Intracellular nucleotides and polyamines inhibit the Ca2+- activated cation channel TRPM4b

Pflugers Archiv European Journal of Physiology

Volumn 448, Issue 1, 2004, Pages 70-75

  Nilius, Bernd ^a   Prenen, Jean ^a   Voets, Thomas ^a   Droogmans, Guy ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Ca2+ activated cation channels; Intracellular nucleotides; Polyamines; TRPM4b (transient receptor potential channel, melastatin subfamily)

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL; CALCIUM ION; CATION CHANNEL; CYTIDINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE; ION CHANNEL; MAGNESIUM ION; MEMBRANE PROTEIN; NUCLEOTIDE; POLYAMINE; SPERMINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL MELASTATIN SUBFAMILY 4B; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE; VOLTAGE GATED CALCIUM CHANNEL;

ARTICLE; CALCIUM CELL LEVEL; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; ION TRANSPORT; KIDNEY; MEMBRANE CURRENT; PATCH CLAMP; PRIORITY JOURNAL;

ADENINE NUCLEOTIDES; CALCIUM; CALCIUM CHANNELS; CATION TRANSPORT PROTEINS; CELL LINE; CELLS, CULTURED; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY; PATCH-CLAMP TECHNIQUES; SPERMINE; TRPM CATION CHANNELS;

EID: 2442653881     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-003-1221-x     Document Type: Article

References (23)

1. Clapham DE, Runnels LW, Strubing C (2001) The trp ion channel family. Nature Rev Neurosci 2:387-396
2. Fernandez AI, Cantabrana B, Sanchez M, Hidalgo A (1995) Extracellular and intracellular effects of polyamines on smooth muscle contractions. Life Sci 57:855-861
3. 2+-activated nonselective cation channel during dedifferentiation of cultured rat ventricular cardiomyocytes. J Membr Biol 188:127-135
4. Halonen J, Nedergaard J (2002) Adenosine 5′-monophosphate is a selective inhibitor of the brown adipocyte nonselective cation channel. J Membr Biol 188:183-197
5. 2+-activated monovalent selective cation channel. Curr Biol 13:1153-1158
6. Hurwitz CG, Hu VY, Segal AS (2002) A mechanogated nonselective cation channel in proximal tubule that is ATP sensitive. Am J Physiol 283:F93-F104
7. Kerschbaum HH, Kozak JA, Cahalan MD (2003) Polyvalent cations as permeant probes of MIC and TRPM7 pores. Biophys J 84:2293-2305
8. Kubo Y, Murata Y (2001) Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel. J Physiol (Lond) 531:645-660
9. 2+-activated nonselective cation channel mediating cell membrane depolarization. Cell 109:397-407
10. 2+-activated cation channel from hamster vomeronasal sensory neurons. J Physiol (Lond) 548:777-787
11. +] dependence of polyamine-induced rectification in inward rectifier potassium channels (IRK1, Kir2.1). J Gen Physiol 108:105-113
12. Mott DD, Washburn MS, Zhang S, Dingledine RJ (2003) Subunit-dependent modulation of kainate receptors by extracellular protons and polyamines. J Neurosci 23:1179-1188
13. 2+-activated cation channel TRPM4. J Biol Chem 278:30813-30820
14. 2+. Cell Calcium 29:417-428
15. 2+ channel ECaC. Br J Pharmacol 134:453-462
16. i. Proc Natl Acad Sci USA 100:15166-15171
17. Sabirov RZ, Prenen J, Tomita T, Droogmans G, Nilius B (2000) Reduction of ionic strength activates single volume-regulated anion channels (VRAC) in endothelial cells. Pflugers Arch 439:315-320
18. 2+-activated non-selective cation current in macrovascular endothelial cells. Pflugers Arch 444:438-445
19. Vennekens R, Voets T, Bindels RJ, Droogmans G, Nilius B (2002) Current understanding of mammalian TRP homologues. Cell Calcium 31:253-264
20. 2+-dependent gating and strong inward rectification of the cation channel TRPV6. J Gen Physiol 121:245-260
21. Voets T, Prenen J, Fleig A, Vennekens R, Watanabe H, Hoenderop JGJ, Bindels RJM, Droogmans G, Penner R, Nilius B (2001) CaT1 and the calcium release-activated calcium channel manifest distinct pore properties. J Biol Chem 276:47767-47770
22. Voets T, Prenen J, Vriens J, Watanabe H, Janssens A, Wissenbach U, Bödding M, Droogmans G, Nilius B (2002) Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem 277:33704-33710
23. Washburn MS, Dingledine R (1996) Block of alpha-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid (AMPA) receptors by polyamines and polyamine toxins. J Pharmacol Exp Ther 278:669-678