-
1
-
-
84894327787
-
Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma
-
Ambati SR, Lopes EC, Kosugi K, Mony U, Zehir A, Shah SK, Taldone T, Moreira AL, Meyers PA, Chiosis G, et al. (2014). Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma. Mol Oncol 8, 323-336.
-
(2014)
Mol Oncol
, vol.8
, pp. 323-336
-
-
Ambati, S.R.1
Lopes, E.C.2
Kosugi, K.3
Mony, U.4
Zehir, A.5
Shah, S.K.6
Taldone, T.7
Moreira, A.L.8
Meyers, P.A.9
Chiosis, G.10
-
2
-
-
0026032050
-
MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration
-
Ambros IM, Ambros PF, Strehl S, Kovar H, Gadner H, Salzer-Kuntschik M (1991). MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 67, 1886-1893.
-
(1991)
Cancer
, vol.67
, pp. 1886-1893
-
-
Ambros, I.M.1
Ambros, P.F.2
Strehl, S.3
Kovar, H.4
Gadner, H.5
Salzer-Kuntschik, M.6
-
3
-
-
14644403064
-
The actin cytoskeleton-associated protein zyxin acts as a tumor suppressor in Ewing tumor cells
-
Amsellem V, Kryszke MH, Hervy M, Subra F, Athman R, Leh H, Brachet-Ducos C, Auclair C (2005). The actin cytoskeleton-associated protein zyxin acts as a tumor suppressor in Ewing tumor cells. Exp Cell Res 304, 443-456.
-
(2005)
Exp Cell Res
, vol.304
, pp. 443-456
-
-
Amsellem, V.1
Kryszke, M.H.2
Hervy, M.3
Subra, F.4
Athman, R.5
Leh, H.6
Brachet-Ducos, C.7
Auclair, C.8
-
4
-
-
80053444351
-
Filopodia and adhesion in cancer cell motility
-
Arjonen A, Kaukonen R, Ivaska J (2011). Filopodia and adhesion in cancer cell motility. Cell Adh Migr 5, 421-430.
-
(2011)
Cell Adh Migr
, vol.5
, pp. 421-430
-
-
Arjonen, A.1
Kaukonen, R.2
Ivaska, J.3
-
5
-
-
0344171979
-
Common musculoskeletal tumors of childhood and adolescence
-
Arndt CA, Crist WM (1999). Common musculoskeletal tumors of childhood and adolescence. N Engl J Med 341, 342-352.
-
(1999)
N Engl J Med
, vol.341
, pp. 342-352
-
-
Arndt, C.A.1
Crist, W.M.2
-
6
-
-
77952801325
-
Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro
-
Aryee DN, Niedan S, Kauer M, Schwentner R, Bennani-Baiti IM, Ban J, Muehlbacher K, Kreppel M, Walker RL, Meltzer P, et al. (2010). Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro. Cancer Res 70, 4015-4023.
-
(2010)
Cancer Res
, vol.70
, pp. 4015-4023
-
-
Aryee, D.N.1
Niedan, S.2
Kauer, M.3
Schwentner, R.4
Bennani-Baiti, I.M.5
Ban, J.6
Muehlbacher, K.7
Kreppel, M.8
Walker, R.L.9
Meltzer, P.10
-
7
-
-
0021262110
-
Translocation involving chromosome 22 in Ewing's sarcoma. A cytogenetic study of four fresh tumors
-
Aurias A, Rimbaut C, Buffe D, Zucker JM, Mazabraud A (1984). Translocation involving chromosome 22 in Ewing's sarcoma. A cytogenetic study of four fresh tumors. Cancer Genet Cytogenet 12, 21-25.
-
(1984)
Cancer Genet Cytogenet
, vol.12
, pp. 21-25
-
-
Aurias, A.1
Rimbaut, C.2
Buffe, D.3
Zucker, J.M.4
Mazabraud, A.5
-
9
-
-
80054814917
-
Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: A report from the Children's Oncology Group
-
Borinstein SC, Barkauskas DA, Krailo M, Scher D, Scher L, Schlottmann S, Kallakury B, Dickman PS, Pawel BR, West DC, et al. (2011). Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: a report from the Children's Oncology Group. Cancer 117, 4966-4976.
-
(2011)
Cancer
, vol.117
, pp. 4966-4976
-
-
Borinstein, S.C.1
Barkauskas, D.A.2
Krailo, M.3
Scher, D.4
Scher, L.5
Schlottmann, S.6
Kallakury, B.7
Dickman, P.S.8
Pawel, B.R.9
West, D.C.10
-
10
-
-
33845425959
-
Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma
-
Braunreiter CL, Hancock JD, Coffin CM, Boucher KM, Lessnick SL (2006). Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma. Cell Cycle 5, 2753-2759.
