The clone wars - revenge of the metastatic rogue state: The sarcoma paradigm

Frontiers in Oncology

Volumn 2, Issue JAN, 2012, Pages

  Spraker, Holly L ^a,b   Price, Shawn L ^b,c   Chaturvedi, Aashi ^b,c   Schiffman, Joshua D ^a,b,c   Jones, Kevin B ^b,c   Lessnick, Stephen L ^a,b,c   Beckerle, Mary ^b,c   Randall, R Lor ^b,c  

^a PRIMARY CHILDREN'S MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Ewing sarcoma; Metastatic

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; FIBROBLAST GROWTH FACTOR; IFOSFAMIDE; IRINOTECAN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; SMALL INTERFERING RNA; STEM CELL FACTOR; TOPOTECAN; TRANSFORMING GROWTH FACTOR BETA; VINCRISTINE;

CELL PROLIFERATION; CELL SURVIVAL; COPY NUMBER VARIATION; DIAGNOSTIC IMAGING; DISEASE CLASSIFICATION; DNA DAMAGE; DRUG MEGADOSE; EWING SARCOMA; FLOW CYTOMETRY; GENETIC ASSOCIATION; HUMAN; METASTASIS; NOTE; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SURVIVAL TIME; TUMOR CELL; TUMOR MICROENVIRONMENT; TUMOR VOLUME;

EID: 84870965277     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2012.00002     Document Type: Note

References (42)

