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Volumn 30, Issue 9, 2013, Pages 2188-2198

Hepatocyte nuclear factor 4 alpha and farnesoid X receptor co-regulates gene transcription in mouse livers on a genome-wide scale

Author keywords

ChIP Seq; co regulation; Fxr; Hnf4 ; nuclear receptor interaction

Indexed keywords

FARNESOID X RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LUCIFERASE;

EID: 84883272387     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1006-7     Document Type: Article
Times cited : (24)

References (43)
  • 1
    • 0033591387 scopus 로고    scopus 로고
    • Bile acids: Natural ligands for an orphan nuclear receptor
    • 10334993 10.1126/science.284.5418.1365 1:CAS:528:DyaK1MXjs1WhtLw%3D
    • Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, et al. Bile acids: natural ligands for an orphan nuclear receptor. Science. 1999;284:1365-8.
    • (1999) Science. , vol.284 , pp. 1365-1368
    • Parks, D.J.1    Blanchard, S.G.2    Bledsoe, R.K.3    Chandra, G.4    Consler, T.G.5
  • 2
    • 0033591297 scopus 로고    scopus 로고
    • Identification of a nuclear receptor for bile acids
    • 10334992 10.1126/science.284.5418.1362 1:CAS:528:DyaK1MXjs1WhtL4%3D
    • Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, et al. Identification of a nuclear receptor for bile acids. Science. 1999;284:1362-5.
    • (1999) Science. , vol.284 , pp. 1362-1365
    • Makishima, M.1    Okamoto, A.Y.2    Repa, J.J.3    Tu, H.4    Learned, R.M.5
  • 3
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor Fxr/Bar
    • 10360171 10.1016/S1097-2765(00)80348-2 1:CAS:528:DyaK1MXjslCqurg%3D
    • Wang H, Chen J, Hollister K, Sowers LC, Forman BM. Endogenous bile acids are ligands for the nuclear receptor Fxr/Bar. Mol Cell. 1999;3:543-53.
    • (1999) Mol Cell. , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 4
    • 0028836714 scopus 로고
    • Isolation of proteins that interact specifically with the retinoid X receptor: Two novel orphan receptors
    • 7760852 10.1210/me.9.1.72 1:CAS:528:DyaK2MXjsFGhsrs%3D
    • Seol W, Choi HS, Moore DD. Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995;9:72-85.
    • (1995) Mol Endocrinol. , vol.9 , pp. 72-85
    • Seol, W.1    Choi, H.S.2    Moore, D.D.3
  • 5
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor Fxr/Bar impairs bile acid and lipid homeostasis
    • 11030617 10.1016/S0092-8674(00)00062-3 1:CAS:528:DC%2BD3cXmvFShtr8%3D
    • Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, et al. Targeted disruption of the nuclear receptor Fxr/Bar impairs bile acid and lipid homeostasis. Cell. 2000;102:731-44.
    • (2000) Cell. , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5
  • 6
    • 0142211282 scopus 로고    scopus 로고
    • Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice
    • 12917447 10.1074/jbc.M306309200 1:CAS:528:DC%2BD3sXot1amtr0%3D
    • Kok T, Hulzebos CV, Wolters H, Havinga R, Agellon LB, et al. Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice. J Biol Chem. 2003;278:41930-7.
    • (2003) J Biol Chem. , vol.278 , pp. 41930-41937
    • Kok, T.1    Hulzebos, C.V.2    Wolters, H.3    Havinga, R.4    Agellon, L.B.5
  • 7
    • 0028148776 scopus 로고
    • Disruption of the Hnf-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos
    • 7958910 10.1101/gad.8.20.2466 1:CAS:528:DyaK2MXhslejs7w%3D
    • Chen WS, Manova K, Weinstein DC, Duncan SA, Plump AS, et al. Disruption of the Hnf-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 1994;8:2466-77.
