Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 36, 2014, Pages 13057-13062

  Boiteux, Céline ^a   Vorobyov, Igor ^b   French, Robert J ^c   French, Christopher ^d   Yarov Yarovoy, Vladimir ^e   Allen, Toby W ^a,b  

^a RMIT UNIVERSITY   (Australia)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bacterial sodium channel; Drug binding

Indexed keywords

ANTICONVULSIVE AGENT; ARTIFICIAL MEMBRANE; BENZOCAINE; LOCAL ANESTHETIC AGENT; PHENYTOIN; PROTEIN SUBUNIT; VOLTAGE GATED SODIUM CHANNEL;

AMINO ACID SEQUENCE; ARCOBACTER; ARTIFICIAL MEMBRANE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN SUBUNIT; SEQUENCE ALIGNMENT; THERMODYNAMICS;

AMINO ACID SEQUENCE; ANESTHETICS, LOCAL; ANTICONVULSANTS; ARCOBACTER; BENZOCAINE; BINDING SITES; COMPUTER SIMULATION; MEMBRANES, ARTIFICIAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHENYTOIN; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; SEQUENCE ALIGNMENT; THERMODYNAMICS; VOLTAGE-GATED SODIUM CHANNELS;

EID: 84907001506     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1408710111     Document Type: Article

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