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Volumn 48, Issue 1, 2014, Pages 94-101

Increased susceptibility to apoptosis in cultured fibroblasts from antipsychotic-naïve first-episode schizophrenia patients

Author keywords

Antipsychotic na ve; Apoptosis; Fibroblast culture; First episode; Schizophrenia; Skin biopsy

Indexed keywords

CASPASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLSERINE; PROTEIN AKT1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; STAUROSPORINE; UNCLASSIFIED DRUG;

EID: 84888429628     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2013.09.017     Document Type: Article
Times cited : (43)

References (52)
  • 2
    • 2342451962 scopus 로고    scopus 로고
    • Antipsychotic drugs clozapine and olanzapine upregulate bcl-2 mRNA and protein in rat frontal cortex and hippocampus
    • Bai O., Zhang H., Li X.M. Antipsychotic drugs clozapine and olanzapine upregulate bcl-2 mRNA and protein in rat frontal cortex and hippocampus. Brain Research 2004, 1010:81-86.
    • (2004) Brain Research , vol.1010 , pp. 81-86
    • Bai, O.1    Zhang, H.2    Li, X.M.3
  • 3
    • 77953009325 scopus 로고    scopus 로고
    • Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-β activity
    • Benedetti F., Poletti S., Radaelli D., Bernasconi A., Cavallaro R., Falini A., et al. Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-β activity. Genes, Brain and Behaviour 2010, 9:365-371.
    • (2010) Genes, Brain and Behaviour , vol.9 , pp. 365-371
    • Benedetti, F.1    Poletti, S.2    Radaelli, D.3    Bernasconi, A.4    Cavallaro, R.5    Falini, A.6
  • 5
    • 33644622093 scopus 로고    scopus 로고
    • The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia
    • Benes F.M., Matzilevich D., Burke R.E., Walsh J. The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia. Molecular Psychiatry 2006, 11:241-251.
    • (2006) Molecular Psychiatry , vol.11 , pp. 241-251
    • Benes, F.M.1    Matzilevich, D.2    Burke, R.E.3    Walsh, J.4
  • 6
    • 33748299477 scopus 로고    scopus 로고
    • The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways
    • Beurel E., Jope R.S. The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Progress in Neurobiology 2006, 79:173-189.
    • (2006) Progress in Neurobiology , vol.79 , pp. 173-189
    • Beurel, E.1    Jope, R.S.2
  • 10
    • 34447302836 scopus 로고    scopus 로고
    • Neurodevelopmental involvement in schizophrenia: the olfactory epithelium as an alternative model for research
    • Cascella N.G., Takaki M., Lin S., Sawa A. Neurodevelopmental involvement in schizophrenia: the olfactory epithelium as an alternative model for research. Journal of Neurochemistry 2007, 102:587-594.
    • (2007) Journal of Neurochemistry , vol.102 , pp. 587-594
    • Cascella, N.G.1    Takaki, M.2    Lin, S.3    Sawa, A.4
  • 12
    • 41849119908 scopus 로고    scopus 로고
    • Cancer incidence in patients with schizophrenia and their first-degree relatives - a meta-analysis
    • Catts V.S., Catts S.V., O'Toole B.I., Frost A.D. Cancer incidence in patients with schizophrenia and their first-degree relatives - a meta-analysis. Acta Psychiatrica Scandinavica 2008, 117:323-336.
    • (2008) Acta Psychiatrica Scandinavica , vol.117 , pp. 323-336
    • Catts, V.S.1    Catts, S.V.2    O'Toole, B.I.3    Frost, A.D.4
  • 14
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: critical control points
    • Danial N.N., Korsmeyer S.J. Cell death: critical control points. Cell 2004, 116:205-219.
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 15
    • 65349191920 scopus 로고    scopus 로고