    • (1994) Genes Dev. , vol.8 , pp. 2466-2477
    • Chen, W.S.1    Manova, K.2    Weinstein, D.C.3    Duncan, S.A.4    Plump, A.S.5
  • 8
    • 30844454448 scopus 로고    scopus 로고
    • Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha
    • 16264197 10.1194/jlr.M500430-JLR200 1:CAS:528:DC%2BD28XpvVersQ%3D%3D
    • Inoue Y, Yu AM, Yim SH, Ma X, Krausz KW, et al. Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha. J Lipid Res. 2006;47:215-27.
    • (2006) J Lipid Res. , vol.47 , pp. 215-227
    • Inoue, Y.1    Yu, A.M.2    Yim, S.H.3    Ma, X.4    Krausz, K.W.5
  • 9
    • 1642494712 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha is a central regulator of bile acid conjugation
    • 14583614 10.1074/jbc.M311015200 1:CAS:528:DC%2BD2cXkslOluw%3D%3D
    • Inoue Y, Yu AM, Inoue J, Gonzalez FJ. Hepatocyte nuclear factor 4alpha is a central regulator of bile acid conjugation. J Biol Chem. 2004;279:2480-9.
    • (2004) J Biol Chem. , vol.279 , pp. 2480-2489
    • Inoue, Y.1    Yu, A.M.2    Inoue, J.3    Gonzalez, F.J.4
  • 10
    • 0042666932 scopus 로고    scopus 로고
    • Farnesoid X receptor agonists suppress hepatic apolipoprotein Ciii expression
    • 12891557 10.1016/S0016-5085(03)00896-5 1:CAS:528:DC%2BD3sXmvFynsro%3D
    • Claudel T, Inoue Y, Barbier O, Duran-Sandoval D, Kosykh V, et al. Farnesoid X receptor agonists suppress hepatic apolipoprotein Ciii expression. Gastroenterology. 2003;125:544-55.
    • (2003) Gastroenterology. , vol.125 , pp. 544-555
    • Claudel, T.1    Inoue, Y.2    Barbier, O.3    Duran-Sandoval, D.4    Kosykh, V.5
  • 11
    • 0034035239 scopus 로고    scopus 로고
    • Genotype/phenotype relationships in Hnf-4alpha/Mody1: Haploinsufficiency is associated with reduced apolipoprotein (Aii), apolipoprotein (Ciii), lipoprotein (a), and triglyceride levels
    • 10905494 10.2337/diabetes.49.5.832 1:CAS:528:DC%2BD3cXjsF2msL8%3D
    • Shih DQ, Dansky HM, Fleisher M, Assmann G, Fajans SS, et al. Genotype/phenotype relationships in Hnf-4alpha/Mody1: haploinsufficiency is associated with reduced apolipoprotein (Aii), apolipoprotein (Ciii), lipoprotein (a), and triglyceride levels. Diabetes. 2000;49:832-7.
    • (2000) Diabetes. , vol.49 , pp. 832-837
    • Shih, D.Q.1    Dansky, H.M.2    Fleisher, M.3    Assmann, G.4    Fajans, S.S.5
  • 12
    • 0033954261 scopus 로고    scopus 로고
    • Hnf4 and Coup-Tfii interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (Cyp7a1)
    • 10627496 1:CAS:528:DC%2BD3cXltFOjtw%3D%3D
    • Stroup D, Chiang JY. Hnf4 and Coup-Tfii interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (Cyp7a1). J Lipid Res. 2000;41:1-11.
    • (2000) J Lipid Res. , vol.41 , pp. 1-11
    • Stroup, D.1    Chiang, J.Y.2
  • 13
    • 0037327003 scopus 로고    scopus 로고
    • The orphan nuclear receptor Hnf4alpha determines Pxr- and car-mediated xenobiotic induction of Cyp3a4
    • 12514743 10.1038/nm815 1:CAS:528:DC%2BD3sXotlShtA%3D%3D
    • Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, et al. The orphan nuclear receptor Hnf4alpha determines Pxr- and car-mediated xenobiotic induction of Cyp3a4. Nat Med. 2003;9:220-4.
