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Volumn 25, Issue 18, 2014, Pages 2695-2709

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA5 INTEGRIN; INTEGRIN; REGULATOR PROTEIN; RNA BINDING PROTEIN EWS; TRANSCRIPTION FACTOR FLI 1; ZYXIN; CD51 ANTIGEN; EWS-FLI FUSION PROTEIN; ONCOPROTEIN; ZYX PROTEIN, HUMAN;

EID: 84907222566     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E14-01-0007     Document Type: Article
Times cited : (44)

References (77)
  • 2
    • 0026032050 scopus 로고
    • MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration
    • Ambros IM, Ambros PF, Strehl S, Kovar H, Gadner H, Salzer-Kuntschik M (1991). MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 67, 1886-1893.
    • (1991) Cancer , vol.67 , pp. 1886-1893
    • Ambros, I.M.1    Ambros, P.F.2    Strehl, S.3    Kovar, H.4    Gadner, H.5    Salzer-Kuntschik, M.6
  • 4
    • 80053444351 scopus 로고    scopus 로고
    • Filopodia and adhesion in cancer cell motility
    • Arjonen A, Kaukonen R, Ivaska J (2011). Filopodia and adhesion in cancer cell motility. Cell Adh Migr 5, 421-430.
    • (2011) Cell Adh Migr , vol.5 , pp. 421-430
    • Arjonen, A.1    Kaukonen, R.2    Ivaska, J.3
  • 5
    • 0344171979 scopus 로고    scopus 로고
    • Common musculoskeletal tumors of childhood and adolescence
    • Arndt CA, Crist WM (1999). Common musculoskeletal tumors of childhood and adolescence. N Engl J Med 341, 342-352.
    • (1999) N Engl J Med , vol.341 , pp. 342-352
    • Arndt, C.A.1    Crist, W.M.2
  • 7
    • 0021262110 scopus 로고
    • Translocation involving chromosome 22 in Ewing's sarcoma. A cytogenetic study of four fresh tumors
    • Aurias A, Rimbaut C, Buffe D, Zucker JM, Mazabraud A (1984). Translocation involving chromosome 22 in Ewing's sarcoma. A cytogenetic study of four fresh tumors. Cancer Genet Cytogenet 12, 21-25.
    • (1984) Cancer Genet Cytogenet , vol.12 , pp. 21-25
    • Aurias, A.1    Rimbaut, C.2    Buffe, D.3    Zucker, J.M.4    Mazabraud, A.5
  • 8
  • 10
    • 33845425959 scopus 로고    scopus 로고
    • Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma
    • Braunreiter CL, Hancock JD, Coffin CM, Boucher KM, Lessnick SL (2006). Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma. Cell Cycle 5, 2753-2759.
    • (2006) Cell Cycle , vol.5 , pp. 2753-2759
    • Braunreiter, C.L.1    Hancock, J.D.2    Coffin, C.M.3    Boucher, K.M.4    Lessnick, S.L.5
  • 12
    • 0023215290 scopus 로고
    • Experimental evidence for a neural origin of Ewing's sarcoma of bone
    • Cavazzana AO, Miser JS, Jefferson J, Triche TJ (1987). Experimental evidence for a neural origin of Ewing's sarcoma of bone. Am J Pathol 127, 507-518.
    • (1987) Am J Pathol , vol.127 , pp. 507-518
    • Cavazzana, A.O.1    Miser, J.S.2    Jefferson, J.3    Triche, T.J.4
  • 13
    • 3343024743 scopus 로고    scopus 로고
    • Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: Actin and zyxin as key intracellular mediators
    • Cerisano V, Aalto Y, Perdichizzi S, Bernard G, Manara MC, Benini S, Cenacchi G, Preda P, Lattanzi G, Nagy B, et al. (2004). Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: actin and zyxin as key intracellular mediators. Oncogene 23, 5664-5674.
