-
1
-
-
0029046931
-
Identification of a nuclear receptor that is activated by farnesol metabolites
-
Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, et al. (1995) Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 81: 687-693.
-
(1995)
Cell
, vol.81
, pp. 687-693
-
-
Forman, B.M.1
Goode, E.2
Chen, J.3
Oro, A.E.4
Bradley, D.J.5
-
2
-
-
0037414757
-
Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
-
Zhang Y, Kast-Woelbern HR, Edwards PA (2003) Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J Biol Chem 278: 104-110.
-
(2003)
J Biol Chem
, vol.278
, pp. 104-110
-
-
Zhang, Y.1
Kast-Woelbern, H.R.2
Edwards, P.A.3
-
3
-
-
0033591297
-
Identification of a nuclear receptor for bile acids
-
Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, et al. (1999) Identification of a nuclear receptor for bile acids. Science 284: 1362-1365.
-
(1999)
Science
, vol.284
, pp. 1362-1365
-
-
Makishima, M.1
Okamoto, A.Y.2
Repa, J.J.3
Tu, H.4
Learned, R.M.5
-
4
-
-
0034664729
-
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
-
Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, et al. (2000) Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102: 731-744.
-
(2000)
Cell
, vol.102
, pp. 731-744
-
-
Sinal, C.J.1
Tohkin, M.2
Miyata, M.3
Ward, J.M.4
Lambert, G.5
-
5
-
-
33645509321
-
Farnesoid X receptor is essential for normal glucose homeostasis
-
Ma K, Saha PK, Chan L, Moore DD (2006) Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 116: 1102-1109.
-
(2006)
J Clin Invest
, vol.116
, pp. 1102-1109
-
-
Ma, K.1
Saha, P.K.2
Chan, L.3
Moore, D.D.4
-
6
-
-
56149085041
-
Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
-
Wang YD, Chen WD, Wang M, Yu D, Forman BM, et al. (2008) Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 48: 1632-1643.
-
(2008)
Hepatology
, vol.48
, pp. 1632-1643
-
-
Wang, Y.D.1
Chen, W.D.2
Wang, M.3
Yu, D.4
Forman, B.M.5
-
7
-
-
34447098081
-
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
-
Kim I, Morimura K, Shah Y, Yang Q, Ward JM, et al. (2007) Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 28: 940-946.
-
(2007)
Carcinogenesis
, vol.28
, pp. 940-946
-
-
Kim, I.1
Morimura, K.2
Shah, Y.3
Yang, Q.4
Ward, J.M.5
-
8
-
-
58149234445
-
Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity
-
Jia L, Berman BP, Jariwala U, Yan X, Cogan JP, et al. (2008) Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity. PLoS One 3: e3645.
-
(2008)
PLoS One
, vol.3
, pp. e3645
-
-
Jia, L.1
Berman, B.P.2
Jariwala, U.3
Yan, X.4
Cogan, J.P.5
-
9
-
-
38049007472
-
Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver
-
Gao H, Falt S, Sandelin A, Gustafsson JA, Dahlman-Wright K (2008) Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver. Mol Endocrinol 22: 10-22.
-
(2008)
Mol Endocrinol
, vol.22
, pp. 10-22
-
-
Gao, H.1
Falt, S.2
Sandelin, A.3
Gustafsson, J.A.4
Dahlman-Wright, K.5
-
10
-
-
40649106738
-
Interaction of the glucocorticoid receptor with the chromatin landscape
-
John S, Sabo PJ, Johnson TA, Sung MH, Biddie SC, et al. (2008) Interaction of the glucocorticoid receptor with the chromatin landscape. Mol Cell 29: 611-624.
-
(2008)
Mol Cell
, vol.29
, pp. 611-624
-
-
John, S.1
Sabo, P.J.2
Johnson, T.A.3
Sung, M.H.4
Biddie, S.C.5
-
11
-
-
77950605769
-
Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine
-
Thomas AM, Hart SN, Kong B, Fang J, Zhong XB, et al. (2010) Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine. Hepatology 51: 1410-1419.