-
(2006)
Cell Cycle
, vol.5
, pp. 2753-2759
-
-
Braunreiter, C.L.1
Hancock, J.D.2
Coffin, C.M.3
Boucher, K.M.4
Lessnick, S.L.5
-
11
-
-
84863900703
-
Integrin structure, activation, and interactions
-
Campbell ID, Humphries MJ (2011). Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol 3, a004994.
-
(2011)
Cold Spring Harb Perspect Biol
, vol.3
, pp. a004994
-
-
Campbell, I.D.1
Humphries, M.J.2
-
12
-
-
0023215290
-
Experimental evidence for a neural origin of Ewing's sarcoma of bone
-
Cavazzana AO, Miser JS, Jefferson J, Triche TJ (1987). Experimental evidence for a neural origin of Ewing's sarcoma of bone. Am J Pathol 127, 507-518.
-
(1987)
Am J Pathol
, vol.127
, pp. 507-518
-
-
Cavazzana, A.O.1
Miser, J.S.2
Jefferson, J.3
Triche, T.J.4
-
13
-
-
3343024743
-
Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: Actin and zyxin as key intracellular mediators
-
Cerisano V, Aalto Y, Perdichizzi S, Bernard G, Manara MC, Benini S, Cenacchi G, Preda P, Lattanzi G, Nagy B, et al. (2004). Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: actin and zyxin as key intracellular mediators. Oncogene 23, 5664-5674.
-
(2004)
Oncogene
, vol.23
, pp. 5664-5674
-
-
Cerisano, V.1
Aalto, Y.2
Perdichizzi, S.3
Bernard, G.4
Manara, M.C.5
Benini, S.6
Cenacchi, G.7
Preda, P.8
Lattanzi, G.9
Nagy, B.10
-
14
-
-
84869843232
-
The EWS/FLI Oncogene drives changes in cellular morphology, adhesion, and migration in Ewing sarcoma
-
Chaturvedi A, Hoffman LM, Welm AL, Lessnick SL, Beckerle MC (2012). The EWS/FLI Oncogene drives changes in cellular morphology, adhesion, and migration in Ewing sarcoma. Genes Cancer 3, 102-116.
-
(2012)
Genes Cancer
, vol.3
, pp. 102-116
-
-
Chaturvedi, A.1
Hoffman, L.M.2
Welm, A.L.3
Lessnick, S.L.4
Beckerle, M.C.5
-
15
-
-
0026686674
-
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
-
Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, de Jong P, Rouleau G, et al. (1992). Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 359, 162-165.
-
(1992)
Nature
, vol.359
, pp. 162-165
-
-
Delattre, O.1
Zucman, J.2
Plougastel, B.3
Desmaze, C.4
Melot, T.5
Peter, M.6
Kovar, H.7
Joubert, I.8
De Jong, P.9
Rouleau, G.10
-
16
-
-
81255135837
-
Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
-
DeRose YS, Wang G, Lin YC, Bernard PS, Buys SS, Ebbert MT, Factor R, Matsen C, Milash BA, Nelson E, et al. (2011). Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nat Med 17, 1514-1520.
-
(2011)
Nat Med
, vol.17
, pp. 1514-1520
-
-
Derose, Y.S.1
Wang, G.2
Lin, Y.C.3
Bernard, P.S.4
Buys, S.S.5
Ebbert, M.T.6
Factor, R.7
Matsen, C.8
Milash, B.A.9
Nelson, E.10
-
17
-
-
0002502298
-
Diffuse endothelioma of bone
-
Ewing J (1921). Diffuse endothelioma of bone. Proc NY Pathol Soc 21, 17-24.
-
(1921)
Proc NY Pathol Soc
, vol.21
, pp. 17-24
-
-
Ewing, J.1
-
18
-
-
0025915426
-
Immunohistochemical analysis of Ewing's sarcoma cell surface antigen p30/32MIC2
-
Fellinger EJ, Garin-Chesa P, Triche TJ, Huvos AG, Rettig WJ (1991). Immunohistochemical analysis of Ewing's sarcoma cell surface antigen p30/32MIC2. Am J Pathol 139, 317-325.
-
(1991)
Am J Pathol
, vol.139
, pp. 317-325
-
-
Fellinger, E.J.1
Garin-Chesa, P.2
Triche, T.J.3
Huvos, A.G.4
Rettig, W.J.5
-
19
-
-
80053298724
-
Molecular architecture and function of matrix adhesions
-
Geiger B, Yamada KM (2011). Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol 3, a005033.
