Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding

Molecular Pharmacology

Volumn 76, Issue 4, 2009, Pages 861-871

  Yamagishi, Toshio ^a   Xiong, Wei ^a   Kondratiev, Andre ^a   Vélez, Patricio ^a   Méndez Fitzwilliam, Ailsa ^a   Balser, Jeffrey R ^b   Marbán, Eduardo ^a   Tomaselli, Gordon F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; LIDOCAINE ETHOBROMIDE; LOCAL ANESTHETIC AGENT; VOLTAGE GATED SODIUM CHANNEL;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; GENE MUTATION; HUMAN; HUMAN CELL; LOCAL ANESTHESIA; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; SKELETAL MUSCLE;

ANESTHETICS, LOCAL; ANIMALS; ION CHANNEL GATING; KINETICS; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUTAGENESIS, SITE-DIRECTED; RATS; SODIUM CHANNELS;

EID: 70349334284     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.055863     Document Type: Article

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