Molecular Genetics and Functional Anomalies in a Series of 248 Brugada Cases with 11 Mutations in the TRPM4 Channel

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Liu, Hui ^a,b   Chatel, Stéphanie ^c,d   Simard, Christophe ^e   Syam, Ninda ^f   Salle, Laurent ^e   Probst, Vincent ^c,d   Morel, Julie ^e   Millat, Gilles ^a,h   Lopez, Michel ^g   Abriel, Hugues ^f   Schott, Jean Jacques ^c,d   Guinamard, Romain ^e   Bouvagnet, Patrice ^a,b  

^a HOSPICES CIVILS DE LYON   (France)

^b UNIVERSITÉ LYON 1   (France)

^c L INSTITUT DU THORAX   (France)

^d UNIVERSITÉ DE NANTES   (France)

^e France   (France)

^f UNIVERSITY OF BERN   (Switzerland)

^g Hôpital Saint Luc Saint Joseph   (France)

^h University Claude Bernard Lyon 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; SODIUM CHANNEL NAV1.5; TRANSIENT RECEPTOR POTENTIAL CHANNEL M4;

ADULT; AGED; ANION TO CATION PERMEABILITY RATIO; ARTICLE; BIFASCICULAR BLOCK; BRUGADA SYNDROME; CELL MEMBRANE CONDUCTANCE; CELL STRAIN HEK293; CELL SURFACE; CHEMICAL PARAMETERS; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA POLYMORPHISM; DNA SCREENING; ELECTRIC POTENTIAL; FEMALE; GENE; GENE EXPRESSION; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HEART BLOCK; HEART RIGHT BUNDLE BRANCH BLOCK; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MOLECULAR GENETICS; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; QRS COMPLEX; SENSITIVITY ANALYSIS; SODIUM CHANNEL 5 ALPHA SUBUNIT GENE; TRANSIENT RECEPTOR POTENTIAL MELASTIN PROTEIN NUMBER 4 GENE;

ADULT; ALLELES; BRUGADA SYNDROME; DEATH, SUDDEN, CARDIAC; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; MALE; MEMBRANE POTENTIALS; MIDDLE AGED; MUTATION; SODIUM CHANNELS; TRPM CATION CHANNELS;

EID: 84873828417     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054131     Document Type: Article

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