-
(2011)
Cold Spring Harb Perspect Biol
, vol.3
, pp. a005033
-
-
Geiger, B.1
Yamada, K.M.2
-
20
-
-
80054031545
-
Overcoming anoikis-pathways to anchorage-independent growth in cancer
-
Guadamillas MC, Cerezo A, Del Pozo MA (2011). Overcoming anoikis-pathways to anchorage-independent growth in cancer. J Cell Sci 124, 3189-3197.
-
(2011)
J Cell Sci
, vol.124
, pp. 3189-3197
-
-
Guadamillas, M.C.1
Cerezo, A.2
Pozo Ma, D.3
-
21
-
-
51049114726
-
Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma
-
Guan H, Zhou Z, Gallick GE, Jia SF, Morales J, Sood AK, Corey SJ, Kleinerman ES (2008). Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma. Mol Cancer Ther 7, 1807-1816.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1807-1816
-
-
Guan, H.1
Zhou, Z.2
Gallick, G.E.3
Jia, S.F.4
Morales, J.5
Sood, A.K.6
Corey, S.J.7
Kleinerman, E.S.8
-
22
-
-
17644403503
-
A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model
-
Guan H, Zhou Z, Wang H, Jia SF, Liu W, Kleinerman ES (2005). A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model. Clin Cancer Res 11, 2662-2669.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2662-2669
-
-
Guan, H.1
Zhou, Z.2
Wang, H.3
Jia, S.F.4
Liu, W.5
Kleinerman, E.S.6
-
23
-
-
84866409537
-
Mena binds alpha5 integrin directly and modulates alpha5beta1 function
-
Gupton SL, Riquelme D, Hughes-Alford SK, Tadros J, Rudina SS, Hynes RO, Lauffenburger D, Gertler FB (2012). Mena binds alpha5 integrin directly and modulates alpha5beta1 function. J Cell Biol 198, 657-676.
-
(2012)
J Cell Biol
, vol.198
, pp. 657-676
-
-
Gupton, S.L.1
Riquelme, D.2
Hughes-Alford, S.K.3
Tadros, J.4
Rudina, S.S.5
Hynes, R.O.6
Lauffenburger, D.7
Gertler, F.B.8
-
24
-
-
84872537847
-
DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma
-
Hauer K, Calzada-Wack J, Steiger K, Grunewald TG, Baumhoer D, Plehm S, Buch T, Prazeres da Costa O, Esposito I, Burdach S, et al. (2013). DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma. Cancer Res 73, 967-977.
-
(2013)
Cancer Res
, vol.73
, pp. 967-977
-
-
Hauer, K.1
Calzada-Wack, J.2
Steiger, K.3
Grunewald, T.G.4
Baumhoer, D.5
Plehm, S.6
Buch, T.7
Prazeres Da Costa, O.8
Esposito, I.9
Burdach, S.10
-
25
-
-
67649862045
-
Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target
-
Herrero-Martin D, Osuna D, Ordonez JL, Sevillano V, Martins AS, Mackintosh C, Campos M, Madoz-Gurpide J, Otero-Motta AP, Caballero G, et al. (2009). Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target. Br J Cancer 101, 80-90.
-
(2009)
Br J Cancer
, vol.101
, pp. 80-90
-
-
Herrero-Martin, D.1
Osuna, D.2
Ordonez, J.L.3
Sevillano, V.4
Martins, A.S.5
Mackintosh, C.6
Campos, M.7
Madoz-Gurpide, J.8
Otero-Motta, A.P.9
Caballero, G.10
-
26
-
-
79952855550
-
The LIM protein zyxin binds CARP-1 and promotes apoptosis
-
Hervy M, Hoffman LM, Jensen CC, Smith M, Beckerle MC (2010). The LIM protein zyxin binds CARP-1 and promotes apoptosis. Genes Cancer 1, 506-515.
-
(2010)
Genes Cancer
, vol.1
, pp. 506-515
-
-
Hervy, M.1
Hoffman, L.M.2
Jensen, C.C.3
Smith, M.4
Beckerle, M.C.5
-
27
-
-
84861156881
-
Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators
-
Hoffman LM, Jensen CC, Chaturvedi A, Yoshigi M, Beckerle MC (2012). Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Mol Biol Cell 23, 1846-1859.
-
(2012)
Mol Biol Cell
, vol.23
, pp. 1846-1859
-
-
Hoffman, L.M.1
Jensen, C.C.2
Chaturvedi, A.3
Yoshigi, M.4
Beckerle, M.C.5
-
28
-
-
33644503878
-
Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling
-
Hoffman LM, Jensen CC, Kloeker S, Wang CL, Yoshigi M, Beckerle MC (2006). Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling. J Cell Biol 172, 771-782.