    • (2003) Nat Med. , vol.9 , pp. 220-224
    • Tirona, R.G.1    Lee, W.2    Leake, B.F.3    Lan, L.B.4    Cline, C.B.5
  • 14
    • 32244447570 scopus 로고    scopus 로고
    • Activation of the nuclear receptor Fxr improves hyperglycemia and hyperlipidemia in diabetic mice
    • 16410358 10.1073/pnas.0506982103 1:CAS:528:DC%2BD28XhsVKgtLY%3D
    • Zhang Y, Lee FY, Barrera G, Lee H, Vales C, et al. Activation of the nuclear receptor Fxr improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A. 2006;103:1006-11.
    • (2006) Proc Natl Acad Sci U S A. , vol.103 , pp. 1006-1011
    • Zhang, Y.1    Lee, F.Y.2    Barrera, G.3    Lee, H.4    Vales, C.5
  • 15
    • 85047694456 scopus 로고    scopus 로고
    • Bile acids lower triglyceride levels via a pathway involving Fxr, Shp, and Srebp-1c
    • 15146238 1:CAS:528:DC%2BD2cXktlCltro%3D
    • Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, et al. Bile acids lower triglyceride levels via a pathway involving Fxr, Shp, and Srebp-1c. J Clin Invest. 2004;113:1408-18.
    • (2004) J Clin Invest. , vol.113 , pp. 1408-1418
    • Watanabe, M.1    Houten, S.M.2    Wang, L.3    Moschetta, A.4    Mangelsdorf, D.J.5
  • 16
    • 34347401852 scopus 로고    scopus 로고
    • Bile acid sequestrants and the treatment of type 2 diabetes mellitus
    • 17600387 10.2165/00003495-200767100-00001 1:CAS:528:DC%2BD2sXpsVOjsb4%3D
    • Staels B, Kuipers F. Bile acid sequestrants and the treatment of type 2 diabetes mellitus. Drugs. 2007;67:1383-92.
    • (2007) Drugs. , vol.67 , pp. 1383-1392
    • Staels, B.1    Kuipers, F.2
  • 17
    • 33645531297 scopus 로고    scopus 로고
    • The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice
    • 16446356 10.1074/jbc.M510258200 1:CAS:528:DC%2BD28XjsFWjs7w%3D
    • Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk TH, Grefhorst A, et al. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem. 2006;281:11039-49.
    • (2006) J Biol Chem. , vol.281 , pp. 11039-11049
    • Cariou, B.1    Van Harmelen, K.2    Duran-Sandoval, D.3    Van Dijk, T.H.4    Grefhorst, A.5
  • 18
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • 16557297 10.1172/JCI25604 1:CAS:528:DC%2BD28XjsVWnurk%3D
    • Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006;116:1102-9.
    • (2006) J Clin Invest. , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 19
    • 59649084903 scopus 로고    scopus 로고
    • Fxr deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development
    • Maran RR, Thomas A, Roth M, Sheng Z, Esterly N, et al. Fxr deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development. J Pharmacol Exp Ther. 2009;328:469-77.
    • (2009) J Pharmacol Exp Ther. , vol.328 , pp. 469-477
    • Maran, R.R.1    Thomas, A.2    Roth, M.3    Sheng, Z.4    Esterly, N.5
  • 20
    • 57149118460 scopus 로고    scopus 로고
    • Nuclear bile acid receptor Fxr protects against intestinal tumorigenesis
    • 19047134 10.1158/0008-5472.CAN-08-1791 1:CAS:528:DC%2BD1cXhsVegtbrM
    • Modica S, Murzilli S, Salvatore L, Schmidt DR, Moschetta A. Nuclear bile acid receptor Fxr protects against intestinal tumorigenesis. Cancer Res. 2008;68:9589-94.