-
(2010)
Hepatology
, vol.51
, pp. 1410-1419
-
-
Thomas, A.M.1
Hart, S.N.2
Kong, B.3
Fang, J.4
Zhong, X.B.5
-
12
-
-
77954987308
-
Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1
-
Chong HK, Infante AM, Seo YK, Jeon TI, Zhang Y, et al. (2010) Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1. Nucleic Acids Res 38: 6007-6017.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 6007-6017
-
-
Chong, H.K.1
Infante, A.M.2
Seo, Y.K.3
Jeon, T.I.4
Zhang, Y.5
-
13
-
-
84863512181
-
Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice
-
Lee J, Seok S, Yu P, Kim K, Smith Z, et al. (2012) Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice. Hepatology 56: 108-117.
-
(2012)
Hepatology
, vol.56
, pp. 108-117
-
-
Lee, J.1
Seok, S.2
Yu, P.3
Kim, K.4
Smith, Z.5
-
14
-
-
77954821918
-
Farnesoid X receptor activation mediates head-to-tail chromatin looping in the nr0b2 gene encoding small heterodimer partner
-
Li G, Thomas AM, Hart SN, Zhong X, Wu D, et al. (2010) Farnesoid X receptor activation mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner. Mol Endocrinol 24: 1404-1412.
-
(2010)
Mol Endocrinol
, vol.24
, pp. 1404-1412
-
-
Li, G.1
Thomas, A.M.2
Hart, S.N.3
Zhong, X.4
Wu, D.5
-
15
-
-
84865439276
-
Tissue specific induction of p62/Sqstm1 by farnesoid X receptor
-
Williams JA, Thomas AM, Li G, Kong B, Zhan L, et al. (2012) Tissue specific induction of p62/Sqstm1 by farnesoid X receptor. PLoS One 7: e43961.
-
(2012)
PLoS One
, vol.7
, pp. e43961
-
-
Williams, J.A.1
Thomas, A.M.2
Li, G.3
Kong, B.4
Zhan, L.5
-
16
-
-
84857919534
-
Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR
-
Chong HK, Biesinger J, Seo YK, Xie X, Osborne TF (2012) Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR. BMC Genomics 13: 51.
-
(2012)
BMC Genomics
, vol.13
, pp. 51
-
-
Chong, H.K.1
Biesinger, J.2
Seo, Y.K.3
Xie, X.4
Osborne, T.F.5
-
17
-
-
84883272387
-
Hepatocyte nuclear factor 4 alpha and farnesoid X receptor co-regulates gene transcription in mouse livers on a genome-wide scale
-
Thomas AM, Hart SN, Li G, Lu H, Fang Y, et al. (2013) Hepatocyte Nuclear Factor 4 Alpha and Farnesoid X Receptor Co-regulates Gene Transcription in Mouse Livers on a Genome-Wide Scale. Pharm Res 30: 2188-2198.
-
(2013)
Pharm Res
, vol.30
, pp. 2188-2198
-
-
Thomas, A.M.1
Hart, S.N.2
Li, G.3
Lu, H.4
Fang, Y.5
-
18
-
-
84885443998
-
Phytosterols promote liver injury and kupffer cell activation in parenteral nutrition-associated liver disease
-
El Kasmi KC, Anderson AL, Devereaux MW, Vue PM, Zhang W, et al. (2013) Phytosterols promote liver injury and kupffer cell activation in parenteral nutrition-associated liver disease. Sci Transl Med 5: 206ra137.
-
(2013)
Sci Transl Med
, vol.5
, pp. 206ra137
-
-
El Kasmi, K.C.1
Anderson, A.L.2
Devereaux, M.W.3
Vue, P.M.4
Zhang, W.5
-
19
-
-
84898051705
-
FXR is a molecular target for the effects of vertical sleeve gastrectomy
-
Ryan KK, Tremaroli V, Clemmensen C, Kovatcheva-Datchary P, Myronovych A, et al. (2014) FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature.