    • (2004) Oncogene , vol.23 , pp. 5664-5674
    • Cerisano, V.1    Aalto, Y.2    Perdichizzi, S.3    Bernard, G.4    Manara, M.C.5    Benini, S.6    Cenacchi, G.7    Preda, P.8    Lattanzi, G.9    Nagy, B.10
  • 14
    • 84869843232 scopus 로고    scopus 로고
    • The EWS/FLI Oncogene drives changes in cellular morphology, adhesion, and migration in Ewing sarcoma
    • Chaturvedi A, Hoffman LM, Welm AL, Lessnick SL, Beckerle MC (2012). The EWS/FLI Oncogene drives changes in cellular morphology, adhesion, and migration in Ewing sarcoma. Genes Cancer 3, 102-116.
    • (2012) Genes Cancer , vol.3 , pp. 102-116
    • Chaturvedi, A.1    Hoffman, L.M.2    Welm, A.L.3    Lessnick, S.L.4    Beckerle, M.C.5
  • 16
    • 81255135837 scopus 로고    scopus 로고
    • Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
    • DeRose YS, Wang G, Lin YC, Bernard PS, Buys SS, Ebbert MT, Factor R, Matsen C, Milash BA, Nelson E, et al. (2011). Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nat Med 17, 1514-1520.
    • (2011) Nat Med , vol.17 , pp. 1514-1520
    • Derose, Y.S.1    Wang, G.2    Lin, Y.C.3    Bernard, P.S.4    Buys, S.S.5    Ebbert, M.T.6    Factor, R.7    Matsen, C.8    Milash, B.A.9    Nelson, E.10
  • 17
    • 0002502298 scopus 로고
    • Diffuse endothelioma of bone
    • Ewing J (1921). Diffuse endothelioma of bone. Proc NY Pathol Soc 21, 17-24.
    • (1921) Proc NY Pathol Soc , vol.21 , pp. 17-24
    • Ewing, J.1
  • 19
    • 80053298724 scopus 로고    scopus 로고
    • Molecular architecture and function of matrix adhesions
    • Geiger B, Yamada KM (2011). Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol 3, a005033.
    • (2011) Cold Spring Harb Perspect Biol , vol.3 , pp. a005033
    • Geiger, B.1    Yamada, K.M.2
  • 20
    • 80054031545 scopus 로고    scopus 로고
    • Overcoming anoikis-pathways to anchorage-independent growth in cancer
    • Guadamillas MC, Cerezo A, Del Pozo MA (2011). Overcoming anoikis-pathways to anchorage-independent growth in cancer. J Cell Sci 124, 3189-3197.
    • (2011) J Cell Sci , vol.124 , pp. 3189-3197
    • Guadamillas, M.C.1    Cerezo, A.2    Pozo Ma, D.3
  • 22
    • 17644403503 scopus 로고    scopus 로고
    • A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model
    • Guan H, Zhou Z, Wang H, Jia SF, Liu W, Kleinerman ES (2005). A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model. Clin Cancer Res 11, 2662-2669.
    • (2005) Clin Cancer Res , vol.11 , pp. 2662-2669
    • Guan, H.1    Zhou, Z.2    Wang, H.3    Jia, S.F.4    Liu, W.5    Kleinerman, E.S.6
  • 27
    • 84861156881 scopus 로고    scopus 로고
    • Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators
    • Hoffman LM, Jensen CC, Chaturvedi A, Yoshigi M, Beckerle MC (2012). Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Mol Biol Cell 23, 1846-1859.
    • (2012) Mol Biol Cell , vol.23 , pp. 1846-1859
    • Hoffman, L.M.1    Jensen, C.C.2    Chaturvedi, A.3    Yoshigi, M.4    Beckerle, M.C.5
  • 28
    • 33644503878 scopus 로고    scopus 로고
    • Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling
    • Hoffman LM, Jensen CC, Kloeker S, Wang CL, Yoshigi M, Beckerle MC (2006). Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling. J Cell Biol 172, 771-782.
