Taraxacum official (dandelion) leaf extract alleviates high-fat diet-induced nonalcoholic fatty liver

Food and Chemical Toxicology

Volumn 58, Issue , 2013, Pages 30-36

  Davaatseren, Munkhtugs ^a,b   Hur, Haeng Jeon ^a   Yang, Hye Jeong ^a   Hwang, Jin Taek ^a   Park, Jae Ho ^a   Kim, Hyun Jin ^c   Kim, Min Jung ^a   Kwon, Dae Young ^a   Sung, Mi Jeong ^a  

^a Korea Food Research Institute   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Gyeongsang National University   (South Korea)

Author keywords

AMPK; Fatty liver; High fat diet; Insulin resistance; Taraxacum official (dandelion)

Indexed keywords

CHOLESTEROL; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LIVER ENZYME; LIVER PROTECTIVE AGENT; LUTEOLIN; MUSCLE PROTEIN; PHENOL; PLANT EXTRACT; ROSIGLITAZONE; TARAXACUM OFFICIAL EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DANDELION; DIET SUPPLEMENTATION; DISEASE CONTROL; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FATTY LIVER; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID STORAGE; LIVER PROTECTION; LIVER WEIGHT; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; PROTEIN INDUCTION; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL;

AMPK; FATTY LIVER; HIGH-FAT DIET; INSULIN RESISTANCE; TARAXACUM OFFICIAL (DANDELION);

ADENYLATE KINASE; ANIMALS; BLOTTING, WESTERN; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIET, HIGH-FAT; ENZYME ACTIVATION; FATTY LIVER; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN; LIPIDS; LUTEOLIN; MALE; MICE; MICE, INBRED C57BL; PLANT EXTRACTS; PLANT LEAVES; TARAXACUM;

EID: 84877351479     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.04.023     Document Type: Article

References (39)

