메뉴 건너뛰기




Volumn 20, Issue 6, 2011, Pages 1197-1211

Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; CALCIUM ION; GLIAL FIBRILLARY ACIDIC PROTEIN; MITOCHONDRIAL PROTEIN; PARKIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TYROSINE 3 MONOOXYGENASE;

EID: 79952020818     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddq564     Document Type: Article
Times cited : (74)

References (52)
  • 2
    • 42549125512 scopus 로고    scopus 로고
    • Review: familial Parkinson's disease-genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease
    • Schiesling, C., Kieper, N., Seidel, K. and Kruger, R. (2008) Review: familial Parkinson's disease-genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease. Neuropathol. Appl. Neurobiol., 34, 255-271.
    • (2008) Neuropathol. Appl. Neurobiol. , vol.34 , pp. 255-271
    • Schiesling, C.1    Kieper, N.2    Seidel, K.3    Kruger, R.4
  • 3
    • 33644543761 scopus 로고    scopus 로고
    • Expanding insights of mitochondrial dysfunction in Parkinson's disease
    • Abou-Sleiman, P.M., Muqit, M.M. and Wood, N.W. (2006) Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat. Rev. Neurosci., 7, 207-219.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 207-219
    • Abou-Sleiman, P.M.1    Muqit, M.M.2    Wood, N.W.3
  • 4
    • 37049004489 scopus 로고    scopus 로고
    • Mitochondria in the aetiology and pathogenesis of Parkinson's disease
    • Schapira, A.H. (2008) Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol., 7, 97-109.
    • (2008) Lancet Neurol. , vol.7 , pp. 97-109
    • Schapira, A.H.1
  • 7
    • 1542617769 scopus 로고    scopus 로고
    • Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP
    • Song, D.D., Shults, C.W., Sisk, A., Rockenstein, E. and Masliah, E. (2004) Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP. Exp. Neurol., 186, 158-172.
    • (2004) Exp. Neurol. , vol.186 , pp. 158-172
    • Song, D.D.1    Shults, C.W.2    Sisk, A.3    Rockenstein, E.4    Masliah, E.5
  • 10
    • 34249946941 scopus 로고    scopus 로고
    • Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage
    • Stichel, C.C., Zhu, X.R., Bader, V., Linnartz, B., Schmidt, S. and Lubbert, H. (2007) Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage. Hum. Mol. Genet., 16, 2377-2393.
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 2377-2393
    • Stichel, C.C.1    Zhu, X.R.2    Bader, V.3    Linnartz, B.4    Schmidt, S.5    Lubbert, H.6
  • 11
    • 28844439032 scopus 로고    scopus 로고
    • Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function
    • Periquet, M., Corti, O., Jacquier, S. and Brice, A. (2005) Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function. J. Neurochem., 95, 1259-1276.
    • (2005) J. Neurochem. , vol.95 , pp. 1259-1276
    • Periquet, M.1    Corti, O.2    Jacquier, S.3    Brice, A.4
  • 12
    • 14744305520 scopus 로고    scopus 로고
    • Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice-a model of familial Parkinson's disease
    • Poon, H.F., Frasier, M., Shreve, N., Calabrese, V., Wolozin, B. and Butterfield, D.A. (2005) Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice-a model of familial Parkinson's disease. Neurobiol. Dis., 18, 492-498.
    • (2005) Neurobiol. Dis. , vol.18 , pp. 492-498
    • Poon, H.F.1    Frasier, M.2    Shreve, N.3    Calabrese, V.4    Wolozin, B.5    Butterfield, D.A.6
  • 13
    • 0036315240 scopus 로고    scopus 로고
    • Demonstration of alpha-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatment
    • Mori, F., Tanji, K., Yoshimoto, M., Takahashi, H. and Wakabayashi, K. (2002) Demonstration of alpha-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatment. Exp. Neurol., 176, 98-104.
    • (2002) Exp. Neurol. , vol.176 , pp. 98-104
    • Mori, F.1    Tanji, K.2    Yoshimoto, M.3    Takahashi, H.4    Wakabayashi, K.5
  • 14
    • 33749836242 scopus 로고    scopus 로고
    • Alpha-synuclein expression modulates microglial activation phenotype
    • Austin, S.A., Floden, A.M., Murphy, E.J. and Combs, C.K. (2006) Alpha-synuclein expression modulates microglial activation phenotype. J. Neurosci., 26, 10558-10563.
    • (2006) J. Neurosci. , vol.26 , pp. 10558-10563
    • Austin, S.A.1    Floden, A.M.2    Murphy, E.J.3    Combs, C.K.4
  • 16
    • 57449089358 scopus 로고    scopus 로고
    • DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone
    • Mullett, S.J. and Hinkle, D.A. (2009) DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone. Neurobiol. Dis., 33, 28-36.
