-
1
-
-
0026686674
-
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
-
Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 1992; 359: 162-165.
-
(1992)
Nature
, vol.359
, pp. 162-165
-
-
Delattre, O.1
Zucman, J.2
Plougastel, B.3
Desmaze, C.4
Melot, T.5
Peter, M.6
-
2
-
-
0027362619
-
The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI- 1
-
May WA, Lessnick SL, Braun BS, Klemsz M, Lewis BC, Lunsford LB et al. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol 1993; 13: 7393-7398. (Pubitemid 23354263)
-
(1993)
Molecular and Cellular Biology
, vol.13
, Issue.12
, pp. 7393-7398
-
-
May, W.A.1
Lessnick, S.L.2
Braun, B.S.3
Klemsz, M.4
Lewis, B.C.5
Lunsford, L.B.6
Hromas, R.7
Denny, C.T.8
-
3
-
-
27544515095
-
ETS transcription factors and their emerging roles in human cancer
-
DOI 10.1016/j.ejca.2005.08.013, PII S0959804905007148, Transcription Factors in Cancer
-
Seth A, Watson DK. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer 2005; 41: 2462-2478. (Pubitemid 41540623)
-
(2005)
European Journal of Cancer
, vol.41
, Issue.16
, pp. 2462-2478
-
-
Seth, A.1
Watson, D.K.2
-
4
-
-
0032490843
-
Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II
-
Petermann R, Mossier BM, Aryee DN, Khazak V, Golemis EA, Kovar H. Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II. Oncogene 1998; 17: 603-610. (Pubitemid 28401029)
-
(1998)
Oncogene
, vol.17
, Issue.5
, pp. 603-610
-
-
Petermann, R.1
Mossier, B.M.2
Aryee, D.N.T.3
Khazak, V.4
Golemis, E.A.5
Kovar, H.6
-
5
-
-
4844224145
-
Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1
-
DOI 10.1038/sj.onc.1207927
-
Ramakrishnan R, Fujimura Y, Zou JP, Liu F, Lee L, Rao VN et al. Role of proteinprotein interactions in the antiapoptotic function of EWS-Fli-1. Oncogene 2004; 23: 7087-7094. (Pubitemid 39319170)
-
(2004)
Oncogene
, vol.23
, Issue.42
, pp. 7087-7094
-
-
Ramakrishnan, R.1
Fujimura, Y.2
Zou, J.P.3
Liu, F.4
Lee, L.5
Rao, V.N.6
Reddy, E.S.P.7
-
6
-
-
0028821578
-
Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene
-
Lessnick SL, Braun BS, Denny CT, May WA. Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene. Oncogene 1995; 10: 423-431.
-
(1995)
Oncogene
, vol.10
, pp. 423-431
-
-
Lessnick, S.L.1
Braun, B.S.2
Denny, C.T.3
May, W.A.4
-
7
-
-
33646366123
-
Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma
-
DOI 10.1016/j.ccr.2006.04.004, PII S1535610806001140
-
Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR et al. Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell 2006; 9: 405-416. (Pubitemid 43668735)
-
(2006)
Cancer Cell
, vol.9
, Issue.5
, pp. 405-416
-
-
Smith, R.1
Owen, L.A.2
Trem, D.J.3
Wong, J.S.4
Whangbo, J.S.5
Golub, T.R.6
Lessnick, S.L.7
-
8
-
-
3543026281
-
EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
-
DOI 10.1128/MCB.24.16.7275-7283.2004
-
Prieur A, Tirode F, Cohen P, Delattre O. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol 2004; 24: 7275-7283. (Pubitemid 39014452)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.16
, pp. 7275-7283
-
-
Prieur, A.1
Tirode, F.2
Cohen, P.3
Delattre, O.4
-
9
-
-
44849085869
-
EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma
-
Owen LA, Kowalewski AA, Lessnick SL. EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma. PLoS ONE 2008; 3: e1965.
-
(2008)
PLoS ONE
, vol.3
-
-
Owen, L.A.1
Kowalewski, A.A.2
Lessnick, S.L.3
-
10
-
-
71549134306
-
EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma
-
Kinsey M, Smith R, Iyer AK, McCabe ER, Lessnick SL. EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma. Cancer Res 2009; 69: 9047-9055.
