Slow sodium channel inactivation and use-dependent block modulated by the same domain IV S6 residue

Journal of Membrane Biology

Volumn 207, Issue 2, 2005, Pages 107-117

  Carboni, M ^a   Zhang, Z S ^a   Neplioueva, V ^a   Starmer, C F ^a   Grant, A O ^a  

^a NONE

Author keywords

Anti arrhythmic drug action; Cardiac sodium channel; Slow inactivation

Indexed keywords

LIDOCAINE; SODIUM CHANNEL; THIOL DERIVATIVE;

ARTICLE; BINDING SITE; CHANNEL GATING; CHEMICAL MODIFICATION; CONTROLLED STUDY; COVALENT BOND; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; MUTATION; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; STEADY STATE;

ANTI-ARRHYTHMIA AGENTS; GENE SILENCING; HUMANS; MEMBRANE POTENTIALS; MUSCLE PROTEINS; PATCH-CLAMP TECHNIQUES; PHENYLALANINE; SODIUM CHANNELS;

EID: 32544449654     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-005-0805-0     Document Type: Article

References (28)

1. Bai, C.-X., Glaaser, I.W., Sawanobori, T., Sunami, A. 2003. Involvement of local anesthetic binding sites on IVS6 of sodium channels in fast and slow inactivation. Neurosci. Lett. 337:41-45
2. Bean, B.P., Shrager, P., Goldstein, D.A. 1981. Modification of sodium and potassium channel gating kinetics by ether and halothane. J. Gen. Physiol. 77:233-253
3. Bendahhou, S., Cummins, T.R., Tawil, R., Waxman, S.G., Ptacek, L.J. 1999. Activation and inactivation of the voltage-gated sodium channel: Role of segment S5 revealed by a novel hyperkalaemic periodic paralysis mutation. J. Neuroscience 19:4762-4771
4. Brocklehurst, K. 1979. Specific covalent modification of thiols: Applications in the study of enzymes and other biomolecules. Int. J. Biochem. 10:259-274
5. Gilliam, F.R.I., Starmer, C.F., Grant, A.O. 1989. Blockade of rabbit atrial sodium channels by lidocaine: Characterization of continuous and frequency-dependent blocking. Circ. Res. 65:723-739
6. Grant, A.O., Chandra, R., Keller, C., Carboni, M., Starmer, C.F. 2000. Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells. Biophys. J. 79:3019-3035
7. Grant, A.O., Wendt, D.J., Zilberter Y., Starmer, C.F. 1993. Kinetics of interaction of disopyramide with the cardiac sodium channel: Fast dissociation from open channels at normal rest potentials. J. Membrane Biol. 136:199-214
8. Hondeghem, L.M., Katzung, B.G. 1977. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim. Biophys. Acta. 472:373-398
9. Kambouris, N.G., Hastings, L.A., Stepanovic, S., Marban, E., Tomaselli, G.F., Basler, J.R. 1998. Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat μ1 skeletal muscle sodium channel. J. Physiol. 512:693-705
10. Khodorov, B., Shishkova, L., Peganov, E., Revenko, S. 1976. Inhibition of sodium currents in frog Ranvier node treated with local anesthetics. Role of slow sodium inactivation. Biochim. et Biophy. Acta 433:409-435
11. + channels open channel block by propafenone and pragmalium. Pfluegers Arch. 408:R 38
12. Lee, S.-Y., MaCKinnon, R. 2004. A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature 430:232-235
13. Li, H.-L., Galue, A., Meadows, L., Ragsdale, D.S. 1999. A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel. Molec. Pharmacol. 55:134-141
14. Matsuki, N., Quandt, F.N., Ten Eick, R.E., Yeh, J.Z. 1984. Characterization of the block of sodium channels by phenytoin in mouse neuroblastoma Cells. J. Pharamacol. Exp. Ther. 228:523-530
15. Mitrovoic, N., George Jr., A.L., Horn, R. 2000. Role of domain 4 in sodium channel slow inactivation. J. Gen. Physiol. 115:707-717
16. Ong, B., Tomaselll, G., Basler, J. 2000. A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence. J. Gen. Physiol. 116:653-661
17. + channels by local anesthetics. Science 265:1724-1728
18. Rudy, B. 1978. Slow inactivation of the sodium conductance in squid giant axons. Pronase resistance. J. Physiol. 283:1-21
19. Stricharytz, G.R. 1973. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J. Gen. Physiol. 62:37-57
20. + channel to methanethio-sulfonate reagents. J. Physiol. 561:403-413
21. + channels. J. Gen. Physiol. 111:83-93
22. + channels. J. Gen. Physiol. 113:7-16
23. Vilin, Y.Y., Makita, N., George Jr., A.L., Ruben, P.C. 1999. Structural determinants of slow inactivation in human cardiac and skeletal muscle sodium channels. Biophys. J. 77:1384-1393
24. Wang, S.-Y., Wang, G.K. 1997. A Mutation in segment I-S6 Alter slow inactivation of sodium channels. Biophys. J. 72:1633-1640
25. Zaborovskaya, L.D., Khodorov, B.I. 1984. The role of inactivation in the cumulative blockage of voltage-dependent sodium channels by local anesthetics and antiarrhythmics. Gen. Physiol. Biophys. 3:517-520
26. Zhu, G., Zhang, Y., Xu, J., Hang, C. 1998. Identification of endogenous outward currents in the human embryonic kidney (HEK293) cell line. J. Neuroci. Methods 81:73-83
27. Zilberter, Y., Motin, L., Sokolova, S., Papin., A., Khodorov, B. 1991. Ca-sensitive slow inactivation and lidocaine-induced block of sodium channels in rat cardiac cells. J. Mol. Cell Cardiol. 23:Suppl 1, 61-72
28. Zilberter, Y.I., Motin, L.G. 1991. Existence of two fast inactivation states in cardiac Na channels confirmed by two-stage of proteolytic enzymes. Biochim. Biophys. Acta. 1068:77-80