Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and antioxidative effect

Applied Microbiology and Biotechnology

Volumn 79, Issue 5, 2008, Pages 829-841

  Lee, Chun Lin ^a   Wang, Jyh Jye ^b   Pan, Tzu Ming ^c  

^a Sunway Biotechnology Company Limited   (Taiwan)

^b TAJEN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Alzheimer's disease; Amyloid; Anti inflammatory; Antioxidative; Monacolin K; Monascus

Indexed keywords

CHOLESTEROL; DISEASES; HEALTH HAZARDS; PEPTIDES;

ALZHEIMER'S DISEASE; AMYLOID; ANTI-INFLAMMATORY; MONACOLIN K; MONASCUS;

CROPS;

AMYLOID BETA PROTEIN; MEVINOLIN; RE 568; XUEZHIKANG;

ANTIOXIDANT; FUNGUS; METABOLITE; PEPTIDE; RICE; SYNERGISM; TOXICITY;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN PROTECTION; CELL STRAIN; DRUG INHIBITION; DRUG POTENCY; DRUG POTENTIATION; ENZYME REPRESSION; MONASCUS; NERVE CELL CULTURE; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; CELL SURVIVAL; DRUG SYNERGISM; DRUGS, CHINESE HERBAL; HUMANS; INFLAMMATION; LOVASTATIN; MONASCUS; ORYZA SATIVA; OXIDATIVE STRESS; PC12 CELLS; RATS; SIGNAL TRANSDUCTION;

MONASCUS; MONASCUS PURPUREUS;

EID: 46549083738     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-008-1480-8     Document Type: Article

References (46)