-
(2014)
Nature
-
-
Ryan, K.K.1
Tremaroli, V.2
Clemmensen, C.3
Kovatcheva-Datchary, P.4
Myronovych, A.5
-
20
-
-
84876749355
-
Identification of chemerin as a novel FXR target gene down-regulated in the progression of nonalcoholic steatohepatitis
-
Deng Y, Wang H, Lu Y, Liu S, Zhang Q, et al. (2013) Identification of Chemerin as a Novel FXR Target Gene Down-Regulated in the Progression of Nonalcoholic Steatohepatitis. Endocrinology 154: 1794-1801.
-
(2013)
Endocrinology
, vol.154
, pp. 1794-1801
-
-
Deng, Y.1
Wang, H.2
Lu, Y.3
Liu, S.4
Zhang, Q.5
-
21
-
-
84876896348
-
Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease
-
McMahan RH, Wang XX, Cheng LL, Krisko T, Smith M, et al. (2013) Bile Acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic Fatty liver disease. J Biol Chem 288: 11761-11770.
-
(2013)
J Biol Chem
, vol.288
, pp. 11761-11770
-
-
McMahan, R.H.1
Wang, X.X.2
Cheng, L.L.3
Krisko, T.4
Smith, M.5
-
22
-
-
0035800772
-
Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
-
Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ (2001) Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 276: 28857-28865.
-
(2001)
J Biol Chem
, vol.276
, pp. 28857-28865
-
-
Ananthanarayanan, M.1
Balasubramanian, N.2
Makishima, M.3
Mangelsdorf, D.J.4
Suchy, F.J.5
-
23
-
-
0037663483
-
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
-
Holt JA, Luo G, Billin AN, Bisi J, McNeill YY, et al. (2003) Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev 17: 1581-1591.
-
(2003)
Genes Dev
, vol.17
, pp. 1581-1591
-
-
Holt, J.A.1
Luo, G.2
Billin, A.N.3
Bisi, J.4
McNeill, Y.Y.5
-
24
-
-
9144243644
-
Farnesoid X receptor activates transcription of the phospholipid pump MDR3
-
Huang L, Zhao A, Lew JL, Zhang T, Hrywna Y, et al. (2003) Farnesoid X receptor activates transcription of the phospholipid pump MDR3. J Biol Chem 278: 51085-51090.
-
(2003)
J Biol Chem
, vol.278
, pp. 51085-51090
-
-
Huang, L.1
Zhao, A.2
Lew, J.L.3
Zhang, T.4
Hrywna, Y.5
-
25
-
-
22544439958
-
Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes
-
Qin P, Borges-Marcucci LA, Evans MJ, Harnish DC (2005) Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes. Am J Physiol Gastrointest Liver Physiol 289: G267-273.
-
(2005)
Am J Physiol Gastrointest Liver Physiol
, vol.289
, pp. G267-273
-
-
Qin, P.1
Borges-Marcucci, L.A.2
Evans, M.J.3
Harnish, D.C.4
-
26
-
-
0032794135
-
The use of human hepatocyte cultures to study the induction of cytochrome P-450
-
Kostrubsky VE, Ramachandran V, Venkataramanan R, Dorko K, Esplen JE, et al. (1999) The use of human hepatocyte cultures to study the induction of cytochrome P-450. Drug Metab Dispos 27: 887-894.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 887-894
-
-
Kostrubsky, V.E.1
Ramachandran, V.2
Venkataramanan, R.3
Dorko, K.4
Esplen, J.E.5
-
27
-
-
84455173436
-
The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction
-
Li D, Gaedigk R, Hart SN, Leeder JS, Zhong XB (2012) The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction. Mol Pharmacol 81: 86-96.