    • (2006) J Cell Biol , vol.172 , pp. 771-782
    • Hoffman, L.M.1    Jensen, C.C.2    Kloeker, S.3    Wang, C.L.4    Yoshigi, M.5    Beckerle, M.C.6
  • 30
    • 25444482607 scopus 로고    scopus 로고
    • Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
    • Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ (2005). Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 65, 8984-8992.
    • (2005) Cancer Res , vol.65 , pp. 8984-8992
    • Hu-Lieskovan, S.1    Heidel, J.D.2    Bartlett, D.W.3    Davis, M.E.4    Triche, T.J.5
  • 31
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes RO (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 32
    • 77955870517 scopus 로고    scopus 로고
    • Ewing sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions
    • Jedlicka P (2010). Ewing sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions. Int J Clin Exp Pathol 3, 338-347.
    • (2010) Int J Clin Exp Pathol , vol.3 , pp. 338-347
    • Jedlicka, P.1
  • 34
    • 0029585330 scopus 로고
    • Significance of tumor-host interactions in cancer growth and metastases
    • Kerbel RS (1995). Significance of tumor-host interactions in cancer growth and metastases. Cancer Metastasis Rev 14, 259-262.
    • (1995) Cancer Metastasis Rev , vol.14 , pp. 259-262
    • Kerbel, R.S.1
  • 35
    • 84863357474 scopus 로고    scopus 로고
    • Anoikis resistance: An essential prerequisite for tumor metastasis
    • Kim YN, Koo KH, Sung JY, Yun UJ, Kim H (2012). Anoikis resistance: an essential prerequisite for tumor metastasis. Int J Cell Biol 2012 306879.
    • (2012) Int J Cell Biol , vol.2012 , pp. 306879
    • Kim, Y.N.1    Koo, K.H.2    Sung, J.Y.3    Yun, U.J.4    Kim, H.5
  • 36
    • 0031975149 scopus 로고    scopus 로고
    • Primitive neuroectodermal tumours: Anatomic location, extent of surgery, and outcome
    • Kimber C, Michalski A, Spitz L, Pierro A (1998). Primitive neuroectodermal tumours: anatomic location, extent of surgery, and outcome. J Pediatr Surg 33, 39-41.
    • (1998) J Pediatr Surg , vol.33 , pp. 39-41
    • Kimber, C.1    Michalski, A.2    Spitz, L.3    Pierro, A.4
  • 37
    • 33845344030 scopus 로고    scopus 로고
    • NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma
    • Kinsey M, Smith R, Lessnick SL (2006). NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma. Mol Cancer Res 4, 851-859.
    • (2006) Mol Cancer Res , vol.4 , pp. 851-859
    • Kinsey, M.1    Smith, R.2    Lessnick, S.L.3
  • 38
    • 17044415589 scopus 로고    scopus 로고
    • Context matters: The hen or egg problem in Ewing's sarcoma
    • Kovar H (2005). Context matters: the hen or egg problem in Ewing's sarcoma. Semin Cancer Biol 15, 189-196.
    • (2005) Semin Cancer Biol , vol.15 , pp. 189-196
    • Kovar, H.1
  • 39
    • 0028821578 scopus 로고
    • Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene
    • Lessnick SL, Braun BS, Denny CT, May WA (1995). Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene. Oncogene 10, 423-431.
    • (1995) Oncogene , vol.10 , pp. 423-431
    • Lessnick, S.L.1    Braun, B.S.2    Denny, C.T.3    May, W.A.4
  • 40
    • 0036560740 scopus 로고    scopus 로고
    • The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts
    • Lessnick SL, Dacwag CS, Golub TR (2002). The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell 1, 393-401.
