-
1
-
-
34247604930
-
When good drugs go bad
-
Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, et al. (2007) When good drugs go bad. Nature 446: 975-977.
-
(2007)
Nature
, vol.446
, pp. 975-977
-
-
Giacomini, K.M.1
Krauss, R.M.2
Roden, D.M.3
Eichelbaum, M.4
Hayden, M.R.5
-
2
-
-
0035291754
-
Drug-related morbidity and mortality: Updating the cost-of-illness model
-
Ernst FR, Grizzle AJ (2001) Drug-related morbidity and mortality: updating the cost-of-illness model. J Am Pharm Assoc (Wash) 41: 192-199.
-
(2001)
J Am Pharm Assoc (Wash)
, vol.41
, pp. 192-199
-
-
Ernst, F.R.1
Grizzle, A.J.2
-
3
-
-
84875446195
-
The economic costs of diabetes: Is it time for a new treatment paradigm?
-
Herman WH (2013) The Economic Costs of Diabetes: Is It Time for a New Treatment Paradigm? Diabetes Care 36: 775-776.
-
(2013)
Diabetes Care
, vol.36
, pp. 775-776
-
-
Herman, W.H.1
-
4
-
-
77950507168
-
Heart failure events with rosiglitazone in type 2 diabetes: Data from the RECORD clinical trial
-
Komajda M, McMurray JJ, Beck-Nielsen H, Gomis R, Hanefeld M, et al. (2010) Heart failure events with rosiglitazone in type 2 diabetes: data from the RECORD clinical trial. Eur Heart J 31: 824-831.
-
(2010)
Eur Heart J
, vol.31
, pp. 824-831
-
-
Komajda, M.1
McMurray, J.J.2
Beck-Nielsen, H.3
Gomis, R.4
Hanefeld, M.5
-
5
-
-
55749105531
-
Cardiovascular events associated with rofecoxib: Final analysis of the APPROVe trial
-
Baron JA, Sandler RS, Bresalier RS, Lanas A, Morton DG, et al. (2008) Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial. Lancet 372: 1756-1764.
-
(2008)
Lancet
, vol.372
, pp. 1756-1764
-
-
Baron, J.A.1
Sandler, R.S.2
Bresalier, R.S.3
Lanas, A.4
Morton, D.G.5
-
6
-
-
84870774465
-
Reducing safety-related drug attrition: The use of in vitro pharmacological profiling
-
Bowes J, Brown AJ, Hamon J, Jarolimek W, Sridhar A, et al. (2012) Reducing safety-related drug attrition: The use of in vitro pharmacological profiling. Nat Rev Drug Discov 11: 909-922.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 909-922
-
-
Bowes, J.1
Brown, A.J.2
Hamon, J.3
Jarolimek, W.4
Sridhar, A.5
-
7
-
-
26944446576
-
Keynote review: In vitro safety pharmacology profiling: An essential tool for successful drug development
-
Whitebread S, Hamon J, Bojanic D, Urban L (2005) Keynote review: In vitro safety pharmacology profiling: An essential tool for successful drug development. Drug Discovery Today 10: 1421-1433.
-
(2005)
Drug Discovery Today
, vol.10
, pp. 1421-1433
-
-
Whitebread, S.1
Hamon, J.2
Bojanic, D.3
Urban, L.4
-
8
-
-
32344440237
-
Analysis of druginduced effect patterns to link structure and side effects of medicines
-
Fliri AF, Loging WT, Thadeio PF, Volkmann RA (2005) Analysis of druginduced effect patterns to link structure and side effects of medicines. Nat Chem Biol 1: 389-397.
-
(2005)
Nat Chem Biol
, vol.1
, pp. 389-397
-
-
Fliri, A.F.1
Loging, W.T.2
Thadeio, P.F.3
Volkmann, R.A.4
-
9
-
-
84896508914
-
Predicting drug- target interactions using probabilistic matrix factorization
-
Cobanoglu MC, Liu C, Hu F, Oltvai ZN, Bahar I (2013) Predicting Drug- Target Interactions Using Probabilistic Matrix Factorization. Journal of Chemical Information and Modeling 53: 3399-3409.
-
(2013)
Journal of Chemical Information and Modeling
, vol.53
, pp. 3399-3409
-
-
Cobanoglu, M.C.1
Liu, C.2
Hu, F.3
Oltvai, Z.N.4
Bahar, I.5
-
10
-
-
47249146126
-
Drug target identification using side-effect similarity
-
Campillos M, Kuhn M, Gavin A-C, Jensen LJ, Bork P (2008) Drug Target Identification Using Side-Effect Similarity. Science 321: 263-266.