    • The neurodevelopmental hypothesis of schizophrenia, revisited
    • Fatemi S.H., Folsom T.D. The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophrenia Bulletin 2009, 35:528-548.
    • (2009) Schizophrenia Bulletin , vol.35 , pp. 528-548
    • Fatemi, S.H.1    Folsom, T.D.2
  • 16
    • 0345072484 scopus 로고    scopus 로고
    • Altered adhesion, proliferation and death in neural cultures from adults with schizophrenia
    • Féron F., Perry C., Hirning M.H., McGrath J., Mackay-Sim A. Altered adhesion, proliferation and death in neural cultures from adults with schizophrenia. Schizophrenia Research 1999, 40:211-218.
    • (1999) Schizophrenia Research , vol.40 , pp. 211-218
    • Féron, F.1    Perry, C.2    Hirning, M.H.3    McGrath, J.4    Mackay-Sim, A.5
  • 18
    • 0042831025 scopus 로고    scopus 로고
    • Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility?
    • Gilman C.P., Mattson M.P. Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility?. Neuromolecular Medicine 2002, 2:197-214.
    • (2002) Neuromolecular Medicine , vol.2 , pp. 197-214
    • Gilman, C.P.1    Mattson, M.P.2
  • 20
    • 34848908637 scopus 로고    scopus 로고
    • The pro-apoptotic ARTS/Sept4 protein is significantly reduced in post-mortem brains from schizophrenic patients
    • Gottfried Y., Rotem A., Klein E., Larisch S. The pro-apoptotic ARTS/Sept4 protein is significantly reduced in post-mortem brains from schizophrenic patients. Schizophrenia Research 2007, 96:257-266.
    • (2007) Schizophrenia Research , vol.96 , pp. 257-266
    • Gottfried, Y.1    Rotem, A.2    Klein, E.3    Larisch, S.4
  • 23
    • 78149428430 scopus 로고    scopus 로고
    • Rethinking schizophrenia
    • Insel T.R. Rethinking schizophrenia. Nature 2010, 468:187-193.
    • (2010) Nature , vol.468 , pp. 187-193
    • Insel, T.R.1
  • 25
    • 1442264399 scopus 로고    scopus 로고
    • Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation
    • Jarskog L.F., Selinger E.S., Lieberman J.A., Gilmore J.H. Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation. American Journal of Psychiatry 2004, 161:109-115.
    • (2004) American Journal of Psychiatry , vol.161 , pp. 109-115
    • Jarskog, L.F.1    Selinger, E.S.2    Lieberman, J.A.3    Gilmore, J.H.4
  • 27
    • 0037228202 scopus 로고    scopus 로고
    • Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia
    • Kasai K., Shenton M.E., Salisbury D.F., Hirayasu Y., Lee C.U., Ciszewski A.A., et al. Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. American Journal of Psychiatry 2003, 160:156-164.
    • (2003) American Journal of Psychiatry , vol.160 , pp. 156-164
    • Kasai, K.1    Shenton, M.E.2    Salisbury, D.F.3    Hirayasu, Y.4    Lee, C.U.5    Ciszewski, A.A.6
  • 28
    • 75949107129 scopus 로고    scopus 로고
    • Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients
    • Kim H.W., Rapoport S.I., Rao J.S. Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients. Neurobiology of Disease 2010, 37:596-603.
    • (2010) Neurobiology of Disease , vol.37 , pp. 596-603
    • Kim, H.W.1    Rapoport, S.I.2    Rao, J.S.3
  • 30
    • 65349115000 scopus 로고    scopus 로고
    • Schizophrenia as a systemic disease
    • Kirkpatrick B. Schizophrenia as a systemic disease. Schizophrenia Bulletin 2009, 35:381-382.
    • (2009) Schizophrenia Bulletin , vol.35 , pp. 381-382
    • Kirkpatrick, B.1
  • 31
    • 0033625098 scopus 로고    scopus 로고
    • Low GSK-3beta immunoreactivity in postmortem frontal cortex of schizophrenic patients