-
(2009)
Cancer Res
, vol.69
, pp. 9047-9055
-
-
Kinsey, M.1
Smith, R.2
Iyer, A.K.3
McCabe, E.R.4
Lessnick, S.L.5
-
11
-
-
0032848660
-
Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein
-
DOI 10.1038/13854
-
Hahm KB, Cho K, Lee C, Im YH, Chang J, Choi SG et al. Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein. Nat Genet 1999; 23: 222-227. (Pubitemid 29455398)
-
(1999)
Nature Genetics
, vol.23
, Issue.2
, pp. 222-227
-
-
Hahm, K.-B.1
Cho, K.2
Lee, C.3
Im, Y.-H.4
Chang, J.5
Choi, S.-G.6
Sorensen, P.H.B.7
Thiele, C.J.8
Kim, S.-J.9
-
12
-
-
48249127913
-
Microsatellites as EWS/FLI response elements in Ewing's sarcoma
-
Gangwal K, Sankar S, Hollenhorst PC, Kinsey M, Haroldsen SC, Shah AA et al. Microsatellites as EWS/FLI response elements in Ewing's sarcoma. Proc Natl Acad Sci USA 2008; 105: 10149-10154.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 10149-10154
-
-
Gangwal, K.1
Sankar, S.2
Hollenhorst, P.C.3
Kinsey, M.4
Haroldsen, S.C.5
Shah, A.A.6
-
13
-
-
40849114332
-
Microarray analysis of Ewing's sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy
-
Schaefer KL, Eisenacher M, Braun Y, Brachwitz K, Wai DH, Dirksen U et al. Microarray analysis of Ewing's sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy. Eur J Cancer 2008; 44: 699-709.
-
(2008)
Eur J Cancer
, vol.44
, pp. 699-709
-
-
Schaefer, K.L.1
Eisenacher, M.2
Braun, Y.3
Brachwitz, K.4
Wai, D.H.5
Dirksen, U.6
-
14
-
-
65549090018
-
A molecular function map of Ewing's sarcoma
-
Kauer M, Ban J, Kofler R, Walker B, Davis S, Meltzer P et al. A molecular function map of Ewing's sarcoma. PLoS ONE 2009; 4: e5415.
-
(2009)
PLoS ONE
, vol.4
-
-
Kauer, M.1
Ban, J.2
Kofler, R.3
Walker, B.4
Davis, S.5
Meltzer, P.6
-
15
-
-
0028209984
-
DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma
-
Bailly RA, Bosselut R, Zucman J, Cormier F, Delattre O, Roussel M et al. DNAbinding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol Cell Biol 1994; 14: 3230-3241. (Pubitemid 24132736)
-
(1994)
Molecular and Cellular Biology
, vol.14
, Issue.5
, pp. 3230-3241
-
-
Bailly, R.-A.1
Bosselut, R.2
Zucman, J.3
Cormier, F.4
Delattre, O.5
Roussel, M.6
Thomas, G.7
Ghysdael, J.8
-
16
-
-
0035393826
-
1,2
-
Arvand A, Welford SM, Teitell MA, Denny CT. The COOH-terminal domain of FLI-1 is necessary for full tumorigenesis and transcriptional modulation by EWS/FLI-1. Cancer Res 2001; 61: 5311-5317. (Pubitemid 32681570)
-
(2001)
Cancer Research
, vol.61
, Issue.13
, pp. 5311-5317
-
-
Arvand, A.1
Welford, S.M.2
Teitell, M.A.3
Denny, C.T.4
-
17
-
-
0027230568
-
Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation
-
May WA, Gishizky ML, Lessnick SL, Lunsford LB, Lewis BC, Delattre O et al. Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci USA 1993; 90: 5752-5756. (Pubitemid 23176240)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.12
, pp. 5752-5756
-
-
May, W.A.1
Gishizky, M.L.2
Lessnick, S.L.3
Lunsford, L.B.4
Lewis, B.C.5
Delattre, O.6
Zucman, J.7
Thomas, G.8
Denny, C.T.9
-
18
-
-
33845425959
-
Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma
-
Braunreiter CL, Hancock JD, Coffin CM, Boucher KM, Lessnick SL. Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma. Cell Cycle 2006; 5: 2753-2759. (Pubitemid 44901737)
-
(2006)
Cell Cycle
, vol.5
, Issue.23
, pp. 2753-2759
-
-
Braunreiter, C.L.1
Hancock, J.D.2
Coffin, C.M.3
Boucher, K.M.4
Lessnick, S.L.5
-
19
-
-
54049141305
-
Microsatellites are EWS/FLI response elements: Genomic "junk" is EWS/FLI's treasure
-
Gangwal K, Lessnick SL. Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure. Cell Cycle 2008; 7: 3127-3132.
-
(2008)
Cell Cycle
, vol.7
, pp. 3127-3132
-
-
Gangwal, K.1
Lessnick, S.L.2
-
20
-
-
40549086265
-
A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature
-
Hancock JD, Lessnick SL. A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature. Cell Cycle 2008; 7: 250-256. (Pubitemid 351366526)
-
(2008)
Cell Cycle
, vol.7
, Issue.2
, pp. 250-256
-
-
Hancock, J.D.1
Lessnick, S.L.2
-
21
-
-
33749661948
-
Identification of target genes in their native cellular context: An analysis of EWS/FLI in Ewing's sarcoma
-
Owen LA, Lessnick SL. Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's Sarcoma. Cell Cycle 2006; 5: 2049-2053. (Pubitemid 44553736)
-
(2006)
Cell Cycle
, vol.5
, Issue.18
, pp. 2049-2053
-
-
Owen, L.A.1
Lessnick, S.L.2
-
22
-
-
75649135910
-
Deconstructing repression: Evolving models of co-repressor action
-
Perissi V, Jepsen K, Glass CK, Rosenfeld MG. Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet 2010; 11: 109-123.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 109-123
-
-
Perissi, V.1
Jepsen, K.2
Glass, C.K.3
Rosenfeld, M.G.4
-
23
-
-
68749108259
-
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer
-
Wang Y, Zhang H, Chen Y, Sun Y, Yang F, Yu W et al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 2009; 138: 660-672.