-
(2008)
Science
, vol.321
, pp. 263-266
-
-
Campillos, M.1
Kuhn, M.2
Gavin, A.-C.3
Jensen, L.J.4
Bork, P.5
-
11
-
-
79955969387
-
Predicting drug side-effect profiles: A chemical fragment-based approach
-
Pauwels E, Stoven V, Yamanishi Y (2011) Predicting drug side-effect profiles: A chemical fragment-based approach. BMC Bioinformatics 12: 169.
-
(2011)
BMC Bioinformatics
, vol.12
-
-
Pauwels, E.1
Stoven, V.2
Yamanishi, Y.3
-
13
-
-
84871595040
-
Drug side-effect prediction based on the integration of chemical and biological spaces
-
Yamanishi Y, Pauwels E, Kotera M (2012) Drug side-effect prediction based on the integration of chemical and biological spaces. J Chem Inf Model 52: 3284- 3292.
-
(2012)
J Chem Inf Model
, vol.52
, pp. 3284-3292
-
-
Yamanishi, Y.1
Pauwels, E.2
Kotera, M.3
-
14
-
-
84863548955
-
Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs
-
Liu M, Wu Y, Chen Y, Sun J, Zhao Z, et al. (2012) Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs. Journal of the American Medical Informatics Association 19: e28-e35.
-
(2012)
Journal of the American Medical Informatics Association
, vol.19
, pp. e28-e35
-
-
Liu, M.1
Wu, Y.2
Chen, Y.3
Sun, J.4
Zhao, Z.5
-
16
-
-
84866460840
-
Relating drugprotein interaction network with drug side effects
-
Mizutani S, Pauwels E, Stoven V, Goto S, Yamanishi Y (2012) Relating drugprotein interaction network with drug side effects. Bioinformatics 28: i522-i528.
-
(2012)
Bioinformatics
, vol.28
, pp. i522-i528
-
-
Mizutani, S.1
Pauwels, E.2
Stoven, V.3
Goto, S.4
Yamanishi, Y.5
-
17
-
-
38549182474
-
Super target and matador: Resources for exploring drug-target relationships
-
Gunther S, Kuhn M, Dunkel M, Campillos M, Senger C, et al. (2008) Super Target and Matador: resources for exploring drug-target relationships. Nucleic Acids Res 36: D919-D922.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. D919-D922
-
-
Gunther, S.1
Kuhn, M.2
Dunkel, M.3
Campillos, M.4
Senger, C.5
-
18
-
-
76149120425
-
A side effect resource to capture phenotypic effects of drugs
-
Kuhn M, Campillos M, Letunic I, Jensen LJ, Bork P (2010) A side effect resource to capture phenotypic effects of drugs. Mol Syst Biol 6: 343.
-
(2010)
Mol Syst Biol
, vol.6
-
-
Kuhn, M.1
Campillos, M.2
Letunic, I.3
Jensen, L.J.4
Bork, P.5
-
19
-
-
0037805576
-
The KEGG database
-
discussion 101-103, 119-128, 244-152
-
Kanehisa M (2002) The KEGG database. Novartis Found Symp 247: 91-101; discussion 101-103, 119-128, 244-152.
-
(2002)
Novartis Found Symp
, vol.247
, pp. 91-101
-
-
Kanehisa, M.1
-
20
-
-
0346801873
-
The Gene Ontology (GO) database and informatics resource
-
Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, et al. (2004) The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res 32: D258- D261.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. D258-D261
-
-
Harris, M.A.1
Clark, J.2
Ireland, A.3
Lomax, J.4
Ashburner, M.5
-
21
-
-
84881116194
-
Systematic identification of proteins that elicit drug side effects
-
Kuhn M, Al Banchaabouchi M, Campillos M, Jensen LJ, Gross C, et al. (2013) Systematic identification of proteins that elicit drug side effects. Mol Syst Biol 9: 663.
-
(2013)
Mol Syst Biol
, vol.9
-
-
Kuhn, M.1
Al, B.M.2
Campillos, M.3
Jensen, L.J.4
Gross, C.5
-
22
-
-
77449114835
-
Predicting drug side-effects by chemical systems biology
-
Tatonetti NP, Liu T, Altman RB (2009) Predicting drug side-effects by chemical systems biology. Genome Biol 10: 238.
-
(2009)
Genome Biol
, vol.10
-
-
Tatonetti, N.P.1
Liu, T.2
Altman, R.B.3
-
23
-
-
65249092595
-
Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis
-
Scheiber J, Chen B, Milik M, Sukuru SCK, Bender A, et al. (2009) Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis. Journal of Chemical Information and Modeling 49: 308-317.