    • Kozlovsky N., Belmaker R.H., Agam G. Low GSK-3beta immunoreactivity in postmortem frontal cortex of schizophrenic patients. American Journal of Psychiatry 2000, 157:831-833.
    • (2000) American Journal of Psychiatry , vol.157 , pp. 831-833
    • Kozlovsky, N.1    Belmaker, R.H.2    Agam, G.3
  • 32
    • 0035666578 scopus 로고    scopus 로고
    • The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches
    • Lieberman J.A., Perkins D., Belger A., Chakos M., Jarskog F., Boteva K., et al. The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches. Biological Psychiatry 2001, 50:884-897.
    • (2001) Biological Psychiatry , vol.50 , pp. 884-897
    • Lieberman, J.A.1    Perkins, D.2    Belger, A.3    Chakos, M.4    Jarskog, F.5    Boteva, K.6
  • 33
    • 54049141721 scopus 로고    scopus 로고
    • Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection
    • Lieberman J.A., Bymaster F.P., Meltzer H.Y., Deutch A.Y., Duncan G.E., Marx C.E., et al. Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection. Pharmacological Reviews 2008, 60:358-403.
    • (2008) Pharmacological Reviews , vol.60 , pp. 358-403
    • Lieberman, J.A.1    Bymaster, F.P.2    Meltzer, H.Y.3    Deutch, A.Y.4    Duncan, G.E.5    Marx, C.E.6
  • 34
    • 0030292998 scopus 로고    scopus 로고
    • Cultured skin fibroblasts as a cell model for investigating schizophrenia
    • Mahadik S.P., Mukherjee S. Cultured skin fibroblasts as a cell model for investigating schizophrenia. Journal of Psychiatric Research 1996, 30:421-439.
    • (1996) Journal of Psychiatric Research , vol.30 , pp. 421-439
    • Mahadik, S.P.1    Mukherjee, S.2
  • 35
    • 34548297658 scopus 로고    scopus 로고
    • Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway
    • Matigian N., Windus L., Smith H., Filippich C., Pantelis C., McGrath J., et al. Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway. Molecular Psychiatry 2007, 12:815-825.
    • (2007) Molecular Psychiatry , vol.12 , pp. 815-825
    • Matigian, N.1    Windus, L.2    Smith, H.3    Filippich, C.4    Pantelis, C.5    McGrath, J.6
  • 37
    • 33344472348 scopus 로고    scopus 로고
    • Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses
    • McCurdy R.D., Féron F., Perry C., Chant D.C., McLean D., Matigian N., et al. Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses. Schizophrenia Research 2006, 82:163-173.
    • (2006) Schizophrenia Research , vol.82 , pp. 163-173
    • McCurdy, R.D.1    Féron, F.2    Perry, C.3    Chant, D.C.4    McLean, D.5    Matigian, N.6
  • 39
    • 0038018122 scopus 로고    scopus 로고
    • The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+-induced apoptosis
    • Qing H., Xu H., Wei Z., Gibson K., Li X.M. The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+-induced apoptosis. European Journal of Neuroscience 2003, 17:1563-1570.
    • (2003) European Journal of Neuroscience , vol.17 , pp. 1563-1570
    • Qing, H.1    Xu, H.2    Wei, Z.3    Gibson, K.4    Li, X.M.5
  • 40
    • 77954175124 scopus 로고    scopus 로고
    • Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression
    • Rieder S.A., Chauhan A., Singh U., Nagarkatti M., Nagarkatti P. Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. Immunobiology 2010, 215:598-605.
    • (2010) Immunobiology , vol.215 , pp. 598-605
    • Rieder, S.A.1    Chauhan, A.2    Singh, U.3    Nagarkatti, M.4    Nagarkatti, P.5
  • 41
    • 33644876842 scopus 로고    scopus 로고
    • Human fibroblast-derived cell lines have characteristics of embryonic stem cells and cells of neuro-ectodermal origin
    • Rieske P., Krynska B., Azizi S.A. Human fibroblast-derived cell lines have characteristics of embryonic stem cells and cells of neuro-ectodermal origin. Differentiation 2005, 73:474-483.