    • (2002) Cancer Cell , vol.1 , pp. 393-401
    • Lessnick, S.L.1    Dacwag, C.S.2    Golub, T.R.3
  • 41
    • 0033902814 scopus 로고    scopus 로고
    • Intestinal restitution: Progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing
    • Lotz MM, Rabinovitz I, Mercurio AM (2000). Intestinal restitution: progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing. Am J Pathol 156, 985-996.
    • (2000) Am J Pathol , vol.156 , pp. 985-996
    • Lotz, M.M.1    Rabinovitz, I.2    Mercurio, A.M.3
  • 42
    • 84875813499 scopus 로고    scopus 로고
    • Overview of human primary tumorgraft models: Comparisons with traditional oncology preclinical models and the clinical relevance and utility of primary tumorgrafts in basic and translational oncology research
    • Lum DH, Matsen C, Welm AL, Welm BE (2012). Overview of human primary tumorgraft models: comparisons with traditional oncology preclinical models and the clinical relevance and utility of primary tumorgrafts in basic and translational oncology research. Curr Protoc Pharmacol 14, 14-22.
    • (2012) Curr Protoc Pharmacol , vol.14 , pp. 14-22
    • Lum, D.H.1    Matsen, C.2    Welm, A.L.3    Welm, B.E.4
  • 43
    • 84855163922 scopus 로고    scopus 로고
    • Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin
    • Margadant F, Chew LL, Hu X, Yu H, Bate N, Zhang X, Sheetz M (2011). Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin. PLoS Biol 9, e1001223.
    • (2011) PLoS Biol , vol.9 , pp. e1001223
    • Margadant, F.1    Chew, L.L.2    Hu, X.3    Yu, H.4    Bate, N.5    Zhang, X.6    Sheetz, M.7
  • 44
    • 1642540093 scopus 로고    scopus 로고
    • Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation
    • Mateo-Lozano S, Tirado OM, Notario V (2003). Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation. Oncogene 22, 9282-9287.
    • (2003) Oncogene , vol.22 , pp. 9282-9287
    • Mateo-Lozano, S.1    Tirado, O.M.2    Notario, V.3
  • 46
    • 0027362619 scopus 로고
    • The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
    • May WA, Lessnick SL, Braun BS, Klemsz M, Lewis BC, Lunsford LB, Hromas R, Denny CT (1993b). The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol 13, 7393-7398.
    • (1993) Mol Cell Biol , vol.13 , pp. 7393-7398
    • May, W.A.1    Lessnick, S.L.2    Braun, B.S.3    Klemsz, M.4    Lewis, B.C.5    Lunsford, L.B.6    Hromas, R.7    Denny, C.T.8
  • 47
    • 29844442165 scopus 로고    scopus 로고
    • The potential for molecular therapeutic targets in Ewing's sarcoma
    • McAllister NR, Lessnick SL (2005). The potential for molecular therapeutic targets in Ewing's sarcoma. Curr Treat Options Oncol 6, 461-471.
    • (2005) Curr Treat Options Oncol , vol.6 , pp. 461-471
    • McAllister, N.R.1    Lessnick, S.L.2
  • 48
    • 79551530752 scopus 로고    scopus 로고
    • Integrin alpha5beta1 facilitates cancer cell invasion through enhanced contractile forces
    • Mierke CT, Frey B, Fellner M, Herrmann M, Fabry B (2011). Integrin alpha5beta1 facilitates cancer cell invasion through enhanced contractile forces. J Cell Sci 124, 369-383.
    • (2011) J Cell Sci , vol.124 , pp. 369-383
    • Mierke, C.T.1    Frey, B.2    Fellner, M.3    Herrmann, M.4    Fabry, B.5
  • 50
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: Causes, consequences and therapeutic opportunities
    • Mundy GR (2002). Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2, 584-593.
