The TRPM4 channel inhibitor 9-phenanthrol

British Journal of Pharmacology

Volumn 171, Issue 7, 2014, Pages 1600-1613

  Guinamard, R ^a,b   Hof, T ^a   Del Negro, C A ^b  

^a France   (France)

^b The College of William and Mary   (United States)

Author keywords

9 phenanthrol; calcium activated non selective cation channel; cardioprotection; NSCCa; TRPM4

Indexed keywords

5 BUTYL 7 CHLORO 6 HYDROXYBENZO[C]QUINOLIZINIUM CHLORIDE; 9 PHENANTHROL; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; FLUFENAMIC ACID; GLIBENCLAMIDE; MESSENGER RNA; PHENANTHRENE DERIVATIVE; QUINIDINE; QUININE; RECOMBINANT PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M4; TRANSIENT RECEPTOR POTENTIAL CHANNEL M5; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CALCIUM CURRENT; CHANNEL GATING; CONCENTRATION RESPONSE; DIASTOLIC DEPOLARIZATION; DRUG EFFECT; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SPECIFICITY; DRUG STRUCTURE; EARLY AFTER DEPOLARIZATION; HEART DEPOLARIZATION; HEART FUNCTION; HEART FUNCTION MODULATION; HEART MUSCLE CELL; HEART PROTECTION; HEART RHYTHM; HEK293 CELL LINE; HUMAN; IC50; MOLECULAR DYNAMICS; MUSCLE FIBER CONTRACTION; NEUROMODULATION; NONHUMAN; OXIDATIVE STRESS; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINOATRIAL NODE CELL; SMOOTH MUSCLE FIBER; WHOLE CELL PATCH CLAMP;

9-PHENANTHROL; CALCIUM-ACTIVATED NON-SELECTIVE CATION CHANNEL; CARDIOPROTECTION; NSCCA; TRPM4;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MEMBRANE POTENTIALS; MEMBRANE TRANSPORT MODULATORS; MOLECULAR STRUCTURE; PHENANTHRENES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

EID: 84907005123     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12582     Document Type: Article

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