메뉴 건너뛰기




Volumn 9, Issue 5, 2006, Pages 405-416

Expression Profiling of EWS/FLI Identifies NKX2.2 as a Critical Target Gene in Ewing's Sarcoma (DOI:10.1016/j.ccr.2006.04.004);Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN;

EID: 33646366123     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2006.12.009     Document Type: Erratum
Times cited : (296)

References (48)
  • 1
    • 0026032050 scopus 로고
    • MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration
    • Ambros I.M., Ambros P.F., Strehl S., Kovar H., Gadner H., and Salzer-Kuntschik M. MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 67 (1991) 1886-1893
    • (1991) Cancer , vol.67 , pp. 1886-1893
    • Ambros, I.M.1    Ambros, P.F.2    Strehl, S.3    Kovar, H.4    Gadner, H.5    Salzer-Kuntschik, M.6
  • 2
    • 0032558788 scopus 로고    scopus 로고
    • EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction
    • Arvand A., Bastians H., Welford S.M., Thompson A.D., Ruderman J.V., and Denny C.T. EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction. Oncogene 17 (1998) 2039-2045
    • (1998) Oncogene , vol.17 , pp. 2039-2045
    • Arvand, A.1    Bastians, H.2    Welford, S.M.3    Thompson, A.D.4    Ruderman, J.V.5    Denny, C.T.6
  • 3
    • 0035393826 scopus 로고    scopus 로고
    • The COOH-terminal domain of FLI-1 is necessary for full tumorigenesis and transcriptional modulation by EWS/FLI-1
    • Arvand A., Welford S.M., Teitell M.A., and Denny C.T. The COOH-terminal domain of FLI-1 is necessary for full tumorigenesis and transcriptional modulation by EWS/FLI-1. Cancer Res. 61 (2001) 5311-5317
    • (2001) Cancer Res. , vol.61 , pp. 5311-5317
    • Arvand, A.1    Welford, S.M.2    Teitell, M.A.3    Denny, C.T.4
  • 4
    • 0028209984 scopus 로고
    • DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma
    • Bailly R.A., Bosselut R., Zucman J., Cormier F., Delattre O., Roussel M., Thomas G., and Ghysdael J. DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol. Cell. Biol. 14 (1994) 3230-3241
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3230-3241
    • Bailly, R.A.1    Bosselut, R.2    Zucman, J.3    Cormier, F.4    Delattre, O.5    Roussel, M.6    Thomas, G.7    Ghysdael, J.8
  • 6
    • 0029004567 scopus 로고
    • Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis
    • Braun B.S., Frieden R., Lessnick S.L., May W.A., and Denny C.T. Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis. Mol. Cell. Biol. 15 (1995) 4623-4630
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4623-4630
    • Braun, B.S.1    Frieden, R.2    Lessnick, S.L.3    May, W.A.4    Denny, C.T.5
  • 8
    • 0023215290 scopus 로고
    • Experimental evidence for a neural origin of Ewing's sarcoma of bone
    • Cavenzzana A.O., Miser J.S., Jefferson J., and Triche T.J. Experimental evidence for a neural origin of Ewing's sarcoma of bone. Am. J. Pathol. 127 (1987) 507-518
    • (1987) Am. J. Pathol. , vol.127 , pp. 507-518
    • Cavenzzana, A.O.1    Miser, J.S.2    Jefferson, J.3    Triche, T.J.4
  • 11
    • 0034968428 scopus 로고    scopus 로고
    • Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression
    • Dauphinot L., De Oliveira C., Melot T., Sevenet N., Thomas V., Weissman B.E., and Delattre O. Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression. Oncogene 20 (2001) 3258-3265
    • (2001) Oncogene , vol.20 , pp. 3258-3265