    • (2008) Cancer Res. , vol.68 , pp. 9589-9594
    • Modica, S.1    Murzilli, S.2    Salvatore, L.3    Schmidt, D.R.4    Moschetta, A.5
  • 21
    • 34447098081 scopus 로고    scopus 로고
    • Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
    • 17183066 10.1093/carcin/bgl249 1:CAS:528:DC%2BD2sXlvFGls7Y%3D
    • Kim I, Morimura K, Shah Y, Yang Q, Ward JM, et al. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis. 2007;28:940-6.
    • (2007) Carcinogenesis. , vol.28 , pp. 940-946
    • Kim, I.1    Morimura, K.2    Shah, Y.3    Yang, Q.4    Ward, J.M.5
  • 22
    • 33847044019 scopus 로고    scopus 로고
    • Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
    • 17283114 10.1158/0008-5472.CAN-06-1078 1:CAS:528:DC%2BD2sXht1yntL8%3D
    • Yang F, Huang X, Yi T, Yen Y, Moore DD, et al. Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res. 2007;67:863-7.
    • (2007) Cancer Res. , vol.67 , pp. 863-867
    • Yang, F.1    Huang, X.2    Yi, T.3    Yen, Y.4    Moore, D.D.5
  • 23
    • 77950605769 scopus 로고    scopus 로고
    • Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine
    • 20091679 10.1002/hep.23450 1:CAS:528:DC%2BC3cXls1Cnurg%3D
    • Thomas AM, Hart SN, Kong B, Fang J, Zhong XB, et al. Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine. Hepatology. 2010;51:1410-9.
    • (2010) Hepatology. , vol.51 , pp. 1410-1419
    • Thomas, A.M.1    Hart, S.N.2    Kong, B.3    Fang, J.4    Zhong, X.B.5
  • 24
    • 77954987308 scopus 로고    scopus 로고
    • Genome-wide interrogation of hepatic Fxr reveals an asymmetric Ir-1 motif and synergy with Lrh-1
    • 20483916 10.1093/nar/gkq397 1:CAS:528:DC%2BC3cXhtlSmsr7I
    • Chong HK, Infante AM, Seo Y-K, Jeon T-I, Zhang Y, et al. Genome-wide interrogation of hepatic Fxr reveals an asymmetric Ir-1 motif and synergy with Lrh-1. Nucleic Acids Res. 2010;38:6007-17.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 6007-6017
    • Chong, H.K.1    Infante, A.M.2    Seo, Y.-K.3    Jeon, T.-I.4    Zhang, Y.5
  • 25
    • 42249106086 scopus 로고    scopus 로고
    • Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription
    • 18305369 10.2133/dmpk.23.2 1:CAS:528:DC%2BD1cXkvFegtrg%3D
    • Gonzalez FJ. Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription. Drug Metab Pharmacokinet. 2008;23:2-7.
    • (2008) Drug Metab Pharmacokinet. , vol.23 , pp. 2-7
    • Gonzalez, F.J.1
  • 26
    • 0034632762 scopus 로고    scopus 로고
    • Identification of a chemical tool for the orphan nuclear receptor Fxr
    • 10956205 10.1021/jm0002127 1:CAS:528:DC%2BD3cXltVSiur0%3D
    • Maloney PR, Parks DJ, Haffner CD, Fivush AM, Chandra G, et al. Identification of a chemical tool for the orphan nuclear receptor Fxr. J Med Chem. 2000;43:2971-4.
    • (2000) J Med Chem. , vol.43 , pp. 2971-2974
    • Maloney, P.R.1    Parks, D.J.2    Haffner, C.D.3    Fivush, A.M.4    Chandra, G.5
  • 27
    • 0035141324 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha (nuclear receptor 2a1) is essential for maintenance of hepatic gene expression and lipid homeostasis
    • 11158324 10.1128/MCB.21.4.1393-1403.2001 1:CAS:528:DC%2BD3MXovVCmuw%3D%3D
    • Hayhurst GP, Lee YH, Lambert G, Ward JM, Gonzalez FJ. Hepatocyte nuclear factor 4alpha (nuclear receptor 2a1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol. 2001;21:1393-403.
