9-Phenanthrol, a TRPM4 Inhibitor, Protects Isolated Rat Hearts from Ischemia-Reperfusion Injury

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Wang, Jing ^a,b   Takahashi, Ken ^b   Piao, Hulin ^b,c   Qu, Peng ^a   Naruse, Keiji ^b  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b OKAYAMA UNIVERSITY   (Japan)

^c THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

9 PHENANTHROL; CARDIOVASCULAR AGENT; LACTATE DEHYDROGENASE; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME RELEASE; HEART INFARCTION; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISOLATED HEART; MALE; NONHUMAN; RAT; REPERFUSION INJURY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BIOLOGICAL MARKERS; CARDIOTONIC AGENTS; DECANOIC ACIDS; ENZYME INHIBITORS; GLUCOSE; HEART; HYDROXY ACIDS; KATP CHANNELS; L-LACTATE DEHYDROGENASE; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; TROMETHAMINE; TRPM CATION CHANNELS;

EID: 84880812128     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070587     Document Type: Article

References (30)

1. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ, (2006) Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367: 1747-1757.
2. Guo Y, Tukaye DN, Wu WJ, Zhu X, Book M, et al. (2012) The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning. Plos One 7: e41178.
3. Minamino T, (2012) Cardioprotection from ischemia/reperfusion injury: basic and translational research. Circ J 76: 1074-1082.
4. Kloner RA, Rezkalla SH, (2006) Preconditioning, postconditioning and their application to clinical cardiology. Cardiovasc Res 70: 297-307.
5. Sanbe A, Marunouchi T, Yamauchi J, Tanonaka K, Nishigori H, et al. (2011) Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice. Plos One 6: e18922.
6. Das DK, Maulik N, (2006) Cardiac genomic response following preconditioning stimulus. Cardiovasc Res 70: 254-263.
7. Ovize M, Kloner RA, Przyklenk K, (1994) Stretch preconditions canine myocardium. Am J Physiol 266: H137-146.
8. Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, et al. (2002) TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell 109: 397-407.
9. Liu H, El Zein L, Kruse M, Guinamard R, Beckmann A, et al. (2012) Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease. Circ Cardiovasc Genet 3: 374-385.
10. Kruse M, Schulze-Bahr E, Corfield V, Beckmann A, Stallmeyer B, et al. (2009) Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I. J Clin Invest. 119: 2737-2744.
11. Grand T, Demion M, Norez C, Mettey Y, Launay P, et al. (2008) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br J Pharmacol 153: 1697-1705.
12. Gonzales AL, Garcia ZI, Amberg GC, Earley S, (2012) Pharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle. Am J Physiol Cell Physiol 299: C1195-1202.
13. Simard C, Salle L, Rouet R, Guinamard R, (2012) Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br J Pharmacol 165: 2354-2364.
14. Sutherland FJ, Hearse DJ, (2000) The isolated blood and perfusion fluid perfused heart. Pharmacol Res 41: 613-627.
15. Schultz JE, Qian YZ, Gross GJ, Kukreja RC, (1997) The ischemia-selective KATP channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart. J Mol Cell Cardiol 29: 1055-1060.
16. Wang L, Cherednichenko G, Hernandez L, Halow J, Camacho SA, et al. (2001) Preconditioning limits mitochondrial Ca(2+) during ischemia in rat hearts: role of K(ATP) channels. Am J Physiol Heart Circ Physiol 280: H2321-2328.
17. Khalil PN, Siebeck M, Huss R, Pollhammer M, Khalil MN, et al. (2006) Histochemical assessment of early myocardial infarction using 2,3,5-triphenyltetrazolium chloride in blood-perfused porcine hearts. J Pharmacol Toxicol Methods 54: 307-312.
18. Schneider CA, Rasband WS, Eliceiri KW, (2012) NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9: 671-675.
19. Ono N, Yamaguchi T, Ishikawa H, Arakawa M, Takahashi N, et al. (2009) Morphological varieties of the Purkinje fiber network in mammalian hearts, as revealed by light and electron microscopy. Arch Histol Cytol 72: 139-149.
20. Airey JA, Almeida-Porada G, Colletti EJ, Porada CD, Chamberlain J, et al. (2004) Human mesenchymal stem cells form Purkinje fibers in fetal sheep heart. Circulation 109: 1401-1407.
21. Cavalheiro RA, Marin RM, Rocco SA, Cerqueira FM, da Silva CC, et al. (2010) Potent cardioprotective effect of the 4-anilinoquinazoline derivative PD153035: involvement of mitochondrial K(ATP) channel activation. Plos One 5: e10666.
22. Alizadeh AM, Faghihi M, Sadeghipour HR, Mohammadghasemi F, Imani A, et al. (2010) Oxytocin protects rat heart against ischemia-reperfusion injury via pathway involving mitochondrial ATP-dependent potassium channel. Peptides 31: 1341-1345.
23. Takeuchi T, Ishii Y, Kikuchi K, Hasebe N, (2011) Ischemic preconditioning effect of prodromal angina is attenuated in acute myocardial infarction patients with hypertensive left ventricular hypertrophy. Circ J 75: 1192-1199.
24. Lee TM, Chou TF, (2003) Impairment of myocardial protection in type 2 diabetic patients. J Clin Endocrinol Metab 88: 531-537.
25. Abriel H, Syam N, Sottas V, Amarouch MY, Rougier JS, (2012) TRPM4 channels in the cardiovascular system: Physiology, pathophysiology, and pharmacology. Biochem Pharmacol 84: 873-881.
26. Simon F, Leiva-Salcedo E, Armisen R, Riveros A, Cerda O, et al. (2010) Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death. J Biol Chem 285: 37150-37158.
27. Simard JM, Woo SK, Gerzanich V, (2012) Transient receptor potential melastatin 4 and cell death. Pflugers Arch 464: 573-582.
28. Becerra A, Echeverria C, Varela D, Sarmiento D, Armisen R, et al. (2011) Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death. Cardiovasc Res 91: 677-684.
29. Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, et al. (2012) TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med 18: 1805-1811.
30. Sayk F, Kruger S, Bechtel JF, Feller AC, Sievers HH, et al. (2004) Significant damage of the conduction system during cardioplegic arrest is due to necrosis not apoptosis. Eur J Cardiothorac Surg 25: 801-806.