    • Dauphinot, L.1    De Oliveira, C.2    Melot, T.3    Sevenet, N.4    Thomas, V.5    Weissman, B.E.6    Delattre, O.7
  • 13
    • 0035845859 scopus 로고    scopus 로고
    • Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation
    • Deneen B., and Denny C.T. Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation. Oncogene 20 (2001) 6731-6741
    • (2001) Oncogene , vol.20 , pp. 6731-6741
    • Deneen, B.1    Denny, C.T.2
  • 14
    • 0041672262 scopus 로고    scopus 로고
    • Functional analysis of the EWS/ETS target gene uridine phosphorylase
    • Deneen B., Hamidi H., and Denny C.T. Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res. 63 (2003) 4268-4274
    • (2003) Cancer Res. , vol.63 , pp. 4268-4274
    • Deneen, B.1    Hamidi, H.2    Denny, C.T.3
  • 16
    • 0037427070 scopus 로고    scopus 로고
    • Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma
    • Fukuma M., Okita H., Hata J., and Umezawa A. Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma. Oncogene 22 (2003) 1-9
    • (2003) Oncogene , vol.22 , pp. 1-9
    • Fukuma, M.1    Okita, H.2    Hata, J.3    Umezawa, A.4
  • 17
    • 0032848660 scopus 로고    scopus 로고
    • Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein
    • Hahm K.B., Cho K., Lee C., Im Y.H., Chang J., Choi S.G., Sorensen P.H., Thiele C.J., and Kim S.J. Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein. Nat. Genet. 23 (1999) 222-227
    • (1999) Nat. Genet. , vol.23 , pp. 222-227
    • Hahm, K.B.1    Cho, K.2    Lee, C.3    Im, Y.H.4    Chang, J.5    Choi, S.G.6    Sorensen, P.H.7    Thiele, C.J.8    Kim, S.J.9
  • 18
    • 25444482607 scopus 로고    scopus 로고
    • Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
    • Hu-Lieskovan S., Heidel J.D., Bartlett D.W., Davis M.E., and Triche T.J. Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res. 65 (2005) 8984-8992
    • (2005) Cancer Res. , vol.65 , pp. 8984-8992
    • Hu-Lieskovan, S.1    Heidel, J.D.2    Bartlett, D.W.3    Davis, M.E.4    Triche, T.J.5
  • 19
    • 19644386697 scopus 로고    scopus 로고
    • EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors
    • Hu-Lieskovan S., Zhang J., Wu L., Shimada H., Schofield D.E., and Triche T.J. EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res. 65 (2005) 4633-4644
    • (2005) Cancer Res. , vol.65 , pp. 4633-4644
    • Hu-Lieskovan, S.1    Zhang, J.2    Wu, L.3    Shimada, H.4    Schofield, D.E.5    Triche, T.J.6
  • 20
    • 11344255740 scopus 로고    scopus 로고
    • Defining and assaying RNAi in mammalian cells
    • Huppi K., Martin S.E., and Caplen N.J. Defining and assaying RNAi in mammalian cells. Mol. Cell 17 (2005) 1-10
    • (2005) Mol. Cell , vol.17 , pp. 1-10
    • Huppi, K.1    Martin, S.E.2    Caplen, N.J.3
  • 23
    • 0033619101 scopus 로고    scopus 로고
    • Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity
    • Jaishankar S., Zhang J., Roussel M.F., and Baker S.J. Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity. Oncogene 18 (1999) 5592-5597
    • (1999) Oncogene , vol.18 , pp. 5592-5597
    • Jaishankar, S.1    Zhang, J.2    Roussel, M.F.3    Baker, S.J.4
  • 26
    • 0028821578 scopus 로고
    • Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI- 1 fusion gene
    • Lessnick S.L., Braun B.S., Denny C.T., and May W.A. Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI- 1 fusion gene. Oncogene 10 (1995) 423-431
    • (1995) Oncogene , vol.10 , pp. 423-431