    • (2001) Mol Cell Biol. , vol.21 , pp. 1393-1403
    • Hayhurst, G.P.1    Lee, Y.H.2    Lambert, G.3    Ward, J.M.4    Gonzalez, F.J.5
  • 28
    • 77953062527 scopus 로고    scopus 로고
    • Five-vertebrate Chip-Seq reveals the evolutionary dynamics of transcription factor binding
    • 20378774 10.1126/science.1186176 1:CAS:528:DC%2BC3cXmtFCnsb8%3D
    • Schmidt D, Wilson MD, Ballester B, Schwalie PC, Brown GD, et al. Five-vertebrate Chip-Seq reveals the evolutionary dynamics of transcription factor binding. Science. 2010;328:1036-40.
    • (2010) Science. , vol.328 , pp. 1036-1040
    • Schmidt, D.1    Wilson, M.D.2    Ballester, B.3    Schwalie, P.C.4    Brown, G.D.5
  • 30
    • 77951770756 scopus 로고    scopus 로고
    • Bedtools: A flexible suite of utilities for comparing genomic features
    • 20110278 10.1093/bioinformatics/btq033 1:CAS:528:DC%2BC3cXivFGkurc%3D
    • Quinlan AR, Hall IM. Bedtools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010;26:841-2.
    • (2010) Bioinformatics. , vol.26 , pp. 841-842
    • Quinlan, A.R.1    Hall, I.M.2
  • 32
    • 0038005018 scopus 로고    scopus 로고
    • David: Database for annotation, visualization, and integrated discovery
    • 12734009 10.1186/gb-2003-4-5-p3
    • Dennis Jr G, Sherman BT, Hosack DA, Yang J, Gao W, et al. David: database for annotation, visualization, and integrated discovery. Genome Biol. 2003;4:P3.
    • (2003) Genome Biol. , vol.4 , pp. 3
    • Dennis, Jr.G.1    Sherman, B.T.2    Hosack, D.A.3    Yang, J.4    Gao, W.5
  • 33
    • 77954821918 scopus 로고    scopus 로고
    • Farnesoid X receptor activation mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner
    • 20444884 10.1210/me.2010-0014 1:CAS:528:DC%2BC3cXpt1Cntrc%3D
    • Li G, Thomas AM, Hart SN, Zhong X, Wu D, et al. Farnesoid X receptor activation mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner. Mol Endocrinol. 2010;24:1404-12.
    • (2010) Mol Endocrinol. , vol.24 , pp. 1404-1412
    • Li, G.1    Thomas, A.M.2    Hart, S.N.3    Zhong, X.4    Wu, D.5
  • 34
    • 84859986063 scopus 로고    scopus 로고
    • Farnesoid X receptor induces murine scavenger receptor class B type i via intron binding
    • 22540009 10.1371/journal.pone.0035895 1:CAS:528:DC%2BC38Xms1Clsrg%3D
    • Li G, Thomas AM, Williams JA, Kong B, Liu J, et al. Farnesoid X receptor induces murine scavenger receptor class B type I via intron binding. PLoS One. 2012;7:e35895.
    • (2012) PLoS One. , vol.7 , pp. 35895
    • Li, G.1    Thomas, A.M.2    Williams, J.A.3    Kong, B.4    Liu, J.5
  • 35
    • 84865439276 scopus 로고    scopus 로고
    • Tissue specific induction of P62/Sqstm1 by farnesoid X receptor
    • 22952826 10.1371/journal.pone.0043961 1:CAS:528:DC%2BC38Xht1Olt77P
    • Williams JA, Thomas AM, Li G, Kong B, Zhan L, et al. Tissue specific induction of P62/Sqstm1 by farnesoid X receptor. PLoS One. 2012;7:e43961.
    • (2012) PLoS One. , vol.7 , pp. 43961
    • Williams, J.A.1    Thomas, A.M.2    Li, G.3    Kong, B.4    Zhan, L.5
  • 36
    • 0037094415 scopus 로고    scopus 로고
    • Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters
    • 12062799 10.1016/S0378-1119(02)00557-7 1:CAS:528:DC%2BD38XktlartL4%3D
    • Huber RM, Murphy K, Miao B, Link JR, Cunningham MR, et al. Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters. Gene. 2002;290:35-43.