-
(2009)
Journal of Chemical Information and Modeling
, vol.49
, pp. 308-317
-
-
Scheiber, J.1
Chen, B.2
Milik, M.3
Sukuru, S.C.K.4
Bender, A.5
-
24
-
-
84255163374
-
Predicting adverse side effects of drugs
-
Huang LC, Wu X, Chen JY (2011) Predicting adverse side effects of drugs. BMC Genomics 12 Suppl 5: S11.
-
(2011)
BMC Genomics
, vol.12
, pp. S11
-
-
Huang, L.C.1
Wu, X.2
Chen, J.Y.3
-
25
-
-
84872733056
-
Predicting adverse drug reaction profiles by integrating protein interaction networks with drug structures
-
Huang LC, Wu X, Chen JY (2013) Predicting adverse drug reaction profiles by integrating protein interaction networks with drug structures. Proteomics 13: 313-324.
-
(2013)
Proteomics
, vol.13
, pp. 313-324
-
-
Huang, L.C.1
Wu, X.2
Chen, J.Y.3
-
26
-
-
0033954256
-
The protein data bank
-
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, et al. (2000) The Protein Data Bank. Nucleic Acids Res 28: 235-242.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 235-242
-
-
Berman, H.M.1
Westbrook, J.2
Feng, Z.3
Gilliland, G.4
Bhat, T.N.5
-
27
-
-
68249128647
-
Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome
-
Yang L, Chen J, He L (2009) Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome. PLoS Comput Biol 5: e1000441.
-
(2009)
PLoS Comput Biol
, vol.5
, pp. e1000441
-
-
Yang, L.1
Chen, J.2
He, L.3
-
28
-
-
84862510972
-
Large-scale prediction and testing of drug activity on side-effect targets
-
Lounkine E, Keiser MJ, Whitebread S, Mikhailov D, Hamon J, et al. (2012) Large-scale prediction and testing of drug activity on side-effect targets. Nature 486: 361-367.
-
(2012)
Nature
, vol.486
, pp. 361-367
-
-
Lounkine, E.1
Keiser, M.J.2
Whitebread, S.3
Mikhailov, D.4
Hamon, J.5
-
29
-
-
77957954504
-
A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways
-
Wallach I, Jaitly N, Lilien R (2010) A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways. PLoS One 5: e12063.
-
(2010)
PLoS One
, vol.5
, pp. e12063
-
-
Wallach, I.1
Jaitly, N.2
Lilien, R.3
-
30
-
-
67049100457
-
Drug discovery using chemical systems biology: Identification of the protein-ligand binding network to explain the side effects of CETP inhibitors
-
Xie L, Li J, Xie L, Bourne PE (2009) Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network to Explain the Side Effects of CETP Inhibitors. PLoS Computational Biology 5(5): e1000387.
-
(2009)
PLoS Computational Biology
, vol.5
, Issue.5
, pp. e1000387
-
-
Xie, L.1
Li, J.2
Xie, L.3
Bourne, P.E.4
-
31
-
-
84891723065
-
Project ranks billions of drug interactions
-
Reardon S (2013) Project ranks billions of drug interactions. Nature 503: 449- 450.
-
(2013)
Nature
, vol.503
, pp. 449-450
-
-
Reardon, S.1
-
33
-
-
84875366733
-
Message passing interface and multithreading hybrid for parallel molecular docking of large databases on petascale high performance computing machines
-
Zhang X, Wong SE, Lightstone FC (2013) Message passing interface and multithreading hybrid for parallel molecular docking of large databases on petascale high performance computing machines. J Comput Chem 34: 915-927.
-
(2013)
J Comput Chem
, vol.34
, pp. 915-927
-
-
Zhang, X.1
Wong, S.E.2
Lightstone, F.C.3
-
34
-
-
33750991346
-
Benchmarking sets for molecular docking
-
Huang N, Shoichet BK, Irwin JJ (2006) Benchmarking sets for molecular docking. J Med Chem 49: 6789-6801.
-
(2006)
J Med Chem
, vol.49
, pp. 6789-6801
-
-
Huang, N.1
Shoichet, B.K.2
Irwin, J.J.3
-
35
-
-
84893388298
-
Toward fully automated high performance computing drug discovery: A massively parallel virtual screening pipeline for docking and molecular mechanics/generalized born surface area rescoring to improve enrichment
-
Zhang X, Wong SE, Lightstone FC (2014) Toward Fully Automated High Performance Computing Drug Discovery: A Massively Parallel Virtual Screening Pipeline for Docking and Molecular Mechanics/Generalized Born Surface Area Rescoring to Improve Enrichment. J Chem Inf Model 54: 324- 337.
-
(2014)
J Chem Inf Model
, vol.54
, pp. 324-337
-
-
Zhang, X.1
Wong, S.E.2
Lightstone, F.C.3
-
37
-
-
0032991290
-
The medical dictionary for regulatory activities (MedDRA)
-
Brown EG, Wood L, Wood S (1999) The medical dictionary for regulatory activities (MedDRA). Drug Saf 20: 109-117.