    • (2005) Differentiation , vol.73 , pp. 474-483
    • Rieske, P.1    Krynska, B.2    Azizi, S.A.3
  • 42
    • 0032851595 scopus 로고    scopus 로고
    • Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization
    • Sawa A., Wiegand G.W., Cooper J., Margolis R.L., Sharp A.H., Lawler J.F., et al. Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization. Nature Medicine 1999, 5:1194-1198.
    • (1999) Nature Medicine , vol.5 , pp. 1194-1198
    • Sawa, A.1    Wiegand, G.W.2    Cooper, J.3    Margolis, R.L.4    Sharp, A.H.5    Lawler, J.F.6
  • 43
    • 0032967531 scopus 로고    scopus 로고
    • The reduced neuropil hypothesis: a circuit based model of schizophrenia
    • Selemon L.D., Goldman-Rakic P.S. The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biological Psychiatry 1999, 45:17-25.
    • (1999) Biological Psychiatry , vol.45 , pp. 17-25
    • Selemon, L.D.1    Goldman-Rakic, P.S.2
  • 44
    • 2642545991 scopus 로고    scopus 로고
    • Neurotoxic potential of haloperidol in comparison with risperidone: implication of Akt-mediated signal changes by haloperidol
    • Ukai W., Ozawa H., Tateno M., Hashimoto E., Saito T. Neurotoxic potential of haloperidol in comparison with risperidone: implication of Akt-mediated signal changes by haloperidol. Journal of Neural Transmission 2004, 111:667-681.
    • (2004) Journal of Neural Transmission , vol.111 , pp. 667-681
    • Ukai, W.1    Ozawa, H.2    Tateno, M.3    Hashimoto, E.4    Saito, T.5
  • 45
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034
    • Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology 2002, 3. RESEARCH0034.
    • (2002) Genome Biology , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6
  • 48
    • 0344118141 scopus 로고    scopus 로고
    • Atypical antipsychotics attenuate neurotoxicity of beta-amyloid(25-35) by modulating Bax and Bcl-X(l/s) expression and localization
    • Wei Z., Mousseau D.D., Richardson J.S., Dyck L.E., Li X.M. Atypical antipsychotics attenuate neurotoxicity of beta-amyloid(25-35) by modulating Bax and Bcl-X(l/s) expression and localization. Journal of Neuroscience Research 2003, 74:942-947.
    • (2003) Journal of Neuroscience Research , vol.74 , pp. 942-947
    • Wei, Z.1    Mousseau, D.D.2    Richardson, J.S.3    Dyck, L.E.4    Li, X.M.5
  • 50
    • 4644341668 scopus 로고    scopus 로고
    • Tumor suppressor gene TP53 is genetically associated with schizophrenia in the Chinese population
    • Yang Y., Xiao Z., Chen W., Sang H., Guan Y., Peng Y., et al. Tumor suppressor gene TP53 is genetically associated with schizophrenia in the Chinese population. Neuroscience Letters 2004, 369:126-131.
    • (2004) Neuroscience Letters , vol.369 , pp. 126-131
    • Yang, Y.1    Xiao, Z.2    Chen, W.3    Sang, H.4    Guan, Y.5    Peng, Y.6
  • 51
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: opposing activities that mediate cell death
    • Youle R.J., Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nature Reviews Molecular Cell Biology 2008, 9:47-59.
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 52
    • 0037007645 scopus 로고    scopus 로고
    • Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    • Zhu S., Stavrovskaya I.G., Drozda M., Kim B.Y., Ona V., Li M., et al. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 2002, 417:74-78.
    • (2002) Nature , vol.417 , pp. 74-78
    • Zhu, S.1    Stavrovskaya, I.G.2    Drozda, M.3    Kim, B.Y.4    Ona, V.5    Li, M.6


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