-
(2006)
J Cell Biol
, vol.172
, pp. 771-782
-
-
Hoffman, L.M.1
Jensen, C.C.2
Kloeker, S.3
Wang, C.L.4
Yoshigi, M.5
Beckerle, M.C.6
-
29
-
-
77958614914
-
Evaluation of cytarabine against Ewing sarcoma xenografts by the pediatric preclinical testing program
-
Houghton PJ, Morton CL, Kang M, Reynolds CP, Billups CA, Favours E, Payne-Turner D, Tucker C, Smith MA (2010). Evaluation of cytarabine against Ewing sarcoma xenografts by the pediatric preclinical testing program. Pediatr Blood Cancer 55, 1224-1226.
-
(2010)
Pediatr Blood Cancer
, vol.55
, pp. 1224-1226
-
-
Houghton, P.J.1
Morton, C.L.2
Kang, M.3
Reynolds, C.P.4
Billups, C.A.5
Favours, E.6
Payne-Turner, D.7
Tucker, C.8
Smith, M.A.9
-
30
-
-
25444482607
-
Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
-
Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ (2005). Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 65, 8984-8992.
-
(2005)
Cancer Res
, vol.65
, pp. 8984-8992
-
-
Hu-Lieskovan, S.1
Heidel, J.D.2
Bartlett, D.W.3
Davis, M.E.4
Triche, T.J.5
-
31
-
-
0037145037
-
Integrins: Bidirectional, allosteric signaling machines
-
Hynes RO (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.
-
(2002)
Cell
, vol.110
, pp. 673-687
-
-
Hynes, R.O.1
-
32
-
-
77955870517
-
Ewing sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions
-
Jedlicka P (2010). Ewing sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions. Int J Clin Exp Pathol 3, 338-347.
-
(2010)
Int J Clin Exp Pathol
, vol.3
, pp. 338-347
-
-
Jedlicka, P.1
-
34
-
-
0029585330
-
Significance of tumor-host interactions in cancer growth and metastases
-
Kerbel RS (1995). Significance of tumor-host interactions in cancer growth and metastases. Cancer Metastasis Rev 14, 259-262.
-
(1995)
Cancer Metastasis Rev
, vol.14
, pp. 259-262
-
-
Kerbel, R.S.1
-
35
-
-
84863357474
-
Anoikis resistance: An essential prerequisite for tumor metastasis
-
Kim YN, Koo KH, Sung JY, Yun UJ, Kim H (2012). Anoikis resistance: an essential prerequisite for tumor metastasis. Int J Cell Biol 2012 306879.
-
(2012)
Int J Cell Biol
, vol.2012
, pp. 306879
-
-
Kim, Y.N.1
Koo, K.H.2
Sung, J.Y.3
Yun, U.J.4
Kim, H.5
-
36
-
-
0031975149
-
Primitive neuroectodermal tumours: Anatomic location, extent of surgery, and outcome
-
Kimber C, Michalski A, Spitz L, Pierro A (1998). Primitive neuroectodermal tumours: anatomic location, extent of surgery, and outcome. J Pediatr Surg 33, 39-41.
-
(1998)
J Pediatr Surg
, vol.33
, pp. 39-41
-
-
Kimber, C.1
Michalski, A.2
Spitz, L.3
Pierro, A.4
-
37
-
-
33845344030
-
NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma
-
Kinsey M, Smith R, Lessnick SL (2006). NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma. Mol Cancer Res 4, 851-859.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 851-859
-
-
Kinsey, M.1
Smith, R.2
Lessnick, S.L.3
-
38
-
-
17044415589
-
Context matters: The hen or egg problem in Ewing's sarcoma
-
Kovar H (2005). Context matters: the hen or egg problem in Ewing's sarcoma. Semin Cancer Biol 15, 189-196.
-
(2005)
Semin Cancer Biol
, vol.15
, pp. 189-196
-
-
Kovar, H.1
-
39
-
-
0028821578
-
Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene
-
Lessnick SL, Braun BS, Denny CT, May WA (1995). Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene. Oncogene 10, 423-431.
-
(1995)
Oncogene
, vol.10
, pp. 423-431
-
-
Lessnick, S.L.1
Braun, B.S.2
Denny, C.T.3
May, W.A.4
-
40
-
-
0036560740
-
The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts
-
Lessnick SL, Dacwag CS, Golub TR (2002). The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell 1, 393-401.