-
(1999)
Drug Saf
, vol.20
, pp. 109-117
-
-
Brown, E.G.1
Wood, L.2
Wood, S.3
-
38
-
-
84877633286
-
Rapid catalytic template searching as an enzyme function prediction procedure
-
Nilmeier JP, Kirshner DA, Wong SE, Lightstone FC (2013) Rapid catalytic template searching as an enzyme function prediction procedure. PLoS One 8: e62535.
-
(2013)
PLoS One
, vol.8
, pp. e62535
-
-
Nilmeier, J.P.1
Kirshner, D.A.2
Wong, S.E.3
Lightstone, F.C.4
-
39
-
-
84883562020
-
Catalytic site identification-A web server to identify catalytic site structural matches throughout PDB
-
Kirshner DA, Nilmeier JP, Lightstone FC (2013) Catalytic site identification-a web server to identify catalytic site structural matches throughout PDB. Nucleic Acids Res 41: W256-W265.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. W256-W265
-
-
Kirshner, D.A.1
Nilmeier, J.P.2
Lightstone, F.C.3
-
40
-
-
65249117514
-
Identifying and characterizing binding sites and assessing druggability
-
Halgren TA (2009) Identifying and Characterizing Binding Sites and Assessing Druggability. Journal of Chemical Information and Modeling 49: 377-389.
-
(2009)
Journal of Chemical Information and Modeling
, vol.49
, pp. 377-389
-
-
Halgren, T.A.1
-
41
-
-
84864264343
-
Directory of useful decoys, enhanced (DUD-E): Better ligands and decoys for better benchmarking
-
Mysinger MM, Carchia M, Irwin JJ, Shoichet BK (2012) Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking. J Med Chem 55: 6582-6594.
-
(2012)
J Med Chem
, vol.55
, pp. 6582-6594
-
-
Mysinger, M.M.1
Carchia, M.2
Irwin, J.J.3
Shoichet, B.K.4
-
42
-
-
0037763817
-
Comparative evaluation of 11 scoring functions for molecular docking
-
Wang RX, Lu YP, Wang SM (2003) Comparative evaluation of 11 scoring functions for molecular docking. J Med Chem 46: 2287-2303.
-
(2003)
J Med Chem
, vol.46
, pp. 2287-2303
-
-
Wang, R.X.1
Lu, Y.P.2
Wang, S.M.3
-
43
-
-
33749260698
-
A critical assessment of docking programs and scoring functions
-
Warren GL, Andrews CW, Capelli AM, Clarke B, LaLonde J, et al. (2006) A critical assessment of docking programs and scoring functions. J Med Chem 49: 5912-5931.
-
(2006)
J Med Chem
, vol.49
, pp. 5912-5931
-
-
Warren, G.L.1
Andrews, C.W.2
Capelli, A.M.3
Clarke, B.4
LaLonde, J.5
-
44
-
-
0017429069
-
Areas, volumes, packing and protein structure
-
Richards FM (1977) Areas, volumes, packing and protein structure. Annu Rev Biophys Bioeng 6: 151-176.
-
(1977)
Annu Rev Biophys Bioeng
, vol.6
, pp. 151-176
-
-
Richards, F.M.1
-
45
-
-
0020491251
-
A geometric approach to macromolecule-ligand interactions
-
Kuntz ID, Blaney JM, Oatley SJ, Langridge R, Ferrin TE (1982) A geometric approach to macromolecule-ligand interactions. J Mol Biol 161: 269-288.
-
(1982)
J Mol Biol
, vol.161
, pp. 269-288
-
-
Kuntz, I.D.1
Blaney, J.M.2
Oatley, S.J.3
Langridge, R.4
Ferrin, T.E.5
-
46
-
-
23444454552
-
The Amber biomolecular simulation programs
-
Case DA, Cheatham TE 3rd, Darden T, Gohlke H, Luo R, et al. (2005) The Amber biomolecular simulation programs. J Comput Chem 26: 1668-1688.
-
(2005)
J Comput Chem
, vol.26
, pp. 1668-1688
-
-
Case, D.A.1
Cheatham, T.E.2
Darden, T.3
Gohlke, H.4
Luo, R.5
-
47
-
-
84906998113
-
-
San Francisco, CA: Universty of California San Francisco
-
Case DA, Darden TA, Cheatham TE, Simmerling CL, Wang J, et al. (2012) AMBER12 and AMBERTOOLS13. San Francisco, CA: Universty of California San Francisco.