-
(2009)
Cell
, vol.138
, pp. 660-672
-
-
Wang, Y.1
Zhang, H.2
Chen, Y.3
Sun, Y.4
Yang, F.5
Yu, W.6
-
24
-
-
80054755085
-
Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells
-
Hollenhorst PC, Ferris MW, Hull MA, Chae H, Kim S, Graves BJ. Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells. Genes Dev 2011; 25: 2147-2157.
-
(2011)
Genes Dev
, vol.25
, pp. 2147-2157
-
-
Hollenhorst, P.C.1
Ferris, M.W.2
Hull, M.A.3
Chae, H.4
Kim, S.5
Graves, B.J.6
-
25
-
-
84864350704
-
The rationale for targeting the LOX family in cancer
-
Barker HE, Cox TR, Erler JT. The rationale for targeting the LOX family in cancer. Nat Rev Cancer 2012; 12: 540-552.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 540-552
-
-
Barker, H.E.1
Cox, T.R.2
Erler, J.T.3
-
26
-
-
84856555606
-
Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways
-
Shukla N, Ameur N, Yilmaz I, Nafa K, Lau CY, Marchetti A et al. Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways. Clin Cancer Res 2012; 18: 748-757.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 748-757
-
-
Shukla, N.1
Ameur, N.2
Yilmaz, I.3
Nafa, K.4
Lau, C.Y.5
Marchetti, A.6
-
27
-
-
34547641224
-
Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family
-
DOI 10.1101/gad.1561707
-
Hollenhorst PC, Shah AA, Hopkins C, Graves BJ. Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev 2007; 21: 1882-1894. (Pubitemid 47204928)
-
(2007)
Genes and Development
, vol.21
, Issue.15
, pp. 1882-1894
-
-
Hollenhorst, P.C.1
Shah, A.A.2
Hopkins, C.3
Graves, B.J.4
-
28
-
-
0036828101
-
MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors
-
Jaboin J, Wild J, Hamidi H, Khanna C, Kim CJ, Robey R et al. MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors. Cancer Res 2002; 62: 6108-6115. (Pubitemid 35244459)
-
(2002)
Cancer Research
, vol.62
, Issue.21
, pp. 6108-6115
-
-
Jaboin, J.1
Wild, J.2
Hamidi, H.3
Khanna, C.4
Kim, C.J.5
Robey, R.6
Bates, S.E.7
Thiele, C.J.8
-
29
-
-
67651205908
-
Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program
-
Keshelava N, Houghton PJ, Morton CL, Lock RB, Carol H, Keir ST et al. Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program. Pediatr Blood Cancer 2009; 53: 505-508.
-
(2009)
Pediatr Blood Cancer
, vol.53
, pp. 505-508
-
-
Keshelava, N.1
Houghton, P.J.2
Morton, C.L.3
Lock, R.B.4
Carol, H.5
Keir, S.T.6
-
30
-
-
84863987775
-
Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma
-
Bennani-Baiti IM, Machado I, Llombart-Bosch A, Kovar H. Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Hum Pathol 2012; 43: 1300-1307.
-
(2012)
Hum Pathol
, vol.43
, pp. 1300-1307
-
-
Bennani-Baiti, I.M.1
MacHado, I.2
Llombart-Bosch, A.3
Kovar, H.4
-
31
-
-
0036560740
-
The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts
-
DOI 10.1016/S1535-6108(02)00056-9
-
Lessnick SL, Dacwag CS, Golub TR. The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell 2002; 1: 393-401. (Pubitemid 41039140)
-
(2002)
Cancer Cell
, vol.1
, Issue.4
, pp. 393-401
-
-
Lessnick, S.L.1
Dacwag, C.S.2
Golub, T.R.3
-
32
-
-
33845344030
-
NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma
-
DOI 10.1158/1541-7786.MCR-06-0090
-
Kinsey M, Smith R, Lessnick SL. NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's Sarcoma. Mol Cancer Res 2006; 4: 851-859. (Pubitemid 44877015)
-
(2006)
Molecular Cancer Research
, vol.4
, Issue.11
, pp. 851-859
-
-
Kinsey, M.1
Smith, R.2
Lessnick, S.L.3
-
33
-
-
64749092881
-
Use of in vivo biotinylation to study proteinprotein and protein-DNA interactions in mouse embryonic stem cells
-
Kim J, Cantor AB, Orkin SH, Wang J. Use of in vivo biotinylation to study proteinprotein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc 2009; 4: 506-517.
-
(2009)
Nat Protoc
, vol.4
, pp. 506-517
-
-
Kim, J.1
Cantor, A.B.2
Orkin, S.H.3
Wang, J.4
-
34
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
DOI 10.1073/pnas.0506580102
-
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102: 15545-15550. (Pubitemid 41528093)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.43
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
|