyanagi, K. (2011) Temporary cerebral ischemia results in swollen astrocytic end-feet that compress microvessels and lead to delayed focal cortical infarction. J. Cereb. Blood Flow Metab. 31, 328-338 CrossRef PubMed
45. Mathiisen, T.M., Lehre, K.P., Danbolt, N.C. and Ottersen, O.P. (2010) The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction. Glia 58, 1094-1103 CrossRef PubMed
46. Lovatt, D., Sonnewald, U., Waagepetersen, H.S., Schousboe, A., He, W., Lin, J.H., Han, X., Takano, T., Wang, S., Sim, F.J. et al. (2007) The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J. Neurosci. 27, 12255-12266 CrossRef PubMed
47. Morris, R.L. and Hollenbeck, P.J. (1995) Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons. J. Cell Biol. 131, 1315-1326 CrossRef PubMed
48. Hollenbeck, P.J. and Saxton, W.M. (2005) The axonal transport of mitochondria. J. Cell Sci. 118, 5411-5419 CrossRef PubMed
49. Hollenbeck, P.J. (2005) Mitochondria and neurotransmission: evacuating the synapse. Neuron 47, 331-333 CrossRef PubMed
50. Ligon, L.A. and Steward, O. (2000) Movement of mitochondria in the axons and dendrites of cultured hippocampal neurons. J. Comp. Neurol. 427, 340-350 CrossRef PubMed
51. 2+-dependent interaction between mitochondria and actin filaments. Cell Calcium 53, 85-93 CrossRef PubMed
52. Cahoy, J.D., Emery, B., Kaushal, A., Foo, L.C., Zamanian, J.L., Christopherson, K.S., Xing, Y., Lubischer, J.L., Krieg, P.A., Krupenko, S.A. et al. (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J. Neurosci. 28, 264-278 CrossRef PubMed
53. Fransson, A., Ruusala, A. and Aspenstrom, P. (2003) Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J. Biol. Chem. 278, 6495-6502 CrossRef PubMed
54. Russo, G.J., Louie, K., Wellington, A., Macleod, G.T., Hu, F., Panchumarthi, S. and Zinsmaier, K.E. (2009) Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport. J. Neurosci. 29, 5443-5455 CrossRef PubMed
55. 2+-dependent regulation of kinesin-mediated mitochondrial motility. Cell 136, 163-174 CrossRef PubMed
56. 2+-dependent control of mitochondrial dynamics by the Miro GTPase. Proc. Natl. Acad. Sci. U.S.A. 105, 20728-20733 CrossRef PubMed
57. van Spronsen, M., Mikhaylova, M., Lipka, J., Schlager, M.A., van den Heuvel, D.J., Kuijpers, M., Wulf, P.S., Keijzer, N., Demmers, J., Kapitein, L.C. et al. (2013) TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. Neuron 77, 485-502 CrossRef PubMed
58. Glater, E.E., Megeath, L.J., Stowers, R.S. and Schwarz, T.L. (2006) Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent. J. Cell Biol. 173, 545-557 CrossRef PubMed
59. Smith, M.J., Pozo, K., Brickley, K. and Stephenson, F.A. (2006) Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes. J. Biol. Chem. 281, 27216-27228 CrossRef PubMed
60. Morotz, G.M., De Vos, K.J., Vagnoni, A., Ackerley, S., Shaw, C.E. and Miller, C.C.J. (2012) Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria. Hum. Mol. Genet. 21, 1979-1988 CrossRef PubMed
61. Cai, Q. and Sheng, Z.H. (2009) Moving or stopping mitochondria: Miro as a traffic cop by sensing calcium. Neuron 61, 493-496 CrossRef PubMed
62. Chen, Y. and Sheng, Z.H. (2013) Kinesin-1-syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport. J. Cell Biol. 202, 351-364 CrossRef PubMed