    • (2009) Neurobiol. Dis. , vol.33 , pp. 28-36
    • Mullett, S.J.1    Hinkle, D.A.2
  • 17
    • 30644471051 scopus 로고    scopus 로고
    • Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
    • Martin, L.J., Pan, Y., Price, A.C., Sterling, W., Copeland, N.G., Jenkins, N.A., Price, D.L. and Lee, M.K. (2006) Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J. Neurosci., 26, 41-50.
    • (2006) J. Neurosci. , vol.26 , pp. 41-50
    • Martin, L.J.1    Pan, Y.2    Price, A.C.3    Sterling, W.4    Copeland, N.G.5    Jenkins, N.A.6    Price, D.L.7    Lee, M.K.8
  • 20
    • 33749669607 scopus 로고    scopus 로고
    • Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration
    • Croisier, E. and Graeber, M.B. (2006) Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration. Acta Neuropathol., 112, 517-530.
    • (2006) Acta Neuropathol. , vol.112 , pp. 517-530
    • Croisier, E.1    Graeber, M.B.2
  • 21
    • 35549006420 scopus 로고    scopus 로고
    • Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease
    • Lobsiger, C.S. and Cleveland, D.W. (2007) Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat. Neurosci., 10, 1355-1360.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1355-1360
    • Lobsiger, C.S.1    Cleveland, D.W.2
  • 24
    • 0031710975 scopus 로고    scopus 로고
    • Modulation of cell calcium signals by mitochondria
    • Jouaville, L.S., Ichas, F. and Mazat, J.P. (1998) Modulation of cell calcium signals by mitochondria. Mol. Cell. Biochem., 184, 371-376.
    • (1998) Mol. Cell. Biochem. , vol.184 , pp. 371-376
    • Jouaville, L.S.1    Ichas, F.2    Mazat, J.P.3
  • 25
    • 0027538111 scopus 로고
    • An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism
    • Hayashida, K., Oyanagi, S., Mizutani, Y. and Yokochi, M. (1993) An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism. Acta Neuropathol. (Berl.), 85, 445-448.
    • (1993) Acta Neuropathol. (Berl.) , vol.85 , pp. 445-448
    • Hayashida, K.1    Oyanagi, S.2    Mizutani, Y.3    Yokochi, M.4
  • 26
    • 33646948530 scopus 로고    scopus 로고
    • Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled
    • Keeney, P.M., Xie, J., Capaldi, R.A. and Bennett, J.P. Jr (2006) Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. J. Neurosci., 26, 5256-5264.
    • (2006) J. Neurosci. , vol.26 , pp. 5256-5264
    • Keeney, P.M.1    Xie, J.2    Capaldi, R.A.3    Bennett Jr., J.P.4
  • 27
    • 55849122639 scopus 로고    scopus 로고
    • Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
    • Henchcliffe, C. and Beal, M.F. (2008) Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat. Clin. Pract. Neurol., 4, 600-609.
    • (2008) Nat. Clin. Pract. Neurol. , vol.4 , pp. 600-609
    • Henchcliffe, C.1    Beal, M.F.2
  • 28
    • 33846702991 scopus 로고    scopus 로고
    • Autophagy, organelles and ageing
    • Terman, A., Gustafsson, B. and Brunk, U.T. (2007) Autophagy, organelles and ageing. J. Pathol., 211, 134-143.
    • (2007) J. Pathol. , vol.211 , pp. 134-143
    • Terman, A.1    Gustafsson, B.2    Brunk, U.T.3
  • 29
    • 0035487007 scopus 로고    scopus 로고
    • The mitochondrial permeability transition initiates autophagy in rat hepatocytes
    • Elmore, S.P., Qian, T., Grissom, S.F. and Lemasters, J.J. (2001) The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J., 15, 2286-2287.
    • (2001) FASEB J. , vol.15 , pp. 2286-2287
    • Elmore, S.P.1    Qian, T.2    Grissom, S.F.3    Lemasters, J.J.4
  • 31
    • 55749090654 scopus 로고    scopus 로고
    • The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
    • Deng, H., Dodson, M.W., Huang, H. and Guo, M. (2008) The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. Natl Acad. Sci. USA, 105, 14503-14508.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 14503-14508
    • Deng, H.1    Dodson, M.W.2    Huang, H.3    Guo, M.4
  • 34
    • 40749094842 scopus 로고    scopus 로고
    • Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease
    • Lee, S.J. (2008) Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease. J. Mol. Neurosci., 34, 17-22.
    • (2008) J. Mol. Neurosci. , vol.34 , pp. 17-22
    • Lee, S.J.1
  • 35
    • 20144389524 scopus 로고    scopus 로고
    • Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    • Zhang, W., Wang, T., Pei, Z., Miller, D.S., Wu, X., Block, M.L., Wilson, B., Zhang, W., Zhou, Y., Hong, J.S. et al. (2005) Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J., 19, 533-542.
    • (2005) FASEB J. , vol.19 , pp. 533-542
    • Zhang, W.1    Wang, T.2    Pei, Z.3    Miller, D.S.4    Wu, X.5    Block, M.L.6    Wilson, B.7    Zhang, W.8    Zhou, Y.9    Hong, J.S.10
  • 37
    • 12144281220 scopus 로고    scopus 로고
    • Phagocytosis of degenerating myelin in transected feline optic nerve: an immunohistochemical study
    • Chew, S.H. (2004) Phagocytosis of degenerating myelin in transected feline optic nerve: an immunohistochemical study. Biotech. Histochem., 79, 177-183.