    • Lessnick, S.L.1    Braun, B.S.2    Denny, C.T.3    May, W.A.4
  • 27
    • 0036560740 scopus 로고    scopus 로고
    • The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts
    • Lessnick S.L., Dacwag C.S., and Golub T.R. The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell 1 (2002) 393-401
    • (2002) Cancer Cell , vol.1 , pp. 393-401
    • Lessnick, S.L.1    Dacwag, C.S.2    Golub, T.R.3
  • 29
    • 0031596443 scopus 로고    scopus 로고
    • Mullerian inhibiting substance, α-inhibin, and CD99 expression in sex cord-stromal tumors and endometrioid ovarian carcinomas resembling sex cord-stromal tumors
    • Matias-Guiu X., Pons C., and Prat J. Mullerian inhibiting substance, α-inhibin, and CD99 expression in sex cord-stromal tumors and endometrioid ovarian carcinomas resembling sex cord-stromal tumors. Hum. Pathol. 29 (1998) 840-845
    • (1998) Hum. Pathol. , vol.29 , pp. 840-845
    • Matias-Guiu, X.1    Pons, C.2    Prat, J.3
  • 32
    • 0027362619 scopus 로고
    • The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
    • May W.A., Lessnick S.L., Braun B.S., Klemsz M., Lewis B.C., Lunsford L.B., Hromas R., and Denny C.T. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol. Cell. Biol. 13 (1993) 7393-7398
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7393-7398
    • May, W.A.1    Lessnick, S.L.2    Braun, B.S.3    Klemsz, M.4    Lewis, B.C.5    Lunsford, L.B.6    Hromas, R.7    Denny, C.T.8
  • 33
    • 0034665873 scopus 로고    scopus 로고
    • Neural patterning: the role of Nkx genes in the ventral spinal cord
    • McMahon A.P. Neural patterning: the role of Nkx genes in the ventral spinal cord. Genes Dev. 14 (2000) 2261-2264
    • (2000) Genes Dev. , vol.14 , pp. 2261-2264
    • McMahon, A.P.1
  • 35
    • 0030713279 scopus 로고    scopus 로고
    • Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis
    • Mu J., Skurat A.V., and Roach P.J. Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis. J. Biol. Chem. 272 (1997) 27589-27597
    • (1997) J. Biol. Chem. , vol.272 , pp. 27589-27597
    • Mu, J.1    Skurat, A.V.2    Roach, P.J.3
  • 36
    • 0021212914 scopus 로고
    • On the histogenesis of Ewing's sarcoma. An ultrastructural, immunohistochemical, and cytochemical study
    • Navas-Palacios J.J., Aparicio-Duque R., and Valdes M.D. On the histogenesis of Ewing's sarcoma. An ultrastructural, immunohistochemical, and cytochemical study. Cancer 53 (1984) 1882-1901
    • (1984) Cancer , vol.53 , pp. 1882-1901
    • Navas-Palacios, J.J.1    Aparicio-Duque, R.2    Valdes, M.D.3
  • 38
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • Prieur A., Tirode F., Cohen P., and Delattre O. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol. Cell. Biol. 24 (2004) 7275-7283
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3    Delattre, O.4
  • 39
    • 0034914553 scopus 로고    scopus 로고
    • Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor
    • Qi Y., Cai J., Wu Y., Wu R., Lee J., Fu H., Rao M., Sussel L., Rubenstein J., and Qiu M. Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development 128 (2001) 2723-2733
    • (2001) Development , vol.128 , pp. 2723-2733
    • Qi, Y.1    Cai, J.2    Wu, Y.3    Wu, R.4    Lee, J.5    Fu, H.6    Rao, M.7    Sussel, L.8    Rubenstein, J.9    Qiu, M.10
  • 41
    • 0036167093 scopus 로고    scopus 로고
    • CD99 plays a major role in the migration of monocytes through endothelial junctions