63. Misko, A., Jiang, S., Wegorzewska, I., Milbrandt, J. and Baloh, R.H. (2010) Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex. J. Neurosci. 30, 4232-4240 CrossRef PubMed
64. Birsa, N., Norkett, R., Wauer, T., Mevissen, T.E., Wu, H.C., Foltynie, T., Bhatia, K., Hirst, W.D., Komander, D., Plun-Favreau, H. and Kittler, J.T. (2014) Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. J. Biol. Chem. 289, 14569-14582 CrossRef PubMed
65. Rusakov, D.A., Bard, L., Stewart, M.G. and Henneberger, C. (2014) Diversity of astroglial functions alludes to subcellular specialisation. Trends Neurosci. 37, 228-242 CrossRef PubMed
66. Sun, W., McConnell, E., Pare, J.F., Xu, Q., Chen, M., Peng, W., Lovatt, D., Han, X., Smith, Y. and Nedergaard, M. (2013) Glutamate-dependent neuroglial calcium signaling differs between young and adult brain. Science 339, 197-200 CrossRef PubMed
67. 2+signaling evoked by sensory stimulation in vivo. Nat. Neurosci. 9, 816-823 CrossRef PubMed
68. Hertz, L., Peng, L. and Dienel, G.A. (2007) Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis. J. Cereb. Blood Flow Metab. 27, 219-249 CrossRef PubMed
69. Peng, L., Hertz, L., Huang, R., Sonnewald, U., Petersen, S.B., Westergaard, N., Larsson, O. and Schousboe, A. (1993) Utilization of glutamine and of TCA cycle constituents as precursors for transmitter glutamate and GABA. Dev. Neurosci. 15, 367-377 CrossRef PubMed
70. Bauer, D.E., Jackson, J.G., Genda, E.N., Montoya, M.M., Yudkoff, M. and Robinson, M.B. (2012) The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism. Neurochem. Int. 61, 566-574 CrossRef PubMed
71. Genda, E.N., Jackson, J.G., Sheldon, A.L., Locke, S.F., Greco, T.M., O'Donnell, J.C., Spruce, L.A., Xiao, R., Guo, W., Putt, M. et al. (2011) Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J. Neurosci. 31, 18275-18288 CrossRef PubMed
72. Goldman, W.F., Yarowsky, P.J., Juhaszova, M., Krueger, B.K. and Blaustein, M.P. (1994) Sodium/calcium exchange in rat cortical astrocytes. J. Neurosci. 14, 5834-5843 PubMed
73. isignal induced by hypo-osmotic stress in rat cerebellar astrocytes: the effect of osmolarity on exchange activity. J. Physiol. Sci. 58, 277-279 CrossRef PubMed
74. Tan, A.R., Cai, A.Y., Deheshi, S. and Rintoul, G.L. (2011) Elevated intracellular calcium causes distinct mitochondrial remodelling and calcineurin-dependent fission in astrocytes. Cell Calcium 49, 108-114 CrossRef PubMed
75. Chang, D.T. and Reynolds, I.J. (2006) Mitochondrial trafficking and morphology in healthy and injured neurons. Prog. Neurobiol. 80, 241-268 CrossRef PubMed
76. Chang, C.R. and Blackstone, C. (2010) Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1. Ann. N.Y. Acad. Sci. 1201, 34-39 CrossRef PubMed
77. Santel, A. and Fuller, M.T. (2001) Control of mitochondrial morphology by a human mitofusin. J. Cell Sci. 114, 867-874 PubMed
78. Liesa, M., Palacin, M. and Zorzano, A. (2009) Mitochondrial dynamics in mammalian health and disease. Physiol. Rev. 89, 799-845 CrossRef PubMed
79. Rintoul, G.L., Filiano, A.J., Brocard, J.B., Kress, G.J. and Reynolds, I.J. (2003) Glutamate decreases mitochondrial size and movement in primary forebrain neurons. J. Neurosci. 23, 7881-7888 PubMed
