Modulation of a voltage-gated Na+ channel by sevoflurane involves multiple sites and distinct mechanisms

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 18, 2014, Pages 6726-6731

  Barber, Annika F ^a   Carnevale, Vincenzo ^b   Klein, Michael L ^b   Eckenhoff, Roderic G ^c   Covarrubias, Manuel ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b Temple University   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Anesthesia; Anesthetics; MD simulations; Membrane proteins

Indexed keywords

SEVOFLURANE; SODIUM ION; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; ELECTROPHYSIOLOGY; GENERAL ANESTHESIA; MOLECULAR DYNAMICS; PRIORITY JOURNAL;

ANESTHESIA; ANESTHETICS; MD SIMULATIONS; MEMBRANE PROTEINS;

ANESTHETICS, INHALATION; BACTERIAL PROTEINS; BINDING SITES; ELECTROPHYSIOLOGICAL PHENOMENA; HEK293 CELLS; HUMANS; ION CHANNEL GATING; KINETICS; METHYL ETHERS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SODIUM CHANNELS;

EID: 84899840455     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1405768111     Document Type: Article

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