-
(2012)
Mol Pharmacol
, vol.81
, pp. 86-96
-
-
Li, D.1
Gaedigk, R.2
Hart, S.N.3
Leeder, J.S.4
Zhong, X.B.5
-
28
-
-
62349130698
-
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
-
Langmead B, Trapnell C, Pop M, Salzberg SL (2009) Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol 10: R25.
-
(2009)
Genome Biol
, vol.10
, pp. R25
-
-
Langmead, B.1
Trapnell, C.2
Pop, M.3
Salzberg, S.L.4
-
29
-
-
53849146020
-
Model-based analysis of ChIP-seq (MACS)
-
Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, et al. (2008) Model-based analysis of ChIP-Seq (MACS). Genome Biol 9: R137.
-
(2008)
Genome Biol
, vol.9
, pp. R137
-
-
Zhang, Y.1
Liu, T.2
Meyer, C.A.3
Eeckhoute, J.4
Johnson, D.S.5
-
30
-
-
67849122320
-
MEME SUITE: Tools for motif discovery and searching
-
Bailey TL, Boden M, Buske FA, Frith M, Grant CE, et al. (2009) MEME SUITE: tools for motif discovery and searching. Nucleic Acids Res 37: W202-208.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. W202-208
-
-
Bailey, T.L.1
Boden, M.2
Buske, F.A.3
Frith, M.4
Grant, C.E.5
-
31
-
-
84865540426
-
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice
-
Kong B, Wang L, Chiang JY, Zhang Y, Klaassen CD, et al. (2012) Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology 56: 1034-1043.
-
(2012)
Hepatology
, vol.56
, pp. 1034-1043
-
-
Kong, B.1
Wang, L.2
Chiang, J.Y.3
Zhang, Y.4
Klaassen, C.D.5
-
32
-
-
84859885816
-
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and cufflinks
-
Trapnell C, Roberts A, Goff L, Pertea G, Kim D, et al. (2012) Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc 7: 562-578.
-
(2012)
Nat Protoc
, vol.7
, pp. 562-578
-
-
Trapnell, C.1
Roberts, A.2
Goff, L.3
Pertea, G.4
Kim, D.5
-
33
-
-
0036081355
-
Gene expression omnibus: Ncbi gene expression and hybridization array data repository
-
Edgar R, Domrachev M, Lash AE (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30: 207-210.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 207-210
-
-
Edgar, R.1
Domrachev, M.2
Lash, A.E.3
-
34
-
-
0033637121
-
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
-
Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, et al. (2000) A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6: 517-526.
-
(2000)
Mol Cell
, vol.6
, pp. 517-526
-
-
Goodwin, B.1
Jones, S.A.2
Price, R.R.3
Watson, M.A.4
McKee, D.D.5
-
35
-
-
40849085514
-
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription
-
Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, et al. (2008) FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell 132: 958-970.
-
(2008)
Cell
, vol.132
, pp. 958-970
-
-
Lupien, M.1
Eeckhoute, J.2
Meyer, C.A.3
Wang, Q.4
Zhang, Y.5
-
36
-
-
0242317684
-
The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily
-
Maglich JM, Caravella JA, Lambert MH, Willson TM, Moore JT, et al. (2003) The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily. Nucleic Acids Res 31: 4051-4058.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 4051-4058
-
-
Maglich, J.M.1
Caravella, J.A.2
Lambert, M.H.3
Willson, T.M.4
Moore, J.T.5
-
37
-
-
84876814799
-
Differential regulation of bile acid and cholesterol metabolism by the farnesoid X receptor in ldlr -/- Mice versus hamsters
-
Gardes C, Chaput E, Staempfli A, Blum D, Richter H, et al. (2013) Differential regulation of bile acid and cholesterol metabolism by the farnesoid X receptor in Ldlr -/- mice versus hamsters. J Lipid Res 54: 1283-1299.
-
(2013)
J Lipid Res
, vol.54
, pp. 1283-1299
-
-
Gardes, C.1
Chaput, E.2
Staempfli, A.3
Blum, D.4
Richter, H.5
|