    • (2002) Gene. , vol.290 , pp. 35-43
    • Huber, R.M.1    Murphy, K.2    Miao, B.3    Link, J.R.4    Cunningham, M.R.5
  • 37
    • 33645808917 scopus 로고    scopus 로고
    • Rifampicin induction of Cyp3a4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression
    • 16455805 10.1124/dmd.105.007575 1:CAS:528:DC%2BD28Xks1SksLs%3D
    • Li T, Chiang JY. Rifampicin induction of Cyp3a4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression. Drug Metab Dispos. 2006;34:756-64.
    • (2006) Drug Metab Dispos. , vol.34 , pp. 756-764
    • Li, T.1    Chiang, J.Y.2
  • 38
    • 85047682066 scopus 로고    scopus 로고
    • Nubiscan, an in silico approach for prediction of nuclear receptor response elements
    • 12040014 10.1210/me.16.6.1269 1:CAS:528:DC%2BD38XktlWktb4%3D
    • Podvinec M, Kaufmann MR, Handschin C, Meyer UA. Nubiscan, an in silico approach for prediction of nuclear receptor response elements. Mol Endocrinol. 2002;16:1269-79.
    • (2002) Mol Endocrinol. , vol.16 , pp. 1269-1279
    • Podvinec, M.1    Kaufmann, M.R.2    Handschin, C.3    Meyer, U.A.4
  • 39
    • 0025690311 scopus 로고
    • Liver-enriched transcription factor Hnf-4 is a novel member of the steroid hormone receptor superfamily
    • 2279702 10.1101/gad.4.12b.2353 1:CAS:528:DyaK3MXltVOgurs%3D
    • Sladek FM, Zhong WM, Lai E, Darnell Jr JE. Liver-enriched transcription factor Hnf-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 1990;4:2353-65.
    • (1990) Genes Dev. , vol.4 , pp. 2353-2365
    • Sladek, F.M.1    Zhong, W.M.2    Lai, E.3    Darnell, Jr.J.E.4
  • 41
    • 79955442715 scopus 로고    scopus 로고
    • Deciphering the nuclear bile acid receptor Fxr paradigm
    • 21383957 1:CAS:528:DC%2BC3cXhs1WiurfJ
    • Modica S, Gadaleta RM, Moschetta A. Deciphering the nuclear bile acid receptor Fxr paradigm. Nucl Recept Signal. 2010;8:e005.
    • (2010) Nucl Recept Signal. , vol.8 , pp. 005
    • Modica, S.1    Gadaleta, R.M.2    Moschetta, A.3
  • 42
    • 78651250284 scopus 로고    scopus 로고
    • Foxa1 is a key determinant of estrogen receptor function and endocrine response
    • 21151129 10.1038/ng.730 1:CAS:528:DC%2BC3cXhsFGgtrnK
    • Hurtado A, Holmes KA, Ross-Innes CS, Schmidt D, Carroll JS. Foxa1 is a key determinant of estrogen receptor function and endocrine response. Nat Genet. 2011;43:27-33.
    • (2011) Nat Genet. , vol.43 , pp. 27-33
    • Hurtado, A.1    Holmes, K.A.2    Ross-Innes, C.S.3    Schmidt, D.4    Carroll, J.S.5
  • 43
    • 40849085514 scopus 로고    scopus 로고
    • Foxa1 translates epigenetic signatures into enhancer-driven lineage-specific transcription
    • 18358809 10.1016/j.cell.2008.01.018 1:CAS:528:DC%2BD1cXkt1Wqs7c%3D
    • Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, et al. Foxa1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell. 2008;132:958-70.
    • (2008) Cell. , vol.132 , pp. 958-970
    • Lupien, M.1    Eeckhoute, J.2    Meyer, C.A.3    Wang, Q.4    Zhang, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.