Lidocaine reduces the transition to slow inactivation in Na v1.7 voltage-gated sodium channels

British Journal of Pharmacology

Volumn 164, Issue 2 B, 2011, Pages 719-730

  Sheets, Patrick L ^a,b   Jarecki, Brian W ^a,c   Cummins, Theodore R ^a  

^a INDIANA UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

channelopathies; inactivation; local anaesthetics; Na v1.7; neuropathic pain; voltage gated sodium channel

Indexed keywords

LIDOCAINE; SODIUM CHANNEL NAV1.7;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DRUG INHIBITION; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR RECORDING; PAIN; PATCH CLAMP; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; WHOLE CELL;

ACTION POTENTIALS; ANESTHETICS, LOCAL; CELLS, CULTURED; HEK293 CELLS; HUMANS; LIDOCAINE; MUTATION; NEURONS; PAIN; PATCH-CLAMP TECHNIQUES; SODIUM CHANNELS; TETRODOTOXIN;

EID: 80052237889     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01209.x     Document Type: Article

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