Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125

Journal of Biological Chemistry

Volumn 283, Issue 31, 2008, Pages 21495-21500

  Chu, Matthew L H ^a   Chavas, Leonard M G ^a   Douglas, Kenneth T ^a   Eyers, Patrick A ^a   Tabernero, Lydia ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; CANCER.; CATALYTIC DOMAINS; CELL CYCLES; CHROMOSOMAL INSTABILITIES; COMPETITIVE INHIBITORS; GAIN INSIGHTS; HYDROPHOBIC INTERACTIONS; MALIGNANT CELLS; MOLECULAR MECHANISMS; NEW THERAPEUTIC AGENTS; POTENTIAL MECHANISMS; PROTEIN KINASES; RATIONAL DESIGNS; SMALL MOLECULES; X-RAY STRUCTURES;

BINDING ENERGY; BINDING SITES; CELL GROWTH; FLOW INTERACTIONS; GROWTH KINETICS; HYDROPHOBICITY; SECURITY OF DATA;

CRYSTAL STRUCTURE;

ADENOSINE TRIPHOSPHATE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; MONOPOLAR SPINDLE 1 PROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN; ENZYME INHIBITOR; PROTEIN SERINE THREONINE KINASE; TTK PROTEIN, HUMAN;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STABILITY; HYDROPHOBICITY; INHIBITION KINETICS; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; STRUCTURE ANALYSIS; BINDING COMPETITION; CHEMISTRY; CONFORMATION; HUMAN; METHODOLOGY; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; ANTHRACENES; ANTINEOPLASTIC AGENTS; BINDING SITES; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CELL CYCLE PROTEINS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MOLECULAR CONFORMATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES;

EID: 52049119927     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803026200     Document Type: Article

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