1. Akihisa T, Tokuda H, Yasukawa K, Ukiya M, Kiyota A, Sakamoto N, Suzuki T, Tanabe N, Nishino H (2005) Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects. J Agric Food Chem 53:562-565
2. Aniya Y, Yokomakura T, Yonamine M, Shimada K, Nagamine T, Shimabukuro M, Gibo H (1999) Screening of antioxidant action of various molds and protection of Monascus anka against experimentally induced liver injuries of rats. Gen Pharmacol 32:225-231
3. Aniya Y, Ohtani II, Higa T, Miyagi C, Gibo H, Shimabukuro M, Nakanishi H, Taira J (2000) Dimerumic acid as an antioxidant of the mold, Monascus anka. Free Radic Biol Med 28:999-1004
4. Beers RFJ, Sizer IW (1952) A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 195:133-140
5. Buxbaum JD, Thinakaran G, Koliatsos V, O, Callahan J, Slunt HH, Price DL, Sisodia SS (1998) Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. J Neurosci 18:9629-9637
6. Cahlin C, Gelin J, Andersson M, Lonnroth C, Lundholm K (2005) The effects of non-selective, preferential-selective and selective COX-inhibitors on the growth of experimental and human tumors in mice related to prostanoid receptors. Int J Oncol 27:913-923
7. Cordle A, Landreth G (2005) 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. J Neurosci 25:299-307
8. Cordle A, Koenigsknecht-Talboo J, Wilkinson B, Limpert A, Landreth G (2005) Mechanisms of statin-mediated inhibition of small G-protein function. J Biol Chem 280:34202-34209
9. Davignon J, Mabile L (2001) Mechanisms of action of statins and their pleiotropic effects. Ann Endocrinol (Paris) 62:101-112
10. Endo A (1979) Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J Antibiot (Tokyo) 32:852-854
11. Esposito G, De Filippis D, Maiuri MC, De Stefano D, Carnuccio R, Iuvone T (2006) Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. Neurosci Lett 399:91-95
12. Gao X, Tang XC (2006) Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism. J Neurosci Res 83:1048-1057
13. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126:131-138
14. Heber D, Yip I, Ashley JM, Elashoff DA, Elashoff RM, Go VL (1999) Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am J Clin Nutr 69:231-236
15. Heo HJ, Kim DO, Choi SJ, Shin DH, Lee CY (2004) Potent inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity. J Agric Food Chem 52:4128-4132
16. Hoglund K, Wiklund O, Vanderstichele H, Eikenberg O, Vanmechelen E, Blennow K (2004) Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins. Arch Neurol 61:333-337
17. Iskra B, Zivko M, Kes P (2005) Rhabdomyolysis as a side effect of simvastatin treatment. Acta Med Croatica 59:325-328
18. Iuvone T, De Filippis D, Esposito G, D, Amico A, Izzo AA (2006) The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-beta peptide-induced neurotoxicity. J Pharmacol Exp Ther 317:1143-1149
19. Jang JH, Aruoma OI, Jen LS, Chung HY, Surh YJ (2004) Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death. Free Radic Biol Med 36:288-299
20. Juzlova P, Martinkova L, Kren V (1996a) Secondary metabolites of the fungus Monascus: a review. J Ind Microbiol 16:163-170
21. Juzlova P, Rezanka T, Martinkova L, Kren V (1996b) Long-chain fatty acids from Monascus purpureus. Phytochemistry 43:151-153
22. Lee SY, Lee JW, Lee H, Yoo HS, Yun YP, Oh KW, Ha TY, Hong JT (2005) Inhibitory effect of green tea extract on beta-amyloid-induced PC12 cell death by inhibition of the activation of NF-kappaB and ERK/p38 MAP kinase pathway through antioxidant mechanisms. Brain Res Mol Brain Res 140:45-54
23. Lee CL, Tsai TY, Wang JJ, Pan TM (2006a) In vivo hypolipidemic effects and safety of low dosage Monascus powder in a hamster model of hyperlipidemia. Appl Microbiol Biotechnol 70:533-540
24. Lee CL, Wang JJ, Kuo SL, Pan TM (2006b) Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent-monacolin K and anti-inflammation agent-monascin. Appl Microbiol Biotechnol 72:1254-1262
25. Lee CL, Wang JJ, Pan TM (2006c) Synchronous analysis method for detection of citrinin and the lactone and acid forms of monacolin K in red mold rice. J AOAC Int 89:669-677
26. Lee HG, Zhu X, Nunomura A, Perry G, Smith MA (2006d) Amyloid beta: the alternate hypothesis. Curr Alzheimer Res 3:75-80
27. Lee CL, Hung HK, Wang JJ, Pan TM (2007) Red mold dioscorea has greater hypolipidemic and antiatherosclerotic effect than traditional red mold rice and unfermented dioscorea in hamsters. J Agric Food Chem 55:7162-7169
28. Li Z, Seeram NP, Lee R, Thames G, Minutti C, Wang HJ, Heber D (2005) Plasma clearance of lovastatin versus Chinese red yeast rice in healthy volunteers. J Altern Complement Med 11:1031-1038
29. Liao JK, Laufs U (2005) Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 45:89-118
30. Lingnert H, Vallentin K, Eriksson CE (1979) Measurement of antioxidative in model system. J Food Process Preserv 3:87-103
31. Oyaizu M (1986) Antioxidative activity of browning products of glucosamine fractionated by organic solvent and thin-layer chromatography. Nippon Shokuhin Kogyo Gakkaishi 35:771-775
32. Pollack SJ, Sadler II, Hawtin SR, Tailor VJ, Shearman MS (1995) Sulfated glycosaminoglycans and dyes attenuate the neurotoxic effects of beta-amyloid in rat PC12 cells. Neurosci Lett 184:113-116
33. Raja SG, Dreyfus GD (2004) Statins: much more than just a lipid-lowering therapy. Indian Heart J 56:204-209
34. Rhyu MR, Kim DK, Kim HY, Kim BK (2000) Nitric oxide-mediated endothelium-dependent relaxation of rat thoracic aorta induced by aqueous extract of red rice fermented with Monascus ruber. J Ethnopharmacol 70:29-34
35. Rockwood K, Kirkland S, Hogan DB, MacKnight C, Merry H, Verreault R, Wolfson C, McDowell I (2002) Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people. Arch Neurol 59:223-227
36. Sastre M, Klockgether T, Heneka MT (2006) Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. Int J Dev Neurosci 24:167-176
37. Scott HD, Laake K (2001) Statins for the prevention of Alzheimer's disease. Cochrane Database Syst Rev 2001(3):CD003160
38. Setnikar I, Senin P, Rovati LC (2005) Antiatherosclerotic efficacy of policosanol, red yeast rice extract and astaxanthin in the rabbit. Arzneimittelforschung 55:312-317
39. Su YC, Wang JJ, Lin TT, Pan TM (2003) Production of the secondary metabolites gamma-aminobutyric acid and monacolin K by Monascus. J Ind Microbiol Biotechnol 30:41-46
40. Townsend KP, Pratico D (2005) Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. Faseb J 19:1592-1601
41. Wei W, Li C, Wang Y, Su H, Zhu J, Kritchevsky D (2003) Hypolipidemic and anti-atherogenic effects of long-term Cholestin (Monascus purpureus-fermented rice, red yeast rice) in cholesterol fed rabbits. J Nutr Biochem 14:314-318
42. Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G (2000) Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 57:1439-1443
43. Wu LC, Chen YC, Ho JA, Yang CS (2003) Inhibitory effect of red koji extracts on mushroom tyrosinase. J Agric Food Chem 51:4240-4246
44. Xiao XQ, Wang R, Tang XC (2000) Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury. J Neurosci Res 61:564-569
45. Yallampalli S, Micci MA, Taglialatela G (1998) Ascorbic acid prevents beta-amyloid-induced intracellular calcium increase and cell death in PC12 cells. Neurosci Lett 251:105-108
46. Zhao B (2005) Natural antioxidants for neurodegenerative diseases. Mol Neurobiol 31:283-293