80. Motori, E., Puyal, J., Toni, N., Ghanem, A., Angeloni, C., Malaguti, M., Cantelli-Forti, G., Berninger, B., Conzelmann, K.K., Gotz, M. et al. (2013) Inflammation-induced alteration of astrocyte mitochondrial dynamics requires autophagy for mitochondrial network maintenance. Cell Metab. 18, 844-859 CrossRef PubMed
81. Heneka, M.T. and Feinstein, D.L. (2001) Expression and function of inducible nitric oxide synthase in neurons. J. Neuroimmunol. 114, 8-18 CrossRef PubMed
82. Heneka, M.T., Sastre, M., Dumitrescu-Ozimek, L., Dewachter, I., Walter, J., Klockgether, T. and Van Leuven, F. (2005) Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. J. Neuroinflammation 2, 22 CrossRef PubMed
83. Sheng, Z.H. and Cai, Q. (2012) Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat. Rev. Neurosci. 13, 77-93 CrossRef PubMed
84. Chen, H. and Chan, D.C. (2009) Mitochondrial dynamics - fusion, fission, movement, and mitophagy - in neurodegenerative diseases. Hum. Mol. Genet. 18, R169-R176 CrossRef PubMed
85. Westermann, B. (2010) Mitochondrial fusion and fission in cell life and death. Nat. Rev. Mol. Cell Biol. 11, 872-884 CrossRef PubMed
86. Sheng, Z.H. (2014) Mitochondrial trafficking and anchoring in neurons: new insight and implications. J. Cell Biol. 204, 1087-1098 CrossRef PubMed
87. Cai, Q., Zakaria, H.M. and Sheng, Z.H. (2012) Long time-lapse imaging reveals unique features of PARK2/Parkin-mediated mitophagy in mature cortical neurons. Autophagy 8, 976-978 CrossRef PubMed
88. Yoshii, S.R., Kishi, C., Ishihara, N. and Mizushima, N. (2011) Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J. Biol. Chem. 286, 19630-19640 CrossRef PubMed
89. Geisler, S., Holmstrom, K.M., Treis, A., Skujat, D., Weber, S.S., Fiesel, F.C., Kahle, P.J. and Springer, W. (2010) The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy 6, 871-878 CrossRef PubMed
90. Poole, A.C., Thomas, R.E., Yu, S., Vincow, E.S. and Pallanck, L. (2010) The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS ONE 5, e10054 CrossRef PubMed
91. Wang, X., Winter, D., Ashrafi, G., Schlehe, J., Wong, Y.L., Selkoe, D., Rice, S., Steen, J., LaVoie, M.J. and Schwarz, T.L. (2011) PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147, 893-906 CrossRef PubMed
92. Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H.I., Campbell, D.G., Gourlay, R., Burchell, L., Walden, H., Macartney, T.J., Deak, M. et al. (2012) PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating serine 65. Open Biol. 2, 120080 CrossRef PubMed
93. Narendra, D., Walker, J.E. and Youle, R. (2012) Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism. Cold Spring Harb. Perspect. Biol. 4, a011338 PubMed
94. Ziviani, E., Tao, R.N. and Whitworth, A.J. (2010) Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc. Natl. Acad. Sci. U.S.A. 107, 5018-5023 CrossRef PubMed
95. Exner, N., Lutz, A.K., Haass, C. and Winklhofer, K.F. (2012) Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J. 31, 3038-3062 CrossRef PubMed
96. Thomas, B. and Beal, M.F. (2007) Parkinson's disease. Hum. Mol. Genet. 16, R183-R194 CrossRef PubMed
97. Weihofen, A., Thomas, K.J., Ostaszewski, B.L., Cookson, M.R. and Selkoe, D.J. (2009) Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry 48, 2045-2052 CrossRef PubMed