-
(2012)
AMBER12 and AMBERTOOLS13
-
-
Case, D.A.1
Darden, T.A.2
Cheatham, T.E.3
Simmerling, C.L.4
Wang, J.5
-
48
-
-
33847713183
-
Generalized born model with a simple, robust molecular volume correction
-
Mongan J, Simmerling C, McCammon JA, Case DA, Onufriev A (2007) Generalized Born Model with a Simple, Robust Molecular Volume Correction. J Chem Theory Comput 3: 156-169.
-
(2007)
J Chem Theory Comput
, vol.3
, pp. 156-169
-
-
Mongan, J.1
Simmerling, C.2
McCammon, J.A.3
Case, D.A.4
Onufriev, A.5
-
49
-
-
1842479952
-
Exploring protein native states and large-scale conformational changes with a modified generalized born model
-
Onufriev A, Bashford D, Case DA (2004) Exploring protein native states and large-scale conformational changes with a modified generalized born model. Proteins: Structure, Function, and Bioinformatics 55: 383-394.
-
(2004)
Proteins: Structure, Function, and Bioinformatics
, vol.55
, pp. 383-394
-
-
Onufriev, A.1
Bashford, D.2
Case, D.A.3
-
50
-
-
77951997313
-
Quantum mechanical pairwise decomposition analysis of protein kinase B inhibitors: Validating a new tool for guiding drug design
-
Zhang X, Gibbs AC, Reynolds CH, Peters MB, Westerhoff LM (2010) Quantum mechanical pairwise decomposition analysis of protein kinase B inhibitors: validating a new tool for guiding drug design. J Chem Inf Model 50: 651-661.
-
(2010)
J Chem Inf Model
, vol.50
, pp. 651-661
-
-
Zhang, X.1
Gibbs, A.C.2
Reynolds, C.H.3
Peters, M.B.4
Westerhoff, L.M.5
-
52
-
-
45749138489
-
MM-GB/SA rescoring of docking poses in structure-based lead optimization
-
Guimaraes CR, Cardozo M (2008) MM-GB/SA rescoring of docking poses in structure-based lead optimization. J Chem Inf Model 48: 958-970.
-
(2008)
J Chem Inf Model
, vol.48
, pp. 958-970
-
-
Guimaraes, C.R.1
Cardozo, M.2
-
54
-
-
40349087133
-
Towards the development of universal, fast and highly accurate docking/scoring methods: A long way to go
-
Moitessier N, Englebienne P, Lee D, Lawandi J, Corbeil CR (2008) Towards the development of universal, fast and highly accurate docking/scoring methods: A long way to go. Br J Pharmacol 153 Suppl 1: S7-S26.
-
(2008)
Br J Pharmacol
, vol.153
, pp. S7-S26
-
-
Moitessier, N.1
Englebienne, P.2
Lee, D.3
Lawandi, J.4
Corbeil, C.R.5
-
55
-
-
34548430376
-
The role of quantum mechanics in structure-based drug design
-
Raha K, Peters MB, Wang B, Yu N, Wollacott AM, et al. (2007) The role of quantum mechanics in structure-based drug design. Drug Discov Today 12: 725-731.
-
(2007)
Drug Discov Today
, vol.12
, pp. 725-731
-
-
Raha, K.1
Peters, M.B.2
Wang, B.3
Yu, N.4
Wollacott, A.M.5
-
56
-
-
0037763817
-
Comparative evaluation of 11 scoring functions for molecular docking
-
Wang R, Lu Y, Wang S (2003) Comparative Evaluation of 11 Scoring Functions for Molecular Docking. Journal of Medicinal Chemistry 46: 2287-2303.
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, pp. 2287-2303
-
-
Wang, R.1
Lu, Y.2
Wang, S.3
-
57
-
-
33748276474
-
Protein-ligand docking: Current status and future challenges
-
Sousa SF, Fernandes PA, Ramos MJ (2006) Protein-ligand docking: current status and future challenges. Proteins 65: 15-26.
-
(2006)
Proteins
, vol.65
, pp. 15-26
-
-
Sousa, S.F.1
Fernandes, P.A.2
Ramos, M.J.3
-
58
-
-
84874299846
-
Approaches to efficiently estimate solvation and explicit water energetics in ligand binding: The use of water map
-
Yang Y, Lightstone FC, Wong SE (2013) Approaches to efficiently estimate solvation and explicit water energetics in ligand binding: The use of water map. Expert Opinion on Drug Discovery 8: 277-287.
-
(2013)
Expert Opinion on Drug Discovery
, vol.8
, pp. 277-287
-
-
Yang, Y.1
Lightstone, F.C.2
Wong, S.E.3
-
61
-
-
62549115747
-
Genome-wide association analysis by lasso penalized logistic regression
-
Wu TT, Chen YF, Hastie T, Sobel E, Lange K (2009) Genome-wide association analysis by lasso penalized logistic regression. Bioinformatics 25: 714-721.