-
(2002)
Cancer Cell
, vol.1
, pp. 393-401
-
-
Lessnick, S.L.1
Dacwag, C.S.2
Golub, T.R.3
-
41
-
-
0033902814
-
Intestinal restitution: Progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing
-
Lotz MM, Rabinovitz I, Mercurio AM (2000). Intestinal restitution: progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing. Am J Pathol 156, 985-996.
-
(2000)
Am J Pathol
, vol.156
, pp. 985-996
-
-
Lotz, M.M.1
Rabinovitz, I.2
Mercurio, A.M.3
-
42
-
-
84875813499
-
Overview of human primary tumorgraft models: Comparisons with traditional oncology preclinical models and the clinical relevance and utility of primary tumorgrafts in basic and translational oncology research
-
Lum DH, Matsen C, Welm AL, Welm BE (2012). Overview of human primary tumorgraft models: comparisons with traditional oncology preclinical models and the clinical relevance and utility of primary tumorgrafts in basic and translational oncology research. Curr Protoc Pharmacol 14, 14-22.
-
(2012)
Curr Protoc Pharmacol
, vol.14
, pp. 14-22
-
-
Lum, D.H.1
Matsen, C.2
Welm, A.L.3
Welm, B.E.4
-
43
-
-
84855163922
-
Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin
-
Margadant F, Chew LL, Hu X, Yu H, Bate N, Zhang X, Sheetz M (2011). Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin. PLoS Biol 9, e1001223.
-
(2011)
PLoS Biol
, vol.9
, pp. e1001223
-
-
Margadant, F.1
Chew, L.L.2
Hu, X.3
Yu, H.4
Bate, N.5
Zhang, X.6
Sheetz, M.7
-
44
-
-
1642540093
-
Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation
-
Mateo-Lozano S, Tirado OM, Notario V (2003). Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation. Oncogene 22, 9282-9287.
-
(2003)
Oncogene
, vol.22
, pp. 9282-9287
-
-
Mateo-Lozano, S.1
Tirado, O.M.2
Notario, V.3
-
45
-
-
0027230568
-
Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation
-
May WA, Gishizky ML, Lessnick SL, Lunsford LB, Lewis BC, Delattre O, Zucman J, Thomas G, Denny CT (1993a). Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci USA 90, 5752-5756.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 5752-5756
-
-
May, W.A.1
Gishizky, M.L.2
Lessnick, S.L.3
Lunsford, L.B.4
Lewis, B.C.5
Delattre, O.6
Zucman, J.7
Thomas, G.8
Denny, C.T.9
-
46
-
-
0027362619
-
The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
-
May WA, Lessnick SL, Braun BS, Klemsz M, Lewis BC, Lunsford LB, Hromas R, Denny CT (1993b). The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol 13, 7393-7398.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 7393-7398
-
-
May, W.A.1
Lessnick, S.L.2
Braun, B.S.3
Klemsz, M.4
Lewis, B.C.5
Lunsford, L.B.6
Hromas, R.7
Denny, C.T.8
-
47
-
-
29844442165
-
The potential for molecular therapeutic targets in Ewing's sarcoma
-
McAllister NR, Lessnick SL (2005). The potential for molecular therapeutic targets in Ewing's sarcoma. Curr Treat Options Oncol 6, 461-471.
-
(2005)
Curr Treat Options Oncol
, vol.6
, pp. 461-471
-
-
McAllister, N.R.1
Lessnick, S.L.2
-
48
-
-
79551530752
-
Integrin alpha5beta1 facilitates cancer cell invasion through enhanced contractile forces
-
Mierke CT, Frey B, Fellner M, Herrmann M, Fabry B (2011). Integrin alpha5beta1 facilitates cancer cell invasion through enhanced contractile forces. J Cell Sci 124, 369-383.
-
(2011)
J Cell Sci
, vol.124
, pp. 369-383
-
-
Mierke, C.T.1
Frey, B.2
Fellner, M.3
Herrmann, M.4
Fabry, B.5
-
49
-
-
0037437153
-
Integrin-specific signaling pathways controlling focal adhesion formation and cell migration
-
Mostafavi-Pour Z, Askari JA, Parkinson SJ, Parker PJ, Ng TT, Humphries MJ (2003). Integrin-specific signaling pathways controlling focal adhesion formation and cell migration. J Cell Biol 161, 155-167.
-
(2003)
J Cell Biol
, vol.161
, pp. 155-167
-
-
Mostafavi-Pour, Z.1
Askari, J.A.2
Parkinson, S.J.3
Parker, P.J.4
Ng, T.T.5
Humphries, M.J.6
-
50
-
-
0036675220
-
Metastasis to bone: Causes, consequences and therapeutic opportunities
-
Mundy GR (2002). Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2, 584-593.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 584-593
-
-
Mundy, G.R.1
-
51
-
-
84860273145
-
Crystal structure of alpha5beta1 integrin ectodomain: Atomic details of the fibronectin receptor
-
Nagae M, Re S, Mihara E, Nogi T, Sugita Y, Takagi J (2012). Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor. J Cell Biol 197, 131-140.
