Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1

Molecular Cancer Therapeutics

Volumn 10, Issue 12, 2011, Pages 2267-2275

  Tardif, Keith D ^a,b   Rogers, Aaron ^a   Cassiano, Jared ^a,d   Roth, Bruce L ^a   Cimbora, Daniel M ^a   McKinnon, Rena ^a,e   Peterson, Ashley ^a,c   Douce, Thomas B ^a   Robinson, Rosann ^a,h   Dorweiler, Irene ^a,d   Davis, Thaylon ^a,g   Hess, Mark A ^a   Ostanin, Kirill ^a,e   Papac, Damon I ^a,f   Baichwal, Vijay ^a   McAlexander, Ian ^a   Willardsen, J Adam ^a   Saunders, Michael ^a,c   Christophe, Hoarau ^a   Kumar, D Vijay ^a   Wettstein, Daniel A ^a   Carlson, Robert O ^a   Williams, Brandi L ^a,h   more..

^a Myrexis Inc   (United States)

^b ARUP LABORATORIES   (United States)

^c Supergen Inc   (United States)

^d UNIVERSITY OF UTAH   (United States)

^e NAVIGEN INC   (United States)

^f SOUTHERN RESEARCH INSTITUTE   (United States)

^g UNIVERSITY OF UTAH   (United States)

^h UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BUB1 RELATED PROTEIN; CHECKPOINT KINASE RAD3; CYCLIN B; CYTOTOXIC AGENT; ENZYME INHIBITOR; FLUOROURACIL; MPI 0479605; MPI 0485812; PROTEIN KINASE; PROTEIN KINASE MPS1; PROTEIN P21; PROTEIN P53; SECURIN; SERINE; THREONINE; UNCLASSIFIED DRUG;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL STRAIN HCT116; CELL STRAIN HEK293; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DOSE RESPONSE; DRUG SCREENING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; MICRONUCLEUS; MITOSIS SPINDLE; MOUSE; NEUTROPENIA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SINGLE DRUG DOSE; SPINDLE ASSEMBLY CHECKPOINT; WILD TYPE;

ADENINE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HCT116 CELLS; HUMANS; MICE; MICE, NUDE; MITOSIS; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; MORPHOLINES; NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; SMALL MOLECULE LIBRARIES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 83355174038     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-11-0453     Document Type: Article

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