    • Schenkel A.R., Mamdouh Z., Chen X., Liebman R.M., and Muller W.A. CD99 plays a major role in the migration of monocytes through endothelial junctions. Nat. Immunol. 3 (2002) 143-150
    • (2002) Nat. Immunol. , vol.3 , pp. 143-150
    • Schenkel, A.R.1    Mamdouh, Z.2    Chen, X.3    Liebman, R.M.4    Muller, W.A.5
  • 42
    • 8544237013 scopus 로고    scopus 로고
    • DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets
    • Staege M.S., Hutter C., Neumann I., Foja S., Hattenhorst U.E., Hansen G., Afar D., and Burdach S.E. DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets. Cancer Res. 64 (2004) 8213-8221
    • (2004) Cancer Res. , vol.64 , pp. 8213-8221
    • Staege, M.S.1    Hutter, C.2    Neumann, I.3    Foja, S.4    Hattenhorst, U.E.5    Hansen, G.6    Afar, D.7    Burdach, S.E.8
  • 43
    • 0033398391 scopus 로고    scopus 로고
    • EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblasts
    • Teitell M.A., Thompson A.D., Sorensen P.H., Shimada H., Triche T.J., and Denny C.T. EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblasts. Lab. Invest. 79 (1999) 1535-1543
    • (1999) Lab. Invest. , vol.79 , pp. 1535-1543
    • Teitell, M.A.1    Thompson, A.D.2    Sorensen, P.H.3    Shimada, H.4    Triche, T.J.5    Denny, C.T.6
  • 44
    • 0030446259 scopus 로고    scopus 로고
    • EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene
    • Thompson A.D., Braun B.S., Arvand A., Stewart S.D., May W.A., Chen E., Korenberg J., and Denny C. EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. Oncogene 13 (1996) 2649-2658
    • (1996) Oncogene , vol.13 , pp. 2649-2658
    • Thompson, A.D.1    Braun, B.S.2    Arvand, A.3    Stewart, S.D.4    May, W.A.5    Chen, E.6    Korenberg, J.7    Denny, C.8
  • 45
    • 0033619191 scopus 로고    scopus 로고
    • Divergent Ewing's sarcoma EWS/ETS fusions confer a common tumorigenic phenotype on NIH3T3 cells
    • Thompson A.D., Teitell M.A., Arvand A., and Denny C.T. Divergent Ewing's sarcoma EWS/ETS fusions confer a common tumorigenic phenotype on NIH3T3 cells. Oncogene 18 (1999) 5506-5513
    • (1999) Oncogene , vol.18 , pp. 5506-5513
    • Thompson, A.D.1    Teitell, M.A.2    Arvand, A.3    Denny, C.T.4
  • 46
    • 0035834675 scopus 로고    scopus 로고
    • DNA binding domain independent pathways are involved in EWS/FLI1 mediated oncogenesis
    • Welford S.M., Hebert S.P., Deneen B., Arvand A., and Denny C.T. DNA binding domain independent pathways are involved in EWS/FLI1 mediated oncogenesis. J. Biol. Chem. 276 (2001) 41977-41984
    • (2001) J. Biol. Chem. , vol.276 , pp. 41977-41984
    • Welford, S.M.1    Hebert, S.P.2    Deneen, B.3    Arvand, A.4    Denny, C.T.5
  • 47
    • 4344703317 scopus 로고    scopus 로고
    • Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
    • Zhang H., Herbert B.S., Pan K.H., Shay J.W., and Cohen S.N. Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions. Oncogene 23 (2004) 6193-6198
    • (2004) Oncogene , vol.23 , pp. 6193-6198
    • Zhang, H.1    Herbert, B.S.2    Pan, K.H.3    Shay, J.W.4    Cohen, S.N.5
  • 48
    • 0035242001 scopus 로고    scopus 로고
    • PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors
    • Zwerner J.P., and May W.A. PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors. Oncogene 20 (2001) 626-633
    • (2001) Oncogene , vol.20 , pp. 626-633
    • Zwerner, J.P.1    May, W.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.