-
(2012)
J Cell Biol
, vol.197
, pp. 131-140
-
-
Nagae, M.1
Re, S.2
Mihara, E.3
Nogi, T.4
Sugita, Y.5
Takagi, J.6
-
52
-
-
44849085869
-
EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma
-
Owen LA, Kowalewski AA, Lessnick SL (2008). EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma. PLoS One 3, e1965.
-
(2008)
PLoS One
, vol.3
, pp. e1965
-
-
Owen, L.A.1
Kowalewski, A.A.2
Lessnick, S.L.3
-
53
-
-
33749661948
-
Identification of target genes in their native cellular context: An analysis of EWS/FLI in Ewing's sarcoma
-
Owen LA, Lessnick SL (2006). Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma. Cell Cycle 5, 2049-2053.
-
(2006)
Cell Cycle
, vol.5
, pp. 2049-2053
-
-
Owen, L.A.1
Lessnick, S.L.2
-
54
-
-
41149157649
-
TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
-
Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massague J (2008). TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133, 66-77.
-
(2008)
Cell
, vol.133
, pp. 66-77
-
-
Padua, D.1
Zhang, X.H.2
Wang, Q.3
Nadal, C.4
Gerald, W.L.5
Gomis, R.R.6
Massague, J.7
-
55
-
-
80455174397
-
Mechanisms of cancer cell metastasis to the bone: A multistep process
-
Patel LR, Camacho DF, Shiozawa Y, Pienta KJ, Taichman RS (2011). Mechanisms of cancer cell metastasis to the bone: a multistep process. Future Oncol 7, 1285-1297.
-
(2011)
Future Oncol
, vol.7
, pp. 1285-1297
-
-
Patel, L.R.1
Camacho, D.F.2
Shiozawa, Y.3
Pienta, K.J.4
Taichman, R.S.5
-
56
-
-
0028211939
-
Ewing's sarcoma-routine diagnostic utilization of MIC2 analysis: A Pediatric Oncology Group/Children's Cancer Group Intergroup Study
-
Perlman EJ, Dickman PS, Askin FB, Grier HE, Miser JS, Link MP (1994). Ewing's sarcoma-routine diagnostic utilization of MIC2 analysis: a Pediatric Oncology Group/Children's Cancer Group Intergroup Study. Hum Pathol 25, 304-307.
-
(1994)
Hum Pathol
, vol.25
, pp. 304-307
-
-
Perlman, E.J.1
Dickman, P.S.2
Askin, F.B.3
Grier, H.E.4
Miser, J.S.5
Link, M.P.6
-
57
-
-
33751350530
-
Direct association between caspase 3 and alpha5beta1 integrin and its role during anoikis of rat fibroblasts
-
Rajeswari J, Pande G (2006). Direct association between caspase 3 and alpha5beta1 integrin and its role during anoikis of rat fibroblasts. Cell Biol Int 30, 963-969.
-
(2006)
Cell Biol Int
, vol.30
, pp. 963-969
-
-
Rajeswari, J.1
Pande, G.2
-
58
-
-
0030752553
-
Integrin function in osteoclasts
-
Rodan SB, Rodan GA (1997). Integrin function in osteoclasts. J Endocrinol 154 (Suppl), S47-S56.
-
(1997)
J Endocrinol
, vol.154
, pp. S47-S56
-
-
Rodan, S.B.1
Rodan, G.A.2
-
59
-
-
33644941036
-
RGD, the Rho'd to cell spreading
-
Salsmann A, Schaffner-Reckinger E, Kieffer N (2006). RGD, the Rho'd to cell spreading. Eur J Cell Biol 85, 249-254.
-
(2006)
Eur J Cell Biol
, vol.85
, pp. 249-254
-
-
Salsmann, A.1
Schaffner-Reckinger, E.2
Kieffer, N.3
-
60
-
-
84886088733
-
Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma
-
Sankar S, Bell R, Stephens B, Zhuo R, Sharma S, Bearss DJ, Lessnick SL (2013a). Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma. Oncogene 32, 5089-5100.
-
(2013)
Oncogene
, vol.32
, pp. 5089-5100
-
-
Sankar, S.1
Bell, R.2
Stephens, B.3
Zhuo, R.4
Sharma, S.5
Bearss, D.J.6
Lessnick, S.L.7
-
61
-
-
80054782854
-
Promiscuous partnerships in Ewing's sarcoma
-
Sankar S, Lessnick SL (2011). Promiscuous partnerships in Ewing's sarcoma. Cancer Genet 204, 351-365.