1. Armengol, G., Tarkkanen, M., Virolainen, M., Forus, A., Valle, J., Bohling, T., Asko-Seljavaara, S., Blomqvist, C., Elomaa, I., Karaharju, E., Kivioja, A. H., Siimes, M. A., Tukiainen, E., Caballín, M. R., Myklebost, O., and Knuutila, S. (1997). Recurrent gains of 1q, 8 and 12 in the Ewing family of tumours by comparative genomic hybridization. Br. J. Cancer 75, 1403-1409.
2. Arndt, C. A., and Crist, W. M. (1999). Common musculoskeletal tumors of childhood and adolescence. N. Engl. J. Med. 341, 342-352.
3. Attiyeh, E. F., London, W. B., Mosse, Y. P., Wang, Q., Winter, C., Khazi, D., McGrady, P. W., Seeger, R. C., Look, A. T., Shimada, H., Brodeur, G. M., Cohn, S. L., Matthay, K. K., Maris, J. M., and Children's Oncology Group. (2005). Chromosome 1p and 11q deletions and outcome in neuroblastoma. N. Engl. J. Med. 353, 2243-2253.
4. Avigad, S., Cohen, I. J., Zilberstein, J., Liberzon, E., Goshen, Y., Ash, S., Meller, I., Kollender, Y., Issakov, J., Zaizov, R., and Yaniv, I. (2004). The predictive potential of molecular detection in the nonmetastatic Ewing family of tumors. Cancer 100, 1053-1058.
5. Bernstein, M., Kovar, H., Paulussen, M., Randall, R. L., Schuck, A., Teot, L. A., and Juergens, H. (2006). Ewing's sarcoma family of tumors: current management. Oncologist 11, 503-519.
6. Brisset, S., Schleiermacher, G., Peter, M., Mairal, A., Oberlin, O., Delattre, O., and Aurias, A. (2001). CGH analysis of secondary genetic changes in Ewing tumors: correlation with metastatic disease in a series of 43 cases. Cancer Genet. Cytogenet. 130, 57-61.
7. Bussard, K. M., Gay, C. V., and Mastro, A. M. (2008). The bone microenvironment in metastasis; what is special about bone? Cancer Metastasis Rev. 27, 41-55.
8. Castillero-Trejo, Y., Eliazer, S., Xiang, L., Richardson, J. A., and Ilaria, R. L. Jr. (2005). Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells results in EWS/FLI-1-dependent, Ewing sarcoma-like tumors. Cancer Res. 65, 8698-8705.
9. Cotterill, S. J., Ahrens, S., Paulussen, M., Jurgens, H. F., Voute, P. A., Gadner, H., and Craft, A. W. (2000). Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J. Clin. Oncol. 18, 3108-3114.
10. Delattre, O., Zucman, J., Plougastel, B., Desmaze, C., Melot, T., Peter, M., Kovar, H., Joubert, I., de Jong, P., Rouleau, G., Aurias, A., and Thomas, G. (1992). Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 359, 162-165.
11. Granowetter, L., Womer, R., Devidas, M., Krailo, M., Wang, C., Bernstein, M., Marina, N., Leavey, P., Gebhardt, M., Healey, J., Shamberger, R. C., Goorin, A., Miser, J., Meyer, J., Arndt, C. A., Sailer, S., Marcus, K., Perlman, E., Dickman, P., and Grier, H. E. (2009). Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children's Oncology Group Study. J. Clin. Oncol. 27, 2536-2541.
12. Grier, H. E., Krailo, M. D., Tarbell, N. J., Link, M. P., Fryer, C. J., Pritchard, D. J., Gebhardt, M. C., Dickman, P. S., Perlman, E. J., Meyers, P. A., Donaldson, S. S., Moore, S., Rausen, A. R., Vietti, T. J., and Miser, J. S. (2003). Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N. Engl. J. Med. 348, 694-701.
13. Guan, H., Zhou, Z., Gallick, G. E., Jia, S. F., Morales, J., Sood, A. K., Corey, S. J., and Kleinerman, E. S. (2008). Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma. Mol. Cancer Ther. 7, 1807-1816.
14. Huang, M., and Lucas, K. (2011). Current therapeutic approaches in metastatic and recurrent Ewing sarcoma. Sarcoma. doi: 10.1155/2011/863210
15. Jahromi, M. S., Jones, K. B., and Schiffman, J. D. (2011). Copy number alterations and methylation in Ewing's sarcoma. Sarcoma 2011, 362173.
16. Kamura, S., Matsumoto, Y., Fukushi, J. I., Fujiwara, T., Iida, K., Okada, Y., and Iwamoto, Y. (2010). Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway. Br. J. Cancer 103, 370-381.
17. Kerbel, R. S. (1995). Significance of tumor-host interactions in cancer growth and metastases. Cancer Metastasis Rev. 14, 259-262.
18. Khanna, C., Wan, X., Bose, S., Cassaday, R., Olomu, O., Mendoza, A., Yeung, C., Gorlick, R., Hewitt, S. M., and Helman, L. J. (2004). The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat. Med. 10, 182-186.
19. Krishnan, K., Bruce, B., Hewitt, S., Thomas, D., Khanna, C., and Helman, L. J. (2006). Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway. Clin. Exp. Metastasis 23, 227-236.
20. Landuzzi, L., De Giovanni, C., Nicoletti, G., Rossi, I., Ricci, C., Astolfi, A., Scopece, L., Scotlandi, K., Serra, M., Bagnara, G. P., Nanni, P., and Lollini, P. L. (2000). The metastatic ability of Ewing's sarcoma cells is modulated by stem cell factor and by its receptor c-kit. Am. J. Pathol. 157, 2123-2131.
21. Larramendy, M. L., Tarkkanen, M., Blomqvist, C., Virolainen, M., Wiklund, T., Asko-Seljavaara, S., Elomaa, I., and Knuutila, S. (1997a). Comparative genomic hybridization of malignant fibrous histiocytoma reveals a novel prognostic marker. Am. J. Pathol. 151, 1153-1161.