1. Bisset N.G. Herbal Drugs and Phytopharmaceuticals 1994, Medpharm, Stuttgart.
2. Bradbury M.W. Lipid metabolism and liver inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290:G194-G198.
3. Bradley P.R. British Herbal Compendium 1992, vol. 1. British Herbal Medicine Association, Bournemouth.
4. Browning J.D., Horton J.D. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest. 2004, 114(2):147-152.
5. Cho S.Y., Park J.Y., Park E.M., Choi M.S., Lee M.K., Jeon S.M., Jang M.K., Kim M.J., Park Y.B. Alternation of hepatic antioxidant enzyme activities and lipid profile in streptozotocin-induced diabetic rats by supplementation of dandelion water extract. Clin. Chim. Acta 2002, 317:109-117.
6. Cho S.Y., Oh Y.J., Park J.Y., Lee M.K., Kim M.J. Effect of dandelion (Taraxacum officinale) leaf extracts on hepatic antioxidative system in rats fed high cholesterol diet. J. Kor. Soc. Food Sci. Nutr. 2003, 32:458-463.
7. Cho A.S., Jeon S.M., Kim M.J., Yeo J., Seo K.I., Choi M.S. Chlorogenic acid inhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem. Toxicol. 2010, 48:937-943.
8. Cornier M.A., Dabelea D., Hernandez T.I., Lindstrom R.C., Steig A.J., Stob N.R., Van Pelt R.E., Wang H., Eckel R.H. The metabolic syndrome. Endocr. Rev. 2008, 29:777-822.
9. Davaatseren M., Hur H.J., Yang H.J., Hwang J.T., Park J.H., Kim H.J., Kim M.S., Kim M.J., Kwon D.Y., Sung.M.J. J. Med. Food 2013, 16:26-33.
10. Després J.P., Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006, 444:881-887.
11. Domitrovića R., Jakovacb H., Tomacc J., Šain I. Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin. Toxicol. Appl. Pharmacol. 2009, 241:311-321.
12. Domitrovića R., Jakovacb H., Romićc Ž., Rahelićd D., Tadiće Ž. Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice. J. Ethnopharmacol. 2010, 130:569-577.
13. Everette J.D., Bryant Q.M., Green A.M., Abbey Y.A., Wangila G.W., Walker R.B. Thorough study of reactivity of various compound classes toward the Folin-Ciocalteu reagent. J. Agric. Food Chem. 2010, 58(14):8139.
14. Goldstein J.L., Rawson R.B., Brown M.S. Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Arch. Biochem. Biophys. 2002, 397:139-148.
15. Hamaguchi M., Kojima T., Takeda N., Nakagawa T., Taniguchi H., Fujii K. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann. Intern. Med. 2005, 143:722-728.
16. Hardie D.G. AMPK: a key regulator of energy balance in the single cell and the whole organism. Int. J. Obes. (Lond.) 2008, 32:7S-12S.
17. Hegarty B.D., Cooney G.J., Kraegen E.W., Furler S.M. Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat diet insulin resistant rats. Diabetes 2002, 51:1477-1484.
18. Hiquchi N., Kato M., Tanaka M., Miyazaki M., Takao S., Kohjima M., Kotoh K., Enjoji M., Nakamuta M., Takayanagi R. Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease. Exp. Ther. Med. 2011, 2:1077-1081.
19. Hu C., Kitts D.D. Dandelion (Taraxacum officinale) flower extract suppresses both reactive oxygen species and nitric oxide and prevents lipid oxidation in vitro. Phytomedicine 2005, 12:588-597.
20. Huanga D.W., Shenb S.C. Caffeic acid and cinnamic acid ameliorate glucose metabolism via modulating glycogenesis and gluconeogenesis in insulin-resistant mouse hepatocytes. J. Funct. Foods 2012, 4:358-366.
21. Ikawa M., Schaper T.D., Dollard C.A., Sasner J.J. Utilization of Folin-Ciocalteu phenol reagent for the detection of certain nitrogen compounds. J. Agric. Food Chem. 2003, 51(7):1811-1815.
22. Jang H.H., Park M.Y., Kim H.W., Lee Y.M., Hwang K.A., Park J.H., Park D.S., Kwon O. Black rice (Oryza satava L.) extract attenuates hepatic steatosis in C57BL6/J mice fed a high-fat diet via fatty acid oxidation. Nutr. Metab. 2012, 9:27.
23. Kim K.J., Lee M.S., Jo K., Hwang J.K. Piperidine alkaloids from Piperretrofractum Vahl. protect against high-fat diet-induced obesity by regulating lipid metabolism and activating AMP-activated protein kinase. Biochem. Biophys. Res. Commun. 2011, 411:219-225.
24. Kim M.S., Hur H.J., Kwon D.Y., Hwang J.T. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and glucose tolerance in high-fat diet-induced obese mice. Mol. Cell. Endocrin. 2012, 358:127-134.
25. Koh Y.J., Cha D.S., Ko J.S., Park H.J., Choi H.D. Anti-inflammatory effect of Taraxacum officinale leaves on lipopolysaccharide-induced inflammatory responses in RAW 264.7 cells. J. Med. Food. 2010, 13:870-878.
26. Melo C.L., Queiroz M.G.R., Fonseca S.G.C., Bizerra A.M.C., Lemos T.L.G., Melo T.S., Santos F.A., Rao V.S. Oleanolic acid, a natural triterpenoid, improves blood glucose in normal mice and ameliorates visceral obesity in mice fed a high-fat diet. Chem. Biol. Interact. 2010, 185:59-65.
27. Mhairi C., Towler D., Gragane G. AMPK-activated protein kinase in metabolic control and insulin signaling. Circ. Res. 2007, 100:328-341.
28. Olefsky J.M. Fat talks, liver and muscle listen. Cell 2008, 134:914-916.
29. Ouadda A.B., Levy E., Ziv E., Lalond G., Sané A.T., Delvin E., Elchebly M. Increased hepatic lipogenesis in insulin resistance and type 2 diabetes is associated with AMPK signaling pathway up-regulation in Psammomys obesus. Biosci. Rep. 2009, 29:283-292.
30. Park C.M., Cha Y.S., Youn H.J., Cho C.W., Song Y.S. Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in Sprague-Dawley rats. Phytother. Res. 2010, 24:1347-1353.
31. Polyzos S.A., Kountouras J., Zavos C. Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines. Curr. Mol. Med. 2009, 9:299-314.
32. Racz-Kotilla E., Racz G., Solomon A. The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals. Planta Med. 1974, 26:212-217.
33. Sarafidis P.A., Nilsson P.M. The metabolic syndrome: a glance at its history. J. Hypertens. 2006, 24:621-626.
34. Schutz K., Kammerer D.R., Carle R., Schieber A. Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 2005, 19:179-186.
35. Schutz K., Carle R., Schieber A. Taraxacum - a review on its phytochemical and pharmacological profile. J. Ethnopharmacol. 2006, 107:313-323.
36. Singleton V.L., Orthofer R., Lamuela-Raventós R.M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. 1999, 299:152.
37. Turner R.C., Holman R.R., Matthews D., Hockaday T.D., Peto J. Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations. Metabolism 1979, 28(11):1086-1096.
38. Williams C.A., Goldstone F., Greenham J. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry 1996, 42:121-127.
39. Zimmet P., Alberti K.G., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414:782-787.