    • (2004) Biotech. Histochem. , vol.79 , pp. 177-183
    • Chew, S.H.1
  • 38
    • 0036679197 scopus 로고    scopus 로고
    • alpha-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
    • Lo, B.C., Ridet, J.L., Schneider, B.L., Deglon, N. and Aebischer, P. (2002) alpha-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc. Natl Acad. Sci. USA, 99, 10813-10818.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 10813-10818
    • Lo, B.C.1    Ridet, J.L.2    Schneider, B.L.3    Deglon, N.4    Aebischer, P.5
  • 39
    • 42049090126 scopus 로고    scopus 로고
    • Mitochondria: the hub of cellular Ca2+ signaling
    • Szabadkai, G. and Duchen, M.R. (2008) Mitochondria: the hub of cellular Ca2+ signaling. Physiology (Bethesda), 23, 84-94.
    • (2008) Physiology (Bethesda) , vol.23 , pp. 84-94
    • Szabadkai, G.1    Duchen, M.R.2
  • 41
    • 61349156769 scopus 로고    scopus 로고
    • Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux
    • Marongiu, R., Spencer, B., Crews, L., Adame, A., Patrick, C., Trejo, M., Dallapiccola, B., Valente, E.M. and Masliah, E. (2009) Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. J. Neurochem., 108, 1561-1574.
    • (2009) J. Neurochem. , vol.108 , pp. 1561-1574
    • Marongiu, R.1    Spencer, B.2    Crews, L.3    Adame, A.4    Patrick, C.5    Trejo, M.6    Dallapiccola, B.7    Valente, E.M.8    Masliah, E.9
  • 42
    • 33745589773 scopus 로고    scopus 로고
    • Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    • Clark, I.E., Dodson, M.W., Jiang, C., Cao, J.H., Huh, J.R., Seol, J.H., Yoo, S.J., Hay, B.A. and Guo, M. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature, 441, 1162-1166.
    • (2006) Nature , vol.441 , pp. 1162-1166
    • Clark, I.E.1    Dodson, M.W.2    Jiang, C.3    Cao, J.H.4    Huh, J.R.5    Seol, J.H.6    Yoo, S.J.7    Hay, B.A.8    Guo, M.9
  • 46
    • 0035842562 scopus 로고    scopus 로고
    • Additive effect of glial cell line-derived neurotrophic factor and neurotrophin-4/5 on rat fetal nigral explant cultures
    • Meyer, M., Matarredona, E.R., Seiler, R.W., Zimmer, J. and Widmer, H.R. (2001) Additive effect of glial cell line-derived neurotrophic factor and neurotrophin-4/5 on rat fetal nigral explant cultures. Neuroscience, 108, 273-284.
    • (2001) Neuroscience , vol.108 , pp. 273-284
    • Meyer, M.1    Matarredona, E.R.2    Seiler, R.W.3    Zimmer, J.4    Widmer, H.R.5
  • 47
    • 14644400390 scopus 로고    scopus 로고
    • GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons
    • Pozas, E. and Ibanez, C.F. (2005) GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons. Neuron, 45, 701-713.
    • (2005) Neuron , vol.45 , pp. 701-713
    • Pozas, E.1    Ibanez, C.F.2
  • 48
    • 0031913672 scopus 로고    scopus 로고
    • Apoptotic cell death of cultured cerebral cortical neurons induced by withdrawal of astroglial trophic support
    • Ohgoh, M., Kimura, M., Ogura, H., Katayama, K. and Nishizawa, Y. (1998) Apoptotic cell death of cultured cerebral cortical neurons induced by withdrawal of astroglial trophic support. Exp. Neurol., 149, 51-63.
    • (1998) Exp. Neurol. , vol.149 , pp. 51-63
    • Ohgoh, M.1    Kimura, M.2    Ogura, H.3    Katayama, K.4    Nishizawa, Y.5
  • 50
    • 0025244904 scopus 로고
    • Ultrastructure of PkC(II/ III)-immunopositive structures in rat primary visual cortex. Exp
    • Stichel, C.C., Singer, W. and Zilles, K. (1990) Ultrastructure of PkC(II/ III)-immunopositive structures in rat primary visual cortex. Exp. Brain Res., 82, 575-584.
    • (1990) Brain Res , vol.82 , pp. 575-584
    • Stichel, C.C.1    Singer, W.2    Zilles, K.3
  • 51
    • 0016724709 scopus 로고
    • Ultrastructure of the nervous system
    • Liu, H.M. and Bahu, R.M. (1975) Ultrastructure of the nervous system. Ann. Clin. Lab Sci., 5, 348-354.
    • (1975) Ann. Clin. Lab Sci. , vol.5 , pp. 348-354
    • Liu, H.M.1    Bahu, R.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.