-
(2009)
Bioinformatics
, vol.25
, pp. 714-721
-
-
Wu, T.T.1
Chen, Y.F.2
Hastie, T.3
Sobel, E.4
Lange, K.5
-
62
-
-
77950537175
-
Regularization paths for generalized linear models via coordinate descent
-
Friedman J, Hastie T, Tibshirani R (2010) Regularization Paths for Generalized Linear Models via Coordinate Descent. J Stat Softw 33: 1-22.
-
(2010)
J Stat Softw
, vol.33
, pp. 1-22
-
-
Friedman, J.1
Hastie, T.2
Tibshirani, R.3
-
63
-
-
0042424602
-
Statistical significance for genomewide studies
-
Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 100: 9440-9445.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 9440-9445
-
-
Storey, J.D.1
Tibshirani, R.2
-
65
-
-
84877933286
-
Protein-ligand docking in the new millennium - A retrospective of 10 years in the field
-
Sousa SF, Ribeiro AJM, Coimbra JTS, Neves RP, Martins SA, et al. (2013) Protein-Ligand Docking in the New Millennium - A Retrospective of 10 Years in the Field. Current Medicinal Chemistry 20: 2296-2314.
-
(2013)
Current Medicinal Chemistry
, vol.20
, pp. 2296-2314
-
-
Sousa, S.F.1
Ribeiro, A.J.M.2
Coimbra, J.T.S.3
Neves, R.P.4
Martins, S.A.5
-
66
-
-
84903312448
-
Selecting an optimal number of binding site waters to improve virtual screening enrichments against the adenosine A2A receptor
-
Lenselink EB, Beuming T, Sherman W, van Vlijmen HW, Ijzerman AP (2014) Selecting an Optimal Number of Binding Site Waters to Improve Virtual Screening Enrichments Against the Adenosine A2A Receptor. J Chem Inf Model 54: 1737-1746.
-
(2014)
J Chem Inf Model
, vol.54
, pp. 1737-1746
-
-
Lenselink, E.B.1
Beuming, T.2
Sherman, W.3
Van Vlijmen, H.W.4
Ijzerman, A.P.5
-
67
-
-
67749099405
-
High-energy water sites determine peptide binding affinity and specificty of PDZ domains
-
Beuming T, Farid R, Sherman W (2009) High-energy water sites determine peptide binding affinity and specificty of PDZ domains. Protein Sc 18: 1609- 1619.
-
(2009)
Protein Sc
, vol.18
, pp. 1609-1619
-
-
Beuming, T.1
Farid, R.2
Sherman, W.3
-
68
-
-
84902437056
-
Inhibitor ranking through QM based chelation calculations for virtual screening of HIV-1 RNase H inhibition
-
Poongavanam V, Steinmann C, Kongsted J (2014) Inhibitor Ranking through QM Based Chelation Calculations for Virtual Screening of HIV-1 RNase H Inhibition. PLOS ONE 9(6): e98659. doi:10.1371/journal.pone.0098659.
-
(2014)
PLOS ONE
, vol.9
, Issue.6
, pp. e98659
-
-
Poongavanam, V.1
Steinmann, C.2
Kongsted, J.3
-
69
-
-
34548304863
-
Evaluation of docking programs for predicting binding of Golgi alpha- mannosidase II inhibitors: A comparison with crystallography
-
Englebienne PF, Fiaux H, Kuntz DA, Corbeil CR, Gerber-Lemaire S, et al. (2007) Evaluation of docking programs for predicting binding of Golgi alpha- mannosidase II inhibitors: A comparison with crystallography. Proteins 69: 160- 176.
-
(2007)
Proteins
, vol.69
, pp. 160-176
-
-
Englebienne, P.F.1
Fiaux, H.2
Kuntz, D.A.3
Corbeil, C.R.4
Gerber-Lemaire, S.5
-
70
-
-
79551476059
-
FINDSITE-metal: Integrating evolutionary information and machine learning for structure-based metal-binding site prediction at the proteome level
-
Brylinski M, Skolnick J (2011) FINDSITE-metal: integrating evolutionary information and machine learning for structure-based metal-binding site prediction at the proteome level. Proteins 79: 735-751.