98. Chan, N.C., Salazar, A.M., Pham, A.H., Sweredoski, M.J., Kolawa, N.J., Graham, R.L., Hess, S. and Chan, D.C. (2011) Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum. Mol. Genet. 20, 1726-1737 CrossRef PubMed
99. Sarraf, S.A., Raman, M., Guarani-Pereira, V., Sowa, M.E., Huttlin, E.L., Gygi, S.P. and Harper, J.W. (2013) Landscape of the Parkin-dependent ubiquitylome in response to mitochondrial depolarization. Nature 496, 372-376 CrossRef PubMed
100. Liu, L., Feng, D., Chen, G., Chen, M., Zheng, Q., Song, P., Ma, Q., Zhu, C., Wang, R., Qi, W. et al. (2012) Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat. Cell Biol. 14, 177-185 CrossRef PubMed
101. Ledesma, M.D., Galvan, C., Hellias, B., Dotti, C. and Jensen, P.H. (2002) Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress. J. Neurochem. 83, 1431-1440 CrossRef PubMed
102. Calabrese, V., Stella, A.M., Butterfield, D.A. and Scapagnini, G. (2004) Redox regulation in neurodegeneration and longevity: role of the heme oxygenase and HSP70 systems in brain stress tolerance. Antioxid. Redox Signal. 6, 895-913 CrossRef PubMed
103. Solano, R.M., Casarejos, M.J., Menendez-Cuervo, J., Rodriguez-Navarro, J.A., Garcia de Yebenes, J. and Mena, M.A. (2008) Glial dysfunction in parkin null mice: effects of aging. J. Neurosci. 28, 598-611 CrossRef PubMed
104. Lev, N., Barhum, Y., Ben-Zur, T., Melamed, E., Steiner, I. and Offen, D. (2013) Knocking out DJ-1 attenuates astrocytes neuroprotection against 6-hydroxydopamine toxicity. J. Mol. Neurosci. 50, 542-550 CrossRef PubMed
105. Larsen, N.J., Ambrosi, G., Mullett, S.J., Berman, S.B. and Hinkle, D.A. (2011) DJ-1 knock-down impairs astrocyte mitochondrial function. Neuroscience 196, 251-264 CrossRef PubMed
106. Schmidt, S., Linnartz, B., Mendritzki, S., Sczepan, T., Lubbert, M., Stichel, C.C. and Lubbert, H. (2011) Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria. Hum. Mol. Genet. 20, 1197-1211 CrossRef PubMed
107. Davis, C.H., Kim, K.Y., Bushong, E.A., Mills, E.A., Boassa, D., Shih, T., Kinebuchi, M., Phan, S., Zhou, Y., Bihlmeyer, N.A. et al. (2014) Transcellular degradation of axonal mitochondria. Proc. Natl. Acad. Sci. U.S.A. 111, 9633-9638 CrossRef PubMed
108. Abramov, A.Y., Canevari, L. and Duchen, M.R. (2004) β-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J. Neurosci. 24, 565-575 CrossRef PubMed
109. Cassina, P., Cassina, A., Pehar, M., Castellanos, R., Gandelman, M., de Leon, A., Robinson, K.M., Mason, R.P., Beckman, J.S., Barbeito, L. and Radi, R. (2008) Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J. Neurosci. 28, 4115-4122 CrossRef PubMed
110. Derouiche, A., Pannicke, T., Haseleu, J., Blaess, S., Grosche, J. and Reichenbach, A. (2012) Beyond polarity: functional membrane domains in astrocytes and Muller cells. Neurochem. Res. 37, 2513-2523 CrossRef PubMed
111. Reichenbach, A., Derouiche, A. and Kirchhoff, F. (2010) Morphology and dynamics of perisynaptic glia. Brain Res. Rev. 63, 11-25 CrossRef PubMed
112. Hirrlinger, J., Hulsmann, S. and Kirchhoff, F. (2004) Astroglial processes show spontaneous motility at active synaptic terminals in situ. Eur. J. Neurosci. 20, 2235-2239 CrossRef PubMed