    • (2002) Nat Rev Cancer , vol.2 , pp. 584-593
    • Mundy, G.R.1
  • 51
    • 84860273145 scopus 로고    scopus 로고
    • Crystal structure of alpha5beta1 integrin ectodomain: Atomic details of the fibronectin receptor
    • Nagae M, Re S, Mihara E, Nogi T, Sugita Y, Takagi J (2012). Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor. J Cell Biol 197, 131-140.
    • (2012) J Cell Biol , vol.197 , pp. 131-140
    • Nagae, M.1    Re, S.2    Mihara, E.3    Nogi, T.4    Sugita, Y.5    Takagi, J.6
  • 52
    • 44849085869 scopus 로고    scopus 로고
    • EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma
    • Owen LA, Kowalewski AA, Lessnick SL (2008). EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma. PLoS One 3, e1965.
    • (2008) PLoS One , vol.3 , pp. e1965
    • Owen, L.A.1    Kowalewski, A.A.2    Lessnick, S.L.3
  • 53
    • 33749661948 scopus 로고    scopus 로고
    • Identification of target genes in their native cellular context: An analysis of EWS/FLI in Ewing's sarcoma
    • Owen LA, Lessnick SL (2006). Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma. Cell Cycle 5, 2049-2053.
    • (2006) Cell Cycle , vol.5 , pp. 2049-2053
    • Owen, L.A.1    Lessnick, S.L.2
  • 54
    • 41149157649 scopus 로고    scopus 로고
    • TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    • Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massague J (2008). TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133, 66-77.
    • (2008) Cell , vol.133 , pp. 66-77
    • Padua, D.1    Zhang, X.H.2    Wang, Q.3    Nadal, C.4    Gerald, W.L.5    Gomis, R.R.6    Massague, J.7
  • 56
    • 0028211939 scopus 로고
    • Ewing's sarcoma-routine diagnostic utilization of MIC2 analysis: A Pediatric Oncology Group/Children's Cancer Group Intergroup Study
    • Perlman EJ, Dickman PS, Askin FB, Grier HE, Miser JS, Link MP (1994). Ewing's sarcoma-routine diagnostic utilization of MIC2 analysis: a Pediatric Oncology Group/Children's Cancer Group Intergroup Study. Hum Pathol 25, 304-307.
    • (1994) Hum Pathol , vol.25 , pp. 304-307
    • Perlman, E.J.1    Dickman, P.S.2    Askin, F.B.3    Grier, H.E.4    Miser, J.S.5    Link, M.P.6
  • 57
    • 33751350530 scopus 로고    scopus 로고
    • Direct association between caspase 3 and alpha5beta1 integrin and its role during anoikis of rat fibroblasts
    • Rajeswari J, Pande G (2006). Direct association between caspase 3 and alpha5beta1 integrin and its role during anoikis of rat fibroblasts. Cell Biol Int 30, 963-969.
    • (2006) Cell Biol Int , vol.30 , pp. 963-969
    • Rajeswari, J.1    Pande, G.2
  • 58
    • 0030752553 scopus 로고    scopus 로고
    • Integrin function in osteoclasts
    • Rodan SB, Rodan GA (1997). Integrin function in osteoclasts. J Endocrinol 154 (Suppl), S47-S56.
    • (1997) J Endocrinol , vol.154 , pp. S47-S56
    • Rodan, S.B.1    Rodan, G.A.2
  • 60
    • 84886088733 scopus 로고    scopus 로고
    • Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma
    • Sankar S, Bell R, Stephens B, Zhuo R, Sharma S, Bearss DJ, Lessnick SL (2013a). Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma. Oncogene 32, 5089-5100.
    • (2013) Oncogene , vol.32 , pp. 5089-5100
    • Sankar, S.1    Bell, R.2    Stephens, B.3    Zhuo, R.4    Sharma, S.5    Bearss, D.J.6    Lessnick, S.L.7
  • 61
    • 80054782854 scopus 로고    scopus 로고
    • Promiscuous partnerships in Ewing's sarcoma
    • Sankar S, Lessnick SL (2011). Promiscuous partnerships in Ewing's sarcoma. Cancer Genet 204, 351-365.