-
(2011)
Cancer Genet
, vol.204
, pp. 351-365
-
-
Sankar, S.1
Lessnick, S.L.2
-
62
-
-
84886998616
-
A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma
-
Sankar S, Tanner JM, Bell R, Chaturvedi A, Randall RL, Beckerle MC, Lessnick SL (2013b). A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma. Mol Cell Biol 33, 4448-60.
-
(2013)
Mol Cell Biol
, vol.33
, pp. 4448-4460
-
-
Sankar, S.1
Tanner, J.M.2
Bell, R.3
Chaturvedi, A.4
Randall, R.L.5
Beckerle, M.C.6
Lessnick, S.L.7
-
63
-
-
0034351716
-
Murine model for skeletal metastases of Ewing's sarcoma
-
Scotlandi K, Benini S, Manara MC, Serra M, Nanni P, Lollini PL, Nicoletti G, Landuzzi L, Chano T, Picci P, et al. (2000). Murine model for skeletal metastases of Ewing's sarcoma. J Orthop Res 18, 959-966.
-
(2000)
J Orthop Res
, vol.18
, pp. 959-966
-
-
Scotlandi, K.1
Benini, S.2
Manara, M.C.3
Serra, M.4
Nanni, P.5
Lollini, P.L.6
Nicoletti, G.7
Landuzzi, L.8
Chano, T.9
Picci, P.10
-
64
-
-
0033527692
-
Focal adhesion motility revealed in stationary fibroblasts
-
Smilenov LB, Mikhailov A, Pelham RJ, Marcantonio EE, Gundersen GG (1999). Focal adhesion motility revealed in stationary fibroblasts. Science 286, 1172-1174.
-
(1999)
Science
, vol.286
, pp. 1172-1174
-
-
Smilenov, L.B.1
Mikhailov, A.2
Pelham, R.J.3
Marcantonio, E.E.4
Gundersen, G.G.5
-
65
-
-
77956602980
-
A zyxin-mediated mechanism for actin stress fiber maintenance and repair
-
Smith MA, Blankman E, Gardel ML, Luettjohann L, Waterman CM, Beckerle MC (2010). A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Dev Cell 19, 365-376.
-
(2010)
Dev Cell
, vol.19
, pp. 365-376
-
-
Smith, M.A.1
Blankman, E.2
Gardel, M.L.3
Luettjohann, L.4
Waterman, C.M.5
Beckerle, M.C.6
-
66
-
-
33646366123
-
Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma
-
Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR, Lessnick SL (2006). Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell 9, 405-416.
-
(2006)
Cancer Cell
, vol.9
, pp. 405-416
-
-
Smith, R.1
Owen, L.A.2
Trem, D.J.3
Wong, J.S.4
Whangbo, J.S.5
Golub, T.R.6
Lessnick, S.L.7
-
67
-
-
84870965277
-
The clone wars-revenge of the metastatic rogue state: The sarcoma paradigm
-
Spraker HL, Price SL, Chaturvedi A, Schiffman JD, Jones KB, Lessnick SL, Beckerle M, Randall RL (2012). The clone wars-revenge of the metastatic rogue state: the sarcoma paradigm. Front Oncol 2, 2.
-
(2012)
Front Oncol
, vol.2
, pp. 2
-
-
Spraker, H.L.1
Price, S.L.2
Chaturvedi, A.3
Schiffman, J.D.4
Jones, K.B.5
Lessnick, S.L.6
Beckerle, M.7
Randall, R.L.8
-
68
-
-
0035851912
-
Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins
-
Stupack DG, Puente XS, Boutsaboualoy S, Storgard CM, Cheresh DA (2001). Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol 155, 459-470.
-
(2001)
J Cell Biol
, vol.155
, pp. 459-470
-
-
Stupack, D.G.1
Puente, X.S.2
Boutsaboualoy, S.3
Storgard, C.M.4
Cheresh, D.A.5
-
69
-
-
33750570283
-
Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells
-
Tirado OM, Mateo-Lozano S, Villar J, Dettin LE, Llort A, Gallego S, Ban J, Kovar H, Notario V (2006). Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells. Cancer Res 66, 9937-9947.
