Structure-based design of orally bioavailable 1 h -Pyrrolo[3,2- C ]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)

Journal of Medicinal Chemistry

Volumn 56, Issue 24, 2013, Pages 10045-10065

  Naud, Sébastien ^a   Westwood, Isaac M ^a   Faisal, Amir ^a   Sheldrake, Peter ^a   Bavetsias, Vassilios ^a   Atrash, Butrus ^a   Cheung, Kwai Ming J ^a   Liu, Manjuan ^a   Hayes, Angela ^a   Schmitt, Jessica ^a   Wood, Amy ^a   Choi, Vanessa ^a   Boxall, Kathy ^a   Mak, Grace ^a   Gurden, Mark ^a   Valenti, Melanie ^a   De Haven Brandon, Alexis ^a   Henley, Alan ^a   Baker, Ross ^a   McAndrew, Craig ^a   Matijssen, Berry ^a   Burke, Rosemary ^a   Hoelder, Swen ^a   Eccles, Suzanne A ^a   Raynaud, Florence I ^a   Linardopoulos, Spiros ^a   Van Montfort, Rob L M ^a   Blagg, Julian ^a   more..

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1H PYRROLO[3,2 C ]PYRIDINE INHIBITOR; 3 CHLORO N,N DIMETHYL 4 [2 (1 METHYL 1H PYRAZOL 4 YL) 1H PYRROLO[3,2 C]PYRIDIN 6 YL AMINO]BENZAMIDE; ENZYME INHIBITOR; MITOTIC KINASE MONOPOLAR SPINDLE 1; PROTEIN KINASE; TERT BUTYL 6 [2 CHLORO 4 (1 METHYL 1H IMIDAZOL 5 YL)PHENYLAMINO] 2 (1 METHYL 1H PYRAZOL 4 YL) 1H PYRROLO[3,2 C]PYRIDINE 1 CARBOXYLATE; TERT BUTYL 6 [2 CHLORO 4 (DIMETHYLCARBAMOYL)PHENYLAMINO] 2 (1 METHYL 1H PYRAZOL 4 YL) 1H PYRROLO[3,2 C]PYRIDINE 1 CARBOXYLATE; UNCLASSIFIED DRUG;

ANEUPLOIDY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; BREAST TUMOR; CELL SURVIVAL; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; GENE; HUMAN; HUMAN CELL; M PHASE CELL CYCLE CHECKPOINT; MOUSE; NONHUMAN; RAT; TUMOR XENOGRAFT; X RAY CRYSTALLOGRAPHY;

EID: 84891298378     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401395s     Document Type: Article

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