    • (2011) Cancer Genet , vol.204 , pp. 351-365
    • Sankar, S.1    Lessnick, S.L.2
  • 69
    • 33750570283 scopus 로고    scopus 로고
    • Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells
    • Tirado OM, Mateo-Lozano S, Villar J, Dettin LE, Llort A, Gallego S, Ban J, Kovar H, Notario V (2006). Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells. Cancer Res 66, 9937-9947.
    • (2006) Cancer Res , vol.66 , pp. 9937-9947
    • Tirado, O.M.1    Mateo-Lozano, S.2    Villar, J.3    Dettin, L.E.4    Llort, A.5    Gallego, S.6    Ban, J.7    Kovar, H.8    Notario, V.9
  • 71
    • 66749083793 scopus 로고    scopus 로고
    • Integrin switching modulates adhesion dynamics and cell migration
    • Truong H, Danen EH (2009). Integrin switching modulates adhesion dynamics and cell migration. Cell Adh Migr 3, 179-181.
    • (2009) Cell Adh Migr , vol.3 , pp. 179-181
    • Truong, H.1    Danen, E.H.2
  • 73
    • 84896907722 scopus 로고    scopus 로고
    • Development of a preclinical orthotopic xenograft model of Ewing sarcoma and other human malignant bone disease using advanced in vivo imaging
    • Vormoor B, Knizia HK, Batey MA, Almeida GS, Wilson I, Dildey P, Sharma A, Blair H, Hide IG, Heidenreich O, et al. (2014). Development of a preclinical orthotopic xenograft model of Ewing sarcoma and other human malignant bone disease using advanced in vivo imaging. PLoS One 7, e85128.
    • (2014) PLoS One , vol.7 , pp. e85128
    • Vormoor, B.1    Knizia, H.K.2    Batey, M.A.3    Almeida, G.S.4    Wilson, I.5    Dildey, P.6    Sharma, A.7    Blair, H.8    Hide, I.G.9    Heidenreich, O.10
  • 74
    • 75149180461 scopus 로고    scopus 로고
    • Inhibiting platelet-derived growth factor beta reduces Ewing's sarcoma growth and metastasis in a novel orthotopic human xenograft model
    • Wang YX, Mandal D, Wang S, Hughes D, Pollock RE, Lev D, Kleinerman E, Hayes-Jordan A (2009). Inhibiting platelet-derived growth factor beta reduces Ewing's sarcoma growth and metastasis in a novel orthotopic human xenograft model. In Vivo 23, 903-909.
    • (2009) Vivo , vol.23 , pp. 903-909
    • Wang, Y.X.1    Mandal, D.2    Wang, S.3    Hughes, D.4    Pollock, R.E.5    Lev, D.6    Kleinerman, E.7    Hayes-Jordan, A.8
  • 75
    • 84891542120 scopus 로고    scopus 로고
    • ZEB2 represses the epithelial phenotype and facilitates metastasis in Ewing sarcoma
    • Wiles ET, Bell R, Thomas D, Beckerle MC, Lessnick SL (2013). ZEB2 represses the epithelial phenotype and facilitates metastasis in Ewing sarcoma. Genes Cancer 4, 486-500.
    • (2013) Genes Cancer , vol.4 , pp. 486-500
    • Wiles, E.T.1    Bell, R.2    Thomas, D.3    Beckerle, M.C.4    Lessnick, S.L.5
  • 76
    • 27544435992 scopus 로고    scopus 로고
    • Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement
    • Yoshigi M, Hoffman LM, Jensen CC, Yost HJ, Beckerle MC (2005). Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. J Cell Biol 171, 209-215.
    • (2005) J Cell Biol , vol.171 , pp. 209-215
    • Yoshigi, M.1    Hoffman, L.M.2    Jensen, C.C.3    Yost, H.J.4    Beckerle, M.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.