Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 23, 2014, Pages 8428-8433

  Bagnéris, Claire ^a   DeCaen, Paul G ^b,c   Naylor, Claire E ^a   Pryde, David C ^d   Nobeli, Irene ^a   Clapham, David E ^b,c   Wallace, B A ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Crystal structure; Pharmacology

Indexed keywords

LAMOTRIGINE; LIDOCAINE; LIDOCAINE ETHOBROMIDE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL NAV1.1; TAMOXIFEN; TAMOXIFEN DERIVATIVE; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; CRYSTAL STRUCTURE; ELECTROPHYSIOLOGY; MAGNETOCOCCUS MARINUS; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROKARYOTE; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN STRUCTURE;

CRYSTAL STRUCTURE; PHARMACOLOGY;

ALPHAPROTEOBACTERIA; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TRIAZINES;

EID: 84902161802     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1406855111     Document Type: Article

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