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Volumn 70, Issue 10, 2010, Pages 4015-4023

Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's Sarcoma cells In vitro

Author keywords

[No Author keywords available]

Indexed keywords

RNA BINDING PROTEIN EWS; TRANSCRIPTION FACTOR FLI 1; TRANSCRIPTOME;

EID: 77952801325     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-4333     Document Type: Article
Times cited : (66)

References (48)
  • 1
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-732
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 2
    • 1342346637 scopus 로고    scopus 로고
    • O2-regulated gene expression: Transcriptional control of cardiorespiratory physiology by HIF-1
    • discussion 0-2
    • Semenza GL. O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. J Appl Physiol 2004;96: 1173-7; discussion 0-2.
    • (2004) J Appl Physiol , vol.96 , pp. 1173-1177
    • Semenza, G.L.1
  • 4
    • 34547107592 scopus 로고    scopus 로고
    • Hypoxia-driven selection of the metastatic phenotype
    • Sullivan R, Graham CH. Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev 2007;26:319-331
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 319-331
    • Sullivan, R.1    Graham, C.H.2
  • 5
    • 4944246547 scopus 로고    scopus 로고
    • The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
    • Greijer AE, van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 2004;57: 1009-1014
    • (2004) J Clin Pathol , vol.57 , pp. 1009-1014
    • Greijer, A.E.1    Van Der Wall, E.2
  • 8
    • 40949142209 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in tumorigenesis
    • Rankin EB, Giaccia AJ. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ 2008;15:678-685
    • (2008) Cell Death Differ , vol.15 , pp. 678-685
    • Rankin, E.B.1    Giaccia, A.J.2
  • 9
    • 0037458545 scopus 로고    scopus 로고
    • Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly
    • DOI 10.1074/jbc.M212534200
    • Denko N, Wernke-Dollries K, Johnson AB, Hammond E, Chiang CM, Barton MC. Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly. J Biol Chem 2003;278:5744-5749 (Pubitemid 36800819)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.8 , pp. 5744-5749
    • Denko, N.1    Wernke-Dollries, K.2    Johnson, A.B.3    Hammond, E.4    Chiang, C.-M.5    Barton, M.C.6
  • 11
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res 1999;59:5830-5835
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 13
    • 0034667433 scopus 로고    scopus 로고
    • Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer
    • Salnikow K, Costa M, Figg WD, Blagosklonny MV. Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer. Cancer Res 2000;60:5630-5634
    • (2000) Cancer Res , vol.60 , pp. 5630-5634
    • Salnikow, K.1    Costa, M.2    Figg, W.D.3    Blagosklonny, M.V.4
  • 15
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxiainducible factor-1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    • Aebersold DM, Burri P, Beer KT, et al. Expression of hypoxiainducible factor-1α: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001;61: 2911-2916
    • (2001) Cancer Res , vol.61 , pp. 2911-2916
    • Aebersold, D.M.1    Burri, P.2    Beer, K.T.3
  • 16
    • 0034282518 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
    • Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G. Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 2000;60:4693-4696
    • (2000) Cancer Res , vol.60 , pp. 4693-4696
    • Birner, P.1    Schindl, M.2    Obermair, A.3    Plank, C.4    Breitenecker, G.5    Oberhuber, G.6
  • 18
    • 0346013210 scopus 로고    scopus 로고
    • Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model
    • DOI 10.1016/S1044-579X(03)00041-5
    • Kovar H, Ban J, Pospisilova S. Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model. Semin Cancer Biol 2003;13:275-281 (Pubitemid 38160919)
    • (2003) Seminars in Cancer Biology , vol.13 , Issue.4 , pp. 275-281
    • Kovar, H.1    Ban, J.2    Pospisilova, S.3
  • 20
    • 66149131842 scopus 로고    scopus 로고
    • GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein
    • Beauchamp E, Bulut G, Abaan O, et al. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem 2009;284:9074-9082
    • (2009) J Biol Chem , vol.284 , pp. 9074-9082
    • Beauchamp, E.1    Bulut, G.2    Abaan, O.3
  • 21
    • 0036560740 scopus 로고    scopus 로고
    • The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts
    • Lessnick SL, Dacwag CS, Golub TR. The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell 2002;1:393-401.
    • (2002) Cancer Cell , vol.1 , pp. 393-401
    • Lessnick, S.L.1    Dacwag, C.S.2    Golub, T.R.3
  • 23
    • 0142121436 scopus 로고    scopus 로고
    • EWS/FLI function varies in different cellular backgrounds
    • DOI 10.1016/S0014-4827(03)00371-9
    • Zwerner JP, Guimbellot J, May WA. EWS/FLI function varies in different cellular backgrounds. Exp Cell Res 2003;290:414-419 (Pubitemid 37272183)
    • (2003) Experimental Cell Research , vol.290 , Issue.2 , pp. 414-419
    • Zwerner, J.P.1    Guimbellot, J.2    May, W.A.3
  • 24
    • 49949085240 scopus 로고    scopus 로고
    • IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells
    • Cironi L, Riggi N, Provero P, et al. IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells. PLoS One 2008;3:e2634.
    • (2008) PLoS One , vol.3
    • Cironi, L.1    Riggi, N.2    Provero, P.3
  • 25
    • 63349090507 scopus 로고    scopus 로고
    • The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function
    • Guillon N, Tirode F, Boeva V, Zynovyev A, Barillot E, Delattre O. The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function. PLoS One 2009;4:e4932.
    • (2009) PLoS One , vol.4
    • Guillon, N.1    Tirode, F.2    Boeva, V.3    Zynovyev, A.4    Barillot, E.5    Delattre, O.6
  • 26
    • 40549086265 scopus 로고    scopus 로고
    • A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature
    • Hancock JD, Lessnick SL. A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature. Cell Cycle 2008;7:250-256
    • (2008) Cell Cycle , vol.7 , pp. 250-256
    • Hancock, J.D.1    Lessnick, S.L.2
  • 27
    • 65549090018 scopus 로고    scopus 로고
    • A molecular function map of Ewing's sarcoma
    • Kauer M, Ban J, Kofler R, et al. A molecular function map of Ewing's sarcoma. PLoS One 2009;4:e5415.
    • (2009) PLoS One , vol.4
    • Kauer, M.1    Ban, J.2    Kofler, R.3
  • 28
    • 56649114486 scopus 로고    scopus 로고
    • Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors
    • Potikyan G, France KA, Carlson MR, Dong J, Nelson SF, Denny CT. Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors. Lab Invest 2008;88:1291-1302
    • (2008) Lab Invest , vol.88 , pp. 1291-1302
    • Potikyan, G.1    France, K.A.2    Carlson, M.R.3    Dong, J.4    Nelson, S.F.5    Denny, C.T.6
  • 29
    • 8544237013 scopus 로고    scopus 로고
    • DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets
    • DOI 10.1158/0008-5472.CAN-03-4059
    • Staege MS, Hutter C, Neumann I, et al. DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets. Cancer Res 2004;64:8213-8221 (Pubitemid 39491758)
    • (2004) Cancer Research , vol.64 , Issue.22 , pp. 8213-8221
    • Staege, M.S.1    Hutter, C.2    Neumann, I.3    Foja, S.4    Hattenhorst, U.E.5    Hansen, G.6    Afar, D.7    Burdach, S.E.G.8
  • 30
    • 0037050258 scopus 로고    scopus 로고
    • Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in Ewing tumors
    • DOI 10.1038/sj.onc.1205053
    • Lawlor ER, Scheel C, Irving J, Sorensen PH. Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in Ewing tumors. Oncogene 2002;21:307-318 (Pubitemid 34102139)
    • (2002) Oncogene , vol.21 , Issue.2 , pp. 307-318
    • Lawlor, E.R.1    Scheel, C.2    Irving, J.3    Sorensen, P.H.B.4
  • 31
    • 52749091889 scopus 로고    scopus 로고
    • Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration
    • Bosco MC, Puppo M, Blengio F, et al. Monocytes and dendritic cells in a hypoxic environment: spotlights on chemotaxis and migration. Immunobiology 2008;213:733-749
    • (2008) Immunobiology , vol.213 , pp. 733-749
    • Bosco, M.C.1    Puppo, M.2    Blengio, F.3
  • 32
    • 17044415589 scopus 로고    scopus 로고
    • Context matters: The hen or egg problem in Ewing's sarcoma
