Phytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease

Science Translational Medicine

Volumn 5, Issue 206, 2013, Pages

  El Kasmi, Karim C ^a,b   Anderson, Aimee L ^a,b   Devereaux, Michael W ^a,b   Vue, Padade M ^a,b   Zhang, Wujuan ^c   Setchell, Kenneth D R ^c   Karpen, Saul J ^d   Sokol, Ronald J ^a,b  

^a Children's Hospital Colorado   (United States)

^b CHILDREN S HOSPITAL COLORADO   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT; CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; FISH OIL; LIPID EMULSION; MESSENGER RNA; PHYTOSTEROL; PROTEIN ABCB11; PROTEIN ABCC2; PROTEIN ABCG5; PROTEIN FXR; PROTEIN LXR; SOYBEAN OIL; STIGMASTEROL; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE SECRETION; CELL ACTIVATION; CHOLESTASIS; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; GENE EXPRESSION; INTESTINE FLORA; INTESTINE INJURY; KUPFFER CELL; LIPID BLOOD LEVEL; LIPID COMPOSITION; LIPID LIVER LEVEL; LIVER DISEASE; LIVER INJURY; LIVER PROTECTION; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PARENTERAL NUTRITION; PARENTERAL NUTRITION ASSOCIATED LIVER DISEASE; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BILE; BILE CANALICULI; BONE MARROW CELLS; DISEASE MODELS, ANIMAL; EMULSIONS; FISH OILS; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; KUPFFER CELLS; LIPIDS; LIVER; LIVER DISEASES; MACROPHAGE ACTIVATION; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MICROBIOTA; PARENTERAL NUTRITION; PHYTOSTEROLS; SIGNAL TRANSDUCTION; SOLUTIONS; STIGMASTEROL; TOLL-LIKE RECEPTOR 4;

EID: 84885443998     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3006898     Document Type: Article

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