Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 14, 2005, Pages 3328-3332

  Yoshida, Masao ^a   Hayakawa, Ichiro ^a   Hayashi, Noriyuki ^a   Agatsuma, Toshinori ^a   Oda, Youko ^a   Tanzawa, Fumie ^a   Iwasaki, Shiho ^a   Koyama, Kumiko ^a   Furukawa, Hidehiko ^a   Kurakata, Shinichi ^a   Sugano, Yuichi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Anticancer

Indexed keywords

2 METHYL 4 NITRO 2H PYRAZOLE 3 CARBOXYLIC ACID[2 (CYCLOHEXANECARBONYLAMINO) BENZOTHIAZOL 6 YL]AMIDE; 2,6 DICHLORO N [2 (CYCLOPROPANECARBONYLAMINO)BENZOTHIAZOL 6 YL]BENZAMIDE; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZAMIDES; BENZOTHIAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; FEMALE; HUMANS; LUNG NEOPLASMS; MICE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TIME FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 20644449686     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.077     Document Type: Article

References (21)

1. J.B. Gibbs Science 287 2000 1969
2. I. Hayakawa, R. Shioya, T. Agatsuma, H. Furukawa, S. Naruto, and Y. Sugano Bioorg. Med. Chem. Lett. 14 2004 455
3. I. Hayakawa, R. Shioya, T. Agatsuma, H. Furukawa, and Y. Sugano Bioorg. Med. Chem. Lett. 14 2004 3411
4. I. Hayakawa, R. Shioya, T. Agatsuma, H. Furukawa, S. Naruto, and Y. Sugano Bioorg. Med. Chem. Lett. 14 2004 4383
5. I. Hayakawa, R. Shioya, T. Agatsuma, and Y. Sugano Chem. Pharm. Bull. 53 2005 638
6. lck inhibitors by J. Das, J. Lin, R.V. Moquin, Z. Shen, S.H. Spergel, J. Wityak, A.M. Doweyko, H.F. DeFex, Q. Fang, S. Pang, S. Pitt, D.R. Shen, G.L. Schieven, and J.C. Barrish Bioorg. Med. Chem. Lett. 13 2003 2145
7. J. Uetrechet J.S. Lee R.S. Obach M.B. Fisher Drug Metabolizing Enzymes 2003 FontisMedia and Marcel Dekker New York 87 145
8. R.E. Dolle J. Comb. Chem. 6 2004 623
9. J. Alsina, K.J. Jensen, F. Albericio, and G. Barany Chem. Eur. J. 5 1999 2787
10. K.J. Jensen, J. Alsina, M.F. Songster, J. Vágner, F. Albericio, and G. Barany J. Am. Chem. Soc. 120 1998 5441
11. C.G. Boojamra, K.M. Burrow, L.A. Thompson, and J.A. Ellman J. Org. Chem. 62 1997 1240
12. A. Nishida, M. Fuwa, S. Naruto, Y. Sugano, H. Saito, and M. Nakagawa Tetrahedron Lett. 41 2000 4791
13. IRORI, a Discovery Partners International Company: http://www. discoverypartners.com/index.html.
14. K.C. Nicolaou, J.A. Pfefferkorn, H.J. Mitchell, A.J. Roecker, S. Barluenga, G.-O. Cao, R.L. Affleck, and J.E. Lillig J. Am. Chem. Soc. 122 2000 9954
15. K.C. Nicolaou, R.M. Evans, A.J. Roecker, R. Hughes, M. Downes, and J.A. Pfefferkorn Org. Biomol. Chem. 1 2003 908
16. L. Katz J. Am. Chem. Soc. 73 1951 4007
17. M. Sedalk, J. Hanuek, M. Holcapek, and V. Sterba J. Phys. Org. Chem. 14 2001 187
18. T. Tsuruo Jpn. J. Cancer Chemother. 14 1987 2809 and other references cited therein
19. +, 448.06533. Found: 448.06831.
20. +, 407.0079. Found: 407.0076.
21. +, 409.0055. Found: 409.0056.