    • DOI 10.1016/j.semcancer.2005.01.004, Fusion Oncogenes - Transformation Mechanisms and Tumor Type Specificity
    • Kovar H. Context matters: the hen or egg problem in Ewing's sarcoma. Semin Cancer Biol 2005;15:189-196 (Pubitemid 40501733)
    • (2005) Seminars in Cancer Biology , vol.15 , Issue.3 , pp. 189-196
    • Kovar, H.1
  • 34
    • 33750536483 scopus 로고    scopus 로고
    • Single-chain antibodies to the EWS NH(2) terminus structurally discriminate between intact and chimeric EWS in Ewing's sarcoma and interfere with the transcriptional activity of EWS in vivo
    • Aryee DN, Kreppel M, Bachmaier R, et al. Single-chain antibodies to the EWS NH(2) terminus structurally discriminate between intact and chimeric EWS in Ewing's sarcoma and interfere with the transcriptional activity of EWS in vivo. Cancer Res 2006;66:9862-9869
    • (2006) Cancer Res , vol.66 , pp. 9862-9869
    • Aryee, D.N.1    Kreppel, M.2    Bachmaier, R.3
  • 35
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • Gentleman RC, Carey VJ, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004;5:R80.
    • (2004) Genome Biol , vol.5
    • Gentleman, R.C.1    Carey, V.J.2    Bates, D.M.3
  • 37
    • 25444502609 scopus 로고    scopus 로고
    • PAGE: Parametric analysis of gene set enrichment
    • Kim SY, Volsky DJ. PAGE: parametric analysis of gene set enrichment. BMC Bioinformatics 2005;6:144.
    • (2005) BMC Bioinformatics , vol.6 , pp. 144
    • Kim, S.Y.1    Volsky, D.J.2
  • 38
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately down-regulated in human diabetes
    • Mootha VK, Lindgren CM, Eriksson KF, et al. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately down-regulated in human diabetes. Nat Genet 2003;34:267-273
    • (2003) Nat Genet , vol.34 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3
  • 40
    • 37149023224 scopus 로고    scopus 로고
    • Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism
    • DOI 10.1593/neo.07568
    • Ackerstaff E, Artemov D, Gillies RJ, Bhujwalla ZM. Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism. Neoplasia 2007;9:1138-1151 (Pubitemid 350255361)
    • (2007) Neoplasia , vol.9 , Issue.12 , pp. 1138-1151
    • Ackerstaff, E.1    Artemov, D.2    Gillies, R.J.3    Bhujwalla, Z.M.4
  • 41
    • 33744502102 scopus 로고    scopus 로고
    • Ewing's sarcoma oncoprotein EWS-FLI1: The perfect target without a therapeutic agent
    • Uren A, Toretsky JA. Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent. Future Oncol 2005;1: 521-528
    • (2005) Future Oncol , vol.1 , pp. 521-528
    • Uren, A.1    Toretsky, J.A.2
  • 42
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-a key regulatory factor in tumour growth
    • Harris AL. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 43
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: Pathophysiology and therapeutics
    • Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 2002;8:S62-7.
    • (2002) Trends Mol Med , vol.8
    • Semenza, G.L.1
  • 44
    • 53149153157 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1α inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death
    • Favaro E, Nardo G, Persano L, et al. Hypoxia inducible factor-1α inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death. Am J Pathol 2008;173:1186-1201
    • (2008) Am J Pathol , vol.173 , pp. 1186-1201
    • Favaro, E.1    Nardo, G.2    Persano, L.3
  • 47
    • 34047105144 scopus 로고    scopus 로고
    • Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance
    • DOI 10.1038/sj.onc.1210008, PII 1210008
    • Kilic M, Kasperczyk H, Fulda S, Debatin KM. Role of hypoxia inducible factor-1 α in modulation of apoptosis resistance. Oncogene 2007;26:2027-2038 (Pubitemid 46514744)
    • (2007) Oncogene , vol.26 , Issue.14 , pp. 2027-2038
    • Kilic, M.1    Kasperczyk, H.2    Fulda, S.3    Debatin, K.-M.4
  • 48
    • 49649108032 scopus 로고    scopus 로고
    • Regulation of gene expression by hypoxia
    • Kenneth NS, Rocha S. Regulation of gene expression by hypoxia. Biochem J 2008;414:19-29.
    • (2008) Biochem J , vol.414 , pp. 19-29
    • Kenneth, N.S.1    Rocha, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.