Induction of apoptosis of β cells of the pancreas by advanced glycation end-products, important mediators of chronic complications of diabetes mellitus

Annals of the New York Academy of Sciences

Volumn 1150, Issue , 2008, Pages 311-315

  Lim, Minsu ^a   Park, Leejin ^a   Shin, Geewook ^a   Hong, Hekyung ^a   Kang, Incheol ^b   Park, Yongsoo ^a,c  

^a Hanyang University College of Medicine   (South Korea)

^b Hoseo University   (South Korea)

^c Hanyang University College of Medicine   (South Korea)

Author keywords

Advanced glycation end products; Reactive oxygen species; Receptor for AGE

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT 3; ADVANCED GLYCATION END PRODUCT RECEPTOR; ADVANCED GLYCATION END PRODUCT RECEPTOR ANTIBODY; ADVANCED GLYCOSYLATION END PRODUCT 2; ANNEXIN V ANTIBODY; ANTIOXIDANT; BOVINE SERUM ALBUMIN; GLUCOALDEHYDE; GLUCOSE; GLYCERALDEHYDE; KI 67 ANTIGEN; LIPOCORTIN 5; METALLOTHIONEIN; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL ANTIBODY; RAD51 PROTEIN; RAD52 PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; CELL CYCLE ARREST; CELL PROLIFERATION; CHRONIC DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DNA RECOMBINATION; DNA REPAIR; FLUORESCENCE ACTIVATED CELL SORTING; HISTOPATHOLOGY; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; NICK END LABELING; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT;

EID: 57749184079     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1447.011     Document Type: Conference Paper

References (9)

1. Wautier, J.L. et al. 2001. Advanced glycation end products, their receptors and diabetic angiopathy. Diab. Metab. 27 : 535 542.
2. Unoki, H. et al. 2007. Advanced glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytes. Diab. Res. Clin. Pract. 76 : 236 244.
3. Kume, S. et al. 2005. Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone. J. Bone Miner. Res. 20 : 1647 1658.
4. Mercer, N. et al. 2007. Regulation of advanced glycation end product (AGE) receptors and apoptosis by AGEs in osteoblast-like cells. Mol. Cell Biochem. 306 : 87 94.
5. Gotoh, M. et al. 1985. An improved method for isolation of mouse pancreatic islets. Transplantation 40 : 437 438.
6. Chen, B.H. et al. 2006. Advanced glycation end-products induce apoptosis involving the signaling pathways of oxidative stress in bovine retinal pericytes. Life Sci. 79 : 1040 1048.
7. Kausch, I. et al. 2003. Antisense treatment against Ki-67 mRNA inhibits proliferation and tumor growth in vitro and in vivo. Int. J. Cancer. 105 : 710 716.
8. Ahn, E.H. et al. 2006. Profiling of differential protein expression in angiogenin-induced HUVECs using antibody-arrayed ProteoChip. Proteomics 6 : 1104 1109.
9. Jackson, S.P. 2001. Detecting, signalling and repairing DNA double-strand breaks. Biochem. Soc. Trans. 29 : 655 661.