Environmental enrichment lessens cognitive decline in APP23 mice without affecting brain sirtuin expression

Journal of Alzheimer's Disease

Volumn 42, Issue 3, 2014, Pages 851-864

  Polito, Letizia ^a,b   Chierchia, Armando ^a   Tunesi, Marta ^c   Bouybayoune, Ihssane ^a   Kehoe, Patrick Gavin ^d   Albani, Diego ^a   Forloni, Gianluigi ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b Golgi Cenci Foundation   (Italy)

^c POLITECNICO DI MILANO   (Italy)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Alzheimer's disease; APP23 mice; cognitive impairment; environmental enrichment; sirtuin

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; INSULINASE; MEMBRANE METALLOENDOPEPTIDASE; MESSENGER RNA; SIRTUIN; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5; SIRTUIN 6; SIRTUIN 7; AMYLOID PRECURSOR PROTEIN; CD11B ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; SIRT1 PROTEIN, MOUSE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENVIRONMENTAL ENRICHMENT; HIPPOCAMPUS; MALE; MENTAL DETERIORATION; MENTAL PERFORMANCE; MORRIS WATER MAZE TEST; MOUSE; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ALZHEIMER DISEASE; ANIMAL; BRAIN; C57BL MOUSE; COGNITION DISORDERS; COMPLICATION; DISEASE MODEL; ENVIRONMENT; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MAZE TEST; METABOLISM; MUTATION; NURSING; PATHOLOGY; PHYSIOLOGY; TIME;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIGENS, CD11B; BRAIN; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ENVIRONMENT; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; SIRTUIN 1; TIME FACTORS;

EID: 84907152556     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-131430     Document Type: Article

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