Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 17, 2014, Pages 4968-4997

  Laufer, Radoslaw ^a   Ng, Grace ^a   Liu, Yong ^a   Patel, Narendra Kumar B ^a   Edwards, Louise G ^a   Lang, Yunhui ^a   Li, Sze Wan ^a   Feher, Miklos ^a   Awrey, Don E ^a   Leung, Genie ^a   Beletskaya, Irina ^a   Plotnikova, Olga ^a   Mason, Jacqueline M ^a   Hodgson, Richard ^a   Wei, Xin ^a   Mao, Guodong ^a   Luo, Xunyi ^a   Huang, Ping ^a   Green, Erin ^a   Kiarash, Reza ^a   Lin, Dan Chi Chia ^a   Harris Brandts, Marees ^a   Ban, Fuqiang ^a   Nadeem, Vincent ^a   Mak, Tak W ^a   Pan, Guohua J ^a   Qiu, Wei ^a   Chirgadze, Nickolay Y ^a   Pauls, Henry W ^a   more..

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Anticancer; antimitotic agents; Indazolyl benzenesulfonamide; Mitotic kinase; Monopolar Spindle 1 kinase (Mps1); Tyrosine Threonine Kinase (TTK)

Indexed keywords

2 (DIMETHYLAMINO) 2 (2 ETHYLPHENYL) N [3 (3 SULFAMOYLPHENYL) 1H INDAZOL 5 YL]ACETAMIDE; 2 (PYRROLIDIN 1 YL) N [3 (3 SULFAMOYLPHENYL) 1H INDAZOL 5 YL] 2 (THIOPHEN 3 YL)ACETAMIDE; 2 METHOXY 2 PHENYL N [3 (3 SULFAMOYLPHENYL) 1H INDAZOL 5 YL]ACETAMIDE; 2 PHENYL N [3 (3 SULFAMOYLPHENYL) 1H INDAZOL 5 YL]ACETAMIDE; 3 (1H INDAZOL 3 YL)BENZENESULFONAMIDE; 3 (1H INDAZOL 3 YL)BENZENESULFONAMIDE DERIVATIVE; 3 (4 CHLORO 1H INDAZOL 3 YL)BENZAMIDE; 3 (4 CHLORO 1H INDAZOL 3 YL)BENZENESULFONAMIDE; 3 (4 METHOXY 1H INDAZOL 3 YL)BENZENESULFONAMIDE; 3 (5 METHOXY 1H INDAZOL 3 YL)BENZENESULFONAMIDE; 3 (5 PHENYL 1H INDAZOL 3 YL)BENZENESULFONAMIDE; 3 (6 PHENYL 1H INDAZOL 3 YL)BENZENESULFONAMIDE; 3 PHENYL 1H INDAZOLE; 3 PHENYL 1H INDAZOLE DERIVATIVE; 3 [4 (2,6 DIFLUOROPHENYL) 1H INDAZOL 3 YL]BENZENESULFONAMIDE; 4 (4 CHLORO 1H INDAZOL 3 YL)BENZENESULFONAMIDE; ACETAMIDE DERIVATIVE; AMIDE; FLUOROURACIL; IMATINIB; INDAZOLE DERIVATIVE; N (1H INDAZOL 5 YL)ACETAMIDE DERIVATIVE; N [3 (3 SULFAMOYLPHENYL) 1H INDAZOL 5 YL]ACETAMIDE; N [3 (3 SULFAMOYLPHENYL) 1H INDAZOL 5 YL]ACETAMIDE DERIVATIVE; PROTEIN KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE THREONINE KINASE; SORAFENIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; [3 (4 CHLORO 1H INDAZOL 3 YL)PHENYL]METHANAMINE; 2-(DIMETHYLAMINO)-2-(2-ETHYLPHENYL)-N-(3-(3-SULFAMOYLPHENYL)-1H-INDAZOL-5-YL)ACETAMIDE; BENZENEACETAMIDE DERIVATIVE; CELL CYCLE PROTEIN; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; TTK PROTEIN, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CELL PROLIFERATION; COLON CARCINOMA; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSAGE SCHEDULE COMPARISON; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOLECULAR MODEL; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; METABOLISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

AMIDES; BENZENEACETAMIDES; CELL CYCLE PROTEINS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; INDAZOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906937206     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.06.027     Document Type: Article

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