Design, synthesis, and structure-activity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents

European Journal of Medicinal Chemistry

Volumn 86, Issue , 2014, Pages 257-269

  Ma, Junjie ^a   Chen, Dong ^b   Lu, Kuan ^a   Wang, Lihui ^a   Han, Xiaoqi ^a   Zhao, Yanfang ^a   Gong, Ping ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Qilu Pharmaceutical Research Institute Qilu Pharmaceutical Co Ltd   (China)

Author keywords

Antitumor; Benzothiazole; Ortho hydroxy N Carbamoylhydrazone moiety; Procaspase 3

Indexed keywords

4 (2 CHLOROBENZYLOXY) 2 HYDROXYBENZALDEHYDE; 4 (3 CHLOROBENZYLOXY) 2 HYDROXYBENZALDEHYDE; 4 (4 CHLOROBENZYLOXY) 2 HYDROXYBENZALDEHYDE; 4 (4 METHYLBENZYLOXY) 2 HYDROXYBENZALDEHYDE; 4 (4 TERT BUTYLBENZYLOXY) 2 HYDROXYBENZALDEHYDE; 4 (MORPHOLINOMETHYL)ANILINE; 4 BENZYLOXY 2 HYDROXYBENZALDEHYDE; 4 MORPHOLINOANILINE; 4 [(4 METHYLPIPERIDIN 1 YL)METHYL]ANILINE; 4 [(DIETHYLAMINO)METHYL]ANILINE; 4 [(DIMETHYLAMINO)METHYL]ANILINE; 6 (MORPHOLINOMETHYL)BENZO[D]THIAZOL 2 AMINE; 6 MORPHOLINOBENZO[D]THIAZOL 2 AMINE; 6 [(4-METHYLPIPERIDIN 1 YL)METHYL]BENZO[D]THIAZOL 2 AMINE; 6 [(DIETHYLAMINO)METHYL]BENZO[D]THIAZOL 2 AMINE; 6 [(DIMETHYLAMINO)METHYL]BENZO[D]THIAZOL 2 AMINE; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE DERIVATIVE; N (6 MORPHOLINOBENZO[D]THIAZOL 2 YL) HYDRAZINECARBOXAMIDE; N [6 (MORPHOLINOMETHYL)BENZO[D]THIAZOL 2 YL] HYDRAZINECARBOXAMIDE; N [6 [(4 METHYLPIPERIDIN 1 YL)METHYL]BENZO[D]THIAZOL 2 YL] HYDRAZINECARBOXAMIDE; N [6 [(DIETHYLAMINO)METHYL]BENZO[D]THIAZOL 2 YL] HYDRAZINECARBOXAMIDE; N [6 [(DIMETHYLAMINO)METHYL]BENZO[D]THIAZOL 2 YL] HYDRAZINECARBOXAMIDE; PHENYL 6 (MORPHOLINOMETHYL)BENZO[D]THIAZOL 2 YLCARBAMATE; PHENYL 6 MORPHOLINOBENZO[D]THIAZOL 2 YLCARBAMATE; PHENYL 6 [(4 METHYLPIPERIDIN 1 YL)METHYL]BENZO[D]THIAZOL 2 YLCARBAMATE; PHENYL 6 [(DIETHYLAMINO)METHYL]BENZO[D]THIAZOL 2 YLCARBAMATE; PHENYL 6 [(DIMETHYLAMINO)METHYL]BENZO[D]THIAZOL 2 YLCARBAMATE; PROCASPASE 3; UNCLASSIFIED DRUG; UNINDEXED DRUG; BENZOTHIAZOLE; HYDRAZINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; MEDIAN EFFECTIVE CONCENTRATION; PH; STRUCTURE ACTIVITY RELATION; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HT 29 CELL LINE; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZOTHIAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; HYDRAZINES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907005799     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.08.058     Document Type: Article

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