-
(2006)
Cancer Res
, vol.66
, pp. 9937-9947
-
-
Tirado, O.M.1
Mateo-Lozano, S.2
Villar, J.3
Dettin, L.E.4
Llort, A.5
Gallego, S.6
Ban, J.7
Kovar, H.8
Notario, V.9
-
70
-
-
34247570879
-
Mesenchymal stem cell features of Ewing tumors
-
Tirode F, Laud-Duval K, Prieur A, Delorme B, Charbord P, Delattre O (2007). Mesenchymal stem cell features of Ewing tumors. Cancer Cell 11, 421-429.
-
(2007)
Cancer Cell
, vol.11
, pp. 421-429
-
-
Tirode, F.1
Laud-Duval, K.2
Prieur, A.3
Delorme, B.4
Charbord, P.5
Delattre, O.6
-
71
-
-
66749083793
-
Integrin switching modulates adhesion dynamics and cell migration
-
Truong H, Danen EH (2009). Integrin switching modulates adhesion dynamics and cell migration. Cell Adh Migr 3, 179-181.
-
(2009)
Cell Adh Migr
, vol.3
, pp. 179-181
-
-
Truong, H.1
Danen, E.H.2
-
72
-
-
0023678656
-
Chromosomes in Ewing's sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12)
-
Turc-Carel C, Aurias A, Mugneret F, Lizard S, Sidaner I, Volk C, Thiery JP, Olschwang S, Philip I, Berger MP, et al. (1988). Chromosomes in Ewing's sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12). Cancer Genet Cytogenet 32, 229-238.
-
(1988)
Cancer Genet Cytogenet
, vol.32
, pp. 229-238
-
-
Turc-Carel, C.1
Aurias, A.2
Mugneret, F.3
Lizard, S.4
Sidaner, I.5
Volk, C.6
Thiery, J.P.7
Olschwang, S.8
Philip, I.9
Berger, M.P.10
-
73
-
-
84896907722
-
Development of a preclinical orthotopic xenograft model of Ewing sarcoma and other human malignant bone disease using advanced in vivo imaging
-
Vormoor B, Knizia HK, Batey MA, Almeida GS, Wilson I, Dildey P, Sharma A, Blair H, Hide IG, Heidenreich O, et al. (2014). Development of a preclinical orthotopic xenograft model of Ewing sarcoma and other human malignant bone disease using advanced in vivo imaging. PLoS One 7, e85128.
-
(2014)
PLoS One
, vol.7
, pp. e85128
-
-
Vormoor, B.1
Knizia, H.K.2
Batey, M.A.3
Almeida, G.S.4
Wilson, I.5
Dildey, P.6
Sharma, A.7
Blair, H.8
Hide, I.G.9
Heidenreich, O.10
-
74
-
-
75149180461
-
Inhibiting platelet-derived growth factor beta reduces Ewing's sarcoma growth and metastasis in a novel orthotopic human xenograft model
-
Wang YX, Mandal D, Wang S, Hughes D, Pollock RE, Lev D, Kleinerman E, Hayes-Jordan A (2009). Inhibiting platelet-derived growth factor beta reduces Ewing's sarcoma growth and metastasis in a novel orthotopic human xenograft model. In Vivo 23, 903-909.
-
(2009)
Vivo
, vol.23
, pp. 903-909
-
-
Wang, Y.X.1
Mandal, D.2
Wang, S.3
Hughes, D.4
Pollock, R.E.5
Lev, D.6
Kleinerman, E.7
Hayes-Jordan, A.8
-
75
-
-
84891542120
-
ZEB2 represses the epithelial phenotype and facilitates metastasis in Ewing sarcoma
-
Wiles ET, Bell R, Thomas D, Beckerle MC, Lessnick SL (2013). ZEB2 represses the epithelial phenotype and facilitates metastasis in Ewing sarcoma. Genes Cancer 4, 486-500.
-
(2013)
Genes Cancer
, vol.4
, pp. 486-500
-
-
Wiles, E.T.1
Bell, R.2
Thomas, D.3
Beckerle, M.C.4
Lessnick, S.L.5
-
76
-
-
27544435992
-
Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement
-
Yoshigi M, Hoffman LM, Jensen CC, Yost HJ, Beckerle MC (2005). Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. J Cell Biol 171, 209-215.
-
(2005)
J Cell Biol
, vol.171
, pp. 209-215
-
-
Yoshigi, M.1
Hoffman, L.M.2
Jensen, C.C.3
Yost, H.J.4
Beckerle, M.C.5
-
77
-
-
34547606042
-
Functional atlas of the integrin adhesome
-
Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B (2007). Functional atlas of the integrin adhesome. Nat Cell Biol 9, 858-867.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 858-867
-
-
Zaidel-Bar, R.1
Itzkovitz, S.2
Ma'ayan, A.3
Iyengar, R.4
Geiger, B.5
|