-
(2011)
Proteins
, vol.79
, pp. 735-751
-
-
Brylinski, M.1
Skolnick, J.2
-
71
-
-
84878740442
-
MMP1, MMP9, and COX2 expressions in promonocytes are induced by breast cancer cells and correlate with collagen degradation, transformation-like morphological changes in MCF- 10A acini, and tumor aggressiveness
-
Chimal-Ramirez GK, Espinoza-Sanchez NA, Utrera-Barillas D, Benítez-Bribiesca L, Velázquez JR, et al. (2013) MMP1, MMP9, and COX2 Expressions in Promonocytes Are Induced by Breast Cancer Cells and Correlate with Collagen Degradation, Transformation-Like Morphological Changes in MCF- 10A Acini, and Tumor Aggressiveness. BioMed Research International, doi:10.1155/2013/279505.
-
(2013)
BioMed Research International
-
-
Chimal-Ramirez, G.K.1
Espinoza-Sanchez, N.A.2
Utrera-Barillas, D.3
Benítez-Bribiesca, L.4
Velázquez, J.R.5
-
72
-
-
84904057722
-
Thromboxane A2 receptor-mediated release of matrix metalloproteinase-1 (MMP-1) induces expression of monocyte chemoattractant protein-1 (MCP-1) by activation of protease-activated receptor 2 (PAR2) in A549 human lung adenocarcinoma cells
-
Li X, Tai HH (2013) Thromboxane A2 receptor-mediated release of matrix metalloproteinase-1 (MMP-1) induces expression of monocyte chemoattractant protein-1 (MCP-1) by activation of protease-activated receptor 2 (PAR2) in A549 human lung adenocarcinoma cells. Molecular Carcinogenesis doi: 10.1002/mc.22020.
-
(2013)
Molecular Carcinogenesis
-
-
Li, X.1
Tai, H.H.2
-
73
-
-
84887579807
-
Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients
-
Lin Y, Wang JF, Gao GZ, Zhang GZ, Wang FL, et al. (2013) Plasma levels of tissue inhibitor of matrix metalloproteinase-1 correlate with diagnosis and prognosis of glioma patients. Chin Med J (Engl) 126: 4295-4300.
-
(2013)
Chin Med J (Engl)
, vol.126
, pp. 4295-4300
-
-
Lin, Y.1
Wang, J.F.2
Gao, G.Z.3
Zhang, G.Z.4
Wang, F.L.5
-
74
-
-
84865466419
-
Cell distribution differences of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in patients with Kawasaki disease
-
Korematsu S, Ohta Y, Tamai N, Takeguchi M, Goto C, et al. (2012) Cell distribution differences of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in patients with Kawasaki disease. Pediatr Infect Dis J 31: 973-974.
-
(2012)
Pediatr Infect Dis J
, vol.31
, pp. 973-974
-
-
Korematsu, S.1
Ohta, Y.2
Tamai, N.3
Takeguchi, M.4
Goto, C.5
-
75
-
-
84862792930
-
Regulatory role of Syk gene on vascular endothelial growth factor C expression in breast cancer
-
Chen XL, Li L, Zhang YJ (2011) [Regulatory role of Syk gene on vascular endothelial growth factor C expression in breast cancer]. Zhonghua Bing Li Xue Za Zhi 40: 805-809.
-
(2011)
Zhonghua Bing Li Xue Za Zhi
, vol.40
, pp. 805-809
-
-
Chen, X.L.1
Li, L.2
Zhang, Y.J.3
-
76
-
-
66349132292
-
Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells
-
Zhang X, Shrikhande U, Alicie BM, Zhou Q, Geahlen RL (2009) Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells. Mol Cancer Res 7: 634-644.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 634-644
-
-
Zhang, X.1
Shrikhande, U.2
Alicie, B.M.3
Zhou, Q.4
Geahlen, R.L.5
-
77
-
-
33845921924
-
Expression of Syk in invasive breast cancer: Correlation to proliferation and invasiveness
-
Repana K, Papazisis K, Foukas P, Valeri R, Kortsaris A, et al. (2006) Expression of Syk in invasive breast cancer: correlation to proliferation and invasiveness. Anticancer Res 26: 4949-4954.
-
(2006)
Anticancer Res
, vol.26
, pp. 4949-4954
-
-
Repana, K.1
Papazisis, K.2
Foukas, P.3
Valeri, R.4
Kortsaris, A.5
-
78
-
-
73549116304
-
Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion
-
Layton T, Stalens C, Gunderson F, Goodison S, Silletti S (2009) Syk Tyrosine Kinase Acts as a Pancreatic Adenocarcinoma Tumor Suppressor by Regulating Cellular Growth and Invasion. The American Journal of Pathology 175: 2625- 2636.
-
(2009)
The American Journal of Pathology
, vol.175
, pp. 2625-2636
-
-
Layton, T.1
Stalens, C.2
Gunderson, F.3
Goodison, S.4
Silletti, S.5
-
79
-
-
84862538817
-
Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer
-
Dowling P, Clarke C, Hennessy K, Torralbo-Lopez B, Ballot J, et al. (2012) Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer. Int J Cancer 131: 911-923.