22. Larramendy, M. L., Tarkkanen, M., Valle, J., Kivioja, A. H., Ervasti, H., Karaharju, E., Salmivalli, T., Elomaa, I., and Knuutila, S. (1997b). Gains, losses, and amplifications of DNA sequences evaluated by comparative genomic hybridization in chondrosarcomas. Am. J. Pathol. 150, 685-691.
23. Leavey, P. J., Mascarenhas, L., Marina, N., Chen, Z., Krailo, M., Miser, J., Brown, K., Tarbell, N., Bernstein, M. L., Granowetter, L., Gebhardt, M., Grier, H. E., and Children's Oncology Group. (2008). Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence following multi-modality therapy: a report from the Children's Oncology Group. Pediatr. Blood Cancer 51, 334-338.
24. Lee, J., Hoang, B. H., Ziogas, A., and Zell, J. A. (2010). Analysis of prognostic factors in Ewing sarcoma using a population-based cancer registry. Cancer 116, 1964-1973.
25. Lessnick, S. L., Dacwag, C. S., and Golub, T. R. (2002). The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell 1, 393-401.
26. May, W. A., Lessnick, S. L., Braun, B. S., Klemsz, M., Lewis, B. C., Lunsford, L. B., Hromas, R., and Denny, C. T. (1993). The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol. Cell. Biol. 13, 7393-7398.
27. Mundy, G. R. (2002). Metastasis to bone: causes, consequences and therapeutic opportunities. Nat. Rev. Cancer 2, 584-593.
28. Ozaki, T., Paulussen, M., Poremba, C., Brinkschmidt, C., Rerin, J., Ahrens, S., Hoffmann, C., Hillmann, A., Wai, D., Schaefer, K. L., Boecker, W., Juergens, H., Winkelmann, W., and Dockhorn-Dworniczak, B. (2001). Genetic imbalances revealed by comparative genomic hybridization in Ewing tumors. Genes Chromosomes Cancer 32, 164-171.
29. Paulussen, M., Ahrens, S., Burdach, S., Craft, A., Dockhorn-Dworniczak, B., Dunst, J., Frohlich, B., Winkelmann, W., Zoubek, A., and Jurgens, H. (1998). Primary metastatic (stage IV) Ewing tumor: survival analysis of 171 patients from the EICESS studies. European Intergroup Cooperative Ewing Sarcoma Studies. Ann. Oncol. 9, 275-281.
30. Riggi, N., and Stamenkovic, I. (2007). The biology of Ewing sarcoma. Cancer Lett. 254, 1-10.
31. Rodriguez-Galindo, C., Navid, F., Liu, T., Billups, C. A., Rao, B. N., and Krasin, M. J. (2008). Prognostic factors for local and distant control in Ewing sarcoma family of tumors. Ann. Oncol. 19, 814-820.
32. Savola, S., Klami, A., Tripathi, A., Niini, T., Serra, M., Picci, P., Kaski, S., Zambelli, D., Scotlandi, K., and Knuutila, S. (2009). Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors. BMC Cancer 9, 17. doi: 10.1186/1471-2407-9-17
33. Smith, R., Owen, L. A., Trem, D. J., Wong, J. S., Whangbo, J. S., Golub, T. R., and Lessnick, S. L. (2006). Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell 9, 405-416.
34. Stahl, M., Ranft, A., Paulussen, M., Bolling, T., Vieth, V., Bielack, S., Gortitz, I., Braun-Munzinger, G., Hardes, J., Jurgens, H., and Dirksen, U. (2011). Risk of recurrence and survival after relapse in patients with Ewing sarcoma. Pediatr. Blood Cancer 57, 549-553.
35. Tarkkanen, M., Karhu, R., Kallioniemi, A., Elomaa, I., Kivioja, A. H., Nevalainen, J., Bohling, T., Karaharju, E., Hyytinen, E., Knuutila, S., and Kallioniemi, O.-P. (1995). Gains and losses of DNA sequences in osteosarcomas by comparative genomic hybridization. Cancer Res. 55, 1334-1338.
36. Tarkkanen, M., Kiuru-Kuhlefelt, S., Blomqvist, C., Armengol, G., Bohling, T., Ekfors, T., Virolainen, M., Lindholm, P., Monge, O., Picci, P., Knuutila, S., and Elomaa, I. (1999). Clinical correlations of genetic changes by comparative genomic hybridization in Ewing sarcoma and related tumors. Cancer Genet. Cytogenet. 114, 35-41.
37. Toomey, E. C., Schiffman, J. D., and Lessnick, S. L. (2010). Recent advances in the molecular pathogenesis of Ewing's sarcoma. Oncogene 29, 4504-4516.
38. Turc-Carel, C., Aurias, A., Mugneret, F., Lizard, S., Sidaner, I., Volk, C., Thiery, J. P., Olschwang, S., Philip, I., Berger, M. P., Philip, T., Lenoir, G. M., and Mazabraud, A. (1988). Chromosomes in Ewing's sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12). Cancer Genet. Cytogenet. 32, 229-238.
39. Wagner, L. (2011). Camptothecin-based regimens for treatment of Ewing sarcoma: past studies, and future directions. Sarcoma 2011, 957957.
40. West, D. C., Grier, H. E., Swallow, M. M., Demetri, G. D., Granowetter, L., and Sklar, J. (1997). Detection of circulating tumor cells in patients with Ewing's sarcoma and peripheral primitive neuroectodermal tumor. J. Clin. Oncol. 15, 583-588.
41. Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., Velculescu, V. E., Kinzler, K. W., Vogelstein, B., and Iacobuzio-Donahue, C. A. (2010). Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467, 1114-1117.
42. Yu, Y., Khan, J., Khanna, C., Helman, L., 'Meltzer, P. S., and Merlino, G. (2004). Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators. Nat. Med. 10, 175-181.