-
(2012)
Int J Cancer
, vol.131
, pp. 911-923
-
-
Dowling, P.1
Clarke, C.2
Hennessy, K.3
Torralbo-Lopez, B.4
Ballot, J.5
-
80
-
-
84859952898
-
Sarcoidosis in a patient with metastatic melanoma sequentially treated with anti- CTLA-4 monoclonal antibody and selective BRAF inhibitor
-
Wilgenhof S, Morlion V, Seghers AC, Du Four S, Van der linden E, et al. (2012) Sarcoidosis in a patient with metastatic melanoma sequentially treated with anti- CTLA-4 monoclonal antibody and selective BRAF inhibitor. Anticancer Res 32: 1355-1359.
-
(2012)
Anticancer Res
, vol.32
, pp. 1355-1359
-
-
Wilgenhof, S.1
Morlion, V.2
Seghers, A.C.3
Du Four, S.4
Van Der Linden, E.5
-
81
-
-
20144389018
-
Cytotoxic tlymphocyte antigen 4 gene polymorphisms in sarcoidosis patients
-
Hattori N, Niimi T, Sato S, Achiwa H, Maeda H, et al. (2005) Cytotoxic Tlymphocyte antigen 4 gene polymorphisms in sarcoidosis patients. Sarcoidosis Vasc Diffuse Lung Dis 22: 27-32.
-
(2005)
Sarcoidosis Vasc Diffuse Lung Dis
, vol.22
, pp. 27-32
-
-
Hattori, N.1
Niimi, T.2
Sato, S.3
Achiwa, H.4
Maeda, H.5
-
82
-
-
3042778974
-
Profilin acts downstream of LDL to mediate diabetic endothelial cell dysfunction
-
Romeo G, Frangioni JV, Kazlauskas A (2004) Profilin acts downstream of LDL to mediate diabetic endothelial cell dysfunction. FASEB J 18: 725-727.
-
(2004)
FASEB J
, vol.18
, pp. 725-727
-
-
Romeo, G.1
Frangioni, J.V.2
Kazlauskas, A.3
-
83
-
-
84870885768
-
The effect of hyperthyroidism on procoagulant, anticoagulant and fibrinolytic factors: A systematic review and meta-analysis
-
Stuijver DJ, van Zaane B, Romualdi E, Brandjes DP, Gerdes VE, et al. (2012) The effect of hyperthyroidism on procoagulant, anticoagulant and fibrinolytic factors: A systematic review and meta-analysis. Thromb Haemost 108: 1077- 1088.
-
(2012)
Thromb Haemost
, vol.108
, pp. 1077-1088
-
-
Stuijver, D.J.1
Van Zaane, B.2
Romualdi, E.3
Brandjes, D.P.4
Gerdes, V.E.5
-
84
-
-
75949107129
-
Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients
-
Kim HW, Rapoport SI, Rao JS (2010) Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients. Neurobiol Dis 37: 596-603.
-
(2010)
Neurobiol Dis
, vol.37
, pp. 596-603
-
-
Kim, H.W.1
Rapoport, S.I.2
Rao, J.S.3
-
85
-
-
84888429628
-
Increased susceptibility to apoptosis in cultured fibroblasts from antipsychotic-naive firstepisode schizophrenia patients
-
Gasso P, Mas S, Molina O, Lafuente A, Bernardo M, et al. (2014) Increased susceptibility to apoptosis in cultured fibroblasts from antipsychotic-naive firstepisode schizophrenia patients. J Psychiatr Res 48: 94-101.
-
(2014)
J Psychiatr Res
, vol.48
, pp. 94-101
-
-
Gasso, P.1
Mas, S.2
Molina, O.3
Lafuente, A.4
Bernardo, M.5
-
86
-
-
64949185311
-
Beta2- integrin activation on T cell subsets is an independent prognostic factor in unstable angina pectoris
-
Konstandin MH, Aksoy H, Wabnitz GH, Volz C, Erbel C, et al. (2009) Beta2- integrin activation on T cell subsets is an independent prognostic factor in unstable angina pectoris. Basic Res Cardiol 104: 341-351.
-
(2009)
Basic Res Cardiol
, vol.104
, pp. 341-351
-
-
Konstandin, M.H.1
Aksoy, H.2
Wabnitz, G.H.3
Volz, C.4
Erbel, C.5
-
87
-
-
0025394992
-
Clozapine and resistant schizophrenia
-
Pere JJ, Chaumet-Riffaud D (1990) [Clozapine and resistant schizophrenia]. Encephale 16: 143-145.
-
(1990)
Encephale
, vol.16
, pp. 143-145
-
-
Pere, J.J.1
Chaumet-Riffaud, D.2
|